CN103933481B - External used medicine of a kind for the treatment of of cancer pain and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of external used medicine being used for the treatment of cancer pain and preparation method thereof, its each crude drug consists of: Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram.This Flos Rosae Rugosae ZHITONG GAO preparation method is simple, and external curing cancer pain is effective, improves analgesic effect, determined curative effect, and can reduce bucinnazine, morphine use amount, reduces the untoward reaction of the Western medicine such as morphine, improves life in patients.

Description

External used medicine of a kind for the treatment of of cancer pain and preparation method thereof

Technical field

The invention belongs to a kind of external medicine preparation and preparation method thereof, particularly belong to external used medicine of a kind for the treatment of of cancer pain and preparation method thereof.

Background technology

Cancer is the formidable enemy of harm humans health, and when cancer generally finds and middle and advanced stage, the method for the treatment of has: operation, chemotherapy, radiotherapy and the combination of Chinese and Western medicine.Middle and terminal cancer patient cancer pain is once outbreak, and hurt like hell, causes very large misery to patient.Western medical treatment cancer pain many employings three rescue by stages, opiates medicine is generally applied in the treatment of middle and advanced stage cancer pain, oral, intramuscular injection or external, but after application, most of patients has dizzy, feels sick, vomiting, perspiration, abdominal distention, the untoward reaction such as constipation, along with the continuous increase of dosage, the frequency, to drug dependence addiction, and there is intestinal obstruction in patient, even delirium, respiration inhibition, the serious adverse reactions such as stupor, add patient suffering and burden, have a strong impact on patients ' life quality.Chinese medicine cancer pain has unique advantage, and Flos Rosae Rugosae ZHITONG GAO of the present invention has removing obstruction in the collateral to relieve pain, effect of detoxicating and resolving stagnation of pathogens.

Summary of the invention

The object of this invention is to provide a kind of external used medicine for the treatment of of cancer pain, another object of the present invention is to provide the preparation method of this medicine.

Technical scheme of the present invention is, a kind of external used medicine for the treatment of of cancer pain, it is characterized in that, its each crude drug consists of: Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram.

Preferred each crude drug consists of: Flos Rosae Rugosae 30 grams, Flos Caryophylli 30 grams, Herba Asari 20 grams, Rhizoma Pinelliae 30 grams, Cortex Cinnamomi 30 grams, Scorpio 10 grams, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis 30 grams, Olibanum 20 grams, Myrrha 20 grams, Radix Et Rhizoma Rhei 20 grams, Rhizoma Wenyujin Concisum 20 grams, the Radix Angelicae Dahuricae 20 grams, Resina Ferulae 20 grams, Rhizoma Kaempferiae 20 grams, Venenum Bufonis 10 grams, artificial Moschus 0.5 gram, Pheretima 20 grams, tetracaine ointment 2 grams, diclofenac ointment 10 grams.

A preparation method for the external used medicine for the treatment of of cancer pain, is characterized in that: mainly comprise the steps:

A, take raw material: take Flos Rosae Rugosae 20-50 gram respectively, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram for subsequent use,

B, powder process: the Flos Rosae Rugosae above-mentioned step A prepared, Flos Caryophylli, Herba Asari, Rhizoma Pinelliae, Cortex Cinnamomi, Scorpio, Rhizoma Arisaematis, Olibanum, Myrrha, Radix Et Rhizoma Rhei, Rhizoma Wenyujin Concisum, the Radix Angelicae Dahuricae, Resina Ferulae, Rhizoma Kaempferiae, Venenum Bufonis, Pheretima are cleaned, dry, pulverized 100 mesh sieves after for subsequent use;

C, cream processed: the Mel getting 300 grams is boiled into middle honey, let cool to 50 DEG C, pour in medicated powder prepared by step B and mix, add Borneolum Syntheticum that above-mentioned step A prepares, artificial Moschus, tetracaine ointment again, diclofenac ointment mixes, and glycerol adding 30 milliliters is transferred to the existing bulk that mixture is held, weigh, subpackage, tiles on sticker, covers with special paster;

D, this Flos Rosae Rugosae analgesic extract closed packaging prepared by above-mentioned steps.

Using method: choose painful area, local skin is sterilized, and open packaging, tear paster, ointment is aimed at painful area and sticks, every 1-2 day changes 1 time.If any new painful area, can external at any time.Observe local with or without pruritus, erythra, the allergic phenomenas such as redness, blister, as pruritus or blister are seriously then stopped using.

Inventor thinks: cancer pain mostly is leaching in cancer poison, and flee passages through which vital energy circulates, poison enters internal organs, and attached muscle bone and formed.The evil institute of poison extremely, coldheat complex, knot in ecchymosis, become estranged, stagnation of QI and blood may bring about pain by passages through which vital energy circulates.Therefore principle for the treatment of should be promoting blood circulation to remove obstruction in the collateral, detoxicating and resolving stagnation of pathogens, simultaneously using both cold and hot drugs, transdermal pain relieving.Cancer pain patient, accompanies anxiety more, and depressed, irritability is stasis for it.The present invention take Flos Rosae Rugosae as monarch drug, and this medicine is sweet; Micro-hardship; Temperature; Nontoxic, " book on Chinese herbal medicine justice ": Flos Rosae Rugosae, fragrance is the denseest, turbid clearly and not, and and violent, easing the affected liver is waken up stomach, and gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud, disconnectedly pushes away among edema caused by disorder of QI medicine, has prompt effect and the most tractable person most, and fragrant all product, there is no equal.Fragrant odour, emotion of releiving, its volatile oil has obvious analgesic activity, dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating blood circulation analgesia; Olibanum regulating qi and activating blood, analgesic therapy, chases after poison." solar corona " cloud, soft extracts pain relieving is put on flesh.CHEN Zang-Qi cloud, moderns are in order to control all pains of internal injury, and the medicine of toxic swelling Orally taken and externally, have from the beginning.Its volatile oil acetic acid n-octyl has obvious analgesic activity; Myrrha eliminating stasis to stop pain, externally used detumescence granulation promoting." Japan hanako materia medica ": broken crux stagnated blood, detumescence poison.Both are ministerial drug altogether, have the function strengthening monarch drug promoting blood circulation to remove obstruction in the collateral, cooperatively strengthen analgesic effect with monarch drug.Flos Caryophylli, Herba Asari, the pain relieving of Cortex Cinnamomi energy dispelling cold by warming the meridian, Shan Zhi mass in the abdomen obstinate disease; The Rhizoma Pinelliae, Rhizoma Arisaematis, Venenum Bufonis, Scorpio detoxicating and resolving stagnation of pathogens, treats skin ulcer, sensible meridians; Borneolum Syntheticum, Radix Et Rhizoma Rhei heat-clearing and toxic substances removing, subduing swelling and relieving pain; Rhizoma Wenyujin Concisum energy removing blood stasis circulation of qi promoting curcumin can inducing apoptosis of tumour cell, and inhibition tumor cell is bred, and has obvious analgesic activity.The Radix Angelicae Dahuricae, Resina Ferulae, the medicines such as Rhizoma Kaempferiae with dredging collateral, pain relieving, be adjuvant drug altogether, make we's not only promoting blood circulation and stopping pain, have more detoxicating and resolving stagnation of pathogens effect, apply together with above-mentioned monarch drug, ministerial drug, further increase analgesic effect, and there is antineoplastic action, there is treatment cancer pain specific aim; By Moschus, Borneolum Syntheticum is subcutaneous for making medicine etc. penetrate, and the institute of through slight illness, is equipped with tetracaine, and diclofenac enters plaster with Chinese and Western and use, and all medicines share plays detoxicating and resolving stagnation of pathogens altogether, the merit of analgesic therapy of invigorating blood circulation.

Observation of curative effect: inventor selects middle and advanced stage cancer pain patient 70 example, is divided into 2 groups by randomization, wherein treatment group 40 example, patients with lung cancer 16 example, patient with esophageal carcinoma 12 example, patients with gastric cancer 7 example, PATIENTS WITH LARGE BOWEL 5 example.Matched group 30 example, patients with lung cancer 13 example, patient with esophageal carcinoma 7 example, patients with gastric cancer 5 example, PATIENTS WITH LARGE BOWEL 5 example.Two groups of medical histories, at the age, sex, pain scores degree there are no significant difference, has comparability.

Therapeutic Method: treatment group is according to digital staging (pain degree digit score scale) scoring and main suit's pain degree staging calibration.Give Flos Rosae Rugosae ZHITONG GAO external application, scoring change before and after record treatment, pain degree changes.Therapentic part: pain is the most acutely located, changes 1 time for 24 hours.Light moderate pain gives Flos Rosae Rugosae ZHITONG GAO external application and applies non-steroidal anti-inflammatory analgesics or tramadol is oral, middle severe Flos Rosae Rugosae ZHITONG GAO external application titration dosage gives sustained-release morphine, oral person can not give bucinnazine or the treatment of injection of morphia liquid.Matched group give application non-steroidal anti-inflammatory analgesics by the light moderate pain of doctor trained in Western medicine cancer pain Normalized Treatment principle or tramadol oral, middle severe titration dosage gives sustained-release morphine, oral person can not give bucinnazine or the treatment of injection of morphia liquid.15 days 1 courses for the treatment of. observe two groups of analgesic effects, morphine slow releasing tablet and bucinnazine and injection of morphia liquid consumption.

Result:

A table 1 liang group pain degree alleviation is compared [n (%)]

Group	Number of cases	Complete incidence graph	Partial rcsponse	Minor responses	Invalid
						Treatment group	40	19	12	9	0(0)
Matched group	30	12	8	7	3(0)

Dose of morphine needed for per course for the treatment of of organizing table 2 liang compares and bucinnazine hydrochloride metering.

Analyze: above tables of data Mingzhi treats rear treatment group Pain management degree and is obviously better than matched group (P < 0.05), sustained-release morphine consumption and bucinnazine and injection of morphia liquid consumption comparatively matched group obviously reduce (P < 0.05): before and after two groups of treatments, digital staging scoring decline degree are better than matched group (P < 0.05).

Beneficial effect of the present invention is: this Flos Rosae Rugosae ZHITONG GAO, raw material is easy to get, preparation method is simple, low price, known by the observation contrast for the treatment of group Pain management degree and matched group after above-mentioned use Flos Rosae Rugosae ZHITONG GAO treatment: Flos Rosae Rugosae ZHITONG GAO external curing cancer pain effectively can improve analgesic effect, determined curative effect, and can reduce bucinnazine, morphine use amount, reduce the untoward reaction of the Western medicine such as morphine, have certain advantage to raising life in patients.

Detailed description of the invention

The specific embodiment of the invention is:

Embodiment 1,

A, take Flos Rosae Rugosae 20 grams, Flos Caryophylli 45 grams, Herba Asari 15 grams, Rhizoma Pinelliae 20 grams, Cortex Cinnamomi 50 grams, Scorpio 5 grams, Borneolum Syntheticum 15 grams, Rhizoma Arisaematis 50 grams, Olibanum 30 grams, Myrrha 10 grams, Radix Et Rhizoma Rhei 10 grams, Rhizoma Wenyujin Concisum 30 grams, the Radix Angelicae Dahuricae 25 grams, Resina Ferulae 10 grams, Rhizoma Kaempferiae 30 grams, Venenum Bufonis 5 grams, artificial Moschus 0.2 gram, Pheretima 10 grams, tetracaine ointment 4 grams, diclofenac ointment 8 grams are for subsequent use;

B, the Flos Rosae Rugosae that above-mentioned step A is prepared, Flos Caryophylli, Herba Asari, Rhizoma Pinelliae, Cortex Cinnamomi, Scorpio, Rhizoma Arisaematis, Olibanum, Myrrha, Radix Et Rhizoma Rhei, Rhizoma Wenyujin Concisum, the Radix Angelicae Dahuricae, Resina Ferulae, Rhizoma Kaempferiae, Venenum Bufonis, Pheretima cleaning, dry, for subsequent use after pulverizing 100 mesh sieves after mixing;

C, cream processed: the Mel getting 300 grams is boiled into middle honey, let cool to 50 DEG C, pour in medicated powder prepared by step B and mix, add Borneolum Syntheticum that above-mentioned step A prepares, artificial Moschus, tetracaine ointment again, diclofenac ointment mixes, and glycerol adding 30 milliliters is transferred to the existing bulk that mixture is held, weigh, subpackage, tiles on sticker, covers with special paster;

D, this Flos Rosae Rugosae analgesic extract closed packaging prepared by above-mentioned steps.

Embodiment 2

A, take Flos Rosae Rugosae 30 grams, Flos Caryophylli 30 grams, Herba Asari 20 grams, Rhizoma Pinelliae 30 grams, Cortex Cinnamomi 30 grams, Scorpio 10 grams, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis 30 grams, Olibanum 20 grams, Myrrha 20 grams, Radix Et Rhizoma Rhei 20 grams, Rhizoma Wenyujin Concisum 20 grams, the Radix Angelicae Dahuricae 20 grams, Resina Ferulae 20 grams, Rhizoma Kaempferiae 20 grams, Venenum Bufonis 10 grams, artificial Moschus 0.5 gram, Pheretima 20 grams, tetracaine ointment 2 grams, diclofenac ointment 10 grams are for subsequent use; All the other steps are identical with embodiment 1.

Embodiment 3

A, take Flos Rosae Rugosae 50 grams, Flos Caryophylli 20 grams, Herba Asari 30 grams, Rhizoma Pinelliae 50 grams, Cortex Cinnamomi 20 grams, Scorpio 20 grams, Borneolum Syntheticum 20 grams, Rhizoma Arisaematis 20 grams, Olibanum 10 grams, Myrrha 30 grams, Radix Et Rhizoma Rhei 25 grams, Rhizoma Wenyujin Concisum 10 grams, the Radix Angelicae Dahuricae 10 grams, Resina Ferulae 25 grams, Rhizoma Kaempferiae 10 grams, Venenum Bufonis 8 grams, artificial Moschus 0.3 gram, Pheretima 25 grams, tetracaine ointment 5 grams, diclofenac ointment 5 grams are for subsequent use; All the other steps are identical with embodiment 1.

Claims (3)

1. an external used medicine for treatment of cancer pain, is characterized in that: its each crude drug consists of: Flos Rosae Rugosae 20-50 gram, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram.

2. the external used medicine of a kind for the treatment of of cancer pain according to claim 1, is characterized in that: its each crude drug consists of: Flos Rosae Rugosae 30 grams, Flos Caryophylli 30 grams, Herba Asari 20 grams, Rhizoma Pinelliae 30 grams, Cortex Cinnamomi 30 grams, Scorpio 10 grams, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis 30 grams, Olibanum 20 grams, Myrrha 20 grams, Radix Et Rhizoma Rhei 20 grams, Rhizoma Wenyujin Concisum 20 grams, the Radix Angelicae Dahuricae 20 grams, Resina Ferulae 20 grams, Rhizoma Kaempferiae 20 grams, Venenum Bufonis 10 grams, artificial Moschus 0.5 gram, Pheretima 20 grams, tetracaine ointment 2 grams, diclofenac ointment 10 grams.

3. the preparation method of the external used medicine of a kind for the treatment of of cancer pain as claimed in claim 1, is characterized in that: comprise the steps:

A, take raw material: take Flos Rosae Rugosae 20-50 gram respectively, Flos Caryophylli 20-50 gram, Herba Asari 10-30 gram, Rhizoma Pinelliae 20-50 gram, Cortex Cinnamomi 20-50 gram, Scorpio 5-20 gram, Borneolum Syntheticum 10-20 gram, Rhizoma Arisaematis 20-50 gram, Olibanum 10-30 gram, Myrrha 10-30 gram, Radix Et Rhizoma Rhei 10-30 gram, Rhizoma Wenyujin Concisum 10-30 gram, Radix Angelicae Dahuricae 10-30 gram, Resina Ferulae 10-30 gram, Rhizoma Kaempferiae 10-30 gram, Venenum Bufonis 5-10 gram, artificial Moschus 0.1-0.5 gram, Pheretima 10-30 gram, tetracaine ointment 2-5 gram, diclofenac ointment 5-10 gram for subsequent use,

B, powder process: the Flos Rosae Rugosae that above-mentioned step A is prepared, Flos Caryophylli, Herba Asari, Rhizoma Pinelliae, Cortex Cinnamomi, Scorpio, Rhizoma Arisaematis, Olibanum, Myrrha, Radix Et Rhizoma Rhei, Rhizoma Wenyujin Concisum, the Radix Angelicae Dahuricae, Resina Ferulae, Rhizoma Kaempferiae, Venenum Bufonis, Pheretima cleaning, dry, for subsequent use after pulverizing 100 mesh sieves;

C, cream processed: the Mel getting 300 grams is boiled into middle honey, let cool to 50 DEG C, pour in medicated powder prepared by step B and mix, add Borneolum Syntheticum that above-mentioned step A prepares, artificial Moschus, tetracaine ointment again, diclofenac ointment mixes, and glycerol adding 30 milliliters is transferred to the existing bulk that mixture is held, weigh, subpackage, tiles on sticker, covers with special paster;

D, this Flos Rosae Rugosae analgesic extract closed packaging prepared by above-mentioned steps.