CN103860933A - Traditional Chinese medicine for treating endosulfan toxication - Google Patents
Traditional Chinese medicine for treating endosulfan toxication Download PDFInfo
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- CN103860933A CN103860933A CN201410103543.6A CN201410103543A CN103860933A CN 103860933 A CN103860933 A CN 103860933A CN 201410103543 A CN201410103543 A CN 201410103543A CN 103860933 A CN103860933 A CN 103860933A
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Abstract
The invention relates to a traditional Chinese medicine for treating endosulfan toxication, which is prepared from the following raw medicinal materials in weight: 10-15 g of rheum officinale, 12-18 g of aloe, 8-12 g of Chinese angelica, 10-15 g of folium sennae, 10-15 g of rhizoma alismatis, 8-12 g of radix bupleuri, 8-12 g of semen plantaginis, 12-18 g of radix rehmanniae, 8-12 g of caulis bambusae in taeniam, 10-15 g of scutellaria baicalensis, 10-15 g of immature bitter orange, and 10-15 g of mangnolia officinalis. The traditional Chinese medicine for treating endosulfan toxication, which is disclosed by the invention, is wide in source, low in cost, simple and reasonable in preparation and good in curative effect, has the effects of improving laxation, discharging fire, clearing heat and removing toxicity, and is capable of effectively treating endosulfan toxication.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of Chinese medicine for the treatment of Endosulfan poisoning.
Background technology
5a,6,9,9a-hexahydro-6,9-methano-2,4 is a kind of high malicious organochlorine insecticides, also referred to as large pellet, match pellet etc., is widely used in preventing and treating all kinds of crop pests, and is difficult to replace with other pesticide.Poison through the mouth is the main approach of Endosulfan poisoning, and the most state of an illness weights of poison through the mouth patient, show as status epilepticus, stupor, pulmonary edema, respiratory failure, hepatic renal dysfunction etc., and multiple organ dysfunction syndrome's incidence rate is high, and mortality rate is high.Therefore the Chinese medicine of researching and developing the safe and effective treatment Endosulfan poisoning of a kind of energy is very with practical value.
Summary of the invention
The object of the invention is the deficiency in order to solve above-mentioned technology, a kind of good effect, short treating period are provided, expense is low, cure rate is high, and has no side effect, and can effectively treat the Chinese medicine of Endosulfan poisoning, by selecting suitable compound ratio, reach the object of safe and effective healing Endosulfan poisoning.
For achieving the above object, a kind of Chinese medicine for the treatment of Endosulfan poisoning, is characterized in that it is to be made up of the material medicine proportioning of following weight: Radix Et Rhizoma Rhei 10-15g, Aloe 12-18g, Radix Angelicae Sinensis 8-12g, Folium Sennae 10-15g, Rhizoma Alismatis 10-15g, Radix Bupleuri 8-12g, Semen Plantaginis 8-12g, Radix Rehmanniae 12-18g, Caulis Bambusae In Taenia 8-12g, Radix Scutellariae 10-15g, Fructus Aurantii Immaturus 10-15g, Cortex Magnoliae Officinalis 10-15g.
Chinese herb rhubarb of the present invention: cold in nature, bitter in the mouth, returns spleen, stomach, large intestine, liver, pericardium channel.Function: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Pyretic toxicity carbuncle and ulcer; Erysipelas.Modern medicine study proves, Radix Et Rhizoma Rhei has blood circulation promoting and blood stasis dispelling, improves microcirculation, promotes enterokinesia, protection intestinal mucosa, eliminate the inflammation medium and endotoxin, infection, antitumor, antioxidation, hypertension and hyperlipemia, adjusting immunity, regulate the effects such as clotting mechanism.Aloe: cold in nature, bitter in the mouth, returns liver, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent, returns liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Folium Sennae: cold in nature, sweet in the mouth, hardship, return large intestine channel.Function cures mainly: the row that purges heat is stagnant, relieving constipation, diuretic.Stagnant for accumulation of heat, constipation stomachache, edema distension.Rhizoma Alismatis: cold in nature, sweet in the mouth, returns kidney, urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.For dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention.Radix Bupleuri: cold nature, bitter in the mouth, pungent, returns Liver Channel, gallbladder meridian.Function cures mainly: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For cold, fever, cold and heat deficient fever, children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Semen Plantaginis: cold in nature, sweet in the mouth, returns liver, kidney, lung, small intestine meridian.Function cures mainly: clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances.For accumulation of heat in the urinary bladder, dysuria, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus.The Radix Rehmanniae: cold in nature, sweet in the mouth, GUIXIN, liver, kidney channel.Function cures mainly: have clearing away heat and cooling blood effect.For the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.Caulis Bambusae In Taenia: cold nature, sweet in the mouth, returns lung, stomach, gallbladder meridian.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, gallbladder fire is held expectorant under the arm, dysphoria with smothery sensation vomiting, and eye, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting are lost in palpitation with fear.Radix Scutellariae: cold in nature, bitter in the mouth, returns lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, and eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Fructus Aurantii Immaturus: cold in nature, bitter in the mouth, pungent, returns spleen, stomach, liver, heart channel.Function cures mainly: in stagnant, stop; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis.Cortex Magnoliae Officinalis: warm in nature, bitter in the mouth, pungent, returns spleen, stomach, lung, large intestine channel.Function cures mainly: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.Breath with cough for humidity hysteresis damaging the spleen and stomach, the vomiting and diarrhoea of gastral cavity painful abdominal mass, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention.Said medicine complements each other, and has collaborative effect of capturing pathogenic fire purging, heat-clearing and toxic substances removing, thereby reaches the object for the treatment of Endosulfan poisoning.
The preparation method of Chinese medicine of the present invention is: take by weight Radix Et Rhizoma Rhei, Aloe, Radix Angelicae Sinensis, Folium Sennae, Rhizoma Alismatis, Radix Bupleuri, Semen Plantaginis, the Radix Rehmanniae, Caulis Bambusae In Taenia, Radix Scutellariae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis; Clean, roguing, dry; Be ground into granule, put in multi-function extractor, decoct with water twice, the decocting that adds up for the first time 10 times of amounts of medical material boils 2 hours, gets filtrate 200ml, and the decocting that adds up for the second time 7 times of amounts of medical material boils 1 hour; Get twice decocting liquid and mix, filter, in heat-sealing bag, every bag of 200ml, 100 ℃ of high temperature sterilizes, pack and get final product.
When the administering mode of Chinese medicine of the present invention uses, inject from nasogastric tube with above-mentioned Chinese herbs decoction 200ml, after stopped pipe 2h, recover gastrointestinal decompression, every 12h is administered once, and is used in conjunction 8 days.
Chinese medicine of the present invention source is wide, cheap, and preparation is simple, reasonable, and good effect has collaborative effect of capturing pathogenic fire purging, heat-clearing and toxic substances removing, and cure rate is high.
The specific embodiment
Embodiment 1: a kind of Chinese medicine for the treatment of Endosulfan poisoning, composition and the content of its preparation are: Radix Et Rhizoma Rhei 15g, Aloe 18g, Radix Angelicae Sinensis 10g, Folium Sennae 15g, Rhizoma Alismatis 15g, Radix Bupleuri 8g, Semen Plantaginis 10g, Radix Rehmanniae 12g, Caulis Bambusae In Taenia 12g, Radix Scutellariae 10g, Fructus Aurantii Immaturus 10g, Cortex Magnoliae Officinalis 12g.Take by weight above-mentioned raw materials, clean, roguing, dry; Be ground into granule, put in multi-function extractor, decoct with water twice, the decocting that adds up for the first time 10 times of amounts of medical material boils 2 hours, gets filtrate, and the decocting that adds up for the second time 7 times of amounts of medical material boils 1 hour; Get twice decocting liquid and mix, filter, in heat-sealing bag, every bag of 200ml, 100 ℃ of high temperature sterilizes, pack and get final product.When use, inject from nasogastric tube with above-mentioned Chinese herbs decoction 200ml, after stopped pipe 2h, recover gastrointestinal decompression, every 12h is administered once, and is used in conjunction 8 days.
Embodiment 2: a kind of Chinese medicine for the treatment of Endosulfan poisoning, composition and the content of its preparation are: Radix Et Rhizoma Rhei 15g, Aloe 18g, Radix Angelicae Sinensis 8g, Folium Sennae 10g, Rhizoma Alismatis 15g, Radix Bupleuri 10g, Semen Plantaginis 10g, Radix Rehmanniae 12g, Caulis Bambusae In Taenia 12g, Radix Scutellariae 10g, Fructus Aurantii Immaturus 12g, Cortex Magnoliae Officinalis 10g.
Embodiment 3: a kind of Chinese medicine for the treatment of Endosulfan poisoning, composition and the content of its preparation are: Radix Et Rhizoma Rhei 15g, Aloe 18g, Radix Angelicae Sinensis 10g, Folium Sennae 10g, Rhizoma Alismatis 12g, Radix Bupleuri 12g, Semen Plantaginis 10g, Radix Rehmanniae 15g, Caulis Bambusae In Taenia 12g, Radix Scutellariae 15g, Fructus Aurantii Immaturus 15g, Cortex Magnoliae Officinalis 12g.
A kind of Clinical Action of Traditional Chinese Drugs observations for the treatment of Endosulfan poisoning
1. clinical data: select Endosulfan poisoning patient 28 examples of accepting for medical treatment during year October in August, 2008 to 2013, be oral Endosulfan poisoning, oral two amount 100～200ml.Be divided into treatment group and matched group according to random contrast principle.Treatment group 14 examples, male 7 examples, female's 7 examples.Matched group 14 examples, male 8 examples, female's 6 examples.Two groups of statistics are learned comparing difference without significance (P > 0.05), have comparability.
2. clinical experiment method
2.1 experimental drugs: Radix Et Rhizoma Rhei 10-15g, Aloe 12-18g, Radix Angelicae Sinensis 8-12g, Folium Sennae 10-15g, Rhizoma Alismatis 10-15g, Radix Bupleuri 8-12g, Semen Plantaginis 8-12g, Radix Rehmanniae 12-18g, Caulis Bambusae In Taenia 8-12g, Radix Scutellariae 10-15g, Fructus Aurantii Immaturus 10-15g, Cortex Magnoliae Officinalis 10-15g.
The preparation of 2.2 medicaments: take by weight above-mentioned raw materials, clean, roguing, dry; Be ground into granule, put in multi-function extractor, decoct with water twice, the decocting that adds up for the first time 10 times of amounts of medical material boils 2 hours, gets filtrate, and the decocting that adds up for the second time 7 times of amounts of medical material boils 1 hour; Get twice decocting liquid and mix, filter, in heat-sealing bag, every bag of 200ml, 100 ℃ of high temperature sterilizes, pack and get final product.
2.3 experimental techniques: treatment group is injected from nasogastric tube with above-mentioned Chinese herbs decoction 200ml, recovers gastrointestinal decompression after stopped pipe 2h, and every 12h is administered once, and is used in conjunction 8 days.Matched group gives the warm water of nasal feeding equivalent equitemperature.Two groups all need to coordinate other identical treatment measures, as thorough gastric lavage, catharsis, fluid infusion, diuresis, nutritional support and symptomatic treatment etc.
2.4 clinical efficacy criterion:
Recovery from illness: clinical symptoms all disappears, it is normal that laboratory examination results recovers.
Take a turn for the better: clinical symptom relief, laboratory examination results improves.
Invalid: clinical symptoms and lab testing are without taking a turn for the better or increasing the weight of.
2.5 statistical methods: with SPSS17.0 statistics software processes, have significance take P < 0.05 as difference.
3. result
After the patient of Endosulfan poisoning applies this Therapeutic Method, total effective rate improves, and treatment group total effective rate is 71.42% (with the relatively equal < 0.05 of P of matched group), matched group total effective rate 57.14%.
Table 1 liang group patient total effective rate
Note: with matched group comparison
ap < 0.05
The present invention verifies through clinical practice, has applied after our medicine in the patient of Endosulfan poisoning, and patient clinical symptom and laboratory examination results are all clearly better, and the present invention can safe and effective treatment Endosulfan poisoning.
Claims (1)
1. treat a Chinese medicine for Endosulfan poisoning, it is characterized in that it is to be made up of the material medicine proportioning of following weight: Radix Et Rhizoma Rhei 10-15g, Aloe 12-18g, Radix Angelicae Sinensis 8-12g, Folium Sennae 10-15g, Rhizoma Alismatis 10-15g, Radix Bupleuri 8-12g, Semen Plantaginis 8-12g, Radix Rehmanniae 12-18g, Caulis Bambusae In Taenia 8-12g, Radix Scutellariae 10-15g, Fructus Aurantii Immaturus 10-15g, Cortex Magnoliae Officinalis 10-15g.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375330A (en) * | 2002-04-12 | 2002-10-23 | 熊火则 | Toxicopathy treating composite medicine |
| CN101569704A (en) * | 2008-04-30 | 2009-11-04 | 曹脉源 | Traditional Chinese medicine for adjuvant therapy of hypnotic poisoning |
| CN102416111A (en) * | 2011-11-26 | 2012-04-18 | 王少云 | Chinese medicinal composition for treating cattle cotton cake positioning and preparation method thereof |
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- 2014-03-13 CN CN201410103543.6A patent/CN103860933A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375330A (en) * | 2002-04-12 | 2002-10-23 | 熊火则 | Toxicopathy treating composite medicine |
| CN101569704A (en) * | 2008-04-30 | 2009-11-04 | 曹脉源 | Traditional Chinese medicine for adjuvant therapy of hypnotic poisoning |
| CN102416111A (en) * | 2011-11-26 | 2012-04-18 | 王少云 | Chinese medicinal composition for treating cattle cotton cake positioning and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 葛淑芬: "急性有机磷农药中毒的中医辨治探微", 《中西医结合实用临床急救》 * |
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Application publication date: 20140618 |