CN103816084B - A kind of whitening and speckle dispelling slow release breast carrier and preparation method thereof - Google Patents
A kind of whitening and speckle dispelling slow release breast carrier and preparation method thereof Download PDFInfo
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- CN103816084B CN103816084B CN201410073407.7A CN201410073407A CN103816084B CN 103816084 B CN103816084 B CN 103816084B CN 201410073407 A CN201410073407 A CN 201410073407A CN 103816084 B CN103816084 B CN 103816084B
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Abstract
The invention discloses a kind of whitening and speckle dispelling slow release breast carrier and preparation method thereof, this is carrier loaded whitening and speckle dispelling active component, it is characterized in that described whitening and speckle dispelling slow release breast carrier components by its percentage by weight is: active component 0.5 ~ 1%; Vitamin E? 0.05 ~ 1%; Emollient 10 ~ 25%; Surfactant 15 ~ 30%; Wetting agent 5 ~ 15%; Mesoporous silicon 3 ~ 5%; PH adjusting agent 0.05 ~ 1%; All the other are deionized water.Whitening and speckle dispelling slow release breast carrier of the present invention belongs to w/o structure, mesoporous silicon easily forms the characteristic of hydrogen bond with the water-wet side of amphipathic surfactant with its structural oxygen atom, one deck shell is formed at oil-water interfaces place, delay the release time of active component, whitening and speckle dispelling slow release breast carrier of the present invention has good stability, preparation method is simple, is applied to the effect greatly can improving existing product in existing whitening cosmetics, has wide market.
Description
Technical field
The present invention relates to the carrier system technical field in novel cosmetic technology of preparing, relate to a kind of slow release breast carrier and preparation method thereof, particularly a kind of slow release breast and preparation method thereof of whitening and speckle dispelling active component.
Background technology
Each women wishes it oneself is the totally glittering and translucent Snow White of the colour of skin, and having delicate pale skin is the ultimate serious hope of women of liking to be beautiful.Mottle not only affects the external image of women, and can damage psychologically to them.
Mottle, refers to the speckle different with surrounding skin color, and it is a kind of dermatosis being common in face formed due to the increase of dermal melanin.Formed the reason of mottle have multiple as pressure greatly, hormone imbalance, metabolic disturbance, mistake make apply some make up and heredity etc.
Current all kinds of whitening and speckle dispelling skin-protection product and functional component continuous appearance as emerged rapidly in large numbersBamboo shoots after a spring rain, some effect and effect of truly having certain whitening and speckle dispelling, but because technical problem etc. can not play the effect of functional component completely in practical application, as active component does not reach lasting slow releasing effect and unstable active components etc., simultaneously regular use whitening and speckle dispelling product can cause the waste of burden and active component to skin.Therefore, to the development trend of probing into becoming science skin protection of the stability of the release time and increase active component that delay active component.
Summary of the invention
The object of whitening and speckle dispelling slow release breast carrier of the present invention is for the deficiencies in the prior art, provides a kind of emulsion with slow release characteristic.When its advantage is preparation w/o breast, solubilize active ingredients is in aqueous phase, be present in the inside of Water-In-Oil structure, mesoporous silicon is easy to its structural oxygen atom the characteristic forming hydrogen bond with surfactant water-wet side, one deck shell can be formed at oil-water interfaces place, because this increasing the barrier of active component release, extending the time of active component release, reaching slow release effect.
The object of the invention is to realize by the following method:
A kind of whitening and speckle dispelling slow release breast carrier, the composition of described slow release breast carrier is divided into by its percentage by weight:
Described slow release breast carrier belongs to w/o structure, and mesoporous silicon easily forms the characteristic of hydrogen bond with the water-wet side of amphipathic surfactant with its structural oxygen atom, forms one deck shell, extend the release time of active component at oil-water interfaces place.
Preferably, described active component be whitening and speckle dispelling active component generally used for cosmetic comprise in arbutin, Radix Glycyrrhizae extract, vitamin C and superoxide dismutase one or both.
Preferably, described emollient is one or more in isopropyl myristate, olive oil, Jojoba oil, Oleum Caryophylli, almond oil, American Avocado Tree oil, isopropyl palmitate, Miglyol 812, Fructus Citri Limoniae oil or octyl palmitate.
Preferably, described surfactant is one or more in polyoxyethylene (7) castor oil hydrogenated, Tween 80 or sorbester p17.
Preferably, described wetting agent is one or more in glycerol, propylene glycol, PEG-400 or ethanol.
Preferably, described mesoporous silicon is hexagonal mesoporous silicon.
Preferably, described pH adjusting agent is one or more in citric acid, tartaric acid, phosphoric acid, salicylic acid, sodium hydroxide or triethanolamine.
The present invention also provides the preparation method of a kind of whitening and speckle dispelling slow release breast carrier, comprises the following steps:
(1) emollient, vitamin E and wetting agent is taken, using their mixing and stirring as oil phase;
(2) take active component and deionized water, heated and stirred mix homogeneously is as aqueous phase;
(3) take mesoporous silicon and surfactant, they are mixed, after ultrasonic 8 ~ 10min, is joined in oil phase;
(4) dropwise being joined in oil phase by aqueous phase under stirring, is 6 ~ 7 by pH adjusting agent adjust ph, continues stirring 8 ~ 12h, forms the slow release breast carrier of whitening and speckle dispelling.
In said method, described stirring is magnetic agitation, and mixing speed is 600 ~ 1000rpm; Described heating-up temperature is 40 ~ 60 DEG C.
Compared with prior art, tool of the present invention has the following advantages:
(1) in the present invention, active ingredient encases, in inside, forms the stable shell of one deck at the water-wet side of oil-water interfaces place mesoporous silicon and surfactant by Van der Waals force.Because this increasing the barrier of active component release, extending the time of active component release, reaching slow release effect, and then reduce skin care item access times, greatly improve effect and the stability of active component.
(2) product of the present invention contains emollient ingredient, and skin has good spreadability, and form a skim at skin surface, skin is played to the effect of moisturizing and water retention, the vitamin E simultaneously added can supplement the nutrients to skin by antioxidation simultaneously;
(3) product of the present invention has good stability, is beneficial to long-term preservation;
(4) preparation method of the present invention is simple, and reproducible, production cost is low.Existing whitening and speckle dispelling active component directly can be added in this emulsion, be a kind of novel cosmetic active ingredient slow-released carrier, there is wide market.
Accompanying drawing explanation
Fig. 1 is the release in vitro behavior curve comparison figure of the embodiment of the present invention 1 and embodiment 5 active component arbutin;
Detailed description of the invention
Below in conjunction with embodiment, explanation is further explained to embodiments of the present invention, but specific embodiment does not do any restriction to the present invention.
Embodiment 1
(1) precise 2.1g Jojoba oil, 0.4g isopropyl myristate, 0.1g vitamin E and 1.5g propylene glycol, using their mixing and stirring as oil phase;
(2) precise 0.1g arbutin and 2.25g deionized water, is heated to 45 DEG C and is uniformly mixed as aqueous phase;
(3) they are mixed, after ultrasonic 10min, are joined in oil phase by the hexagonal mesoporous silicon of precise 0.5g, 2.5g sorbester p17 and 0.5g Tween 80;
(4) dropwise slowly being joined in oil phase by aqueous phase under stirring, is 6.83 by 0.05g triethanolamine adjust ph, continues to stir 12h with 800rpm speed, forms the slow release breast of whitening and speckle dispelling.
Embodiment 2
(1) precise 2.0g Jojoba oil, 0.5g Palmic acid isopropyl propionate, 0.1g vitamin E and 1.5g propylene glycol, using their mixing and stirring as oil phase;
(2) precise 0.05g arbutin and 2.4g deionized water, is heated to 45 DEG C and is uniformly mixed as aqueous phase;
(3) they are mixed, after ultrasonic 10min, are joined in oil phase by the hexagonal mesoporous silicon of precise 0.4g, 0.6g Tween 80 and 2.4g sorbester p17;
(4) dropwise slowly being joined in oil phase by aqueous phase under stirring, is 6.72 by 0.05g sodium hydroxide adjust ph, continues to stir 12h with 800rpm speed, forms the slow release breast of whitening and speckle dispelling.
Embodiment 3
(1) precise 1.3g Jojoba oil, 0.7g Fructus Citri Limoniae oil, 0.1g vitamin E and 1.5g propylene glycol, using their mixing and stirring as oil phase;
(2) precise 0.1g arbutin and 2.8g deionized water, is heated to 55 DEG C and is uniformly mixed as aqueous phase;
(3) they are mixed, after ultrasonic 10min, are joined in oil phase by the hexagonal mesoporous silicon of precise 0.45g, 0.6g Tween 80 and 2.4g sorbester p17;
(4) dropwise slowly being joined in oil phase by aqueous phase under stirring, is 6.35 by 0.05g phosphoric acid adjust ph, continues to stir 12h with 800rpm speed, forms the slow release breast of whitening and speckle dispelling.
Embodiment 4
(1) precise 2.1g Jojoba oil, 0.4g isopropyl myristate, 0.1g vitamin E and 1.5gPEG-400, using their mixing and stirring as oil phase;
(2) precise 0.1g arbutin and 2.25g deionized water, is heated to 45 DEG C and is uniformly mixed as aqueous phase;
(3) they are mixed, after ultrasonic 10min, are joined in oil phase by the hexagonal mesoporous silicon of precise 0.5g and 3g polyoxyethylene (7) castor oil hydrogenated;
(4) dropwise slowly being joined in oil phase by aqueous phase under stirring, is 6.62 by 0.05g triethanolamine adjust ph, continues to stir 12h with 800rpm speed, forms the slow release breast of whitening and speckle dispelling.
Embodiment 5 releasing effect contrast experiment
Without the need to adding mesoporous silicon after what contrast experiment was used be only 2.5g sorbester p17 in step (1) in embodiment 1 and 0.5g Tween 80 to mix without the emulsion of mesoporous silicon and the difference of embodiment 1, all the other steps are all identical with embodiment 1.
Accompanying drawing 1 is shown in the active component arbutin releasing effect contrast of the slow release breast that the present embodiment and embodiment 1 obtain.The curve being positioned at top in figure is the release profiles of the present embodiment, and the curve of below is the release profiles of embodiment 1.Figure can find out thus, adds the release of the emulsion active component of mesoporous silicon obviously than not adding the slow of mesoporous silicon.
Embodiment 6 stability experiment
The slow release breast of the whitening and speckle dispelling of embodiment 1 ~ 4 is divided into 3 parts, and every part of 5ml is put in the vial of sealing, places half a year at being placed in 4 DEG C, 25 DEG C and 40 DEG C respectively, and midway samples observation at any time, all keeps steady statue, has no layering or precipitation appearance.
Measure the physical property of the slow release breast of whitening and speckle dispelling prepared by the embodiment of the present invention 1 ~ 4 respectively, comprise refractive index, pH value, viscosity, electrical conductivity and surface tension, result is as shown in table 1.
Refractive index abbe's refractometer measures; PH meter pH value determination; Viscosity brookfield viscosity instrument measures; Electrical conductivity conductivity meter measures; Surface tension surface tension instrument measures; All samples all measures when measuring under 25 DEG C of conditions.
The physical property of slow release breast carrier prepared by table 1 embodiment of the present invention 1 ~ 4
As shown in Table 1, slow release of the present invention breast carrier has good physical property, and the value of slow release breast carrier pH of the present invention is close to the pH value of human body skin, and viscosity is low, little this emulsion that makes of surface tension is easy to sprawl on skin.
Claims (8)
1. a whitening and speckle dispelling slow release breast carrier, is characterized in that, the composition of described slow release breast carrier is divided into by its percentage by weight:
Active component 0.5% ~ 1%;
Vitamin E 0.05% ~ 1%;
Emollient 10% ~ 25%;
Surfactant 15% ~ 30%;
Wetting agent 5% ~ 15%;
Mesoporous silicon 3% ~ 5%;
PH adjusting agent 0.05% ~ 1%;
All the other are deionized water;
Described slow release breast carrier belongs to w/o structure, and mesoporous silicon easily forms the characteristic of hydrogen bond with the water-wet side of amphipathic surfactant with its structural oxygen atom, forms one deck shell, extend the release time of active component at oil-water interfaces place.
2. a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, it is characterized in that, described active component be whitening and speckle dispelling active component generally used for cosmetic comprise in arbutin, Radix Glycyrrhizae extract, vitamin C and superoxide dismutase one or both.
3. a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, it is characterized in that, described emollient is one or more in isopropyl myristate, olive oil, Jojoba oil, Oleum Caryophylli, almond oil, American Avocado Tree oil, isopropyl palmitate, Miglyol 812, Fructus Citri Limoniae oil or octyl palmitate.
4. a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, is characterized in that, described surfactant is one or more in polyoxyethylene (7) castor oil hydrogenated, Tween 80 or sorbester p17.
5. a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, is characterized in that, described wetting agent is one or more in glycerol, propylene glycol, PEG-400 or ethanol.
6. a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, it is characterized in that, described mesoporous silicon is hexagonal mesoporous silicon.
7. a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, is characterized in that, described pH adjusting agent is one or more in citric acid, tartaric acid, phosphoric acid, salicylic acid, sodium hydroxide or triethanolamine.
8. the preparation method of a kind of whitening and speckle dispelling slow release breast carrier according to claim 1, is characterized in that, comprise the following steps:
(1) emollient, vitamin E and wetting agent is taken, using their mixing and stirring as oil phase;
(2) take active component and deionized water, heated and stirred mix homogeneously is as aqueous phase;
(3) take mesoporous silicon and surfactant, they are mixed, after ultrasonic 8 ~ 10min, is joined in oil phase;
(4) dropwise being joined in oil phase by aqueous phase under stirring, is 6 ~ 7 by pH adjusting agent adjust ph, continues stirring 8 ~ 12h, forms the slow release breast carrier of whitening and speckle dispelling.
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Cited By (1)
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| WO2017127021A1 (en) * | 2016-01-18 | 2017-07-27 | Agency For Science, Technology And Research | Hexagonal silica platelets and methods of synthesis thereof |
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| CN104287979A (en) * | 2014-09-11 | 2015-01-21 | 华南理工大学 | Silver-loaded meso-porous silicon-containing rinse-free antibacterial hand sanitizer and preparation method thereof |
| CN104997674A (en) * | 2015-07-09 | 2015-10-28 | 广东长荣林业发展股份有限公司 | Skin moistening cream and preparation method thereof |
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| JP5878326B2 (en) * | 2011-10-06 | 2016-03-08 | 花王株式会社 | Cleaning composition |
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| CN101732169A (en) * | 2008-11-12 | 2010-06-16 | 王娟 | Arbutin multi-functional skin moisturizer |
| CN103385838A (en) * | 2013-08-05 | 2013-11-13 | 唯美度科技（北京）有限公司 | Anti-freckle whitening emulsion |
| CN103520019A (en) * | 2013-09-27 | 2014-01-22 | 华南理工大学 | Preparation method of beautifying, sun-blocking and isolating emulsion containing hexagonal meso-porous silicon |
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| WO2017127021A1 (en) * | 2016-01-18 | 2017-07-27 | Agency For Science, Technology And Research | Hexagonal silica platelets and methods of synthesis thereof |
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Effective date of registration: 20211222 Address after: 510663 No. a401, 403 and 405, zone a, Guangzhou International Business Incubator, No. 3, Juquan Road, Science City, Huangpu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Zhiyuan Biotechnology Co.,Ltd. Address before: 510640 No. five, 381 mountain road, Guangzhou, Guangdong, Tianhe District Patentee before: SOUTH CHINA University OF TECHNOLOGY |