CN101543523B - Uyghur drug compound recipe extracting technology for chiccory - Google Patents
Uyghur drug compound recipe extracting technology for chiccory Download PDFInfo
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- CN101543523B CN101543523B CN2009101132577A CN200910113257A CN101543523B CN 101543523 B CN101543523 B CN 101543523B CN 2009101132577 A CN2009101132577 A CN 2009101132577A CN 200910113257 A CN200910113257 A CN 200910113257A CN 101543523 B CN101543523 B CN 101543523B
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Abstract
A new extracting technology for existing Uyghur drug chicory, which obtains volatile oil and aqueous extract by water existing celery seed and common fennel fruit, obtains alcohol extract by alcohol existing radicel, fennel root bark, and cichory root, sprinkles volatile oil after mixing the water extract and alcohol extract, then obtains the extract for 'Liver-protecting Cloth Ancestral Thermal', makes the extract into capsules or tablets or oral liquid or medicinal granules through groovy pharmaceutical method, or makes the extract into capsules or tablets or oral liquid or medicinal granules or extended release formulation or controlled release preparation with chinese traditional medicine and Western medicine. The experiment on the drug's effect indicates that the extract from Uyghur drug 'Liver-protecting Cloth Ancestral Thermal' employing the extracting technology can be used to Liver-protecting or preparing drugs for treating the liver-cold stomach-ache, spleen, stop, costaligia, arthrosis, ostalgia, rheumatism, urinary system disease.
Description
Technical field
The present invention relates to the novel technology for extracting of a kind of Uigurs medicine " hepatoprotective Bu Zure ", the extract that is obtained by this technology can be used as the purposes of hepatoprotective class medicine, can be used as also that treatment is liver-cold, the medicinal usage of stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Background technology
Along with the variation of growth in the living standard and social economy, life pattern, human beings'health theory and pursue the consciousness of quality of life and progressively strengthen, huge change has taken place in mankind nowadays spectrum of disease and therapeutic treatment pattern.Development difficulty is big, costly because chemical synthetic drug shows, the lead time is long, the toxic and side effects obvious defects, international medical market is sent out the natural plant product demand that aspects such as disease and health care, life lengthening have unique curative effect and is sharply risen to treatment chronic disease, immune disease, extra-high-speed, have data to show: nearly in the world 60% population almost completely depends on plant amedica and treats disease.Xinjiang is one of the world's four big Changshou Districts, and mysterious over the past thousands of years dimension doctor dimension medicine is being safeguarded the physical and mental health of Xinjiang people of all nationalities always.Under the dimension medical knowledge opinion that has much characteristic instructed, dimension doctor's dimension medicine had been set up based on practical experience, is the scientific system of feature with the wholistic therapy.Along with the development of modern society and the quickening of human lives's rhythm, increasing disease is endangering human beings'health, disease relate to multiple factor, many target spots path and network regulation, so the traditional treatment scheme at single target spot that western medical treatment is adopted in learning is difficult to prove effective.And the therapeutic scheme that dimension medicine is started with from integral body is a single medicinal material, also passes through multipath, many target spots act on the combination of a plurality of syndromes, produce prevention and therapeutic effect, practice for many years shows that it has good and clinical curative effect, has shown great advantage and characteristic.
" hepatoprotective Bu Zure " granule that ministry standard is recorded is that the people of Uygurs are used for the treatment of one of the most frequently used prescription medicine of various hepatitis over the past thousands of years, and its main component is seed of Herba Apii graveolentis, root of Herba Apii graveolentis, seed of Herba Cichorii Intybi, Semen Cuscutae, root of Herba Cichorii, root bark of Foeniculum vulgare Mill., Fructus Foeniculi.According to clinical experiment, the liver cirrhosis that the hot granule therapy viral hepatitis of hepatoprotective cloth group, drug induced hepatitis and alcoholic hepatitis cause, that liver metabolism toxic injury and fatty liver diseases cause is weak, the improvement of abdominal distention, uncomfortable liver area, jaundice, ascites, fatty liver, effect is obvious rapidly, is treatment hepatitis safe and effective medicine.Main Chinese medicinal materials saussurea intybus in the compound recipe has the extensive studies basis at home and abroad; a large amount of domestic and foreign literature report explanations; the saussurea intybus extract can obviously reduce because the rat liver SGPT that carbon tetrachloride causes; SGOT; Alkp and T.Bil level; have preferably anti-liver cytotoxic activity,, alcoholic liver and liver cirrhosis are all had good effect because the rats'liver damage that carbon tetrachloride causes has good protective effect.Research worker has obtained aesculetin after the effective ingredient that extracts in the Herba Cichorii is separated, and it can be protected because the hepatic injury that acetaminophen and carbon tetrachloride cause, this can explain the reason of Herba Cichorii as treatment hepatic injury medicine to a certain extent.In the uighur medicine theory, Uygur's medical material such as saussurea intybus is very general protecting the liver, using in the prescription of hepatoprotective.
" hepatoprotective Bu Zure " adopts traditional decocting cooking method to extract in the primary standard, and extraction process is simple, and effective ingredient is indeterminate, no quality control standard.Therefore, the present invention adopts different solvents to extract square Chinese crude drug classification back by to behind the chemical research of medical material of respectively distinguishing the flavor of in " hepatoprotective Bu Zure " side, effective ingredient in the side of extractioning at utmost, and extract has been carried out treating the pharmacodynamic study of hepatic injury.The stomach method of irritating is adopted in research, its result shows that extract that Uigurs medicine " hepatoprotective Bu Zure " adopts extraction process provided by the invention to obtain has and improves the effect that carbon tetrachloride causes acute liver damage model mice ALT and AST, can be used as the purposes of hepatoprotective class medicine, also can be used as the medicinal usage of liver-cold, the stomachache of treatment, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Summary of the invention
The object of the invention is to provide a kind of technology that existing Uigurs medicine compound recipe " hepatoprotective Bu Zure " is adopted new extraction, the seed of Herba Apii graveolentis of will writing out a prescription, Fructus Foeniculi adopts water extraction, obtain volatile oil and water extract, with seed of Herba Cichorii Intybi, Semen Cuscutae, root of Herba Apii graveolentis, root bark of Foeniculum vulgare Mill., root of Herba Cichorii adopts alcohol extraction, obtain alcohol extract, can obtain " hepatoprotective Bu Zure " extract with being sprayed into volatile oil behind water extract and the alcohol extract mix homogeneously, and with the extract that obtains routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.Show through the test of pesticide effectiveness: the extract that Uigurs medicine " hepatoprotective Bu Zure " adopts extraction process provided by the invention to obtain has and improves the effect that carbon tetrachloride causes acute liver damage model mice ALT and AST, can be used as the purposes of hepatoprotective class medicine, also can be used as the medicinal usage of liver-cold, the stomachache of treatment, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
A kind of Uigurs medicine compound recipe of the present invention " hepatoprotective Bu Zure " extraction process follows these steps to carry out:
A, get seed of Herba Apii graveolentis, Fructus Foeniculi, add the water that 5-15 doubly measures, soaked 1-6 hour, extract volatile oil according to a conventional method, extraction time 1-8 hour, collect volatile oil, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi, Semen Cuscutae, root of Herba Apii graveolentis, root bark of Foeniculum vulgare Mill. and root of Herba Cichorii and mix after, pulverize, add 5-15 alcohol doubly, reflux, extract, 1-5 time, each 2 hours, filter, merging filtrate, being evaporated to does not have the alcohol flavor, the crushed after being dried powdered obtains ethanol extract, and is standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine " hepatoprotective Bu Zure ";
E, with the extract of steps d routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.
Alcohol is methanol or ethanol or isopropyl alcohol or butanols among the step c, preferred alcohol, and its concentration is 50-95%.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the purposes of preparation treatment hepatoprotective class medicine.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the medicinal usage of preparation treatment stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Extract by extraction process acquisition of the present invention, has the effect that improves acute liver damage mice ALT and AST, can be used as the purposes of hepatoprotective class medicine, also can be used as the medicinal usage of liver-cold, the stomachache of treatment, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.Taking aesculetin in this technology simultaneously is index components, has increased stability of formulation, is convenient to quality of the pharmaceutical preparations control.
The specific embodiment
Embodiment 1
A, get the water that seed of Herba Apii graveolentis 53g, Fructus Foeniculi 53g add 5 times of amounts, soaked 1 hour, extract volatile oil according to a conventional method, 1 hour extraction time, collect volatile oil 0.3ml, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi 16g, Semen Cuscutae 4g, root of Herba Apii graveolentis 16g, root bark of Foeniculum vulgare Mill. 16g, root of Herba Cichorii 8g and mix after, pulverize, the concentration that adds 5 times is 50% ethanol, reflux, extract, 1 time, 2 hours time, filter, merging filtrate, being evaporated to does not have alcohol flavor, crushed after being dried powdered, obtain ethanol extract 13g, standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine " hepatoprotective Bu Zure ";
E, with the extract of steps d routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the purposes of preparation treatment hepatoprotective class medicine.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the medicinal usage of preparation treatment stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Embodiment 2
A, get the water that seed of Herba Apii graveolentis 53g, Fructus Foeniculi 53g add 8 times of amounts, soaked 2 hours, extract volatile oil according to a conventional method, 6 hours extraction times, collect volatile oil 0.9ml, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi 16g, Semen Cuscutae 4g, root of Herba Apii graveolentis 16g, root bark of Foeniculum vulgare Mill. 16g, root of Herba Cichorii 8g and mix after, pulverize, adding 8 times of amount concentration is 60% methanol, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, being evaporated to does not have alcohol flavor, crushed after being dried powdered, obtain ethanol extract 16g, standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine " hepatoprotective Bu Zure ";
E, with the extract of steps d routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the purposes of preparation treatment hepatoprotective class medicine.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the medicinal usage of preparation treatment stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Embodiment 3
A, get the water that seed of Herba Apii graveolentis 53g, Fructus Foeniculi 53g add 10 times of amounts, soaked 4 hours, extract volatile oil according to a conventional method, 5 hours extraction times, collect volatile oil 0.6ml, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi 16g, Semen Cuscutae 4g, root of Herba Apii graveolentis 16g, root bark of Foeniculum vulgare Mill. 16g, root of Herba Cichorii 8g and mix after, pulverize, adding 10 times of amount concentration is 70% isopropyl alcohol, reflux, extract, 4 times, each 2 hours, filter, merging filtrate, being evaporated to does not have alcohol flavor, crushed after being dried powdered, obtain ethanol extract 13g, standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine " hepatoprotective Bu Zure ";
E, with the extract of steps d routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the purposes of preparation treatment hepatoprotective class medicine.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the medicinal usage of preparation treatment stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Embodiment 4
A, get the water that seed of Herba Apii graveolentis 53g, Fructus Foeniculi 53g add 15 times of amounts, soaked 6 hours, extract volatile oil according to a conventional method, 8 hours extraction times, collect volatile oil 1.1ml, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi 16g, Semen Cuscutae 4g, root of Herba Apii graveolentis 16g, root bark of Foeniculum vulgare Mill. 16g, root of Herba Cichorii 8g and mix after, pulverize, adding 15 times of concentration is 95% ethanol, reflux, extract, 5 times, each 2 hours, filter, merging filtrate, being evaporated to does not have alcohol flavor, crushed after being dried powdered, obtain ethanol extract 7.6g, standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine " hepatoprotective Bu Zure ";
E, with the extract of steps d routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the purposes of preparation treatment hepatoprotective class medicine.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the medicinal usage of preparation treatment stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Embodiment 5
A, get the water that seed of Herba Apii graveolentis 53g, Fructus Foeniculi 53g add 25 times of amounts, soaked 4 hours, extract volatile oil according to a conventional method, 4 hours extraction times, collect volatile oil 0.8ml, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi 16g, Semen Cuscutae 4g, root of Herba Apii graveolentis 16g, root bark of Foeniculum vulgare Mill. 16g, root of Herba Cichorii 8g and mix after, pulverize, adding 12 times of concentration is 85% butanols, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, being evaporated to does not have alcohol flavor, crushed after being dried powdered, obtain ethanol extract 5.2g, standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine " hepatoprotective Bu Zure ";
E, with the extract of steps d routinely pharmaceutical methods make capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the purposes of preparation treatment hepatoprotective class medicine.
" hepatoprotective Bu Zure " extract that described extraction process obtains is as the medicinal usage of preparation treatment stomachache, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Embodiment 6
The present invention can improve CCl to the extract that Uigurs medicine " hepatoprotective Bu Zure " adopts new extraction process to obtain
4The chmice acute hepatic injury effect that causes.The results are shown in Table:
The result shows: the extract that adopts new technology provided by the invention to obtain, can be used as the purposes of preparation treatment hepatoprotective class medicine, or the medicinal usage of, stomachache liver-cold as the preparation treatment, spleen resistance costalgia, joint osteodynia, rheumatism, diseases of urinary system.
Claims (3)
1. Uyghur drug compound recipe extracting technology for chiccory is characterized in that following these steps to carrying out:
A, get seed of Herba Apii graveolentis, Fructus Foeniculi, add the water that 5-15 doubly measures, soaked 1-6 hour, extract volatile oil according to a conventional method, extraction time 1-8 hour, collect volatile oil, standby;
B, remaining aqueous solution among the step a is filtered, concentrate, the crushed after being dried powdered obtains water extract, and is standby;
C, get seed of Herba Cichorii Intybi, Semen Cuscutae, root of Herba Apii graveolentis, root bark of Foeniculum vulgare Mill. and root of Herba Cichorii and mix after, pulverize, add 5-15 alcohol doubly, reflux, extract, 1-5 time, each 2 hours, filter, merging filtrate, being evaporated to does not have the alcohol flavor, the crushed after being dried powdered obtains ethanol extract, and is standby;
D, with the water extract of step b and the abundant mix homogeneously of ethanol extract of step c, spray the volatile oil that step a collects then, can obtain the extract of Uigurs medicine Herba Cichorii compound recipe.
2. extraction process according to claim 1 is characterized in that alcohol is methanol or ethanol or isopropyl alcohol or butanols among the step c, and its concentration is 50-95%.
3. extraction process according to claim 1, the extract that it is characterized in that steps d pharmaceutical methods is routinely made capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation; Or with extract with in, the Western medicine compatibility makes capsule or tablet or oral liquid or electuary or slow releasing preparation or controlled release preparation and gets final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101132577A CN101543523B (en) | 2009-03-17 | 2009-03-17 | Uyghur drug compound recipe extracting technology for chiccory |
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| CN2009101132577A CN101543523B (en) | 2009-03-17 | 2009-03-17 | Uyghur drug compound recipe extracting technology for chiccory |
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| Publication Number | Publication Date |
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| CN101543523A CN101543523A (en) | 2009-09-30 |
| CN101543523B true CN101543523B (en) | 2011-08-17 |
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| CN106994137A (en) * | 2017-05-05 | 2017-08-01 | 新疆天山红药业有限公司 | Uygur medicine composition for treating hyperuricemia and gout and its preparation method and application |
| CN112353764A (en) * | 2020-06-15 | 2021-02-12 | 新疆维吾尔药业有限责任公司 | Bozuri hot granules and extraction method and application thereof |
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2009
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Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药典委员会编.护肝布祖热颗粒.《中华人民共和国卫生部药品标准维吾尔药分册》.1998,141. * |
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