CN103751519A - Traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof - Google Patents
Traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof Download PDFInfo
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- CN103751519A CN103751519A CN201410026551.5A CN201410026551A CN103751519A CN 103751519 A CN103751519 A CN 103751519A CN 201410026551 A CN201410026551 A CN 201410026551A CN 103751519 A CN103751519 A CN 103751519A
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Abstract
The invention discloses a traditional Chinese medicinal composition with effect of reducing blood sugar and a preparation method thereof. The traditional Chinese medicinal composition comprises the following raw materials in parts by weight: 15-20 parts of Panax notoginseng, 30-35 parts of Salvia miltiorrhiza, 30-35 parts of Ginkgo biloba leaf, 15-20 parts of Semen Cassiae,25-30 parts of Radix Puerariae, 15-20 parts of Dioscorea opposita, 15-20 parts of folium mori, 5-10 parts of Radix Et Rhizoma Rhei, 5-10 parts of Dipsacus asperoides, 5-10 parts of Phyllanthus urinaria, 2-6 parts of Solanum surattense, and 5-10 parts of Ophiopogon japonicus. The preparation method includes reflux-extracting with ethanol, drying, granulating and encapsulating. The traditional Chinese medicinal composition disclosed by the invention uses natural Chinese medicinal herbs to achieve blood glucose reducing effect by synergistic action, and has the advantages of quick action and low toxic and adverse side effects.
Description
Technical field
The present invention relates to a kind of hypoglycemic Chinese medicine prepn, belong to the field of Chinese medicines.
Background technology
Sugar in blood is called blood glucose, is all glucose in most cases.Sugar part is one of requisite nutrition of our healths, the movable required energy major part of each histiocyte is from glucose in body, people take in corn, vegetables and fruits etc., through digestive system, be converted into glucose and enter blood, be transported to systemic cell, as the source of energy, so blood glucose must keep certain level just can maintain the needs of each Organ and tissue in body.Normal person is 4.1～7.0mmol/L in fasting glucose concentration.Fasting glucose concentration exceedes 7.0mmol/L and is called hyperglycemia, at this moment can some glucose with urine, discharges, Here it is glycosuria.
Along with day by day increasing of people's living standard, the patient who suffers from diabetes is also more and more, and diabetes are diseases of a kind of very difficult healing, needs of patients Long-term taking medicine and keeping on a diet, the performance such as diabetes model case often has polyuria, polydipsia, polyphagia, become thin, i.e. " three-many-one-little " symptom.And diabetes very easily cause the complication such as cardiovascular pathological changes, nephropathy, neuropathy.
At present, also there is no a kind of medicine that can effectively treat diabetes on market, in order to treat, this affects the persistent ailment of people's life with prevent diabetes, and people also need further explore and study.
Summary of the invention
The shortcoming existing in order to overcome above-mentioned prior art, the invention provides a kind of hypoglycemic Chinese medicine prepn, and this Chinese medicine preparation blood sugar decreasing effect is obvious.
The present invention is achieved by the following technical solutions: a kind of hypoglycemic Chinese medicine composition, is comprised of the raw material of following weight portion: Radix Notoginseng 15-20 part, Radix Salviae Miltiorrhizae 30-35 part, Folium Ginkgo 30-35 part, Semen Cassiae 15-20 part, Radix Puerariae 25-30 part, Rhizoma Dioscoreae 15-20 part, Folium Mori 15-20 part, Radix Et Rhizoma Rhei 5-10 part, Radix Dipsaci 5-10 part, Herba Phyllanthi Urinariae 5-10 part, fourth eggplant 2-6 part, Radix Ophiopogonis 5-10 part.
Preferably, the raw material of following weight portion composition: Radix Notoginseng 17-19 part, Radix Salviae Miltiorrhizae 31-33 part, Folium Ginkgo 32-34 part, Semen Cassiae 16-18 part, Radix Puerariae 27-29 part, Rhizoma Dioscoreae 16-18 part, Folium Mori 17-19 part, Radix Et Rhizoma Rhei 7-9 part, Radix Dipsaci 6-8 part, Herba Phyllanthi Urinariae 6-9 part, fourth eggplant 3-5 part, Radix Ophiopogonis 6-8 part.
Preferably, by the raw material of following weight portion, formed: 18 parts of Radix Notoginseng, 32 parts of Radix Salviae Miltiorrhizaes, 33 parts of Folium Ginkgos, 17 parts of Semen Cassiaes, 28 parts of Radix Puerariaes, 17 parts of Rhizoma Dioscoreaes, 18 parts, Folium Mori, 8 parts of Radix Et Rhizoma Rhei, 7 parts of Radix Dipsacis, 7 parts of Herba Phyllanthi Urinariaes, 4 parts of fourth eggplants, 7 parts of Radix Ophiopogonis.
A kind of preparation method of hypoglycemic Chinese medicine composition: comprise following process steps: Radix Notoginseng, Radix Salviae Miltiorrhizae, Folium Ginkgo, Semen Cassiae, Radix Puerariae, Rhizoma Dioscoreae, Folium Mori, Radix Et Rhizoma Rhei, Radix Dipsaci, Herba Phyllanthi Urinariae, fourth eggplant, the Radix Ophiopogonis of getting each weight portion by proportion relation; Add mass percent 70% ethanol and soak 30 minutes at 60～65 ℃, reflux, extract, 2-3 time, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 60-100 ℃ of spraying, be ground into 80-100 object fine powder, conventional tabletting or encapsulated after granulating, obtains.
Radix Notoginseng Panax notoginseng (Burk.) F.H.Chen ex C.Chow
Meridian distribution of property and flavor: sweet micro-hardship, temperature.Enter liver, stomach, large intestine channel.
Function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.
Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge
Meridian distribution of property and flavor: hardship, is slightly cold.Enter the heart, Liver Channel.
Function cures mainly: have promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, with all worries set aside, blood sugar lowering and the effect such as antibacterial reduce blood pressure, calm the nerves, to menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect.In addition, modern medicine experiment showed, that Radix Salviae Miltiorrhizae also has the function of anti-platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of adjusting, is the natural Chinese medicine that a kind of safety is treated again cardiovascular disease reliably.
Folium Ginkgo Ginkgo biloba
Meridian distribution of property and flavor: micro-hardship, property is flat.GUIXIN, lung meridian.
Function cures mainly: astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, prevention cardiovascular diseases, but can not take other simultaneously and control cardiovascular drugs (for example aspirin), Semen Ginkgo extrac is concentrated granular shape, there is very strong removing free radical and antioxidation, the synthetic collagen Proteins of flavonoid glycoside, aminoacid and aminoacid in Folium Ginkgo is improved looks to human body, and check melanin growth, keeps skin gloss and elasticity to play no small effect.In addition,, according to modern clinical research, to take negative symptoms as the chronic schizophrenia of main (as social withdrawal, sluggishness, the poverty of thought, the symptom such as dull) has remarkable result, senile dementia is also had to certain effect.
Semen Cassiae Catsia tora Linn.
Meridian distribution of property and flavor: sweet, bitter, salty, be slightly cold.Return liver, large intestine channel.
Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Radix Puerariae: Pueraria lobata
Meridian distribution of property and flavor: sweet, pungent, cool.Return spleen, stomach warp.
Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, and rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, hypertension neck pain.
Rhizoma Dioscoreae Common Yam Rhizome
Meridian distribution of property and flavor: sweet in the mouth, property is flat.Return spleen, lung, kidney channel.
Function cures mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung are breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat are quenched one's thirst.
Folium Mori Folium Mori
Meridian distribution of property and flavor: bitter in the mouth, sweet, cold in nature.Return lung, spleen channel.
Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis.Anemopyretic cold or pathogenic wind-warm be from the beginning of, fever and headache, perspiration and aversion to wind, cough chest pain; Or dryness of the lung dry cough without phlegm; Dry throat and mouth; On wind heat and liver-yang, disturb; Conjunctival congestion and swelling pain.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted
Radix Et Rhizoma Rhei Rhizoma et Radix Rhei Palmat
Meridian distribution of property and flavor: hardship, cold.Return stomach warp; Large intestine channel; Liver Channel; Spleen channel
Function cures mainly: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
Radix Dipsaci Lonicera japonica Thunb
Meridian distribution of property and flavor: bitter, pungent, sweet, tepor.Enter liver, kidney channel.
Function cures mainly: the liver and the kidney tonifying, and activating collaterals to relieve pain, reuniting the fractured tendons and bones, treats injured, Gu through leukorrhagia stopping.
Herba Phyllanthi Urinariae: Phyllanthus urinaria L.
Meridian distribution of property and flavor: sweetness and bitterness, cool.Enter liver, lung two warps.
Function cures mainly: calming liver and clearing heat, promoting diuresis to remove toxic substance.Control enteritis, dysentery, infectious hepatitis, oedema due to nephritis, urinary tract infection, infantile malnutrition, acute catarrhal conjunctivitis corneal nebula, aphtha head sore, innominate toxic swelling.
Fourth eggplant Solanum surattense Burm.f.
Meridian distribution of property and flavor: bitter, pungent, tepor.Poisonous.Function cures mainly: promoting blood circulation to remove blood stasis, analgesia anesthesia.Traumatic injury, lumbago, skelalgia of rheumatism, carbuncle pyogenic infections from tumour or sore, chilblain.
Radix Ophiopogonis Ophiopogon Japonicus
Meridian distribution of property and flavor: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.
Function cures mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
The invention has the beneficial effects as follows: adopt natural Chinese medicinal herb, each taste medicine synergism, reaches and fall hypoglycemic effect, and rapid-action, and toxic and side effects is little.
Clinical observation
1. clinical data
In year June in April, 2013 to 2013, choosing altogether 200 routine diabeticss is treatment target, wherein male 100 people, and female 100 people, average 58.5 years old, are divided into two groups of A, B, every group of each 100 people at random.
2. Therapeutic Method
A group: take glitazone hypoglycemic drug, 2 times/day, each one, as reference group;
B group: take hypoglycemic Chinese medicine prepn of the present invention (specification 0.45g/ grain), 2 times/day, each one.
All patient's drug administrations cut out after 30 days, then observed 30 days.
3. efficacy assessment standard
At drug administration before 1 day, drug administration after the 30th day and after drug administration the 60th day, detects respectively fasting glucose, two hours blood glucoses, index after the meal to every group;
All indexs represent by mean ± standard deviation, and the statistical method of application t check is analyzed result, and P < 0.05 thinks tool significance.
4. therapeutic outcome is as follows:
The comparison (mmol/L) of fasting glucose before and after table 1 liang group patient drug administration
The blood glucose comparison (mmol/L) of two hours after the meal before and after table 2 liang group patient drug administration
By table 1, table 2, can be found out, the blood glucose target ratio that A group and B organize drug administration the 30th day and the 60th day has obvious decline before taking, but can obviously find out, the blood glucose target of the B group of taking Chinese medicine preparation of the present invention after 30 days is starkly lower than the A group of taking Western medicine, after drug withdrawal 30 days, B group patient's blood glucose target floats little, and the rising of A group patient blood glucose target is floated larger.So hypoglycemic Chinese medicine prepn of the present invention has hypoglycemic clear superiority.
Specific embodiment
Embodiment 1
(1) get 15 parts of Radix Notoginseng, 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Folium Ginkgos, 15 parts of Semen Cassiaes, 25 parts of Radix Puerariaes, 15 parts of Rhizoma Dioscoreaes, 15 parts, Folium Mori, 5 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Dipsacis, 5 parts of Herba Phyllanthi Urinariaes, 2 parts of fourth eggplants, 5 parts of Radix Ophiopogonis standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 60 ℃, reflux, extract, 2 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 60 ℃ of sprayings, be ground into 80 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 2
Get 20 parts of Radix Notoginseng, 35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Folium Ginkgos, 20 parts of Semen Cassiaes, 30 parts of Radix Puerariaes, 20 parts of Rhizoma Dioscoreaes, 20 parts, Folium Mori, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Dipsacis, 10 parts of Herba Phyllanthi Urinariaes, 6 parts of fourth eggplants, 10 parts of Radix Ophiopogonis standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 100 ℃ of sprayings, be ground into 100 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 3
(1) get 17 parts of Radix Notoginseng, 31 parts of Radix Salviae Miltiorrhizaes, 32 parts of Folium Ginkgos, 18 parts of Semen Cassiaes, 29 parts of Radix Puerariaes, 18 parts of Rhizoma Dioscoreaes, 19 parts, Folium Mori, 9 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Dipsacis, 9 parts of Herba Phyllanthi Urinariaes, 5 parts of fourth eggplants, 8 parts of Radix Ophiopogonis standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 70 ℃ of sprayings, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 4
(1) get 19 parts of Radix Notoginseng, 33 parts of Radix Salviae Miltiorrhizaes, 34 parts of Folium Ginkgos, 16 parts of Semen Cassiaes, 27 parts of Radix Puerariaes, 16 parts of Rhizoma Dioscoreaes, 17 parts, Folium Mori, 7 parts of Radix Et Rhizoma Rhei, 6 parts of Radix Dipsacis, 6 parts of Herba Phyllanthi Urinariaes, 3 parts of fourth eggplants, 6 parts of Radix Ophiopogonis standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 80 ℃ of sprayings, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 5
(1) get 18 parts of Radix Notoginseng, 32 parts of Radix Salviae Miltiorrhizaes, 33 parts of Folium Ginkgos, 17 parts of Semen Cassiaes, 28 parts of Radix Puerariaes, 17 parts of Rhizoma Dioscoreaes, 18 parts, Folium Mori, 8 parts of Radix Et Rhizoma Rhei, 7 parts of Radix Dipsacis, 7 parts of Herba Phyllanthi Urinariaes, 4 parts of fourth eggplants, 7 parts of Radix Ophiopogonis standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 90 ℃ of sprayings, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Claims (4)
1. a hypoglycemic Chinese medicine composition, is characterized in that being comprised of the raw material of following weight portion: Radix Notoginseng 15-20 part, Radix Salviae Miltiorrhizae 30-35 part, Folium Ginkgo 30-35 part, Semen Cassiae 15-20 part, Radix Puerariae 25-30 part, Rhizoma Dioscoreae 15-20 part, Folium Mori 15-20 part, Radix Et Rhizoma Rhei 5-10 part, Radix Dipsaci 5-10 part, Herba Phyllanthi Urinariae 5-10 part, fourth eggplant 2-6 part, Radix Ophiopogonis 5-10 part.
2. the hypoglycemic Chinese medicine composition of one according to claim 1, is characterized in that being comprised of the raw material of following weight portion: Radix Notoginseng 17-19 part, Radix Salviae Miltiorrhizae 31-33 part, Folium Ginkgo 32-34 part, Semen Cassiae 16-18 part, Radix Puerariae 27-29 part, Rhizoma Dioscoreae 16-18 part, Folium Mori 17-19 part, Radix Et Rhizoma Rhei 7-9 part, Radix Dipsaci 6-8 part, Herba Phyllanthi Urinariae 6-9 part, fourth eggplant 3-5 part, Radix Ophiopogonis 6-8 part.
3. the hypoglycemic Chinese medicine composition of one according to claim 1, is characterized in that being comprised of the raw material of following weight portion: 18 parts of Radix Notoginseng, 32 parts of Radix Salviae Miltiorrhizaes, 33 parts of Folium Ginkgos, 17 parts of Semen Cassiaes, 28 parts of Radix Puerariaes, 17 parts of Rhizoma Dioscoreaes, 18 parts, Folium Mori, 8 parts of Radix Et Rhizoma Rhei, 7 parts of Radix Dipsacis, 7 parts of Herba Phyllanthi Urinariaes, 4 parts of fourth eggplants, 7 parts of Radix Ophiopogonis.
4. according to the preparation method of the arbitrary described a kind of hypoglycemic Chinese medicine composition of claim 1-3: it is characterized in that comprising following process steps: Radix Notoginseng, Radix Salviae Miltiorrhizae, Folium Ginkgo, Semen Cassiae, Radix Puerariae, Rhizoma Dioscoreae, Folium Mori, Radix Et Rhizoma Rhei, Radix Dipsaci, Herba Phyllanthi Urinariae, fourth eggplant, the Radix Ophiopogonis of getting each weight portion by proportion relation; Add mass percent 70% ethanol and soak 30 minutes at 60～65 ℃, reflux, extract, 2-3 time, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 60-100 ℃ of spraying, be ground into 80-100 object fine powder, conventional tabletting or encapsulated after granulating, obtains.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103305A (en) * | 1993-11-27 | 1995-06-07 | 李南山 | Diabetes powder and its preparing method |
| CN103446385A (en) * | 2013-08-26 | 2013-12-18 | 山西康禾农业有限责任公司 | Traditional Chinese medicine preparation for treating diabetic complications |
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2014
- 2014-01-21 CN CN201410026551.5A patent/CN103751519A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103305A (en) * | 1993-11-27 | 1995-06-07 | 李南山 | Diabetes powder and its preparing method |
| CN103446385A (en) * | 2013-08-26 | 2013-12-18 | 山西康禾农业有限责任公司 | Traditional Chinese medicine preparation for treating diabetic complications |
Non-Patent Citations (1)
| Title |
|---|
| 郭云良，等: "《中西医结合医学导论》", 31 May 2013, 科学技术文献出版社 * |
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