CN103784700B - The compound preparation of control livestock and birds respiratory disease - Google Patents
The compound preparation of control livestock and birds respiratory disease Download PDFInfo
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- CN103784700B CN103784700B CN201410078552.4A CN201410078552A CN103784700B CN 103784700 B CN103784700 B CN 103784700B CN 201410078552 A CN201410078552 A CN 201410078552A CN 103784700 B CN103784700 B CN 103784700B
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Abstract
The present invention discloses the compound preparation of control livestock and birds respiratory disease, comprises the component of following weight proportion: auxiliary material 1��2 part, Chinese medicine preparation 30��50 parts, chemical cooperated dose 10��20 parts; Auxiliary material comprises isovaleric aldehyde 5��10 parts, 2-amyl furan 5��10 parts, vanillin food grade,1000.000000ine mesh 5��10 parts, xanthan gum 2��5 parts, chemical cooperated dose comprises aminoglycoside 5��10 parts, florfenicol 5��10 parts, 5��10 parts, amoxycilline Trihydrate bp, Matachrom 5��10 parts, Ferrous Fumarate 2��4 parts. By the configuration to Chinese medicine compound prescription in the present invention, choose and there is synergy, will Chinese medicine formula have multiple physiologically active material extract and with chemical cooperated dose of compatibility, make the medicine after combining that the result for the treatment of of respiratory tract disease is better, can effectively preventing disease occurring, meanwhile, main medicine is Chinese medical extract, can effectively preventing the generation of resistance, drug safety also improves.
Description
Technical field
The present invention relates to the medicine for the treatment of livestock and poultry, it is specifically related to a kind of compound preparation for preventing and treating livestock and birds respiratory disease.
Background technology
The respiratory tract disease of livestock and poultry is a class important diseases of the current animal husbandry development of puzzlement always, and especially the atypical newcastle disease of chicken, infectious bronchitis (InfectiousBronchitis, IB), porcine mycoplasmal pneumonia (Mycoplasmal swell coffee iaofswine) are diseases more occurred frequently in current livestock and poultry cultivation. Although taking the measures such as regular sterilization, urgent immunity, regularly immunity, the antiviral Chinese-western medicine using symptomatic treatment and antibiotics, but there is the problems such as immuning failure, drug residue and resistance, making disease be difficult to effective control, the drug residue produced in animal tissues especially and the resistance of animal body also result in safely very big hidden danger to human food prods.
Newcastle disease, bird flu, infectious bronchitis, infectious laryngotracheitis, chronic respiratory tract disease, infective rhinitis, colibacillosis etc. have respiratory symptom to show, but their cause of disease is different. And more complicated is that two or more respiratory pathogen acts on chicken respiratory simultaneously or successively, synergy of causing a disease between them, can be produced, much more serious than single pathogenic agent associated diseases. Especially some immunosuppressive disease are such as Marek, infectious bursal disease, infectious anemia, leukemia, newcastle disease, bird flu etc., when occurring the chicken group of respiratory tract disease to there is again immunosuppression pathogenic agent, respiratory tract disease can be very serious, and uncontrollable.
In order to solve above-mentioned deficiency of the prior art, the present invention proposes a kind of new solution.
Summary of the invention
It is an object of the invention to provide a kind of Chinese and Western compound preparation that livestock and birds respiratory disease is had good efficacy.
For reaching above-mentioned purpose, the technical solution adopted in the present invention is: provides a kind of compound preparation preventing and treating livestock and birds respiratory disease, comprises the component of following weight proportion:
Auxiliary material 1��2 part, Chinese medicine preparation 30��50 parts, chemical cooperated dose 10��20 parts;
Auxiliary material comprises isovaleric aldehyde 5��10 parts, 2-amyl furan 5��10 parts, vanillin food grade,1000.000000ine mesh 5��10 parts, xanthan gum 2��5 parts;
Chinese medicine preparation raw material comprises Motherwort Herb 3��5 parts, 3��5 parts, Radix Glycyrrhizae, Flower of Royal Paulownia 3��5 parts, Inula Flower 3��5 parts, the flower bud of lily magnolia 3��5 parts, Chinese cassia tree 3��5 parts, 3��5 parts, garlic, Semen Myristicae 3��5 parts, tarragon 3��5 parts, schizonepeta 3��5 parts, 3��5 parts, Turkey-galls, rattletop 5��10 parts, Radix Clematidis 5��10 parts, Herba Lycopi 5��10 parts, 5��10 parts, long fringe wood, Semen Cassiae 5��10 parts, the Radix Astragali 5��10 parts, Chinese violet 5��10 parts, blue 5��10 parts of Pu ground, rutin 5��10 parts, Root of Kirilow Rhodiola 5��10 parts, dark plum 5��10 parts, indigo naturalis 5��10 parts, radix scrophulariae 5��10 parts, Grosvenor Momordica 5��10 parts, Simpleleaf Shrub Chastetree Fruit 5��10 parts, Fruit of Cherokee Rose 5��10 parts, chestnut shell 5��10 parts, pomegranate rind 5��10 parts, the wind-weed 5��10 parts, elscholtiza 5��10 parts, squaw weed 5��10 parts, Root of Chinese Pulsatilla 5��10 parts, Stem of Sargentgloryvine 5��10 parts,
Chemical cooperated dose comprises aminoglycoside 5��10 parts, florfenicol 5��10 parts, 5��10 parts, amoxycilline Trihydrate bp, Matachrom 5��10 parts, Ferrous Fumarate 2��4 parts.
Wherein, aminoglycoside is one or several in amikacin, kantlex, gentamicin.
Wherein, Chinese medicine preparation raw material also comprises 3��5 parts, ginger, Loquat Leaf 3��5 parts, 3��5 parts, madder.
Meanwhile, present invention also offers the preparation method of this compound preparation, comprise the following steps:
A, by formula get all Chinese medicine preparation raw materials, by its coarse crushing, then use the water of its 10 times of weight to carry out boiling 2��4 hours, filter get filtrate, filter residue uses the water boiling of 3 times of weight to filter after 2��4 hours, merging filtrate, heat concentrated filtrate;
B, concentrated solution is adopted 70% ethanolic soln alcohol precipitation, reclaim extract, and by its when 45��60 DEG C dry, dried object is carried out superfine grinding, the particle diameter of pulverizing is less than 3mm;
C, Chinese medicine preparation after superfine grinding add the auxiliary material of formula ratio and chemical cooperated dose, mixes.
In sum, the present invention has the following advantages:
By the configuration to Chinese medicine compound prescription in the present invention, choose and there is synergy, will Chinese medicine formula have multiple physiologically active material extract and with chemical cooperated dose of compatibility, make the medicine after combining that the result for the treatment of of respiratory tract disease is better, can effectively preventing disease occurring, meanwhile, main medicine is Chinese medical extract, can effectively preventing the generation of resistance, drug safety also improves.
Embodiment
Embodiment 1
Get Chinese medicine preparation raw material Motherwort Herb 3kg, Radix Glycyrrhizae 3kg, Flower of Royal Paulownia 3kg, Inula Flower 3kg, flower bud of lily magnolia 3kg, Chinese cassia tree 3kg, garlic 3kg, Semen Myristicae 3kg, tarragon 3kg, schizonepeta 3kg, Turkey-galls 3kg, rattletop 5kg, Radix Clematidis 5kg, Herba Lycopi 5kg, long fringe wood 5kg, Semen Cassiae 5kg, Radix Astragali 5kg, Chinese violet 5kg, the blue 5kg in Pu ground, rutin 5kg, Root of Kirilow Rhodiola 5kg, dark plum 5kg, indigo naturalis 5kg, radix scrophulariae 5kg, Grosvenor Momordica 5kg, Simpleleaf Shrub Chastetree Fruit 5kg, Fruit of Cherokee Rose 5kg, chestnut shell 5kg, pomegranate rind 5kg, wind-weed 5kg, elscholtiza 5kg, squaw weed 5kg, Root of Chinese Pulsatilla 5kg, Stem of Sargentgloryvine 5kg, ginger 3kg, Loquat Leaf 3kg, madder 3kg.
By auxiliary material isovaleric aldehyde 5kg, 2-amyl furan 5kg, vanillin food grade,1000.000000ine mesh 5kg, xanthan gum 2kg mixing is stand-by,
By chemical cooperated dose of aminoglycoside amikacin 5kg, florfenicol 5kg, amoxycilline Trihydrate bp 5kg, Matachrom 5kg, Ferrous Fumarate 2kg, mix stand-by.
By Chinese medicinal materials coarse crushing, then using the water of its 10 times of weight to carry out boiling 2 hours, filter and get filtrate, filter residue uses the water boiling of 3 times of weight to filter after 2 hours, merging filtrate, heating concentrated filtrate; Concentrated solution is adopted the ethanolic soln alcohol precipitation of 70%, reclaims extract, and by its when 45��60 DEG C dry, dried object is carried out superfine grinding, the particle diameter of pulverizing is less than 3mm.
Chinese medicine preparation after superfine grinding adds the auxiliary material of formula ratio and chemical cooperated dose, mixes. Wherein Chinese medicine preparation is 30kg, auxiliary material 1kg, chemical cooperated dose of 10kg.
Embodiment 2
Get Chinese medicine preparation raw material Motherwort Herb 10kg, Radix Glycyrrhizae 10kg, Flower of Royal Paulownia 5kg, Inula Flower 5kg, flower bud of lily magnolia 5kg, Chinese cassia tree 5kg, garlic 5kg, Semen Myristicae 5kg, tarragon 5kg, schizonepeta 5kg, Turkey-galls 5kg, rattletop 10kg, Radix Clematidis 10kg, Herba Lycopi 10kg, long fringe wood 10kg, Semen Cassiae 10kg, Radix Astragali 10kg, Chinese violet 10kg, the blue 10kg in Pu ground, rutin 10kg, Root of Kirilow Rhodiola 10kg, dark plum 10kg, indigo naturalis 10kg, radix scrophulariae 10kg, Grosvenor Momordica 10kg, Simpleleaf Shrub Chastetree Fruit 10kg, Fruit of Cherokee Rose 10kg, chestnut shell 10kg, pomegranate rind 10kg, wind-weed 10kg, elscholtiza 10kg, squaw weed 10kg, Root of Chinese Pulsatilla 10kg, Stem of Sargentgloryvine 10kg, ginger 5kg, Loquat Leaf 5kg, madder 5kg.
By auxiliary material isovaleric aldehyde 10kg, 2-amyl furan 10kg, vanillin food grade,1000.000000ine mesh 10kg, xanthan gum 4kg mixing is stand-by;
Being aminoglycoside 10kg by chemical cooperated dose, florfenicol 5kg, amoxycilline Trihydrate bp 5kg, Matachrom 5kg, Ferrous Fumarate 2kg mixing is stand-by, and wherein aminoglycoside is kantlex or gentamicin.
By Chinese medicinal materials coarse crushing, then using the water of its 10 times of weight to carry out boiling 4 hours, filter and get filtrate, filter residue uses the water boiling of 3 times of weight to filter after 4 hours, merging filtrate, heating concentrated filtrate; Concentrated solution is adopted the ethanolic soln alcohol precipitation of 70%, reclaims extract, and by its when 45��60 DEG C dry, dried object is carried out superfine grinding, the particle diameter of pulverizing is less than 3mm.
Chinese medicine preparation after superfine grinding adds the auxiliary material of formula ratio and chemical cooperated dose, mixes. Wherein Chinese medicine preparation is 50kg, auxiliary material 2kg, chemical cooperated dose of 20kg.
Pharmacological evaluation 1
Laboratory animal: the sick chicken of the infectious bronchitis of natural infection 300.
Main symptom for stretching neck, dehisce breathing, sneeze, sound etc., sick chicken whole body is weak, listless, feather pine disorderly, lethargic sleep. Disease chicken being divided into 3 groups at random, wherein the oral florfenicol 10mg/kg of B group, C group does not take any medicine, and A group takes the compound preparation in embodiment 1, and dosage is 10mg/kg. Within every 48 hours, add and take medicine once, after 5 days, observe the state of an illness.
| Group | Cure number | Do not cure number | Death toll |
| A | 88 | 8 | 4 |
| B | 78 | 14 | 8 |
| C | 10 | 58 | 32 |
Pharmacological evaluation 2
Laboratory animal: flu causes the chick of respiratory tract disease naturally
Main symptom is for cough occur and get rid of nose phenomenon, and the mental status is not good, and ight soil is sparse, and cuing open the visible tracheae of inspection has Catarrhal inflammation, bottom mucosal bleeding, and larynx is congested. Choosing disease chicken 150, be divided into 3 groups at random, A group takes the compound preparation in embodiment 2, and B group takes ceftriaxone, and C group is blank group, and taking dose is 5mg/kg, takes every day once, observing effect after taking continuously 5 days.
| Group | Cure number | Do not cure number | Death toll |
| A | 45 | 3 | 2 |
| B | 34 | 8 | 8 |
| C | 3 | 25 | 22 |
Pharmacological evaluation 3
Laboratory animal: the sick pig 150 naturally suffering from respiratory tract disease
Main symptom is that animal is listless, constantly sends symptoms of respiratory disease such as panting. Now choosing disease pig 150, be divided into 3 groups at random, A group takes the compound preparation in embodiment 2, and B group takes ceftriaxone, and C group is blank group, and taking dose is 10mg/kg. Take every day once, after taking 5 days continuously, observe the state of an illness.
| Group | Cure number | Do not cure number | Death toll |
| A | 46 | 2 | 2 |
| B | 30 | 15 | 5 |
| C | 5 | 20 | 25 |
By upper three animal pharmacological experiments it will be seen that use the compound preparation of embodiment 1 and embodiment 2, compared with the medicine of conventional treatment respiratory tract disease, there is better curative effect.
Claims (3)
1. prevent and treat the compound preparation of livestock and birds respiratory disease, it be made up of the component of following weight proportion:
Auxiliary material 1 ~ 2 part, Chinese medicine preparation 30 ~ 50 parts, chemical cooperated dose 10 ~ 20 parts;
Auxiliary material by isovaleric aldehyde 5 ~ 10 parts, 2-amyl furan 5 ~ 10 parts, vanillin food grade,1000.000000ine mesh 5 ~ 10 parts, xanthan gum 2 ~ 5 parts composition, Chinese medicine preparation raw material is by Motherwort Herb 3 ~ 5 parts, 3 ~ 5 parts, Radix Glycyrrhizae, Flower of Royal Paulownia 3 ~ 5 parts, Inula Flower 3 ~ 5 parts, the flower bud of lily magnolia 3 ~ 5 parts, Chinese cassia tree 3 ~ 5 parts, 3 ~ 5 parts, garlic, Semen Myristicae 3 ~ 5 parts, tarragon 3 ~ 5 parts, schizonepeta 3 ~ 5 parts, 3 ~ 5 parts, Turkey-galls, rattletop 5 ~ 10 parts, Radix Clematidis 5 ~ 10 parts, Herba Lycopi 5 ~ 10 parts, 5 ~ 10 parts, long fringe wood, Semen Cassiae 5 ~ 10 parts, the Radix Astragali 5 ~ 10 parts, Chinese violet 5 ~ 10 parts, blue 5 ~ 10 parts of Pu ground, rutin 5 ~ 10 parts, Root of Kirilow Rhodiola 5 ~ 10 parts, dark plum 5 ~ 10 parts, indigo naturalis 5 ~ 10 parts, radix scrophulariae 5 ~ 10 parts, Grosvenor Momordica 5 ~ 10 parts, Simpleleaf Shrub Chastetree Fruit 5 ~ 10 parts, Fruit of Cherokee Rose 5 ~ 10 parts, chestnut shell 5 ~ 10 parts, pomegranate rind 5 ~ 10 parts, the wind-weed 5 ~ 10 parts, elscholtiza 5 ~ 10 parts, squaw weed 5 ~ 10 parts, Root of Chinese Pulsatilla 5 ~ 10 parts, Stem of Sargentgloryvine 5 ~ 10 parts composition,
Chemical cooperated dose by aminoglycoside 5 ~ 10 parts, florfenicol 5 ~ 10 parts, 5 ~ 10 parts, amoxycilline Trihydrate bp, Matachrom 5 ~ 10 parts, Ferrous Fumarate 2 ~ 4 parts composition.
2. the compound preparation of control livestock and birds respiratory disease as claimed in claim 1, it is characterised in that: described aminoglycoside is one or several in amikacin, kantlex, gentamicin.
3. prevent and treat the preparation process of the compound preparation of livestock and birds respiratory disease described in claim 1, comprise the following steps:
A, by formula get all Chinese medicine preparation raw materials, by its coarse crushing, then use the water of its 10 times of weight to carry out boiling 2 ~ 4 hours, filter get filtrate, filter residue uses the water boiling of 3 times of weight to filter after 2 ~ 4 hours, merging filtrate, heat concentrated filtrate;
B, concentrated solution is adopted 70% ethanolic soln alcohol precipitation, reclaim extract, and by its when 45 ~ 60 DEG C dry, dried object is carried out superfine grinding, the particle diameter of pulverizing is less than 3mm;
C, Chinese medicine preparation after superfine grinding add the auxiliary material of formula ratio and chemical cooperated dose, mixes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410078552.4A CN103784700B (en) | 2014-03-05 | 2014-03-05 | The compound preparation of control livestock and birds respiratory disease |
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| CN201410078552.4A CN103784700B (en) | 2014-03-05 | 2014-03-05 | The compound preparation of control livestock and birds respiratory disease |
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| Publication Number | Publication Date |
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| CN103784700A CN103784700A (en) | 2014-05-14 |
| CN103784700B true CN103784700B (en) | 2016-06-01 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105168444B (en) * | 2015-10-10 | 2019-02-19 | 湖北武当动物药业有限责任公司 | One kind is for preventing and treating livestock and poultry respiratory syndrome drug |
| CN105920576A (en) * | 2016-06-20 | 2016-09-07 | 卞佳林 | Chinese medicine preparation for preventing bird flu and preparation method and application thereof |
| CN107397865A (en) * | 2017-07-28 | 2017-11-28 | 贞丰县金谷黄鸡特色养殖农民专业合作社 | A kind of additive for preventing and treating infectious bronchitis of chicken |
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| CN101695342B (en) * | 2009-10-23 | 2012-01-11 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN102133354B (en) * | 2011-03-24 | 2013-03-13 | 山东省健牧生物药业有限公司 | Chinese medicinal composition for treating respiratory diseases of chicken |
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