CN103781777A - 6-(哌啶-4-基氧基)-2h-异喹啉-1-酮盐酸盐的多晶型物 - Google Patents

6-(哌啶-4-基氧基)-2h-异喹啉-1-酮盐酸盐的多晶型物 Download PDF

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Publication number
CN103781777A
CN103781777A CN201280043622.1A CN201280043622A CN103781777A CN 103781777 A CN103781777 A CN 103781777A CN 201280043622 A CN201280043622 A CN 201280043622A CN 103781777 A CN103781777 A CN 103781777A
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China
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polymorph
isoquinolin
yloxy
piperidin
hydrochloride
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Pending
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CN201280043622.1A
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English (en)
Chinese (zh)
Inventor
N.纳格尔
B.鲍姆加特纳
H.博科托尔德
O.普利坦伯格
D.卡德赖特
M.莫尼克
S.格斯勒
J.蒂尔纳
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Sanofi Aventis France
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Sanofi Aventis France
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Publication of CN103781777A publication Critical patent/CN103781777A/zh
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN201280043622.1A 2011-07-08 2012-06-27 6-(哌啶-4-基氧基)-2h-异喹啉-1-酮盐酸盐的多晶型物 Pending CN103781777A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305891 2011-07-08
EP11305891.1 2011-07-08
EP11306034.7 2011-12-29
EP11306034 2011-12-29
PCT/EP2012/062444 WO2013007519A1 (en) 2011-07-08 2012-06-27 Polymorphs of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride

Publications (1)

Publication Number Publication Date
CN103781777A true CN103781777A (zh) 2014-05-07

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CN201280043622.1A Pending CN103781777A (zh) 2011-07-08 2012-06-27 6-(哌啶-4-基氧基)-2h-异喹啉-1-酮盐酸盐的多晶型物

Country Status (17)

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US (1) US8598201B2 (https=)
EP (1) EP2729461B1 (https=)
JP (1) JP2014518236A (https=)
KR (1) KR102013567B1 (https=)
CN (1) CN103781777A (https=)
AU (1) AU2012283277B2 (https=)
CA (1) CA2843777C (https=)
CY (1) CY1117545T1 (https=)
DK (1) DK2729461T3 (https=)
ES (1) ES2567317T3 (https=)
HR (1) HRP20160358T1 (https=)
HU (1) HUE028550T2 (https=)
IN (1) IN2014CN00834A (https=)
PL (1) PL2729461T3 (https=)
RU (1) RU2014104357A (https=)
SI (1) SI2729461T1 (https=)
WO (1) WO2013007519A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109810173A (zh) * 2017-11-21 2019-05-28 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa, 其制备, 抗静脉血栓活性和应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023320331A1 (en) * 2022-08-01 2025-01-23 Valo Health, Inc. Process for preparing 6-substituted-1-(2h)-isoquinolinones and intermediate compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101228149A (zh) * 2005-07-26 2008-07-23 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的哌啶基取代的异喹啉酮衍生物
CN101616909A (zh) * 2006-12-27 2009-12-30 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物
CN101910123A (zh) * 2007-12-26 2010-12-08 塞诺菲-安万特股份有限公司 6-取代的-1-(2h)-异喹啉酮的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051919A2 (en) * 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
TW200738682A (en) 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101228149A (zh) * 2005-07-26 2008-07-23 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的哌啶基取代的异喹啉酮衍生物
CN101616909A (zh) * 2006-12-27 2009-12-30 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物
CN101910123A (zh) * 2007-12-26 2010-12-08 塞诺菲-安万特股份有限公司 6-取代的-1-(2h)-异喹啉酮的制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109810173A (zh) * 2017-11-21 2019-05-28 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa, 其制备, 抗静脉血栓活性和应用
CN109810173B (zh) * 2017-11-21 2020-11-27 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用

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Publication number Publication date
PL2729461T3 (pl) 2016-06-30
SI2729461T1 (sl) 2016-06-30
KR20140046460A (ko) 2014-04-18
HK1192234A1 (zh) 2014-08-15
WO2013007519A1 (en) 2013-01-17
AU2012283277A1 (en) 2014-02-27
EP2729461A1 (en) 2014-05-14
CA2843777C (en) 2018-11-06
RU2014104357A (ru) 2015-08-20
DK2729461T3 (en) 2016-04-11
US8598201B2 (en) 2013-12-03
HUE028550T2 (en) 2016-12-28
EP2729461B1 (en) 2016-01-20
AU2012283277B2 (en) 2016-07-21
CA2843777A1 (en) 2013-01-17
HRP20160358T1 (hr) 2016-05-06
CY1117545T1 (el) 2017-04-26
IN2014CN00834A (https=) 2015-04-03
KR102013567B1 (ko) 2019-08-23
US20130012479A1 (en) 2013-01-10
ES2567317T3 (es) 2016-04-21
JP2014518236A (ja) 2014-07-28

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Application publication date: 20140507