CN103784700A - Compound preparation for preventing and treating respiratory diseases of beasts and birds - Google Patents
Compound preparation for preventing and treating respiratory diseases of beasts and birds Download PDFInfo
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- CN103784700A CN103784700A CN201410078552.4A CN201410078552A CN103784700A CN 103784700 A CN103784700 A CN 103784700A CN 201410078552 A CN201410078552 A CN 201410078552A CN 103784700 A CN103784700 A CN 103784700A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Abstract
The invention discloses a compound preparation for preventing and treating respiratory diseases of beasts and birds. The compound preparation comprises, by weight, auxiliary materials 1-2 parts, traditional Chinese medicine preparation 30-50 parts and chemical synergist 10-20 parts. The auxiliary materials include isovaleraldehyde 5-10 parts, 2-pentyl-furan 5-10 parts, vanillin 5-10 parts and xanthan gum 2-5 parts. The chemical synergist comprises aminoglycosides 5-10 parts, florfenicol 5-10 parts, amoxicillin 5-10 parts, erythromycin thiocyanate 5-10 parts and ferrous fumarate 2-4 parts. Substance having various physiological activities in a traditional Chinese medicine formula having synergistic effect is extracted and compatible with the chemical synergist through Chinese herbal compound preparation, so that the compounded medicine has good treatment effect on the respiratory diseases and can effectively prevent and treat the diseases. In addition, main medicine is a traditional Chinese medicine extract and can effectively prevent drug resistance, and the medication safety is also improved.
Description
Technical field
The present invention relates to treat the medicine of livestock and poultry, be specifically related to a kind of for preventing and treating the compound preparation of livestock and birds respiratory disease.
Background technology
The respiratory tract disease of poultry is that the atypical newcastle, infectious bronchitis (Infectious Bronchitis, IB), mycoplasmal pneumonia of swine (Mycoplasmal swell coffee ia of swine) of class important diseases, especially a chicken of the current animal husbandry development of puzzlement is disease more occurred frequently in current livestock and poultry cultivation always.Although taked the measure such as antiviral Chinese medicine and western medicine and antibiotics of regular sterilization, urgent immunity, regularly immunity, use symptomatic treatment, but exist the problems such as immuning failure, drug residue and drug resistance, make disease be difficult to effective control, the drug residue producing in animal tissue especially and the drug resistance of animal body have also caused very large hidden danger to human food's safety.
Newcastle, bird flu, infectious bronchitis, infectious laryngotracheitis, chronic respiratory tract disease, infective rhinitis, colibacillosis etc. have respiratory symptom performance, but their cause of disease is different.And more complicated be two or more respiratory pathogen simultaneously or successively act on chicken respiratory, between them, can produce pathogenic synergism, much more serious than single pathogen associated diseases.Especially some immunosuppressive disease are as Marek, infectious bursal disease, infectious anemia, leukemia, newcastle, bird flu etc., while there is again immunosuppressant pathogen in the chicken group of generation respiratory tract disease, respiratory tract disease can be very serious, and uncontrollable.
In order to solve above-mentioned deficiency of the prior art, the present invention proposes a kind of new solution.
Summary of the invention
The object of this invention is to provide a kind of Chinese and Western compound preparation livestock and birds respiratory disease to good efficacy.
For reaching above-mentioned purpose, the technical solution adopted in the present invention is: a kind of compound preparation of preventing and treating livestock and birds respiratory disease is provided, comprises the component of following weight proportion:
1～2 part of adjuvant, 30～50 parts of Chinese medicine preparation, chemical cooperated dose 10～20 parts;
Adjuvant comprises 5～10 parts of isovalerals, 5～10 parts of 2-amyl furans, 5～10 parts of vanillin, 2～5 parts of xanthan gum;
Chinese medicine preparation raw material comprises 3～5 parts of Herba Leonuris, 3～5 parts, Radix Glycyrrhizae, 3～5 parts of Flos Paulowniaes, 3～5 parts of Flos Inulaes, 3～5 parts of Flos Magnoliaes, 3～5 parts of Cortex Cinnamomis, 3～5 parts, Bulbus Allii, 3～5 parts of Semen Myristicaes, 3～5 parts of Folium Artemisiae Argyis, 3～5 parts of Herba Schizonepetae, 3～5 parts of Galla Chinensiss, 5～10 parts of Rhizoma Cimicifugaes, 5～10 parts of Radix Clematidis, 5～10 parts of Herba Lycopi, 5～10 parts, long fringe wood, 5～10 parts of Semen Cassiaes, 5～10 parts of the Radixs Astragali, 5～10 parts of Herba Violaes, blue 5～10 parts of Pu ground, 5～10 parts of rutins, 5～10 parts of Radix Rhodiolaes, 5～10 parts of Fructus Mumes, 5～10 parts of Indigo Naturaliss, 5～10 parts of Radix Scrophulariaes, 5～10 parts of Fructus Momordicaes, 5～10 parts of Fructus Viticises, 5～10 parts of Fructus Rosae Laevigatae, 5～10 parts of chestnut shells, 5～10 parts of Pericarpium Granatis, 5～10 parts of the Rhizoma Anemarrhenaes, 5～10 parts of Herba Moslaes, 5～10 parts of Herba Senecionis Scandentiss, 5～10 parts of the Radix Pulsatillaes, 5～10 parts of Caulis Sargentodoxae,
Chemical cooperated dose comprises 5～10 parts of aminoglycosides, 5～10 parts of florfenicols, 5～10 parts of amoxicillin, 5～10 parts of erythromycin thiocyanates, 2～4 parts of ferrous fumarate.
Wherein, aminoglycoside is one or several in amikacin, kanamycin, gentamycin.
Wherein, Chinese medicine preparation raw material also comprises 3～5 parts, Rhizoma Zingiberis Recens, 3～5 parts of Folium Eriobotryaes, 3～5 parts, Radix Rubiae.
Meanwhile, the present invention also provides the preparation method of this compound preparation, comprises the following steps:
A, get all Chinese medicine preparation raw materials by formula, by its coarse crushing, then use the water of its 10 times of weight to carry out boiling 2～4 hours, cross leaching filtrate, filtering residue uses the decocting in water system of 3 times of weight to filter after 2～4 hours, and merging filtrate heats concentrated filtrate;
B, concentrated solution is adopted to 70% alcoholic solution precipitate with ethanol, reclaim extract, and it is dry under the condition of 45～60 ℃, will be dried thing and carry out superfine grinding, the particle diameter of pulverizing is less than 3mm;
In C, Chinese medicine preparation after superfine grinding, add the adjuvant of formula ratio and chemical cooperated dose, mix homogeneously.
In sum, the present invention has the following advantages:
In the present invention, pass through the configuration to Chinese medicine compound, choose and there is synergism, by in Chinese medicine formula, have multiple physiologically active material extract and with chemical cooperated dose of compatibility, make the medicine after combination better to the therapeutic effect of respiratory tract disease, can effectively preventing disease occur, meanwhile, principal agent is Chinese medicine extract, can effectively prevent drug-fast generation, drug safety also improves.
The specific embodiment
Embodiment 1
Get Chinese medicine preparation raw material Herba Leonuri 3kg, Radix Glycyrrhizae 3kg, Flos Paulowniae 3kg, Flos Inulae 3kg, Flos Magnoliae 3kg, Cortex Cinnamomi 3kg, Bulbus Allii 3kg, Semen Myristicae 3kg, Folium Artemisiae Argyi 3kg, Herba Schizonepetae 3kg, Galla Chinensis 3kg, Rhizoma Cimicifugae 5kg, Radix Clematidis 5kg, Herba Lycopi 5kg, long fringe wood 5kg, Semen Cassiae 5kg, Radix Astragali 5kg, Herba Violae 5kg, the blue 5kg in Pu ground, rutin 5kg, Radix Rhodiolae 5kg, Fructus Mume 5kg, Indigo Naturalis 5kg, Radix Scrophulariae 5kg, Fructus Momordicae 5kg, Fructus Viticis 5kg, Fructus Rosae Laevigatae 5kg, chestnut shell 5kg, Pericarpium Granati 5kg, Rhizoma Anemarrhenae 5kg, Herba Moslae 5kg, Herba Senecionis Scandentis 5kg, Radix Pulsatillae 5kg, Caulis Sargentodoxae 5kg, Rhizoma Zingiberis Recens 3kg, Folium Eriobotryae 3kg, Radix Rubiae 3kg.
By adjuvant isovaleral 5kg, 2-amyl furan 5kg, vanillin 5kg, xanthan gum 2kg mixes stand-by,
By chemical cooperated dose of aminoglycoside amikacin 5kg, florfenicol 5kg, amoxicillin 5kg, erythromycin thiocyanate 5kg, ferrous fumarate 2kg, mixes stand-by.
By Chinese crude drug coarse crushing, then use the water of its 10 times of weight to carry out boiling 2 hours, cross leaching filtrate, filtering residue uses the decocting in water system of 3 times of weight to filter after 2 hours, merging filtrate, heating concentrated filtrate; Concentrated solution is adopted to 70% alcoholic solution precipitate with ethanol, reclaim extract, and it is dry under the condition of 45～60 ℃, will be dried thing and carry out superfine grinding, the particle diameter of pulverizing is less than 3mm.
In Chinese medicine preparation after superfine grinding, add the adjuvant of formula ratio and chemical cooperated dose, mix homogeneously.Wherein Chinese medicine preparation is 30kg, adjuvant 1kg, chemical cooperated dose of 10kg.
Embodiment 2
Get Chinese medicine preparation raw material Herba Leonuri 10kg, Radix Glycyrrhizae 10kg, Flos Paulowniae 5kg, Flos Inulae 5kg, Flos Magnoliae 5kg, Cortex Cinnamomi 5kg, Bulbus Allii 5kg, Semen Myristicae 5kg, Folium Artemisiae Argyi 5kg, Herba Schizonepetae 5kg, Galla Chinensis 5kg, Rhizoma Cimicifugae 10kg, Radix Clematidis 10kg, Herba Lycopi 10kg, long fringe wood 10kg, Semen Cassiae 10kg, Radix Astragali 10kg, Herba Violae 10kg, the blue 10kg in Pu ground, rutin 10kg, Radix Rhodiolae 10kg, Fructus Mume 10kg, Indigo Naturalis 10kg, Radix Scrophulariae 10kg, Fructus Momordicae 10kg, Fructus Viticis 10kg, Fructus Rosae Laevigatae 10kg, chestnut shell 10kg, Pericarpium Granati 10kg, Rhizoma Anemarrhenae 10kg, Herba Moslae 10kg, Herba Senecionis Scandentis 10kg, Radix Pulsatillae 10kg, Caulis Sargentodoxae 10kg, Rhizoma Zingiberis Recens 5kg, Folium Eriobotryae 5kg, Radix Rubiae 5kg.
By adjuvant isovaleral 10kg, 2-amyl furan 10kg, vanillin 10kg, xanthan gum 4kg mixes stand-by;
By chemical cooperated dose be aminoglycoside 10kg, florfenicol 5kg, amoxicillin 5kg, erythromycin thiocyanate 5kg, ferrous fumarate 2kg mix stand-by, wherein aminoglycoside is kanamycin or gentamycin.
By Chinese crude drug coarse crushing, then use the water of its 10 times of weight to carry out boiling 4 hours, cross leaching filtrate, filtering residue uses the decocting in water system of 3 times of weight to filter after 4 hours, merging filtrate, heating concentrated filtrate; Concentrated solution is adopted to 70% alcoholic solution precipitate with ethanol, reclaim extract, and it is dry under the condition of 45～60 ℃, will be dried thing and carry out superfine grinding, the particle diameter of pulverizing is less than 3mm.
In Chinese medicine preparation after superfine grinding, add the adjuvant of formula ratio and chemical cooperated dose, mix homogeneously.Wherein Chinese medicine preparation is 50kg, adjuvant 2kg, chemical cooperated dose of 20kg.
Pharmacological evaluation 1
Laboratory animal: 300 of the sick chickens of the infectious bronchitis of natural infection.
Cardinal symptom is for stretching neck, mouth breathing, sneeze, rale etc., and sick chicken asthenia universalis is listless, feather pine disorderly, lethargy.Sick chicken is divided into 3 groups at random, and wherein B organizes oral florfenicol 10mg/kg, and C group is not taken any medicine, and A group is taken the compound preparation in embodiment 1, and dosage is 10mg/kg.Within every 48 hours, add drug administration once, after 5 days, observe the state of an illness.
| Group | Cure number | Do not cure number | Death toll |
| A | 88 | 8 | 4 |
| B | 78 | 14 | 8 |
| C | 10 | 58 | 32 |
Pharmacological evaluation 2
Laboratory animal: the chickling that flu causes respiratory tract disease naturally
For there is cough and ataxia phenomenon in cardinal symptom, the mental status is not good, and feces is sparse, and cuing open the visible trachea of inspection has catarrhal inflammation, bottom mucosal bleeding, larynx hyperemia.Choose 150 of disease chickens, be divided at random 3 groups, A group is taken the compound preparation in embodiment 2, and B group is taken ceftriaxone, and C group is blank group, and taking dose is 5mg/kg, takes every day once, takes continuously observing effect after 5 days.
| Group | Cure number | Do not cure number | Death toll |
| A | 45 | 3 | 2 |
| B | 34 | 8 | 8 |
| C | 3 | 25 | 22 |
Pharmacological evaluation 3
Laboratory animal: 150 of sick pigs that naturally suffer from respiratory tract disease
Cardinal symptom is that animal is listless, constantly sends the symptoms of respiratory disease such as pant.Now choose 150 of disease pigs, be divided at random 3 groups, A group is taken the compound preparation in embodiment 2, and B group is taken ceftriaxone, and C group is blank group, and taking dose is 10mg/kg.Take every day once, take continuously after 5 days and observe the state of an illness.
| Group | Cure number | Do not cure number | Death toll |
| A | 46 | 2 | 2 |
| B | 30 | 15 | 5 |
| C | 5 | 20 | 25 |
From upper three animal pharmacological experiments, use the compound preparation of embodiment 1 and embodiment 2, compared with conventional medicine for the treatment of respiratory tract disease, there is better curative effect.
Claims (4)
1. prevent and treat the compound preparation of livestock and birds respiratory disease, comprise the component of following weight proportion:
1～2 part of adjuvant, 30～50 parts of Chinese medicine preparation, chemical cooperated dose 10～20 parts;
Adjuvant comprises 5～10 parts of isovalerals, 5～10 parts of 2-amyl furans, 5～10 parts of vanillin, 2～5 parts of xanthan gum, Chinese medicine preparation raw material comprises 3～5 parts of Herba Leonuris, 3～5 parts, Radix Glycyrrhizae, 3～5 parts of Flos Paulowniaes, 3～5 parts of Flos Inulaes, 3～5 parts of Flos Magnoliaes, 3～5 parts of Cortex Cinnamomis, 3～5 parts, Bulbus Allii, 3～5 parts of Semen Myristicaes, 3～5 parts of Folium Artemisiae Argyis, 3～5 parts of Herba Schizonepetae, 3～5 parts of Galla Chinensiss, 5～10 parts of Rhizoma Cimicifugaes, 5～10 parts of Radix Clematidis, 5～10 parts of Herba Lycopi, 5～10 parts, long fringe wood, 5～10 parts of Semen Cassiaes, 5～10 parts of the Radixs Astragali, 5～10 parts of Herba Violaes, blue 5～10 parts of Pu ground, 5～10 parts of rutins, 5～10 parts of Radix Rhodiolaes, 5～10 parts of Fructus Mumes, 5～10 parts of Indigo Naturaliss, 5～10 parts of Radix Scrophulariaes, 5～10 parts of Fructus Momordicaes, 5～10 parts of Fructus Viticises, 5～10 parts of Fructus Rosae Laevigatae, 5～10 parts of chestnut shells, 5～10 parts of Pericarpium Granatis, 5～10 parts of the Rhizoma Anemarrhenaes, 5～10 parts of Herba Moslaes, 5～10 parts of Herba Senecionis Scandentiss, 5～10 parts of the Radix Pulsatillaes, 5～10 parts of Caulis Sargentodoxae,
Chemical cooperated dose comprises 5～10 parts of aminoglycosides, 5～10 parts of florfenicols, 5～10 parts of amoxicillin, 5～10 parts of erythromycin thiocyanates, 2～4 parts of ferrous fumarate.
2. the compound preparation of control livestock and birds respiratory disease as claimed in claim 1, is characterized in that: described aminoglycoside is one or several in amikacin, kanamycin, gentamycin.
3. the compound preparation of control livestock and birds respiratory disease as claimed in claim 1, is characterized in that: described Chinese medicine preparation raw material also comprises 3～5 parts, Rhizoma Zingiberis Recens, 3～5 parts of Folium Eriobotryaes, 3～5 parts, Radix Rubiae.
4. the preparation process of the compound preparation of control livestock and birds respiratory disease, comprises the following steps:
A, get all Chinese medicine preparation raw materials by formula, by its coarse crushing, then use the water of its 10 times of weight to carry out boiling 2～4 hours, cross leaching filtrate, filtering residue uses the decocting in water system of 3 times of weight to filter after 2～4 hours, and merging filtrate heats concentrated filtrate;
B, concentrated solution is adopted to 70% alcoholic solution precipitate with ethanol, reclaim extract, and it is dry under the condition of 45～60 ℃, will be dried thing and carry out superfine grinding, the particle diameter of pulverizing is less than 3mm;
In C, Chinese medicine preparation after superfine grinding, add the adjuvant of formula ratio and chemical cooperated dose, mix homogeneously.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410078552.4A CN103784700B (en) | 2014-03-05 | 2014-03-05 | The compound preparation of control livestock and birds respiratory disease |
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| CN201410078552.4A CN103784700B (en) | 2014-03-05 | 2014-03-05 | The compound preparation of control livestock and birds respiratory disease |
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| CN103784700A true CN103784700A (en) | 2014-05-14 |
| CN103784700B CN103784700B (en) | 2016-06-01 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168444A (en) * | 2015-10-10 | 2015-12-23 | 湖北武当动物药业有限责任公司 | Drug for preventing and treating livestock and poultry respiratory syndrome |
| CN105920576A (en) * | 2016-06-20 | 2016-09-07 | 卞佳林 | Chinese medicine preparation for preventing bird flu and preparation method and application thereof |
| CN107397865A (en) * | 2017-07-28 | 2017-11-28 | 贞丰县金谷黄鸡特色养殖农民专业合作社 | A kind of additive for preventing and treating infectious bronchitis of chicken |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN102133354A (en) * | 2011-03-24 | 2011-07-27 | 山东省农业科学院 | Chinese medicinal composition for treating respiratory diseases of chicken |
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2014
- 2014-03-05 CN CN201410078552.4A patent/CN103784700B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN102133354A (en) * | 2011-03-24 | 2011-07-27 | 山东省农业科学院 | Chinese medicinal composition for treating respiratory diseases of chicken |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168444A (en) * | 2015-10-10 | 2015-12-23 | 湖北武当动物药业有限责任公司 | Drug for preventing and treating livestock and poultry respiratory syndrome |
| CN105168444B (en) * | 2015-10-10 | 2019-02-19 | 湖北武当动物药业有限责任公司 | One kind is for preventing and treating livestock and poultry respiratory syndrome drug |
| CN105920576A (en) * | 2016-06-20 | 2016-09-07 | 卞佳林 | Chinese medicine preparation for preventing bird flu and preparation method and application thereof |
| CN107397865A (en) * | 2017-07-28 | 2017-11-28 | 贞丰县金谷黄鸡特色养殖农民专业合作社 | A kind of additive for preventing and treating infectious bronchitis of chicken |
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| CN103784700B (en) | 2016-06-01 |
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