CN105770116A - Medicine composition for treating burn and scald, method for preparing medicine composition and application thereof - Google Patents
Medicine composition for treating burn and scald, method for preparing medicine composition and application thereof Download PDFInfo
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- CN105770116A CN105770116A CN201610160769.9A CN201610160769A CN105770116A CN 105770116 A CN105770116 A CN 105770116A CN 201610160769 A CN201610160769 A CN 201610160769A CN 105770116 A CN105770116 A CN 105770116A
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- borneol
- beeswax
- raw material
- medicine composition
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention relates to a medicine composition for treating burn and scald, a method for preparing the medicine composition and application thereof. The medicine composition mainly comprises, by weight, 10-30 parts of radix rubiae, 7-17 parts of cortex phellodendri, 20-40 parts of radix scutellariae, 50-80 parts of radix angelicae sinensis, 20-40 parts of radix angelicae dahuricae, 10-30 parts of rhizoma polygoni cuspidate, 7-17 parts of myrrh, 30-50 parts of radix arnebiae seu lithospermi, 20-40 parts of radix glycyrrhizae, 10-30 parts of borneolum syntheticum, 35-65 parts of radix et rhizoma rhei, 10-30 parts of radix astragali, 10-30 parts of flos carthami and 30-60 parts of beeswax. The medicine composition, the method and the application have the advantages that the medicine composition has functions of cooling blood to stop bleeding, relieving swelling and pain, purging fire, removing toxic substances, removing necrotic tissues and promoting tissue regeneration, the micro-circulation capacity and the healing ability of wounded tissues can be improved, the medicine composition is extremely high in anti-infection capacity, and miraculous effects can be clinically realized for slight, moderate and severe burn and scald and different types of wound infection; the method is easy to implement, and effective components in raw materials can be reserved to the greatest extent; patients can conveniently smear and use the ointment medicine composition, and the medicine composition can directly act on burn sites of the patients, can become effective fast and is convenient to use.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of treat the pharmaceutical composition of burn and scald, its preparation side
Method and application.
Background technology
Burn (include scald) be a kind of common by hot water, deep fat, gunpowder, chemicals etc. cause prominent
Sending out sexual trauma, its burn and scald degree is divided into slightly, moderate and severe.Be presently used for treating various burn,
The medicament scalded is the most, and methods for the treatment of is the most varied.
From traditional Chinese medical science angle, main employing external application occlusive dressing, i.e. apply the ointment on the surface of a wound.Burn in traditional Chinese medicinal ointment and scald
Vulnerary Sino-U.S. treasured moistens ointment and jingwanhong soft plaster result for the treatment of is best, is the first-selection of burned patient, also obtains
The favorable comment of burned patient, but MEBO is in clinical treatment uses, and also there is also some shortcomings
Part: one is that pain relieving is slower than effect, the liquefaction phase is longer, wound face healing time is longer；Two is that traditional Chinese medicinal ointment is main
For the surface of a wound of light moderate burn, it controls to infect the best and analgesic effect general, often needs auxiliary in treatment
Use antibiotic.From doctor trained in Western medicine angle, the most simple doctor trained in Western medicine operative treatment burn typically uses Dry Therapy,
I.e. trauma surface infestation is carried out block therapy, severe burn must be carried out operation and cut scab, skin-grafting, its institute
There is the problem that one be can not pain relieving in time, easily infect, particularly self-skin transplant operative treatment,
Increase the weight of the misery of patient, expand wound face；Two is that surgery cost is high, adds the mental burden of patient
And financial burden, cause some patient midways to abandon treatment；It is that treatment time is long again, and it is also possible to leaves
Scar, even resulting in disfeatures disables, dysfunction.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of medicine treating burn and scald
Composition, its preparation method and application.Described pharmaceutical composition, it is possible to quick to burn and scald in various degree
Alleviating pain and detumescence, anti-infection ability is extremely strong, significantly improves microcirculatory ability, and without using antibiotic, controls
Therapeutic effect is obvious.
The technical solution adopted in the present invention is:
A kind of pharmaceutical composition treating burn and scald, mainly includes that the raw material of following weight portion is made: madder
10-30 part, golden cypress 7-17 part, root of large-flowered skullcap 20-40 part, Radix Angelicae Sinensis 50-80 part, root of Dahurain angelica 20-40 part, giant knotweed 10-30
Part, myrrh 7-17 part, Asian puccoon 30-50 part, Radix Glycyrrhizae 20-40 part, borneol 10-30 part, rheum officinale 35-65
Part, Radix Astragali 10-30 part, safflower 10-30 part, beeswax 30-60 part.
Use the pharmaceutical composition that said ratio is made, it is possible to burn and scald quickly alleviating pain in various degree is subsided a swelling,
Anti-infection ability is extremely strong, significantly improves microcirculatory ability, and without using antibiotic, result for the treatment of is obvious.
For further enhancing the drug effect of described pharmaceutical composition, preferred technical scheme is, drug regimen owner
Raw material including following weight portion is made: 20 parts of madder, golden cypress 12 parts, the root of large-flowered skullcap 30 parts, Radix Angelicae Sinensis 65
Part, the root of Dahurain angelica 30 parts, giant knotweed 20 parts, myrrh 12 parts, Asian puccoon 40 parts, 30 parts of Radix Glycyrrhizae, borneol 20 parts,
Rheum officinale 50 parts, the Radix Astragali 20 parts, 20 parts of safflower, beeswax 45 parts.
Present invention also offers the preparation method of a kind of described pharmaceutical composition, comprise the following steps:
A, remaining the raw material sesame oil except safflower, borneol and beeswax is soaked；
B, by described sesame oil together with raw material therein heat after add safflower, stirring；
C, described sesame oil is filtered while hot after, in filter liquor, add borneol make borneol dissolve；
D, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Obtain the described pharmaceutical composition of ointment shape.
Use described preparation method, obtain the pharmaceutical composition of ointment shape, facilitate patient to smear use, directly
Act on burned part, there is onset rapid, advantage easy to use.
Preferably, described preparation method, comprise the following steps:
A, by except safflower, borneol and beeswax remaining raw material with sesame oil soak 4-5 days；The quality of described sesame oil
Part is 800-1000 part；
B, described sesame oil is heated to 140-160 DEG C together with raw material therein, continues 30-60 minute；Rise again
Temperature, to 170-190 DEG C, adds safflower, stirring after continuing 25-45 minute；
C, described sesame oil is filtered while hot, and filter liquor is controlled at 90-110 DEG C, add in filter liquor
Entering borneol makes borneol dissolve；
D, after described borneol all dissolves, add beeswax and after making it all dissolve, cool,
Described pharmaceutical composition to ointment shape.
Part material first use sesame oil soak 4-5 days, it is possible to being fully impregnated with by raw material, follow-up carries
Take work；In heating process, first sesame oil is heated to 140-160 DEG C, continues 30-60 minute, will wherein
The active ingredient preservation as much as possible of raw material extracts, and temperature is less than 140 DEG C or the time was less than 30 minutes
Then extraction efficiency is the lowest, and temperature is too high or overlong time can affect the activity of active ingredient；Again because safflower with
The character of other draft Chinese medicines is different, need to be effective to it under conditions of continuing 25-45 minute at 170-190 DEG C
Composition extracts, temperature less than 170 DEG C or time less than 25 minutes then extraction efficiency the lowest, temperature is too high
Or overlong time can affect the activity of safflower effective ingredients；Again because borneol and beeswax itself can be all to become
It is allocated as using for active ingredient, internal structure can be destroyed when temperature is more than 120 DEG C simultaneously, therefore directly
Add and dissolve use to sesame oil.
For ensureing the quality of final finished, preferred technical scheme is, uses sesame oil to soak raw material in step A
Before, the raw material outside deicing sheet and beeswax dried or shines dry-cure, dry or shine dry-cure successor
In raw material described in, the mass fraction of water is 3-5%.Through drying or shining after dry-cure, the moisture in raw material
Content reduces further, being impregnated with of sesame oil after being conducive to, simultaneously as water content is low, and stablizing of oil phase
Property higher, condition is more preferable, beneficially the finished product of ointment shape preparation, preserve and use.
Further, described drying is carried out in an oven, and described drying and processing is: by described raw material at 60-70 DEG C
Baking oven in dry 8-12h.In the present invention, use no more than the low temperature of 100 DEG C, simultaneously proper extension time
Drying time, dries through row described raw material, the active ingredient being sufficiently reserved in raw material.
For further facilitating the dissolving of described borneol and beeswax, it is maintained at 90-110 DEG C reducing described sesame oil
Time of high temperature, and then reduce the loss of active ingredient, preferred technical scheme is, by described borneol and
Before beeswax adds in described sesame oil, also include pulverization process: described borneol and beeswax are respectively crushed into
The particle of 30-50 mesh.While described particle diameter is prone to processing, drastically reduce the area required dissolution time.
The invention also discloses the application in the medicine of preparation treatment burn and scald of the described pharmaceutical composition.
In order to preferably explain the present invention, below the raw material in the present invention and compatibility relationship are further elaborated.
Madder, formal name used at school: Rubia cordifolia L, for Rubiaceae perennial climbing herb plant.There is cool blood
Invigorate blood circulation, the stasis of blood of dispelling, effect of stimulating the menstrual flow.For spitting blood, bleeding from five sense organs or subcutaneous tissue, metrostaxis, traumatism and bleeding, through close stasis blocking,
Joint pain, tumbling and swelling.
Golden cypress, for the dry bark of rutaceae wampee Phellodendron chinense Schneid., has
Heat-clearing and damp-drying drug, purging intense heat except steaming, effect of detoxification sore treatment, band lower pruritus vulvae red for damp-heat dysentery, jaundice urine,
Heat drenches that puckery pain, tinea pedis impotence be preesed, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, the wet sore of eczema.
The root of large-flowered skullcap, for the dry root of the labiate root of large-flowered skullcap.The root of large-flowered skullcap is used as medicine with root, bitter, cold in nature, has heat-clearing
Eliminating dampness, purging intense heat and detonicating, hemostasis, the effect such as antiabortive, cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat,
Damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swell the diseases such as furuncle sore.
Radix Angelicae Sinensis, for the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels, has and enriches blood
Invigorate blood circulation, menstruction regulating and pain relieving, effect of relaxing bowel, be usually used in that the deficiency of blood is sallow, dizziness palpitaition, irregular menstruation,
Through closing dysmenorrhoea, asthenia cold abdominalgia, arthralgia due to wind-dampness, injury from falling down, ulcer sores, the dry constipation of intestines.
The root of Dahurain angelica, for the samphire root of Dahurain angelica or the dry root of Radix angelicae dahuricae.The root of Dahurain angelica is used as medicine with root, the dehumidifying that gets rid of illness,
Apocenosis myogenic, effect of promoting blood circulation and stopping pain, cure mainly anemofrigid cold, headache, rhinitis, toothache, leukorrhea with reddish discharge,
Bitterly furuncle poison etc. disease.
Giant knotweed, for dry rhizome and the root of polygonaceae plant giant knotweed Polygonum cuspidatum Sieb.et Zucc.,
There is dampness removing removing jaundice, clearing heat and detoxicating, blood stasis removing analgesic, relieving cough and reducing sputum effect, for jaundice with damp-heat pathogen, stranguria with turbid discharge,
Under band, arthralgia due to wind-dampness, carbuncle sore tumefacting virus, scald, through closing, abdominal mass, instep beat damage, cough with lung heat.
Myrrh, for olive subject plant Chinese violet tree Commiphora myrrha Engl. or Ha Didingshu
The dry resin of Commiphora molmol Engl., has scattered stasis of blood analgesic therapy, effect of detumescence and promoting granulation, conventional
In chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea through closing, stasis blocking in postpartum, lump in the abdomen stomachache, arthralgia due to wind-dampness, fall beat damage
Wound, carbuncle swell the treatment of the illnesss such as sore.
Asian puccoon, for the dry root of comfrey lithospermum euchromum Royle, Asian puccoon or arnebia guttata Bunge.Asian puccoon nature and flavor are sweet,
Salty, cold, the thoughts of returning home, Liver Channel；Have cool blood, invigorate blood circulation, the effect of promoting eruption of detoxifying, therefore to blood-head poison Sheng, measles,
Macula is thoroughly sent out and is the most freely waited disease, can be with the application of the compatibility such as periostracum cicada, great burdock achene, the capsule of weeping forsythia, schizonepeta.
Radix Glycyrrhizae, for glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhizae Glycyrrhiza
InflataBat. or the dry root of glycyrrhiza glabra Glycyrrhiza glabraL. and rhizome, have and invigorate the spleen and benefit qi, clearly
Thermal detoxification, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription, be usually used in weakness of the spleen and the stomach, lassitude hypodynamia,
Palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Borneol, have another name called sheet brain, tangerine sheet, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain,
Borneol brain, Mei Bing etc., be by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves through steam distillation also
Recrystallizing and obtain, the most useful turpentine oil obtains through a series of chemical method techniques；Borneol can be used for closing card coma,
For red eye, swell pain, larynx numbness aphtha, swell and ache for sore, do not hold back after bursting.
Rheum officinale, for polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Maxim Rheum
Tanguticum Maxim.ex Balf. or the dry root and rhizome of Rheum officinale Rheum officinale Baill..Greatly
Huang has attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, the stasis of blood of dispelling, effect of removing toxic substances, the logical intestines that are used for purging heat, cool
Blood detoxifies, stimulates the menstrual flow by the stasis of blood.
The Radix Astragali, Classification system Astragalus membranaceus (Fisch.) Bunge, there is enhancing immunity of organism
Function, protect the liver, diuresis, anti-aging, resisting stress, step-down and wide antibacterial action.
Safflower, for the dry flower of feverfew safflower Carthamus tinctorius L., having invigorates blood circulation stimulates the menstrual flow,
Effect of blood stasis removing analgesic.For through closing, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, chest impediment and cardialgia, the stagnant abdomen of the stasis of blood
Bitterly, the shouting pain of the chest side of body, injury from falling down, sore swell and ache.
Beeswax, for the wax of the worker bee such as Apidae insect apis cerana secretion, forms through refined, have removing toxic substances,
Myogenic, effect of analgesic therapy, be used for controlling in anxious the most pained, diarrhea purulence blood, endless diarrhea, vaginal bleeding with fetal movement, sore carbuncle
Attack, for a long time burst do not hold back, scald.
The compatibility relationship of described pharmaceutical composition is: madder, giant knotweed, rheum officinale and myrrh are mainly cool blood, stop
Blood, stagnation resolvation, pain relieving, effect of removing toxicity for detumescence, have collaborative, analgesic activity, it is possible to expansion capilary improves
Microcirculation and anti-inflammatory power, for we's monarch drug in a prescription；Radix Angelicae Sinensis, safflower have promoting blood circulation and removing blood stasis, improve at pathological tissues
Microcirculation ability, assisted the analgesic effect of monarch drug in a prescription, for we ministerial drug；The Radix Astragali, the root of large-flowered skullcap have purging intense heat solution
Poison, hemostatic and antibacterial, effect of myogenic toxin expelling, it is possible to strengthen Effects on local immunological functions and anti-infection ability.Shorten
Treatment cycle, makes medicine for we；Radix Glycyrrhizae, borneol and beeswax have the effect of removing toxic substances pain relieving, to not closing up for a long time
Pain subcutaneous ulcer sore have and well coordinate therapeutic action, diaphragm can be formed at the surface of a wound thus serve stabilizing tissue
The effect of surface of a wound cell membrane, wherein, Radix Glycyrrhizae is first of coordinating the drug actions of a prescription.
The invention have the benefit that
1, the present invention discloses a kind of pharmaceutical composition, coordinated by all medicines, there is cooling blood and hemostasis, detumescence
Pain relieving, purging intense heat and detonicating, effect of removing necrosis and promoting granulation, it is possible to significantly improve the microcirculation ability and more of wound tissue
Conjunction ability, anti-infection ability is superpower, the most odd for light middle severe burn and scald and various trauma surface infestation clinically
Effect.
2, described pharmaceutical composition all has suppression and killing action to the pathogenic bacteria such as Pseudomonas aeruginosa and anaerobic bacteria, its
Anti-infection ability is extremely strong, seldom uses antibiotic in the case of wound drainage is unobstructed, solves abuse at present anti-
While the problem of raw element, also save spending of curing the disease, benefit patient.
3, described pharmaceutical composition can be used not only for Clinical Surgery one to three degree burn and scald and electric injury (skin burning
Burn), moreover it can be used to acid and alkali corrosion wound, bedsore, diabetic's skin of lower extremity itch gangrene always rotten lower limb and
Other surgical infection surface of a wound.
4, present invention also offers the preparation method of a kind of described pharmaceutical composition, use described preparation method,
Easily operated, at utmost remain the active ingredient in described raw material；Obtain the pharmaceutical composition of ointment shape,
Facilitate patient to smear use, directly act on burned part, there is onset rapid, advantage easy to use.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate present disclosure.Should be appreciated that the enforcement of the present invention
Being not limited to the following examples, any pro forma accommodation and/or the change of being made the present invention all will fall
Enter scope.
In the present invention, if not refering in particular to, all of part, percentage are unit of weight, all of equipment and
Raw materials etc. are all commercially available or the industry is conventional.Method in following embodiment, as without saying especially
Bright, it is the conventional method of this area.
Embodiment 1
The invention provides a kind of pharmaceutical composition treating burn and scald, mainly include the raw material of following weight portion
Make: madder 1kg, golden cypress 1.7kg, root of large-flowered skullcap 2kg, Radix Angelicae Sinensis 8kg, root of Dahurain angelica 2kg, giant knotweed 3kg, myrrh
0.7kg, Asian puccoon 5kg, Radix Glycyrrhizae 2kg, borneol 3kg, rheum officinale 3.5kg, Radix Astragali 3kg, safflower 1kg, beeswax
6kg。
The preparation method of a kind of described pharmaceutical composition, comprises the following steps:
A, by except safflower, borneol and beeswax remaining raw material with 80kg sesame oil soak 5 days；
B, described sesame oil is heated to 160 DEG C together with raw material therein, continues 30 minutes；It is warming up to 190 DEG C again,
Safflower, stirring is added after continuing 25 minutes；
C, described sesame oil is filtered while hot, discard filter residue, and filter liquor is controlled at 110 DEG C, to filtration
Adding borneol in filtrate makes borneol dissolve；
D, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Obtain the described pharmaceutical composition of ointment shape.
Embodiment 2
The invention provides a kind of pharmaceutical composition treating burn and scald, mainly include the raw material of following weight portion
Make: madder 3kg, golden cypress 0.7kg, root of large-flowered skullcap 4kg, Radix Angelicae Sinensis 5kg, root of Dahurain angelica 4kg, giant knotweed 1kg, myrrh
1.7kg, Asian puccoon 3kg, Radix Glycyrrhizae 4kg, borneol 1kg, rheum officinale 6.5kg, Radix Astragali 1kg, safflower 3kg, beeswax
3kg。
The preparation method of a kind of described pharmaceutical composition, comprises the following steps:
A, carry out the raw material outside deicing sheet and beeswax shining dry-cure, shine raw material described in dry-cure successor one
The mass fraction of middle water is 3-5%；
B, by except safflower, borneol and beeswax remaining raw material with 100kg sesame oil soak 4 days；
C, described sesame oil is heated to 140 DEG C together with raw material therein, continues 60 minutes；It is warming up to 170 DEG C again,
Safflower, stirring is added after continuing 45 minutes；
D, described sesame oil is filtered while hot, discard filter residue, and filter liquor is controlled at 90 DEG C, to filtration
Adding borneol in filtrate makes borneol dissolve；Before described borneol is added in described sesame oil, by described borneol
It is ground into the particle of 30 mesh；
E, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Described pharmaceutical composition to ointment shape.Before described beeswax is added in described sesame oil, by described beeswax
It is ground into the particle of 30 mesh.
Embodiment 3
The invention provides a kind of pharmaceutical composition treating burn and scald, mainly include the raw material of following weight portion
Make: madder 1kg, golden cypress 1.7kg, root of large-flowered skullcap 2kg, Radix Angelicae Sinensis 8kg, root of Dahurain angelica 2kg, giant knotweed 3kg, myrrh
0.7kg, Asian puccoon 5kg, Radix Glycyrrhizae 2kg, borneol 3kg, rheum officinale 3.5kg, Radix Astragali 3kg, safflower 1kg, beeswax
6kg。
The preparation method of a kind of described pharmaceutical composition, comprises the following steps:
A, the raw material outside deicing sheet and beeswax is dried 12h, drying and processing successor in the baking oven of 60 DEG C
In raw material described in, the mass fraction of water is 3-5%；
B, by except safflower, borneol and beeswax remaining raw material with 80kg sesame oil soak 5 days；
B, described sesame oil is heated to 160 DEG C together with raw material therein, continues 30 minutes；It is warming up to 190 DEG C again,
Safflower, stirring is added after continuing 25 minutes；
C, described sesame oil is filtered while hot, discard filter residue, and filter liquor is controlled at 110 DEG C, to filtration
Adding borneol in filtrate makes borneol dissolve；Before described borneol is added in described sesame oil, by described borneol
It is ground into the particle of 50 mesh；
D, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Obtain the described pharmaceutical composition of ointment shape.Before described beeswax is added in described sesame oil, by described honey
Wax is ground into the particle of 50 mesh.
Embodiment 4
The invention provides a kind of pharmaceutical composition treating burn and scald, mainly include the raw material of following weight portion
Make: madder 3kg, golden cypress 0.7kg, root of large-flowered skullcap 4kg, Radix Angelicae Sinensis 5kg, root of Dahurain angelica 4kg, giant knotweed 1kg, myrrh
1.7kg, Asian puccoon 3kg, Radix Glycyrrhizae 4kg, borneol 1kg, rheum officinale 6.5kg, Radix Astragali 1kg, safflower 3kg, beeswax
3kg。
The preparation method of a kind of described pharmaceutical composition, comprises the following steps:
A, the raw material outside deicing sheet and beeswax is dried in the baking oven of 70 DEG C 8h, arbitrary after drying and processing
In described raw material, the mass fraction of water is 3-5%；
B, by except safflower, borneol and beeswax remaining raw material with 100kg sesame oil soak 4 days；
C, described sesame oil is heated to 140 DEG C together with raw material therein, continues 60 minutes；It is warming up to 170 DEG C again,
Safflower, stirring is added after continuing 45 minutes；
D, described sesame oil is filtered while hot, discard filter residue, and filter liquor is controlled at 90 DEG C, to filtration
Adding borneol in filtrate makes borneol dissolve；Before described borneol is added in described sesame oil, by described borneol
It is ground into the particle of 30 mesh；
E, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Described pharmaceutical composition to ointment shape.Before described beeswax is added in described sesame oil, by described beeswax
It is ground into the particle of 30 mesh.
Embodiment 5
The invention provides a kind of pharmaceutical composition treating burn and scald, mainly include the raw material of following weight portion
Make: madder 2kg, golden cypress 1.2kg, root of large-flowered skullcap 3kg, Radix Angelicae Sinensis 6.5kg, root of Dahurain angelica 3kg, giant knotweed 2kg, do not have
Medicine 1.2kg, Asian puccoon 4kg, Radix Glycyrrhizae 3kg, borneol 2kg, rheum officinale 5kg, Radix Astragali 2kg, safflower 2kg, honey
Wax 4.5kg.
The preparation method of a kind of described pharmaceutical composition, comprises the following steps:
A, the raw material outside deicing sheet and beeswax is dried 10h, drying and processing successor in the baking oven of 65 DEG C
In raw material described in, the mass fraction of water is 3-5%；
B, by except safflower, borneol and beeswax remaining raw material with 90kg sesame oil soak 4 days；
C, described sesame oil is heated to 150 DEG C together with raw material therein, continues 45 minutes；It is warming up to 180 DEG C again,
Safflower, stirring is added after continuing 35 minutes；
D, described sesame oil is filtered while hot, discard filter residue, and filter liquor is controlled at 100 DEG C, to filtration
Adding borneol in filtrate makes borneol dissolve；Before described borneol is added in described sesame oil, by described borneol
It is ground into the particle of 40 mesh；
E, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Described pharmaceutical composition to ointment shape.Before described beeswax is added in described sesame oil, by described beeswax
It is ground into the particle of 40 mesh.
The invention also discloses the application in the medicine of preparation treatment burn and scald of the described pharmaceutical composition.
As a example by embodiment 5, during use by scraper needed amount by the described pharmaceutical composition of ointment shape gently
Scraping is to affected part.
The therapeutic test below done for the described pharmaceutical composition in the present invention:
(1), testing crew physical data
Selecting various burned patient 200 example, in 200 example burned patients, M-F is 1:1, the age
16～57 years old and in normal distribution, 36 years old mean age.
(2), testing crew diagnosis basis
With whole nation higher medical institute teaching material " clinical practice " and " surgery " as standard, with clinical manifestation, doctor
It is foundation that institute's diagnosis, report and burn surface area percentage calculate method, carries out reference, gets rid of Other diseases.
(3), test method
According to above-mentioned using method, by scraper needed amount, the described pharmaceutical composition of ointment shape is swiped gently
To affected part, depending on coincident with severity degree of condition, smearing continuously 60 days, if curing, discontinuing medication.
(4), curative effect determinate standard and result
Cure: clinical symptoms are wholly absent, recover normal life 145 example, cure rate 72.5%
Taking a turn for the better: clinical symptoms partial disappearance, every sign progressively takes a turn for the better 51 examples, improvement rate 25.5%
Cure and take a turn for the better and all count effectively statistics: have 196 examples, total effective rate 98%
Invalid: symptom and sign is not improved 4 examples, inefficiency 2%.
(5), conclusion
From result it can be seen that described pharmaceutical composition has the advantage that cure rate is high.
(6), the concrete case of part:
1, Wang, man, 29 years old, Taiyuan, Shanxi people, the most scalding, arm, shirtfront occurred
A large amount of bubbles, area reaches 10%, is diagnosed as two degree of shallow scalds, after the pharmaceutical composition in the use present invention about
Pain relief in 10 minutes, patient is epidermis incrustation after 7 days, the recovery from illness of two weeks, does not has scar.
2, Lee, man, 38 years old, people from Pingxiang, Jiangxi Province, high-voltage electrical burns Head And Face and double upper limbs, table
Skin has burnt crackle sample, and its burn surface area reaches 18%, is diagnosed as two degree and is deep to third-degree burn.Use in the present invention
Pharmaceutical composition, after one day, illing skin has moist feeling.After 8 days, surface of a wound skin portion comes off, after 20 days
Surface of a wound incrustation produces, and the major part that forms a scab after about 30 comes off.There is no scar, after half a year, recover original skin condition.
3, the summer, female, 44 years old, people from Yichuan, Jiangxi Province, scalded double lower limb by water vapour, color is that purple is dark
Look, area reaches 13%, is diagnosed as third-degree burn.Use the pharmaceutical composition in the present invention, after about 20 minutes
Pain relief.Surface of a wound in-situ regeneration incrustation after 10 days, the excoriation after the surface of a wound is formed a scab after 30 days, three months
The original skin condition of rear recovery.
4, Jiao, female, 30 years old, starfish people from county of Hebei province, because thermos flask blast is burned facial area, examines
Breaking is two degree of shallow scalds, and area is 3%, uses the pharmaceutical composition in the present invention, fully recovers after 15 days.
5, Zhang, man, 45 years old, people from Wudi County, Shandong Province, it is not cautious use of caustic soda and burns right lower extremity, area reaches
13%, it is diagnosed as caustic soda high corrosion wound.Epidermis is pale, and around redness has heat pain, uses in the present invention
Pharmaceutical composition, after about 15 minutes, pain substantially alleviates.Through changing dressings two days, caustic soda has not continued to corrosion,
After medication 5 days, there are mild pain sense, red and swollen disappearance.15 days surface of a wound of medication have healed 60%, under naked eyes
Surface of a wound substrate pinkiness, one month surface of a wound all healed of medication, formed without scar.
It should be noted last that, above example only in order to technical scheme to be described and unrestricted,
Although the present invention being described in detail with reference to preferred embodiment, be it should be understood that and be the foregoing is only
The detailed description of the invention of the present invention, the protection domain being not intended to limit the present invention, all the present invention's
Within spirit and principle, any modification, equivalent substitution and improvement etc. done, should be included in the present invention's
Within protection domain.
Claims (8)
1. the pharmaceutical composition treating burn and scald, it is characterised in that mainly include following weight portion
Raw material is made: madder 10-30 part, golden cypress 7-17 part, root of large-flowered skullcap 20-40 part, Radix Angelicae Sinensis 50-80 part, the root of Dahurain angelica
20-40 part, giant knotweed 10-30 part, myrrh 7-17 part, Asian puccoon 30-50 part, Radix Glycyrrhizae 20-40 part, borneol 10-30
Part, rheum officinale 35-65 part, Radix Astragali 10-30 part, safflower 10-30 part, beeswax 30-60 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that mainly include following weight
Part raw material make: 20 parts of madder, golden cypress 12 parts, the root of large-flowered skullcap 30 parts, Radix Angelicae Sinensis 65 parts, the root of Dahurain angelica 30 parts,
Giant knotweed 20 parts, myrrh 12 parts, Asian puccoon 40 parts, 30 parts of Radix Glycyrrhizae, borneol 20 parts, rheum officinale 50 parts, Huang
Stilbene 20 parts, 20 parts of safflower, beeswax 45 parts.
3. the preparation method of pharmaceutical composition described in a claim 1 or 2, it is characterised in that include
Following steps:
A, remaining the raw material sesame oil except safflower, borneol and beeswax is soaked；
B, by described sesame oil together with raw material therein heat after add safflower, stirring；
After C, while hot filtration, in filter liquor, add borneol and make borneol dissolve；
D, after described borneol all dissolves, add beeswax and after making beeswax all dissolve, cool,
Obtain the described pharmaceutical composition of ointment shape.
Preparation method the most according to claim 3, it is characterised in that comprise the following steps:
A, by except safflower, borneol and beeswax remaining raw material with sesame oil soak 4-5 days；The quality of described sesame oil
Part is 800-1000 part；
B, described sesame oil is heated to 140-160 DEG C together with raw material therein, continues 30-60 minute；Rise again
Temperature, to 170-190 DEG C, adds safflower, stirring after continuing 25-45 minute；
C, described sesame oil is filtered while hot, and filter liquor is controlled at 90-110 DEG C, add in filter liquor
Enter borneol and make borneol dissolve；
D, after described borneol all dissolves, add beeswax and after making it all dissolve, cool,
Described pharmaceutical composition to ointment shape.
Preparation method the most according to claim 4, it is characterised in that use sesame oil leaching in step A
Before bubble raw material, the raw material outside deicing sheet and beeswax dried or shines dry-cure, dry or dry place
After reason, in arbitrary described raw material, the mass fraction of water is 3-5%.
Preparation method the most according to claim 5, it is characterised in that described drying and processing is: will
Described raw material dries 8-12h in the baking oven of 60-70 DEG C.
Preparation method the most according to claim 4, it is characterised in that described borneol and beeswax add
Before, pulverization process is also included: described borneol and beeswax are respectively crushed into the particle of 30-50 mesh.
8. the arbitrary described pharmaceutical composition of claim 1 or 2 answering in the medicine of preparation treatment burn and scald
With.
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| CN201610160769.9A CN105770116A (en) | 2016-03-21 | 2016-03-21 | Medicine composition for treating burn and scald, method for preparing medicine composition and application thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106214824A (en) * | 2016-08-15 | 2016-12-14 | 韦丽丽 | A kind of medicine treating dermatosis and scald and preparation method thereof |
| CN107519335A (en) * | 2017-10-10 | 2017-12-29 | 金得成 | A kind of liquid medicine for treating empyrosis |
| CN110559361A (en) * | 2019-08-23 | 2019-12-13 | 王托资 | Erhuang scorpion gallbladder ointment and its preparation method |
| CN114344379A (en) * | 2022-01-19 | 2022-04-15 | 陈林 | Herbal medicine formula for treating general ulceration and application thereof |
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| CN102579820A (en) * | 2011-01-07 | 2012-07-18 | 韦军来 | Ointment for treating burns and scalds and preparation method of ointment |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214824A (en) * | 2016-08-15 | 2016-12-14 | 韦丽丽 | A kind of medicine treating dermatosis and scald and preparation method thereof |
| CN107519335A (en) * | 2017-10-10 | 2017-12-29 | 金得成 | A kind of liquid medicine for treating empyrosis |
| CN110559361A (en) * | 2019-08-23 | 2019-12-13 | 王托资 | Erhuang scorpion gallbladder ointment and its preparation method |
| CN114344379A (en) * | 2022-01-19 | 2022-04-15 | 陈林 | Herbal medicine formula for treating general ulceration and application thereof |
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