CN103751780A - 用于治疗th2介导的疾病的kim-1抗体 - Google Patents

用于治疗th2介导的疾病的kim-1抗体 Download PDF

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Publication number
CN103751780A
CN103751780A CN201410043208.1A CN201410043208A CN103751780A CN 103751780 A CN103751780 A CN 103751780A CN 201410043208 A CN201410043208 A CN 201410043208A CN 103751780 A CN103751780 A CN 103751780A
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CN
China
Prior art keywords
antibody
fab
aminoacid
seq
kim
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410043208.1A
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English (en)
Chinese (zh)
Inventor
保罗.D.伦纳特
帕特里夏.麦库恩
弗罗尼克.贝利
亚历克西.卢戈夫斯科伊
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Biogen Inc
Biogen MA Inc
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Biogen Idec MA Inc
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Publication date
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Publication of CN103751780A publication Critical patent/CN103751780A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201410043208.1A 2005-03-02 2006-03-02 用于治疗th2介导的疾病的kim-1抗体 Pending CN103751780A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65778905P 2005-03-02 2005-03-02
US60/657,789 2005-03-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800139893A Division CN101166542A (zh) 2005-03-02 2006-03-02 用于治疗th2介导的疾病的kim-1抗体

Publications (1)

Publication Number Publication Date
CN103751780A true CN103751780A (zh) 2014-04-30

Family

ID=36648475

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410043208.1A Pending CN103751780A (zh) 2005-03-02 2006-03-02 用于治疗th2介导的疾病的kim-1抗体
CNA2006800139893A Pending CN101166542A (zh) 2005-03-02 2006-03-02 用于治疗th2介导的疾病的kim-1抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2006800139893A Pending CN101166542A (zh) 2005-03-02 2006-03-02 用于治疗th2介导的疾病的kim-1抗体

Country Status (14)

Country Link
US (2) US8206705B2 (https=)
EP (2) EP2251037B1 (https=)
JP (2) JP2008531719A (https=)
KR (1) KR101213894B1 (https=)
CN (2) CN103751780A (https=)
AT (1) ATE478707T1 (https=)
AU (2) AU2006218489B2 (https=)
BR (1) BRPI0608254A2 (https=)
CA (1) CA2599967C (https=)
DE (1) DE602006016413D1 (https=)
IL (1) IL185653A (https=)
NZ (1) NZ562045A (https=)
WO (1) WO2006094134A2 (https=)
ZA (1) ZA200708372B (https=)

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Publication number Priority date Publication date Assignee Title
WO2008064031A2 (en) * 2006-11-13 2008-05-29 Government Of The United States, As Represented Bythe Secretary Of The Department Of Health And Human Services Potent activation of antigen presenting cells by the hepatitis a virus cellular receptor 1 and its role in the regulation of immune responses
JP6152090B2 (ja) 2011-04-21 2017-06-21 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 視神経脊髄炎を処置するための組成物および方法
CN108472365A (zh) 2015-10-30 2018-08-31 艾丽塔生物治疗剂公司 用于肿瘤转导的组合物和方法
US10508143B1 (en) 2015-10-30 2019-12-17 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer

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Also Published As

Publication number Publication date
AU2006218489B2 (en) 2011-02-24
AU2006218489A1 (en) 2006-09-08
KR101213894B1 (ko) 2012-12-20
CA2599967C (en) 2014-10-21
IL185653A (en) 2013-04-30
EP1865985B1 (en) 2010-08-25
US20100150905A1 (en) 2010-06-17
DE602006016413D1 (de) 2010-10-07
HK1118007A1 (en) 2009-01-30
ZA200708372B (en) 2008-12-31
CN101166542A (zh) 2008-04-23
AU2011202405B2 (en) 2013-03-28
NZ562045A (en) 2010-12-24
CA2599967A1 (en) 2006-09-08
JP2008531719A (ja) 2008-08-14
WO2006094134A3 (en) 2006-10-19
JP2012131825A (ja) 2012-07-12
ATE478707T1 (de) 2010-09-15
EP2251037B1 (en) 2015-01-14
EP2251037A1 (en) 2010-11-17
IL185653A0 (en) 2008-01-06
AU2011202405A1 (en) 2011-06-09
BRPI0608254A2 (pt) 2009-12-08
US20130089539A1 (en) 2013-04-11
US8206705B2 (en) 2012-06-26
EP1865985A2 (en) 2007-12-19
KR20070110411A (ko) 2007-11-16
WO2006094134A2 (en) 2006-09-08

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Address after: Massachusetts, USA

Applicant after: Than Ao Gen MA company

Address before: Massachusetts, USA

Applicant before: Biogen Idec MA Inc.

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Free format text: CORRECT: APPLICANT; FROM: BIOGEN IDEC MA TO: BIOGEN MA INC.

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Application publication date: 20140430