CN104352599A - Traditional Chinese medicine composition for treating burns and scalds - Google Patents

Traditional Chinese medicine composition for treating burns and scalds Download PDF

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Publication number
CN104352599A
CN104352599A CN201410669428.5A CN201410669428A CN104352599A CN 104352599 A CN104352599 A CN 104352599A CN 201410669428 A CN201410669428 A CN 201410669428A CN 104352599 A CN104352599 A CN 104352599A
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chinese medicine
medicine composition
burn
traditional chinese
scald
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刘桂杰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating burns and scalds. The traditional Chinese medicine composition for treating burns and scalds is characterized by being prepared from seven traditional Chinese medicinal materials including dog hairs, calcined gypsum, astragalus membranaceus, garden burnet, frankincense, myrrh and sesame oil. The traditional Chinese medicine composition disclosed by the invention is capable of detoxifying, removing slough, astringing sore, promoting granulation, diminishing swelling, relieving pain, clearing heat, decreasing internal heat, promoting blood circulation to remove blood stasis, rapidly relieving pain, promoting blood circulation, reducing exudation, sterilizing, diminishing inflammation, and promoting skin regeneration and wound healing, and has the unique advantage that scar does not exist after healing; and thus, the traditional Chinese medicine composition disclosed by the invention is particularly applied to patients suffering from second-degree and below burns and scalds.

Description

A kind of Chinese medicine composition for the treatment of burn and scald
Technical field
The invention belongs to tcm field, relate to a kind of Chinese medicine composition for the treatment of burn and scald and preparation method thereof.
Background technology
Burn and scald is the tissue injury caused by high temperature, chemical substance or electricity.The order of severity of burn and scald depends on the burn and scald degree of depth of wounded tissue, and the burn and scald degree of depth can be divided into I degree, II degree and III degree.I degree of burn and scald damage is the lightest.Burn and scald skin rubefaction, pain, obviously touch a tender spot, have and ooze out or edema.During light pressure injury, local bleaches, but does not have vesicle.II degree of burn and scald is divided into again light degree Ⅱ burn and scald and dark II degree of burn and scald two kinds.Light degree Ⅱ burn and scald injures high dermis, and part stratum germinativum is still living and in good health.Local is red and swollen, has vesicle not of uniform size, includes the jelly of yellow or pale red blood plasma sample liquid body or protein coagulation.If without complication such as infection, about 2 Zhou Keyu.More can have pigmentation in a short time after, not stay cicatrix, skin function is good.Dark II degree of burn and scald injures below papillary layer of corium, but still residual fraction lamina reticularis.Local swelling, or have comparatively phlysis.Due to appendages of skin such as remaining intradermal hair follicle, sweat glands, still renewable epithelium, as nothing infects, general 3-4 week can self-heal.The local function obstacle that cicatrix and cicatricial contraction cause can be had after healing.III degree of burn and scald damage is the darkest.Can turn white in burn and scald surface, deliquescing or in black, carbonization hide-like.Owing to being become pale by burning skin, in pale skin people, be often mistaken as normal skin, but no longer variable color during compressing.The erythrocyte destroyed can make burn and scald local skin be cerise, and have vesicle once in a while, the hair in burn and scald district is easy to extract, and feels to go down.III degree of burn and scald region does not generally have the pain sensation.Because the teleneuron of skin is destroyed.Usually through in a few days, dark II degree and III degree of burn and scald will could be distinguished after burn and scald.Ordinary circumstance, I degree, II degree burn and scald only needs Drug therapy, just can cure; For making wound healing, III degree of burn and scald according to circumstances, need do skin grafting.
The traditional Chinese medical science is thought, burn and scald is burning hot poison evil infringement human body, and damage skin, decocts bright body fluid, consumption impairment of YIN blood, and fire-toxin pents up skin and flesh, stagnation of QI-blood, therefore occurs erubescence, pain; QI and blood is corrupt, therefore skin rots, and severe one injures in body, and pyretic toxicity undermines internal organs, so that internal organs discord, and yin and yang imbalance, all diseases are grown thickly.The pathogenesis of this disease pents up skin and flesh with fire-toxin, and the meridian qi and blood stasis of blood is stagnant is this, and according to treatment must aim at the pathogenesis of disease principle, treatment should be detoxified by clearing away heat-fire, promoting blood circulation, removing blood stasis and relieving pain.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of burn and scald.Ointment good drug efficacy of the present invention, incrustation is fast, and cure rate is high, preventing from scar after curing.
For realizing object of the present invention, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition for the treatment of burn and scald, it is characterized in that being prepared from by 7 kinds of Chinese crude drugs:
Pilus Canitis, Gypsum Fibrosum Preparatum, the Radix Astragali, Radix Sanguisorbae, Olibanum, Myrrha, Oleum Sesami.
Preferably, in the present composition, the weight of each Chinese crude drug is:
Pilus Canitis 10-20, Gypsum Fibrosum Preparatum 10-20, Radix Astragali 10-20, Radix Sanguisorbae 10-20, Olibanum 5-10, Myrrha 5-10, Oleum Sesami 60-120.
More preferably, in the present composition, the weight of each Chinese crude drug is:
Pilus Canitis 18, Gypsum Fibrosum Preparatum 18, the Radix Astragali 12, Radix Sanguisorbae 12, Olibanum 6, Myrrha 6, Oleum Sesami 96.
The pharmacological action of Chinese medicine of the present invention is as follows:
Pilus Canitis: pungent; Salty; Flat; GUIXIN; Liver Channel; Effect: preventing the attack (or recurrence) of malaria; Sore.Main malaria; Burn and scald " not Lu ": " main product is difficult." " detailed outline ": " ashing soup takes a money.Control evil malaria; Tail (hair) ashing, applies burn.
Gypsum Fibrosum Preparatum: sweet, pungent, puckery, cold.Attach to the lung and stomach meridians.Removing dampness, granulation promoting, sore, hemostasis.External treatment ulcer being unable to heal, eczema pruritus, burn due to hot liquid or fire, traumatic hemorrhage.
The Radix Astragali: nature and flavor, sweet, temperature.Gui Jing, returns lung, spleen channel.Function cures mainly, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
Radix Sanguisorbae: nature and flavor, bitter, sour, puckery, be slightly cold.Gui Jing, enters liver, large intestine channel.Function cures mainly, cooling blood for hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Olibanum: acrid in the mouth; Bitter; Tepor.The heart; Liver; Spleen channel.Blood-activating and qi-promoting; Inducing menstruation to relieve menalgia; Detumescence and promoting granulation.Main trusted subordinate's pain; Rheumatic arthralgia; Amenorrhea dysmenorrhea; Traumatic injury stasis of blood pain; Swollen ulcer drug; Intestinal carbuncle; The sore being festered and unhealed.
Myrrha: bitter; Flat.Return liver; Spleen; The heart; Kidney channel.Promoting blood circulation and stopping pain; Detumescence and promoting granulation.Main breast abdomen stasis of blood pain; Dysmenorrhea; Amenorrhea; Lump in the abdomen; Traumatic injury; Carbuncle skin infection; Intestinal carbuncle; Conjunctival congestion and swelling pain.
Oleum Sesami: sweet is cool.Moistening dryness for relaxing bowels, removing toxic substances, granulation promoting.Control dryness of the intestine constipation, ascarid, abdominal pain due to retention of food, skin ulcer swells, ulcer, scabies, chapped skin.Can also as lubricant and excipient.For oral administration can intestine moistening, lung moistening; Be used as ointment machin plaster substrate outward.
Clinical experiment proved is invented all taste medical materials and is share the putrefaction removing that can detoxify, expelling pus and promoting granulation, reducing swelling and alleviating pain, resolving heat and reducing pathogenic fire, blood circulation promoting and blood stasis dispelling, energy rapid pain relief, blood circulation promoting, minimizing is oozed out, bactericidal antiphlogistic, promotes skin regeneration and wound healing, and there is the unique advantage not staying cicatrix more, be particularly useful for less than II degree and II degree burned patient and use.
Chinese medicine composition of the present invention can also add other pharmaceutic adjuvants, is prepared into any one exterior-applied formulation.
Described exterior-applied formulation is unguentum, powder, powder, oil preparation, liniment.
Be preferably unguentum.
Present invention also offers a kind of preparation method for the treatment of burn and scald unguentum, its step is as follows:
Take Pilus Canitis according to weight, Gypsum Fibrosum Preparatum, the Radix Astragali, Radix Sanguisorbae, Olibanum, Myrrha put into pulverizer and pulverize, cross 200-600 mesh sieve, mix homogeneously, sterilizing, adds Oleum Sesami, stirs, and is warming up to 90-100 degree Celsius of insulation 30min, obtains unguentum of the present invention.
Clinical report is as follows:
1, physical data
Physical data outpatient service and burned patient 178 example of being in hospital, wherein I degree burn and scald 62 example, light degree Ⅱ burn and scald 60 example, dark II degree of burn and scald 56 example.Be divided into two groups at random: treatment group 89 example and matched group 89 example.At two groups of ages, sex, the comparing differences such as symptom are without significance (P > 0.05).
2, diagnostic criteria
Diagnostic criteria: determine diagnosis according to the diagnostic criteria of burn in " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine issues for 1994: have clear and definite boiling water, flame equivalent damage Shi Kecha.1) I degree (erythema): slightly red, swollen, hot, bitterly, hyperesthesia, does not get blister, epidermis is dry; 2) II degree (blister): a. light degree Ⅱ: severe pain, hyperesthesia, temperature increases, and has vesicle, and substrate is moist, and in evenly red, vesicle is obvious.B. dark II degree: hypalgesia, vesicle is with little or no, throws off epidermis, and substrate drying is pale, and have little petechia, edema is obvious.
3, Therapeutic Method
3.1 treatment groups: use Chinese medicinal ointment prepared by the embodiment of the present invention.The direct smearing ointment of the fresh pollution-free wound surface of patient's burn and scald; Have the wound surface of pollution, remove foreign body, with normal saline flushing, sterile gauze dips in solid carbon dioxide and divides, and then ointment is applied to wound surface, and ointment thickness is 1-2mm, every day 1-2 time, before changing dressings, the medicine remained on wound surface and liquefied substance must be wiped away.Expose topical agent, without the need to wrapping.
3.2 matched groups: moist expose burn ointment, every day 1-2 time, usage is the same.
Two experimental grouies equal 7 days are 1 course for the treatment of, treat observation experiment result after 1 course for the treatment of.
4, therapeutic outcome
4.1 treatment evaluation criterias, judge according to " the Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates:
Cure: General Symptoms disappears, wound healing;
Take a turn for the better: General Symptoms disappears, and wound surface does not heal completely;
Do not heal: General Symptoms has no improvement, traumatic infection can not control.
4.2 therapeutic outcome
4.2.1 two groups of pain disappearing times and average healing days compare, in table 1.
Table 1 liang group pain disappearing time and average healing days compare
Group Number of cases Pain disappearing time (h) Average healing days (my god)
Treatment group 89 27.2±10.6 * 6.8±2.1 #
Matched group 89 48.7±12.4 12.5±5.3
*P＜0.01； #P＜0.01。
Visible, Chinese medicinal ointment of the present invention is at pain disappearing time, and the healing days aspect for the treatment of burn and scald is all significantly better than matched group.Illustrate that Chinese medicine ointment of the present invention has good analgesic effect, the advantage that healing time is short.
4.2.2 two groups of comparitive study, in table 2
Table 2 liang group comparitive study
Group Number of cases Cure Take a turn for the better Do not heal Total effective rate
Treatment group 89 83(93.3％) 6(6.7％) 0 100％
Matched group 89 62(69.7％) 16(18.0％) 11(12.3％) 87.6％
Visible, the cure rate of Chinese medicinal ointment of the present invention or total effective rate are far above matched group.Illustrate that Chinese medicine ointment of the present invention has cure rate, the advantage that total effective rate is high.
5, follow-up observation result after two months
After 2 months, cure patients, follow up a case by regular visits to two groups, treatment group is cured patient and is rarely had cicatrix to produce, and matched group healing patient, there are 18 people to leave cicatrix in various degree, account for 29% of healing number.The specially good effect not staying cicatrix after Chinese medicine ointment of the present invention has healing is described.
Detailed description of the invention
The embodiment of the present invention is only in order to illustrate technical scheme of the present invention; be not intended to limit, those of ordinary skill in the art should be appreciated that the technical scheme described in each embodiment is modified; or equivalent replacement is carried out to wherein portion of techniques feature, all falls into protection scope of the present invention.
EXAMPLE l
Prescription:
Preparation method:
Above-mentioned raw materials is put into pulverizer to pulverize, cross 200 mesh sieves, mix homogeneously, sterilizing, adds Oleum Sesami, stirs, and is warming up to 100 degrees Celsius of insulation 30min, obtains unguentum of the present invention.
Embodiment 2
Prescription:
Preparation method:
Above-mentioned raw materials is put into pulverizer to pulverize, cross 200 mesh sieves, mix homogeneously, sterilizing, adds Oleum Sesami, stirs, and is warming up to 100 degrees Celsius of insulation 30min, obtains unguentum of the present invention.
Embodiment 3
Prescription:
Preparation method:
Above-mentioned raw materials is put into pulverizer to pulverize, cross 200 mesh sieves, mix homogeneously, sterilizing, adds Oleum Sesami, stirs, and is warming up to 100 degrees Celsius of insulation 30min, obtains unguentum of the present invention.
Embodiment 4
Prescription:
Preparation method:
Above-mentioned raw materials is put into pulverizer to pulverize, cross 200 mesh sieves, mix homogeneously, sterilizing, adds Oleum Sesami, stirs, and is warming up to 100 degrees Celsius of insulation 30min, obtains unguentum of the present invention.

Claims (6)

1. treat a Chinese medicine composition for burn and scald, it is characterized in that being prepared from by 7 kinds of Chinese crude drugs: Pilus Canitis, Gypsum Fibrosum Preparatum, the Radix Astragali, Radix Sanguisorbae, Olibanum, Myrrha, Oleum Sesami.
2. the Chinese medicine composition for the treatment of burn and scald according to claim 1, preferably, is prepared from by the Chinese crude drug of following weight portion:
Pilus Canitis 10-20 Gypsum Fibrosum Preparatum 10-20 Radix Astragali 10-20 Radix Sanguisorbae 10-20
Olibanum 5-10 Myrrha 5-10 Oleum Sesami 60-120.
3. the Chinese medicine composition for the treatment of burn and scald according to claim 1, more preferably, is prepared from by the Chinese crude drug of following weight portion:
Pilus Canitis 18 Gypsum Fibrosum Preparatum 18 Radix Astragali 12 Radix Sanguisorbae 12
Olibanum 6 Myrrha 6 Oleum Sesami 96.
4., according to the Chinese medicine composition of the arbitrary described treatment burn and scald of claim 1-3, it is characterized in that it is exterior-applied formulation.
5. the Chinese medicine composition for the treatment of burn and scald according to claim 4, is characterized in that described exterior-applied formulation is unguentum.
6. treat the preparation method of burn and scald unguentum for one kind, its step is as follows: take Pilus Canitis according to weight, Gypsum Fibrosum Preparatum, the Radix Astragali, Radix Sanguisorbae, Olibanum, Myrrha put into pulverizer and pulverize, cross 200-600 mesh sieve, mix homogeneously, sterilizing, adds Oleum Sesami, stirs, be warming up to 90-100 degree Celsius of insulation 30min, obtain unguentum.
CN201410669428.5A 2014-11-20 2014-11-20 Traditional Chinese medicine composition for treating burns and scalds Pending CN104352599A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108721332A (en) * 2018-06-06 2018-11-02 闽江学院 A kind of preparation method of antiphlogistic powder
CN108815289A (en) * 2018-08-16 2018-11-16 贵州苗之源苗药中药饮片有限公司 A kind of seedling medicine and preparation method thereof for treating burn

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
（英）麦克凯斯: "《食物圣经》", 31 March 2013, 安徽科学技术出版社 *
何钱: "《本经》石膏功效释义", 《中国中医药报》 *
兰福森等: "乳没冰蜜膏治疗烧伤效方", 《蜜蜂杂志》 *
李军德等: "《中国药用动物志》", 30 June 2013, 福建科学技术出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108721332A (en) * 2018-06-06 2018-11-02 闽江学院 A kind of preparation method of antiphlogistic powder
CN108815289A (en) * 2018-08-16 2018-11-16 贵州苗之源苗药中药饮片有限公司 A kind of seedling medicine and preparation method thereof for treating burn

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