CN103874682A - 作为rock激酶抑制剂的联苯基羧酰胺 - Google Patents

作为rock激酶抑制剂的联苯基羧酰胺 Download PDF

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CN103874682A
CN103874682A CN201280048511.XA CN201280048511A CN103874682A CN 103874682 A CN103874682 A CN 103874682A CN 201280048511 A CN201280048511 A CN 201280048511A CN 103874682 A CN103874682 A CN 103874682A
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group
cycloalkyl
radical
diseases
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J·阿兰
S·波兰德
A·P·J·布兰
O·戴非尔特
D·雷森
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Amakem NV
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Amakem NV
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    • C07D213/72—Nitrogen atoms
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  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280048511.XA 2011-08-31 2012-08-31 作为rock激酶抑制剂的联苯基羧酰胺 Pending CN103874682A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11179491.3 2011-08-31
EP11179491 2011-08-31
PCT/EP2012/067018 WO2013030367A1 (en) 2011-08-31 2012-08-31 Biphenylcarboxamides as rock kinase inhibitors

Publications (1)

Publication Number Publication Date
CN103874682A true CN103874682A (zh) 2014-06-18

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Application Number Title Priority Date Filing Date
CN201280048511.XA Pending CN103874682A (zh) 2011-08-31 2012-08-31 作为rock激酶抑制剂的联苯基羧酰胺
CN201280048514.3A Pending CN103874683A (zh) 2011-08-31 2012-08-31 新的rock激酶抑制剂
CN201280048515.8A Pending CN103874684A (zh) 2011-08-31 2012-08-31 新的软rock抑制剂

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201280048514.3A Pending CN103874683A (zh) 2011-08-31 2012-08-31 新的rock激酶抑制剂
CN201280048515.8A Pending CN103874684A (zh) 2011-08-31 2012-08-31 新的软rock抑制剂

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Country Link
US (3) US9174939B2 (https=)
EP (3) EP2751078A1 (https=)
JP (3) JP2014525425A (https=)
KR (2) KR20140072879A (https=)
CN (3) CN103874682A (https=)
AU (3) AU2012300833B2 (https=)
BR (3) BR112014004435A2 (https=)
CA (3) CA2846695A1 (https=)
EA (3) EA201490515A1 (https=)
ES (1) ES2560830T3 (https=)
IL (2) IL231123A0 (https=)
MX (3) MX2014002395A (https=)
PT (1) PT2751080E (https=)
SG (2) SG11201400117QA (https=)
WO (3) WO2013030366A1 (https=)
ZA (3) ZA201401418B (https=)

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JP2014525425A (ja) 2011-08-31 2014-09-29 アマケン エンヴェー 新規のｒｏｃｋキナーゼ阻害剤
PL2903618T3 (pl) 2012-10-05 2022-09-19 Kadmon Corporation, Llc Inhibitory kinazy rho
SMT201700317T1 (it) 2013-01-29 2017-09-07 Redx Pharma Plc Derivati piridinici in qualità di inibitori rock teneri
JP5840324B2 (ja) * 2013-04-15 2016-01-06 株式会社レナサイエンス Ｐａｉ−１阻害剤の新規用途
ME03398B (me) * 2013-12-17 2020-01-20 Lilly Co Eli Spojevi dimetilbenzojeve kiseline
US20170114323A1 (en) 2014-06-19 2017-04-27 Whitehead Institute For Biomedical Research Uses of kinase inhibitors for inducing and maintaining pluripotency
CA3110661A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
CN113801111B (zh) * 2020-06-12 2025-10-17 上海翰森生物医药科技有限公司 联苯类衍生物抑制剂及其制备方法和应用
US12371667B2 (en) 2021-05-13 2025-07-29 Washington University Enhanced methods for inducing and maintaining naive human pluripotent stem cells
JPWO2023085369A1 (https=) 2021-11-11 2023-05-19
EP4387730B1 (en) * 2022-09-08 2025-05-28 Redx Pharma Limited Solid forms of a rock inhibitor
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