CN103751333B - Medicinal composition for treating burns and preparation method thereof - Google Patents
Medicinal composition for treating burns and preparation method thereof Download PDFInfo
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- CN103751333B CN103751333B CN201310752028.6A CN201310752028A CN103751333B CN 103751333 B CN103751333 B CN 103751333B CN 201310752028 A CN201310752028 A CN 201310752028A CN 103751333 B CN103751333 B CN 103751333B
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Abstract
The invention relates to a medicinal composition, and in particular relates to a medicinal composition for treating burns. The medicinal composition is prepared from the following bulk drugs: carbonized sanguisorba root, spatholobus suberctu, coptidis rhizome, polygonum cuspidatum, ginseng and honey. Clinical tests prove that the medicinal composition has a remarkable curative effect to burns, and can be used for effectively shortening the course of treatment.
Description
Technical field
The present invention relates to pharmaceutical composition, specifically, relate to a kind of pharmaceutical composition for the treatment of burn and preparation method thereof.
Background technology
Burn is the acute injury acting on body by various factors such as physics, chemistry, lonizing radiation and cause.The traditional Chinese medical science claims " baked wheaten cake skin ulcer ", " burn and scald ", its origin cause of formation is due to flame, and the factors such as hot water cause human body skin and subcutaneous tissue to be burnt, and fur is not deposited, sepage stream Tianjin, usur skin.Light then affect attractive in appearance, heavy then cause multiple General Symptoms, the order of severity of burn depends on scope and the degree of depth of wounded tissue.
Western medical treatment is burnt, and hinder face through cleaning, then add medicine to after carrying out the process of necrotic muscle tissue and rigorous sterilization to wound, then wrap up.Doctor trained in Western medicine is not advocated to hinder face medicine-feeding, mainly based on innerlich anwenden, hinders face and directly processes with any medicine hardly.But this method seems science, in fact effect is not ideal, and cost is extremely expensive.And the traditional Chinese medical science is when treating burn, add medicine to, pain relieving at once, is alleviated and eliminates the pain of injury, fully stimulated the regeneration capacity of human body cell, impel muscular tissue to regrow by external used medicine immediately.But its formula is complicated, effect is still undesirable, and treatment is longer for the course for the treatment of.
Summary of the invention
In order to solve problems of the prior art, the object of this invention is to provide a kind of treat compare the course for the treatment of prior art shorter treatment burn Chinese medicine composition.
In order to realize the object of the invention, first the present invention provides a kind of pharmaceutical composition for the treatment of burn it is characterized in that, described pharmaceutical composition is made up of following crude drug: charred Radix Sanguisorbae, Caulis Spatholobi, Rhizoma Coptidis, Rhizoma Polygoni Cuspidati, Radix Ginseng and Mel.
As preferably, described pharmaceutical composition is made up of the crude drug of following weight portion:
Charred Radix Sanguisorbae 25-30 part Caulis Spatholobi 10-30 part
Rhizoma Coptidis 20-30 part Rhizoma Polygoni Cuspidati 10-30 part
Radix Ginseng 5-10 part Mel 10-30 part.
More preferred, described pharmaceutical composition is made up of the crude drug of following weight portion:
Charred Radix Sanguisorbae 28 portions of Caulis Spatholobis 20 parts
Rhizoma Coptidis 26 parts of Rhizoma Polygoni Cuspidati 10 parts
Radix Ginseng 6 parts of Mel 10 parts.
The present invention also provides the preparation containing foregoing pharmaceutical compositions further, and as preferably, described preparation is unguentum.
The preparation method of described unguentum comprises the steps:
1) above Six-element crude drug, except Mel, is ground into fine powder by five tastes crude drug such as all the other charred Radix Sanguisorbae, crosses 80-200 mesh sieve, with Oleum Brassicae campestris-Oleum Sesami 60-70 part, stirs evenly, place 2 days;
2) separately get white vaseline 770-780 part, lanoline 60 parts, 130 DEG C of heating, after 30 minutes, let cool to 100 DEG C, and add the medicated powder of above-mentioned Oleum Brassicae campestris-Oleum Sesami infiltration, 100 DEG C of constant temperature stir 20 minutes, let cool to 60 DEG C, add Mel, stir evenly, make 1000g, to obtain final product.
Wherein, in described Oleum Brassicae campestris-Oleum Sesami, the ratio of Oleum Brassicae campestris and Oleum Sesami is 15:1.
The preparation method of described Oleum Brassicae campestris-Oleum Sesami is: machine of getting squeezes Oleum Brassicae campestris and is stirred and heated to 215 ~ 225 DEG C, is incubated 5 ~ 10 minutes, lets cool; Separately get Oleum Sesami to mix homogeneously in the ratio of 1:15 with the Oleum Brassicae campestris after above-mentioned refining, under constantly stirring, be heated to 105 DEG C, be incubated 30 minutes, discard floating thing, to obtain final product.
Another object of the present invention is to provide the application of described pharmaceutical composition in the medicine of preparation treatment burn.
In pharmaceutical composition of the present invention:
Charred Radix Sanguisorbae: cooling blood for hemostasis, pathogenic fire purging sore.Its hemostasis and sore effect can be strengthened after Radix Sanguisorbae parch to black.
Caulis Spatholobi: promoting the circulation of blood of enriching blood, the meridian dredging.
Rhizoma Polygoni Cuspidati: heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.
Radix Ginseng: strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.
Mel: skin moistening granulation promoting; Removing toxic substances.
Beneficial effect of the present invention is:
Rhizoma Polygoni Cuspidati in prescription of the present invention: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, heat-clearing and toxic substances removing, for burn due to hot liquid or fire, the swollen sore of pain.Charred Radix Sanguisorbae: cooling blood for hemostasis, pathogenic fire purging sore.Caulis Spatholobi: promoting the circulation of blood of enriching blood, the meridian dredging.Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.Radix Ginseng: strongly invigorating primordial QI, promote the production of body fluid Gu de-, calm the nerves, when pain is contained, gaseous pulse must be anxious, therefore calm the nerves with Radix Ginseng.Mel, skin moistening granulation promoting, removing toxic substances.Oleum Sesami: lubricant and excipient, removing toxic substances and promoting granulation.For ulcer, skin ulcer swells chapped skin.All medicine compatibilities, play heat-clearing and toxic substances removing, putrefaction-removing granulation-promoting altogether, the merit of sore closing in and analgesic therapy.
Pharmaceutical composition of the present invention is verified through clinical trial, evident in efficacy to burn symptom, and treatment to compare prior art shorter the course for the treatment of, thus shorten the recovery time of patient, alleviate the pain of injury of patient.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 drug combination preparation of the present invention (unguentum)
Prescription: charred Radix Sanguisorbae 28g, Caulis Spatholobi 20g, Rhizoma Coptidis 26g, Rhizoma Polygoni Cuspidati 10g, Radix Ginseng 6g, Mel 10g.
Method for making: above Six-element, except Mel (refining), the five tastes such as all the other charred Radix Sanguisorbae are pulverized and are claimed fine powder, cross 80-200 mesh sieve, with Oleum Brassicae campestris-Oleum Sesami (15:1) (refining) 60-70g, stir evenly, place 2 days.Separately get white vaseline 770-780g, lanoline 60g, 130 DEG C of heating, after 30 minutes, let cool to 100 DEG C, add the medicated powder that above-mentioned Oleum Brassicae campestris-Oleum Sesami (15:1) (refining) is permeated, constant temperature (100 DEG C) stirs 20 minutes, lets cool to 60 DEG C, adds Mel (refining), stir evenly, make 1000g, to obtain final product.
Wherein: the method for making of Oleum Brassicae campestris-Oleum Sesami (15:1) (refining): machine of getting squeezes Oleum Brassicae campestris and is stirred and heated to 215 ~ 225 DEG C, is incubated 5 ~ 10 minutes, lets cool; Separately get Oleum Sesami to mix homogeneously in the ratio of 1:15 with the Oleum Brassicae campestris after above-mentioned refining, under constantly stirring, be heated to 105 DEG C, be incubated 30 minutes, discard floating thing, to obtain final product.
Function cures mainly: heat-clearing and toxic substances removing, granulation promoting pain relieving.Burn for shallow/dark two degrees and three degrees/scald, area of burning is less than 10%.
Usage and dosage: clean wound surface with normal saline, by ointment uniform application on antiseptic gauze, the thick about 2mm of powder, flap coverage, is optionally wrapped up or half exposure.1 time on the one.
Embodiment 2 drug combination preparation of the present invention (unguentum)
Prescription: charred Radix Sanguisorbae 25g, Caulis Spatholobi 10g, Rhizoma Coptidis 20g, Rhizoma Polygoni Cuspidati 30g, Radix Ginseng 10g, Mel 15g.
All the other are with embodiment 1.
Embodiment 3 drug combination preparation of the present invention (unguentum)
Prescription: charred Radix Sanguisorbae 30g, Caulis Spatholobi 30g, Rhizoma Coptidis 30g, Rhizoma Polygoni Cuspidati 15g, Radix Ginseng 5g, Mel 30g.
All the other are with embodiment 1.
The clinical trial of experimental example 1 pharmaceutical composition of the present invention
1. clinical data
Clinical observation 161 example (wherein experimental group 86 example, matched group 75 example).Patient is divided into two groups at random, respectively external application ointment of the present invention and ZIHUA SHAOSHANGGAO.
2. Therapeutic Method
2.1 embodiment of the present invention 1 unguentum are applied to affected part equably, change dressings every day once, within 7 days, are a course for the treatment of.
2.2 ZIHUA SHAOSHANGGAO (Shandong Mei Bao pharmaceutcal corporation, Ltd produces, the accurate word Z10930029 of traditional Chinese medicines), external application affected part, determines by affected part size, and every day is changed once, within 7 days, is a course for the treatment of.
3. criterion of therapeutical effect
Criterion of cure: subcutaneous swelling is obviously being disappeared, private prosecution pain and heating obviously alleviate, the initial stage medication no-station pole canopy blister person of appearance.
According to above-mentioned standard, by the time evaluation curative effect that continues medication.Through statistical procedures, two groups of curative effects have significant difference (P <0.01), and experimental group curative effect is better than matched group, and efficacy result is in table 1.
Table 1 liang is formed the average healing days in face and is compared (note: P<0.05)
| Group | Number of cases | Shallow two degree | Dark two degree | Three degree |
| Of the present invention group | 86 | 8±3.5 | 12±4.5 | 21±5.5 |
| ZIHUA SHAOSHANGGAO group | 75 | 11±4.0 | 18±3.5 | 35±6.5 |
Through verification experimental verification, the embodiment of the present invention 2 and embodiment 3 all have therapeutic effect similarly to Example 1.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. treat a pharmaceutical composition for burn, it is characterized in that, described pharmaceutical composition is made up of the crude drug of following weight portion:
Charred Radix Sanguisorbae 25-30 part Caulis Spatholobi 10-30 part
Rhizoma Coptidis 20-30 part Rhizoma Polygoni Cuspidati 10-30 part
Radix Ginseng 5-10 part Mel 10-30 part.
2. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition is made up of the crude drug of following weight portion:
Charred Radix Sanguisorbae 28 portions of Caulis Spatholobis 20 parts
Rhizoma Coptidis 26 parts of Rhizoma Polygoni Cuspidati 10 parts
Radix Ginseng 6 parts of Mel 10 parts.
3. the preparation containing the pharmaceutical composition described in claim 1 or 2, it is characterized in that, described preparation is unguentum.
4. the preparation method of preparation described in claim 3, is characterized in that, comprises the steps:
1) above Six-element crude drug, except Mel, is ground into fine powder by five tastes crude drug such as all the other charred Radix Sanguisorbae, crosses 80-200 mesh sieve, with Oleum Brassicae campestris-Oleum Sesami 60-70 part, stirs evenly, place 2 days;
2) separately get white vaseline 770-780 part, lanoline 60 parts, 130 DEG C of heating, after 30 minutes, let cool to 100 DEG C, and add the medicated powder of above-mentioned Oleum Brassicae campestris-Oleum Sesami infiltration, 100 DEG C of constant temperature stir 20 minutes, let cool to 60 DEG C, add Mel, stir evenly, make 1000g, to obtain final product.
5. preparation method according to claim 4, is characterized in that, in described Oleum Brassicae campestris-Oleum Sesami, the ratio of Oleum Brassicae campestris and Oleum Sesami is 15:1.
6. preparation method according to claim 5, is characterized in that, the preparation method of described Oleum Brassicae campestris-Oleum Sesami is: machine of getting squeezes Oleum Brassicae campestris and is stirred and heated to 215 ~ 225 DEG C, is incubated 5 ~ 10 minutes, lets cool; Separately get Oleum Sesami to mix homogeneously in the ratio of 1:15 with the Oleum Brassicae campestris after above-mentioned refining, under constantly stirring, be heated to 105 DEG C, be incubated 30 minutes, discard floating thing, to obtain final product.
7. the application of the pharmaceutical composition described in claim 1 or 2 in the medicine of preparation treatment burn.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310752028.6A CN103751333B (en) | 2013-12-31 | 2013-12-31 | Medicinal composition for treating burns and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310752028.6A CN103751333B (en) | 2013-12-31 | 2013-12-31 | Medicinal composition for treating burns and preparation method thereof |
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| CN103751333A CN103751333A (en) | 2014-04-30 |
| CN103751333B true CN103751333B (en) | 2015-07-01 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1481826A (en) * | 2002-09-11 | 2004-03-17 | 李宗珊 | Ointment for scald and ulcer and its preparation method |
| CN102416090A (en) * | 2011-12-19 | 2012-04-18 | 大连创达技术交易市场有限公司 | External ointment for treating burn |
| CN102861150A (en) * | 2012-09-25 | 2013-01-09 | 李书明 | Chinese medicine powder for treating burn and scald and anabrosis |
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2013
- 2013-12-31 CN CN201310752028.6A patent/CN103751333B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1481826A (en) * | 2002-09-11 | 2004-03-17 | 李宗珊 | Ointment for scald and ulcer and its preparation method |
| CN102416090A (en) * | 2011-12-19 | 2012-04-18 | 大连创达技术交易市场有限公司 | External ointment for treating burn |
| CN102861150A (en) * | 2012-09-25 | 2013-01-09 | 李书明 | Chinese medicine powder for treating burn and scald and anabrosis |
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| Publication number | Publication date |
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| CN103751333A (en) | 2014-04-30 |
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