CN103816214A - Application of peanut root extract in preparing medicines or foods for preventing and treating prostatic hyperplasia - Google Patents
Application of peanut root extract in preparing medicines or foods for preventing and treating prostatic hyperplasia Download PDFInfo
- Publication number
- CN103816214A CN103816214A CN201410103892.8A CN201410103892A CN103816214A CN 103816214 A CN103816214 A CN 103816214A CN 201410103892 A CN201410103892 A CN 201410103892A CN 103816214 A CN103816214 A CN 103816214A
- Authority
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- China
- Prior art keywords
- peanut root
- peanut
- root extract
- prostatic hyperplasia
- preparation
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- 241001553178 Arachis glabrata Species 0.000 title claims abstract description 32
- 235000020232 peanut Nutrition 0.000 title claims abstract description 32
- 235000017060 Arachis glabrata Nutrition 0.000 title claims abstract description 30
- 235000010777 Arachis hypogaea Nutrition 0.000 title claims abstract description 30
- 235000018262 Arachis monticola Nutrition 0.000 title claims abstract description 30
- 239000000284 extract Substances 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 title claims abstract description 19
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title claims abstract description 16
- 208000004403 Prostatic Hyperplasia Diseases 0.000 title claims abstract description 14
- 235000013305 food Nutrition 0.000 title claims abstract description 11
- 229940079593 drug Drugs 0.000 title claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 239000012141 concentrate Substances 0.000 claims abstract 2
- 239000012154 double-distilled water Substances 0.000 claims abstract 2
- 239000000706 filtrate Substances 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000047 product Substances 0.000 claims 4
- 238000009835 boiling Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 7
- 238000012360 testing method Methods 0.000 abstract description 5
- 239000002547 new drug Substances 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 17
- 238000012453 sprague-dawley rat model Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229960001712 testosterone propionate Drugs 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002424 anti-apoptotic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- WRLGYAWRGXKSKG-UHFFFAOYSA-M phenobarbital sodium Chemical compound [Na+].C=1C=CC=CC=1C1(CC)C(=O)NC([O-])=NC1=O WRLGYAWRGXKSKG-UHFFFAOYSA-M 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及医药食品技术领域，具体是花生根提取物在制备防治前列腺增生的药物或食品中的应用，花生根提取物药液的制备方法：首先将花生根洗净晾干粉粹，然后用提取液溶解，煮沸回流，其次冷却抽滤，将滤液浓缩，最后用双蒸水溶解浓缩物，使之达到药用级，本发明通过SD大鼠试验，验证了服用达到一定剂量的花生根提取物药液，能够有效地降低前列腺指数，抑制前列腺增生，本发明为花生根有可能被开发成一种疗效高、副作用小的防治前列腺增生提供一种新的药物来源，拓展了花生根的应用范围，而由于花生根本就是农作物，对人体的副作用小，具有种植广泛，来源丰富的优势，为花生的种植、农民增收将具有良好的经济效益和社会效益。The invention relates to the technical field of medicine and food, in particular to the application of peanut root extracts in the preparation of medicines or foods for preventing and treating prostatic hyperplasia, and the preparation method of peanut root extract medicinal liquid: firstly, the peanut roots are washed, dried and powdered, and then used The extract is dissolved, boiled and refluxed, then cooled and filtered, the filtrate is concentrated, and finally the concentrate is dissolved in double distilled water to make it reach the pharmaceutical grade. The present invention has passed the SD rat test to verify that the peanut root extract that reaches a certain dose The drug liquid can effectively reduce the prostate index and inhibit the hyperplasia of the prostate gland. The invention provides a new drug source for the prevention and treatment of the hyperplasia of the prostate gland, which may be developed into a peanut root with high curative effect and small side effects, and expands the application range of the peanut root , and because peanuts are basically crops, they have little side effects on the human body, have the advantages of being widely planted and rich in sources, and will have good economic and social benefits for the planting of peanuts and increasing farmers' income.
Description
Technical field
The present invention relates to medical technical field, the specifically application of Roots of Peanut extract in medicine or the food of preparation control prostatic hyperplasia.
Background technology
Benign prostatic hyperplasia (Benign Prostatic Hyperplasia, BPH) is elderly men common disease, frequently-occurring disease, and along with the aging of population in the world, its sickness rate constantly increases.Up to now, the pathogenesis of BPH still imperfectly understands.Have research to think, the generation of BPH is except relevant with the unconventionality expression of amplified gene, apoptogene and anti-apoptotic genes expression, probably also relevant with hero, estrogenic interaction unbalance and various somatomedin.After old people's androgen levels declines, the high expressed of apoptosis-related genes bcl-2 causes prostatic cell apoptosis to decline and is likely the principal element that BPH occurs.
At present, operative treatment BPH is evident in efficacy, but causes certain damage to patient.Seek Drug therapy, particularly plant amedica treatment, with its focus on entirety, control mend have concurrently, concern that side effect is little, stable curative effect is lasting advantage enjoys people.
Saying of among the people have " single side's taste " Roots of Peanut Chinese medicine, effect of the own tonify deficiency of Roots of Peanut, does not still have report but be applied in the medicine of preparation control prostatic hyperplasia or food.
Summary of the invention
The object of the invention is to Roots of Peanut extract to be applied in the medicine or food of preparation control prostatic hyperplasia, Roots of Peanut extract medicinal liquid is to be made up of following steps:
Steps A: collect and throw aside the fresh flowers in field and take root, clean to dry and shatter;
Step B: the ethanol that is 50-80% by volume fraction is as the product of extractant dissolving step A gained, boiling reflux a period of time;
Step C: by the cooling sucking filtration of product of step B gained, get filtrate;
Step D: by the product distilling under reduced pressure of step C gained, must fall concentrate;
Step e: the product of step D gained is dissolved with distilled water, obtain pharmaceutical grade medicinal liquid.
Further improve and be: the quality numerical value of Roots of Peanut described in said method is 1: 2 with the ratio of the volume numerical value of alcohol solvent.
Further improve and be: the liquor strength obtaining in described step e is equivalent to crude drug 10g/ml.
By the pharmacological evaluation to SD (Sprague-Dawley) rat, raise Roots of Peanut extract medicinal liquid and reach the rat of doses and do not fill with and raise Roots of Peanut extract medicinal liquid or filling and raise the low rat of Roots of Peanut extract liquid dose and compare to extra filling of rat, the prostate index of raising the rat that Roots of Peanut extract medicinal liquid reaches doses to the extra filling of rat is better.
The present invention has expanded the new medical applications of Roots of Peanut extract, for medicine or the food of control prostatic hyperplasia provide a kind of new medicament sources, and Roots of Peanut extract safety and low toxicity, side effect is little, raw material sources are abundant, for the medical value that makes full use of this crop of Semen arachidis hypogaeae is laid a good foundation.
The specific embodiment
In order to deepen understanding of the present invention, below in conjunction with embodiment, the present invention is described in further detail, this embodiment, only for explaining the present invention, does not form and limits protection domain.
Embodiment 1: the preparation of Roots of Peanut extract medicinal liquid
Steps A: collect and throw aside the fresh flowers in field and take root, clean to dry and shatter;
Step B: get the Roots of Peanut powder 500g in steps A, the ethanol 1000mi that is 60% by volume fraction dissolves as extractant, boiling reflux 30min;
Step C: the product of step B gained is cooled to 20 ℃ of sucking filtration, gets filtrate;
Step D: by the product distilling under reduced pressure of step C gained, must fall concentrate;
Step e: the product of step D gained is dissolved with 50ml distilled water, obtain pharmaceutical grade medicinal liquid.
The Roots of Peanut extract medicinal liquid of gained is equivalent to crude drug 10g/ml.
Embodiment 2: pharmacological testing
Test material:
1. animal:
Male SD rat, body weight 180-200g, no-special pathogen, is provided by Jiangxi College of Traditional Chinese Medicine animal center.
2. medicine and reagent:
The prepared Roots of Peanut extract of embodiment 1 medicinal liquid, Testosterone Propionate injection (TP) 25mg/ml, Shanghai General Pharmaceutical Co., ltd. produces.
3. test method:
SD rat is divided into 5 groups at random, 12 every group.
Normal group: normal feeding, not medication.
Model group: subcutaneous injection TP50mg/kg, 3 times weekly (Monday, three, five), continuous 14 days.
Treatment group: be divided into 3 groups, not only follow model group injection TP50mg/kg, also from first day just 3 times weekly (Monday, three, five), continuous irrigation is raised the Roots of Peanut extract medicinal liquid of various dose.Wherein, low dose group: Roots of Peanut extract medicinal liquid 1ml/kg; Middle dosage group: Roots of Peanut extract medicinal liquid 5ml/kg; High dose group: 10ml/kg.
The 15 day, fasting 10h, respectively organized rat and gives excessive sodium phenobarbital (100mg/kg) execution, separates rat prostate, takes rat body weight and prostate weight in wet base respectively with analytical balance, calculates prostate index.
Data and statistical disposition: parameters all represents with X ± S, significant difference adopts software spss10.0 to carry out variance analysis.
Model group is prostate weight in wet base and index increase compared with normal group, difference has statistical significance (P<0.01), middle and high dosage group and model group comparison, difference has statistical significance (P<0.05), low dose group is compared with model group, and difference does not possess statistical significance (P>0.05).
Table 1 each group SD rat prostate weight in wet base and index affect dosage group (X ± S, n=12)
4. result of the test:
Except normal group, all the other are respectively organized SD rat and have all injected Testosterone Propionate injection, and this can cause benign prostatic hyperplasia in rats, have set up benign prostatic hyperplasia in rats animal model.
Result of the test: according to the data in table 1, in middle and high dosage group, the prostate weight in wet base of rat is obviously compared model group minimizing, and prostate index has also reduced, and the rat of low dose group is compared model group, and prostate index does not have significant change.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410103892.8A CN103816214B (en) | 2014-03-17 | Application of the peanut root extract in the medicine or food for preparing preventing and treating hyperplasia of prostate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410103892.8A CN103816214B (en) | 2014-03-17 | Application of the peanut root extract in the medicine or food for preparing preventing and treating hyperplasia of prostate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103816214A true CN103816214A (en) | 2014-05-28 |
| CN103816214B CN103816214B (en) | 2018-02-09 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709846A (en) * | 2005-06-17 | 2005-12-21 | 彭秀兰 | Method for producing resveratrol extracted from peanut root |
| CN1903815A (en) * | 2006-08-08 | 2007-01-31 | 河南省农科院农副产品加工研究所 | Method of extracting veralkanol in peanut root using ultrasonic wave |
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709846A (en) * | 2005-06-17 | 2005-12-21 | 彭秀兰 | Method for producing resveratrol extracted from peanut root |
| CN1903815A (en) * | 2006-08-08 | 2007-01-31 | 河南省农科院农副产品加工研究所 | Method of extracting veralkanol in peanut root using ultrasonic wave |
Non-Patent Citations (2)
| Title |
|---|
| 一空蝉一: "花生根 治愈男性摄护腺肥大的药方(图)", 《360DOC个人图书馆，HTTP://WWW.360DOC.COM/CONTENT/12/0607/20/156649_216694136.SHTML》 * |
| 彭金年等: "微波消解-火焰原子吸收光谱法对花生根中六种微量元素的测定", 《中国现代药物应用》 * |
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| CB03 | Change of inventor or designer information |
Inventor after: Ma Yongchao Inventor after: Guo Xiaohui Inventor after: Chen Honglian Inventor after: Bei Zhanyu Inventor after: Luo Xiaobing Inventor after: Wang Min Inventor after: Zhao Lifang Inventor after: Chen Yongfang Inventor before: Bei Zhanyu Inventor before: Cui Yanbing Inventor before: Wang Wenbao Inventor before: Luo Hailan Inventor before: Lu Jianfeng |
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Granted publication date: 20180209 Termination date: 20190317 |
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