CN103830577B - 一种治疗肝胆结石和肾结石的药物组合物及其用途 - Google Patents
一种治疗肝胆结石和肾结石的药物组合物及其用途 Download PDFInfo
- Publication number
- CN103830577B CN103830577B CN201410113464.3A CN201410113464A CN103830577B CN 103830577 B CN103830577 B CN 103830577B CN 201410113464 A CN201410113464 A CN 201410113464A CN 103830577 B CN103830577 B CN 103830577B
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- calculus
- present
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 14
- 208000009911 Urinary Calculi Diseases 0.000 title abstract description 5
- 239000000203 mixture Substances 0.000 title description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 40
- 240000005528 Arctium lappa Species 0.000 claims description 8
- 235000003130 Arctium lappa Nutrition 0.000 claims description 8
- 241000050051 Chelone glabra Species 0.000 claims description 8
- 241000132536 Cirsium Species 0.000 claims description 8
- 244000111489 Gardenia augusta Species 0.000 claims description 8
- 235000018958 Gardenia augusta Nutrition 0.000 claims description 8
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 8
- 239000009636 Huang Qi Substances 0.000 claims description 8
- 241000112528 Ligusticum striatum Species 0.000 claims description 8
- 244000131316 Panax pseudoginseng Species 0.000 claims description 8
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 8
- 241001522129 Pinellia Species 0.000 claims description 8
- 241001250596 Pleione Species 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- -1 aqua Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 13
- 230000000202 analgesic effect Effects 0.000 abstract description 10
- 230000007812 deficiency Effects 0.000 abstract description 3
- 210000004185 liver Anatomy 0.000 description 28
- 238000002360 preparation method Methods 0.000 description 24
- 210000000941 bile Anatomy 0.000 description 19
- 241000699666 Mus <mouse, genus> Species 0.000 description 14
- 239000004575 stone Substances 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 11
- 201000010099 disease Diseases 0.000 description 9
- 239000013641 positive control Substances 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 240000002045 Guettarda speciosa Species 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- 241000132012 Atractylodes Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 210000003445 biliary tract Anatomy 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 201000001352 cholecystitis Diseases 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 210000000232 gallbladder Anatomy 0.000 description 4
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 4
- 229960001661 ursodiol Drugs 0.000 description 4
- 238000010171 animal model Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 125000000017 cortisol group Chemical group 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 208000019423 liver disease Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000021590 normal diet Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 206010008635 Cholestasis Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003809 bile pigment Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000007870 cholestasis Effects 0.000 description 2
- 231100000359 cholestasis Toxicity 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 208000001130 gallstones Diseases 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000007743 Acute Abdomen Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000031868 Calculus ureteric Diseases 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 208000002513 Flank pain Diseases 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000004658 Medicago sativa Species 0.000 description 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000000114 Pain Threshold Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 208000000014 Ureteral Calculi Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001091 chenodeoxycholic acid Drugs 0.000 description 1
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000001096 cystic duct Anatomy 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- BEGBSFPALGFMJI-UHFFFAOYSA-N ethene;sodium Chemical group [Na].C=C BEGBSFPALGFMJI-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 230000037040 pain threshold Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000008812 xiaoyanlidan Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
Description
Claims (2)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610043807.2A CN105535505A (zh) | 2014-03-25 | 2014-03-25 | 一种制备治疗肝胆结石的药物组合物的方法 |
CN201610043744.0A CN105456728A (zh) | 2014-03-25 | 2014-03-25 | 一种药物组合物在制备治疗肝胆结石药物中的用途 |
CN201410113464.3A CN103830577B (zh) | 2014-03-25 | 2014-03-25 | 一种治疗肝胆结石和肾结石的药物组合物及其用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410113464.3A CN103830577B (zh) | 2014-03-25 | 2014-03-25 | 一种治疗肝胆结石和肾结石的药物组合物及其用途 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610043807.2A Division CN105535505A (zh) | 2014-03-25 | 2014-03-25 | 一种制备治疗肝胆结石的药物组合物的方法 |
CN201610043744.0A Division CN105456728A (zh) | 2014-03-25 | 2014-03-25 | 一种药物组合物在制备治疗肝胆结石药物中的用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103830577A CN103830577A (zh) | 2014-06-04 |
CN103830577B true CN103830577B (zh) | 2016-06-01 |
Family
ID=50794679
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410113464.3A Active CN103830577B (zh) | 2014-03-25 | 2014-03-25 | 一种治疗肝胆结石和肾结石的药物组合物及其用途 |
CN201610043807.2A Withdrawn CN105535505A (zh) | 2014-03-25 | 2014-03-25 | 一种制备治疗肝胆结石的药物组合物的方法 |
CN201610043744.0A Withdrawn CN105456728A (zh) | 2014-03-25 | 2014-03-25 | 一种药物组合物在制备治疗肝胆结石药物中的用途 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610043807.2A Withdrawn CN105535505A (zh) | 2014-03-25 | 2014-03-25 | 一种制备治疗肝胆结石的药物组合物的方法 |
CN201610043744.0A Withdrawn CN105456728A (zh) | 2014-03-25 | 2014-03-25 | 一种药物组合物在制备治疗肝胆结石药物中的用途 |
Country Status (1)
Country | Link |
---|---|
CN (3) | CN103830577B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104587428A (zh) * | 2014-12-30 | 2015-05-06 | 黎细乐 | 治疗高尿酸血症合并肝胆结石的中药组合物及其制备方法 |
CN104548016A (zh) * | 2014-12-30 | 2015-04-29 | 黎细乐 | 一种中药组合物在制备治疗高尿酸血症药物中的用途 |
CN105106733A (zh) * | 2015-09-30 | 2015-12-02 | 吴淑芬 | 一种治疗胆囊结石的中药组合物 |
CN105535408A (zh) * | 2016-01-20 | 2016-05-04 | 青岛云天生物技术有限公司 | 一种治疗胆固醇结石的药物组合物及其用途 |
CN105770281A (zh) * | 2016-05-13 | 2016-07-20 | 晋利华 | 一种中西药结合治疗胆石症的组合药物 |
CN106421325A (zh) * | 2016-12-13 | 2017-02-22 | 四川西奈生物科技有限公司 | 软化肝胆结石的组合物 |
CN108578607A (zh) * | 2018-08-10 | 2018-09-28 | 青岛金丽雅医疗新技术发展有限公司 | 一种治疗肾结石的药物组合物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102949546A (zh) * | 2012-10-29 | 2013-03-06 | 逄瑞莲 | 一种治疗胆囊炎胆结石的中药 |
-
2014
- 2014-03-25 CN CN201410113464.3A patent/CN103830577B/zh active Active
- 2014-03-25 CN CN201610043807.2A patent/CN105535505A/zh not_active Withdrawn
- 2014-03-25 CN CN201610043744.0A patent/CN105456728A/zh not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102949546A (zh) * | 2012-10-29 | 2013-03-06 | 逄瑞莲 | 一种治疗胆囊炎胆结石的中药 |
Also Published As
Publication number | Publication date |
---|---|
CN105456728A (zh) | 2016-04-06 |
CN105535505A (zh) | 2016-05-04 |
CN103830577A (zh) | 2014-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103830577B (zh) | 一种治疗肝胆结石和肾结石的药物组合物及其用途 | |
CN102240318B (zh) | 一种益气增乳中药的制备方法和分析方法 | |
CN103705796B (zh) | 一种治疗腹泻的药物组合物及其制备方法 | |
CN104474231A (zh) | 治疗眼目暴赤肿痛、涩泪难开的中药制剂及其制备方法 | |
CN104043042A (zh) | 一种治疗肝胆结石的中药组合物及其用途 | |
CN103585583B (zh) | 一种治疗肝胆结石的中药组合物及其用途 | |
CN101664533B (zh) | 一种治疗急慢性乳腺增生的中药及制备方法 | |
CN104548016A (zh) | 一种中药组合物在制备治疗高尿酸血症药物中的用途 | |
CN103585504B (zh) | 一种治疗干燥综合征的中药组合物及应用 | |
CN110478452A (zh) | 一种治疗痛风的中药组合物及其制备方法 | |
CN102652819B (zh) | 一种妇炎康分散片及其制备方法 | |
CN104888157A (zh) | 一种治疗子宫肌瘤的中药制剂及其制备方法 | |
CN104474112A (zh) | 一种治疗泌尿系统结石的中药及其制备方法 | |
CN104147268B (zh) | 一种治疗肝胆结石的中药组合物及其制剂 | |
CN103191399A (zh) | 用于治疗支气管哮喘急性发作期的中药组合物 | |
CN106110048A (zh) | 一种治疗痤疮的药物组合物 | |
CN104352797A (zh) | 一种治疗晚期肺癌的中药及其应用 | |
CN1047948C (zh) | 治疗子宫肌瘤的口服型天然药物组合物 | |
CN104352629B (zh) | 一种治疗肝胆结石的中药组合物及其用途 | |
CN104491344A (zh) | 一种中药制剂在制备治疗眼目暴赤肿痛药物中的用途 | |
CN104587316B (zh) | 抗痛风组合物及其制备方法和应用 | |
CN103877509B (zh) | 一种治疗白血病的药物及其制备方法 | |
CN105641057A (zh) | 一种治疗脾不统血型原发性肾小球性血尿的药物组合物 | |
CN105853796A (zh) | 一种医治习惯性流产的药物组合物 | |
CN103933469B (zh) | 一种治疗子宫肌瘤的药剂及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Wu Lan Inventor before: Li Jinxia |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160505 Address after: 264003 high tech Zone, Shandong, Yantai science and technology Avenue, No. 39 Applicant after: YANTAI HUAWEN XINXIN PHARMACEUTICAL CO., LTD. Applicant after: Wu Lan Address before: 266200, No. seven, 179 village, Wenquan Town, Jimo, Shandong, Qingdao Applicant before: Cui Xinming |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160713 Address after: 264003 high tech Zone, Shandong, Yantai science and technology Avenue, No. 39 Patentee after: YANTAI HUAWEN XINXIN PHARMACEUTICAL CO., LTD. Address before: 264003 high tech Zone, Shandong, Yantai science and technology Avenue, No. 39 Patentee before: YANTAI HUAWEN XINXIN PHARMACEUTICAL CO., LTD. Patentee before: Wu Lan |
|
CB03 | Change of inventor or designer information |
Inventor after: Wu Lan Inventor after: Dai Yanhua Inventor after: Ding Li Inventor after: Che Ming Inventor after: Pan Yaogong Inventor before: Wu Lan |
|
CB03 | Change of inventor or designer information | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170605 Address after: The 26 group and the village Yin Yang Zhen Qidong city 226000 Jiangsu city of Nantong Province Patentee after: Qidong and Hong agricultural by-products professional cooperatives Address before: 264003 high tech Zone, Shandong, Yantai science and technology Avenue, No. 39 Patentee before: YANTAI HUAWEN XINXIN PHARMACEUTICAL CO., LTD. |
|
TR01 | Transfer of patent right |