CN1038583C - 酰基苯基甘氨酸衍生物及以其为有效成分的胶原酶活性亢进所致疾病的防治药物 - Google Patents

酰基苯基甘氨酸衍生物及以其为有效成分的胶原酶活性亢进所致疾病的防治药物 Download PDF

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Publication number
CN1038583C
CN1038583C CN94193055A CN94193055A CN1038583C CN 1038583 C CN1038583 C CN 1038583C CN 94193055 A CN94193055 A CN 94193055A CN 94193055 A CN94193055 A CN 94193055A CN 1038583 C CN1038583 C CN 1038583C
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CN
China
Prior art keywords
compound
methylamide
phenylglycine
isobutyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94193055A
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English (en)
Chinese (zh)
Other versions
CN1133034A (zh
Inventor
平山良一
月田高博
山本实
池田升司
坂本文夫
小畑雄司
松尾呼野美
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Bell Spinning Co ltd
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Filing date
Publication date
Application filed by Bell Spinning Co ltd filed Critical Bell Spinning Co ltd
Publication of CN1133034A publication Critical patent/CN1133034A/zh
Application granted granted Critical
Publication of CN1038583C publication Critical patent/CN1038583C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN94193055A 1993-08-09 1994-08-03 酰基苯基甘氨酸衍生物及以其为有效成分的胶原酶活性亢进所致疾病的防治药物 Expired - Fee Related CN1038583C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP218124/93 1993-08-09
JP21812493 1993-08-09

Publications (2)

Publication Number Publication Date
CN1133034A CN1133034A (zh) 1996-10-09
CN1038583C true CN1038583C (zh) 1998-06-03

Family

ID=16715014

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94193055A Expired - Fee Related CN1038583C (zh) 1993-08-09 1994-08-03 酰基苯基甘氨酸衍生物及以其为有效成分的胶原酶活性亢进所致疾病的防治药物

Country Status (10)

Country Link
US (1) US5795891A (enExample)
EP (1) EP0712838B1 (enExample)
KR (1) KR100312097B1 (enExample)
CN (1) CN1038583C (enExample)
AT (1) ATE172959T1 (enExample)
DE (1) DE69414396T2 (enExample)
DK (1) DK0712838T3 (enExample)
ES (1) ES2123808T3 (enExample)
TW (1) TW280810B (enExample)
WO (1) WO1995004715A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
WO1997019053A1 (en) 1995-11-23 1997-05-29 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
CN1060804C (zh) * 1997-03-17 2001-01-17 中国科学院微生物研究所 Iv型胶原酶特异性人源基因工程抗体
WO2001052891A1 (fr) * 2000-01-20 2001-07-26 Nippon Organon K. K. Inhibiteurs d'invasion plasmodiale dans des erythrocytes
BR112021006407A8 (pt) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med uso de inibidores do egfr para ceratodermas
CN110554118A (zh) * 2019-10-15 2019-12-10 宁夏师范学院 一种检测尿液中萘酚含量的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US4918105A (en) * 1987-01-06 1990-04-17 Sa Laboratoire Roger Bellon Novel compounds with collagenase-inhibiting activity, a process for their preparation and pharmaceutical compositions in which these compounds are present

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US4918105A (en) * 1987-01-06 1990-04-17 Sa Laboratoire Roger Bellon Novel compounds with collagenase-inhibiting activity, a process for their preparation and pharmaceutical compositions in which these compounds are present

Also Published As

Publication number Publication date
ATE172959T1 (de) 1998-11-15
EP0712838A1 (en) 1996-05-22
WO1995004715A1 (en) 1995-02-16
KR100312097B1 (ko) 2002-11-13
TW280810B (enExample) 1996-07-11
KR960703843A (ko) 1996-08-31
DE69414396D1 (de) 1998-12-10
DE69414396T2 (de) 1999-07-15
US5795891A (en) 1998-08-18
CN1133034A (zh) 1996-10-09
EP0712838B1 (en) 1998-11-04
ES2123808T3 (es) 1999-01-16
DK0712838T3 (da) 1999-07-19
EP0712838A4 (en) 1996-03-19

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Free format text: CORRECT: PATENTEE; FROM: KANEBO LTD. TO: AKZO NOBEL N.V.

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Address after: Holland Arnhem

Patentee after: Akzo Nobel N. V.

Address before: Tokyo, Japan

Patentee before: Kanebo Co., Ltd.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee