CN103933481A - External medicine for treating cancer pain and preparation method thereof - Google Patents
External medicine for treating cancer pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an external medicine for treating cancer pain and a preparation method thereof. The external medicine for treating cancer pain is composed of the following raw material medicines: 20-50 g of flos rosae rugosae, 20-50 g of clove, 10-30 g of asarum, 20-50 g of raw pinellia ternate, 20-50 g of cinnamon, 5-20 g of scorpion, 10-20 g of borneol, 20-50 g of rhizoma arisaematis, 10-30 g of frankincense, 10-30 g of myrrh, 10-30 g of rheum officinale, 10-30 g of zedoary, 10-30 g of radix angelicae, 10-30 g of ferula asafoetida, 10-30 g of resurrection lily rhizome, 5-10 g of venenum bufonis, 0.1-0.5 g of muskone, 10-30 g of raw lumbricus, 2-5 g of tetracaine ointment and 5-10 g of diclofenac ointment. The flos rosae rugosae analgesic balm is simple in preparation method, effective in external treatment on cancer pain, capable of improving analgesic effect, definite in curative effect, and capable of reducing the usage amounts of bucinnazine and morphine, reducing the adverse reactions of Western medicines such as morphine, and improving the survival quality of patients.
Description
Technical field
The invention belongs to a kind of external medicine preparation and preparation method thereof, particularly belong to a kind of external used medicine for the treatment of cancer pain and preparation method thereof.
Background technology
Cancer is the formidable enemy of harm humans health, middle and advanced stage when cancer is generally found, and the method for the treatment of has: operation, chemotherapy, radiotherapy and the combination of Chinese and Western medicine.Once the outbreak of middle and terminal cancer patient cancer pain, hurt like hell, causes very large misery to patient.Western medical treatment cancer pain three rescue by stages that adopt more, opiates medicine is generally applied in the treatment of middle and advanced stage cancer pain, oral, intramuscular injection or external, but after application, most of patients has dizzy, nauseating, vomiting, perspiration, abdominal distention, the untoward reaction such as constipation, along with the continuous increase of dosage, the frequency, patient is to drug dependence addiction, and occurs intestinal obstruction, even delirium, respiration inhibition, the serious adverse reactions such as stupor, increase patient suffering and burden, had a strong impact on patients ' life quality.Chinese medicine cancer pain has unique advantage, and Flos Rosae Rugosae ZHITONG GAO of the present invention has removing obstruction in the collateral to relieve pain, effect of detoxicating and resolving stagnation of pathogens.
Summary of the invention
The object of this invention is to provide a kind of external used medicine for the treatment of cancer pain, another object of the present invention is to provide the preparation method of this medicine.
Technical scheme of the present invention is, a kind of external used medicine for the treatment of cancer pain, it is characterized in that, its each crude drug consists of: Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram.
Preferred each crude drug consists of: 30 grams of Flos Rosae Rugosaes, 30 grams of Flos Caryophyllis, 20 grams of Herba Asaris, 30 grams of Rhizoma Pinelliae, 30 grams of Cortex Cinnamomis, 10 grams of Scorpios, 10 grams of Borneolum Syntheticums, 30 grams of Rhizoma Arisaematiss, 20 grams of Olibanums, 20 grams of Myrrhas, 20 grams of Radix Et Rhizoma Rhei, 20 grams of Rhizoma Wenyujin Concisum, 20 grams of the Radixs Angelicae Dahuricae, 20 grams of Resina Ferulaes, 20 grams of Rhizoma Kaempferiae, 10 grams of Venenum Bufoniss, 0.5 gram of artificial Moschus, 20 grams of Pheretima, 2 grams of tetracaine ointment, 10 grams of diclofenac ointments.
A preparation method for the treatment of the external used medicine of cancer pain, is characterized in that: mainly comprise the steps:
A, take raw material: take respectively Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram for subsequent use,
B, powder process: Flos Rosae Rugosae, Flos Caryophylli, Herba Asari, Rhizoma Pinelliae, Cortex Cinnamomi, Scorpio, Rhizoma Arisaematis, Olibanum, Myrrha, Radix Et Rhizoma Rhei, Rhizoma Wenyujin Concisum, the Radix Angelicae Dahuricae, Resina Ferulae, Rhizoma Kaempferiae, Venenum Bufonis, the Pheretima that above-mentioned A step is prepared cleans, dries, pulverized after 100 mesh sieves for subsequent use;
C, cream processed: the Mel of getting 300 grams is boiled into middle honey, let cool to 50 DEG C, pour in medicated powder prepared by B step and mix, the Borneolum Syntheticum, artificial Moschus, the tetracaine ointment that add again above-mentioned A step to prepare, diclofenac ointment mixes, and 30 milliliters of glycerol addings are transferred to the existing bulk that mixture is held, weigh, subpackage, tiling is to sticker, with special paster covering;
D, this Flos Rosae Rugosae analgesic extract closed packaging prepared by above-mentioned steps.
Using method: choose painful area, local skin sterilization, unpacks, and tears paster, ointment is aimed to painful area and stick, and every 1-2 day is changed 1 time.If any new painful area, at any time external.Observe part and have or not pruritus, erythra, the allergic phenomenas such as redness, blister, as seriously inactive in pruritus or blister.
Inventor thinks: cancer pain mostly is in cancer poison soaks, and flees passages through which vital energy circulates, and poison enters internal organs, and attached muscle bone and formed.Extremely, coldheat complex, ties in ecchymosis the evil institute of poison, and passages through which vital energy circulates is become estranged, stagnation of QI and blood may bring about pain.Therefore principle for the treatment of should be promoting blood circulation to remove obstruction in the collateral, detoxicating and resolving stagnation of pathogens, simultaneously using both cold and hot drugs, transdermal pain relieving.Cancer pain patient, accompanies anxiety more, depression, and irritability is stasis for it.The present invention is taking Flos Rosae Rugosae as monarch drug, and this medicine is sweet; Micro-hardship; Temperature; Nontoxic, " book on Chinese herbal medicine justice ": Flos Rosae Rugosae, fragrance is the denseest, turbid clearly and not, and and not violent, the easing the affected liver stomach of waking up, gas is invigorated blood circulation, a surname is logical stops up stagnant and just dry fraud of absolutely not pungent temperature, disconnectedly push away among edema caused by disorder of QI medicine, have prompt effect most and the most tractable person, fragrant all product, there is no equal.Fragrant odour, the emotion of releiving, its volatile oil has obvious analgesic activity, dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating blood circulation analgesia; Olibanum regulating qi and activating blood, analgesic therapy, chases after poison." solar corona " cloud, soft extracts pain relieving is put on flesh.CHEN Zang-Qi cloud, moderns are in order to control all pains of internal injury, and the medicine of toxic swelling Orally taken and externally, have from the beginning.Its volatile oil acetic acid n-octyl has obvious analgesic activity; Myrrha eliminating stasis to stop pain, externally used detumescence granulation promoting." Japan hanako materia medica ": broken crux stagnated blood, detumescence poison.Both are ministerial drug altogether, have the function that strengthens monarch drug promoting blood circulation to remove obstruction in the collateral, jointly strengthen analgesic effect together with monarch drug.Flos Caryophylli, Herba Asari, the pain relieving of Cortex Cinnamomi energy dispelling cold by warming the meridian, Shan Zhi mass in the abdomen obstinate disease; The Rhizoma Pinelliae, Rhizoma Arisaematis, Venenum Bufonis, Scorpio detoxicating and resolving stagnation of pathogens, treats skin ulcer, sensible meridians; Borneolum Syntheticum, Radix Et Rhizoma Rhei heat-clearing and toxic substances removing, subduing swelling and relieving pain; Rhizoma Wenyujin Concisum energy removing blood stasis circulation of qi promoting curcumin can inducing apoptosis of tumour cell, and inhibition tumor cell propagation, has obvious analgesic activity.The Radix Angelicae Dahuricae, Resina Ferulae, the medicines such as Rhizoma Kaempferiae are with dredging collateral, pain relieving, be adjuvant drug altogether, make not only promoting blood circulation and stopping pain of we, have more detoxicating and resolving stagnation of pathogens effect, apply together with above-mentioned monarch drug, ministerial drug, further increase analgesic effect, and there is antineoplastic action, there is treatment cancer pain specific aim; By Moschus, Borneolum Syntheticum is subcutaneous for medicine etc. is penetrated, and the institute of through slight illness, is equipped with tetracaine, and diclofenac enters plaster with Chinese and Western use, and all medicines share plays detoxicating and resolving stagnation of pathogens altogether, the merit of the analgesic therapy of invigorating blood circulation.
Observation of curative effect: inventor selects middle and advanced stage cancer pain patient 70 examples, is divided into 2 groups by randomization, wherein treatment group 40 examples, patients with lung cancer 16 examples, patient with esophageal carcinoma 12 examples, patients with gastric cancer 7 examples, PATIENTS WITH LARGE BOWEL 5 examples.Matched group 30 examples, patients with lung cancer 13 examples, patient with esophageal carcinoma 7 examples, patients with gastric cancer 5 examples, PATIENTS WITH LARGE BOWEL 5 examples.Two groups of medical histories, the age, sex, pain scores degree there are no significant difference, has comparability.
Therapeutic Method: treatment group is according to digital staging (pain degree digit score scale) scoring and main suit's pain degree staging calibration.Give Flos Rosae Rugosae ZHITONG GAO external application, before and after record treatment, scoring changes, and pain degree changes.Therapentic part: pain is the most acutely located, changes 1 time for 24 hours.Light moderate pain gives Flos Rosae Rugosae ZHITONG GAO external application and applies non-steroidal anti-inflammatory analgesics or tramadol is oral, and middle severe Flos Rosae Rugosae ZHITONG GAO external application titration dosage give sustained-release morphine, can not oral person give bucinnazine or the treatment of injection of morphia liquid.Matched group applies non-steroidal anti-inflammatory analgesics by the light moderate pain of doctor trained in Western medicine cancer pain Normalized Treatment principle or tramadol is oral, and middle severe titration dosage give sustained-release morphine, can not oral person give bucinnazine or the treatment of injection of morphia liquid.15 days 1 courses for the treatment of. observe two groups of analgesic effects, morphine slow releasing tablet and bucinnazine and injection of morphia liquid consumption.
Result:
A table 1 liang group pain degree is alleviated relatively [n (%)]
| Group | Number of cases | Alleviate completely | Partial rcsponse | Slight alleviation | Invalid |
| Treatment group | 40 | 19 | 12 | 9 | 0(0) |
| Matched group | 30 | 12 | 8 | 7 | 3(0) |
Table 2 liang group per course for the treatment of of required dose of morphine comparison and bucinnazine hydrochloride metering.
Analyze: above tables of data Mingzhi treats rear treatment group pain control degree and is obviously better than matched group (P < 0.05), and sustained-release morphine consumption and bucinnazine and injection of morphia liquid consumption obviously reduce (P < 0.05) compared with matched group: before and after two groups of treatments, digital staging scoring decline degree is better than matched group (P < 0.05).
Beneficial effect of the present invention is: this Flos Rosae Rugosae ZHITONG GAO, raw material is easy to get, preparation method is simple, low price, observation contrast by treatment group pain control degree and matched group after above-mentioned use Flos Rosae Rugosae ZHITONG GAO treatment is known: Flos Rosae Rugosae ZHITONG GAO external curing cancer pain can effectively improve analgesic effect, determined curative effect, and can reduce bucinnazine, morphine use amount, reduce the untoward reaction of the Western medicine such as morphine, have certain advantage to improving life in patients.
Detailed description of the invention
The specific embodiment of the invention is:
Embodiment 1,
A, to take 20 grams of Flos Rosae Rugosaes, 45 grams of Flos Caryophyllis, 15 grams of Herba Asaris, 20 grams of Rhizoma Pinelliae, 50 grams of Cortex Cinnamomis, 5 grams of Scorpios, 15 grams of Borneolum Syntheticums, 50 grams of Rhizoma Arisaematiss, 30 grams of Olibanums, 10 grams of Myrrhas, 10 grams of Radix Et Rhizoma Rhei, 30 grams of Rhizoma Wenyujin Concisum, 25 grams of the Radixs Angelicae Dahuricae, 10 grams of Resina Ferulaes, 30 grams of Rhizoma Kaempferiae, 5 grams of Venenum Bufoniss, 0.2 gram of artificial Moschus, 10 grams of Pheretima, 4 grams of tetracaine ointment, 8 grams of diclofenac ointments for subsequent use;
B, the Flos Rosae Rugosae that above-mentioned A step is prepared, Flos Caryophylli, Herba Asari, Rhizoma Pinelliae, Cortex Cinnamomi, Scorpio, Rhizoma Arisaematis, Olibanum, Myrrha, Radix Et Rhizoma Rhei, Rhizoma Wenyujin Concisum, the Radix Angelicae Dahuricae, Resina Ferulae, Rhizoma Kaempferiae, Venenum Bufonis, Pheretima clean, dry, after mixing, pulverized after 100 mesh sieves for subsequent use;
C, cream processed: the Mel of getting 300 grams is boiled into middle honey, let cool to 50 DEG C, pour in medicated powder prepared by B step and mix, the Borneolum Syntheticum, artificial Moschus, the tetracaine ointment that add again above-mentioned A step to prepare, diclofenac ointment mixes, and 30 milliliters of glycerol addings are transferred to the existing bulk that mixture is held, weigh, subpackage, tiling is to sticker, with special paster covering;
D, this Flos Rosae Rugosae analgesic extract closed packaging prepared by above-mentioned steps.
Embodiment 2
A, to take 30 grams of Flos Rosae Rugosaes, 30 grams of Flos Caryophyllis, 20 grams of Herba Asaris, 30 grams of Rhizoma Pinelliae, 30 grams of Cortex Cinnamomis, 10 grams of Scorpios, 10 grams of Borneolum Syntheticums, 30 grams of Rhizoma Arisaematiss, 20 grams of Olibanums, 20 grams of Myrrhas, 20 grams of Radix Et Rhizoma Rhei, 20 grams of Rhizoma Wenyujin Concisum, 20 grams of the Radixs Angelicae Dahuricae, 20 grams of Resina Ferulaes, 20 grams of Rhizoma Kaempferiae, 10 grams of Venenum Bufoniss, 0.5 gram of artificial Moschus, 20 grams of Pheretima, 2 grams of tetracaine ointment, 10 grams of diclofenac ointments for subsequent use; All the other steps are identical with embodiment 1.
Embodiment 3
A, to take 50 grams of Flos Rosae Rugosaes, 20 grams of Flos Caryophyllis, 30 grams of Herba Asaris, 50 grams of Rhizoma Pinelliae, 20 grams of Cortex Cinnamomis, 20 grams of Scorpios, 20 grams of Borneolum Syntheticums, 20 grams of Rhizoma Arisaematiss, 10 grams of Olibanums, 30 grams of Myrrhas, 25 grams of Radix Et Rhizoma Rhei, 10 grams of Rhizoma Wenyujin Concisum, 10 grams of the Radixs Angelicae Dahuricae, 25 grams of Resina Ferulaes, 10 grams of Rhizoma Kaempferiae, 8 grams of Venenum Bufoniss, 0.3 gram of artificial Moschus, 25 grams of Pheretima, 5 grams of tetracaine ointment, 5 grams of diclofenac ointments for subsequent use; All the other steps are identical with embodiment 1.
Claims (3)
1. an external used medicine for the treatment of cancer pain, is characterized in that: its each crude drug consists of: Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, 2-5 gram of tetracaine ointment, diclofenac ointment 5-10 gram.
2. a kind of external used medicine for the treatment of cancer pain according to claim 1, is characterized in that: its each crude drug consists of: 30 grams of Flos Rosae Rugosaes, 30 grams of Flos Caryophyllis, 20 grams of Herba Asaris, 30 grams of Rhizoma Pinelliae, 30 grams of Cortex Cinnamomis, 10 grams of Scorpios, 10 grams of Borneolum Syntheticums, 30 grams of Rhizoma Arisaematiss, 20 grams of Olibanums, 20 grams of Myrrhas, 20 grams of Radix Et Rhizoma Rhei, 20 grams of Rhizoma Wenyujin Concisum, 20 grams of the Radixs Angelicae Dahuricae, 20 grams of Resina Ferulaes, 20 grams of Rhizoma Kaempferiae, 10 grams of Venenum Bufoniss, 0.5 gram of artificial Moschus, 20 grams of Pheretima, 2 grams of tetracaine ointment, 10 grams of diclofenac ointments.
3. the preparation method of a kind of external used medicine for the treatment of cancer pain as claimed in claim 1 or 2, is characterized in that: comprise the steps:
A, take raw material: take respectively Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram for subsequent use,
B, powder process: Flos Rosae Rugosae, Flos Caryophylli, Herba Asari, Rhizoma Pinelliae, Cortex Cinnamomi, Scorpio, Rhizoma Arisaematis, Olibanum, Myrrha, Radix Et Rhizoma Rhei, Rhizoma Wenyujin Concisum, the Radix Angelicae Dahuricae, Resina Ferulae, Rhizoma Kaempferiae, Venenum Bufonis, Pheretima that above-mentioned A step is prepared clean, dry, pulverized after 100 mesh sieves for subsequent use;
C, cream processed: the Mel of getting 300 grams is boiled into middle honey, let cool to 50 DEG C, pour in medicated powder prepared by B step and mix, the Borneolum Syntheticum, artificial Moschus, the tetracaine ointment that add again above-mentioned A step to prepare, diclofenac ointment mixes, and 30 milliliters of glycerol addings are transferred to the existing bulk that mixture is held, weigh, subpackage, tiling is to sticker, with special paster covering;
D, this Flos Rosae Rugosae analgesic extract closed packaging prepared by above-mentioned steps.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878393A (en) * | 2014-12-26 | 2016-08-24 | 李犹璋 | Analgesic patch and preparation method thereof |
| EP4104828A4 (en) * | 2020-02-12 | 2024-05-01 | Hisamitsu Pharmaceutical Co., Inc. | Diclofenac sodium-containing patch |
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| CN1970073A (en) * | 2006-11-28 | 2007-05-30 | 孔祥权 | Chinese medicinal composition for treating pain and preparation process thereof |
| CN101007160A (en) * | 2006-11-27 | 2007-08-01 | 杨立国 | Plaster for treating ostealgia and its preparation method |
| CN101244252A (en) * | 2008-03-13 | 2008-08-20 | 张金星 | Chinese medicine label for eliminating ache and preparation thereof |
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2014
- 2014-04-30 CN CN201410180174.0A patent/CN103933481B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007160A (en) * | 2006-11-27 | 2007-08-01 | 杨立国 | Plaster for treating ostealgia and its preparation method |
| CN1970073A (en) * | 2006-11-28 | 2007-05-30 | 孔祥权 | Chinese medicinal composition for treating pain and preparation process thereof |
| CN101244252A (en) * | 2008-03-13 | 2008-08-20 | 张金星 | Chinese medicine label for eliminating ache and preparation thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878393A (en) * | 2014-12-26 | 2016-08-24 | 李犹璋 | Analgesic patch and preparation method thereof |
| EP4104828A4 (en) * | 2020-02-12 | 2024-05-01 | Hisamitsu Pharmaceutical Co., Inc. | Diclofenac sodium-containing patch |
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