CN104398741A - Traditional Chinese medicinal preparation for treating osteomyelitis - Google Patents

Abstract

A traditional Chinese medicinal preparation for treating osteomyelitis is characterized in that selected raw medicinal materials respectively comprise, by weight, 30 parts of isatis root, 30 parts of honeysuckle flower, 30 parts of dandelion, 30 parts of Corydalis bungeana Turcz., 20 parts of barbat skullcap, 20 parts of pasque flower, 20 parts of heydyotis, 30 parts of radix scrophulariae, 30 parts of Chinese angelica, 15 parts of radix paeoniae rubrathe, 12 parts of myrrh, 10 parts of licorice and 30 parts of Chinese yam. The above selected raw medicinal materials have complementary drug properties and effects. Mutual inhibition, mutual restraint and mutual-detoxication among medicines in compatibility are avoided. Mutual reinforcement and mutual-assistance among the medicines are remarkable. The traditional Chinese medicinal preparation provided by the invention has effects of clearing away heat and toxic materials, eliminating stasis to subdue swelling and sterilizing and diminishing inflammation, is used for treating osteomyelitis and has definite curative effects.

Description

Treat myelitic Chinese medicine preparation

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to one and treat myelitic Chinese medicine preparation.The present invention has effect of heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, bactericidal antiphlogistic, is used for the treatment of osteomyelitis and has definite curative effect.

Background technology

Osteomyelitis refers to that suppurative bacterium infects bone marrow, cortical bone and periosteum and the diseases associated with inflammation that causes, is mostly caused by haematogenous, is also manyly caused by wound or postoperative infection, how by furuncle carbuncleor the suppuration bacterium of other focuses enters blood and reaches osseous tissue.Bones of limbs two ends are subject to invade most, are the most common especially with hip joint.Infect and caused (hematogenous osteomyelitis) by haematogenous microorganism; From infected tissue's diffusion, comprise the infection of replacement joint, contaminative fracture and osseous surgery.Modal pathogen is gram positive bacteria.The microbial osteomyelitis of Grain-negative is found in junkie, drepanocytemia patient and serious diabetes or traumatic patient.Fungus and mycobacterial infections person pathological changes are often confined to bone, and cause the chronic infection of Silent Neuritis.Risk factor comprises wasting diseases, radiotherapy, malignant tumor, diabetes, hemodialysis and intravenous administration.For child, anyly cause bacteremic process all may bring out osteomyelitis.Common clinically have recurrent exerbation, has a strong impact on physical and mental health and work capacity.High heat, local pain during acute osteomyelitis onset, have diabrosis, suppurate, have sequestrum or cavity to be formed when transferring chronic osteomyelitis to.The normal threat to life of patient with severe symptoms, sometimes has to take the emergency approach of amputation, causes patient's lifelong disability.

Summary of the invention

One is the object of the present invention is to provide to treat myelitic Chinese medicine preparation.The present invention has effect of heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, bactericidal antiphlogistic, is used for the treatment of osteomyelitis and has definite curative effect.

The technical solution used in the present invention: the raw medicinal material that the myelitic Chinese medicine preparation of described treatment is selected and components by weight percent respectively: Radix Isatidis 30 parts, Flos Lonicerae 30 parts, Herba Taraxaci 30 parts, Herba Violae 30 parts, Herba Scutellariae Barbatae 20 parts, the Radix Pulsatillae 20 parts, Herba Hedyotidis Diffusae 20 parts, Radix Scrophulariae 30 parts, Radix Angelicae Sinensis 30 parts, Radix Paeoniae Rubra 15 parts, Myrrha 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Dioscoreae 30 parts.

In the raw materials of traditional Chinese medicinal materials that the present invention chooses, its effect and pharmacological action respectively: Radix Isatidis: Isatis indigotica Fort. root containing indigo, indirubin, Anthraquinones, cupreol, clionasterol and several amino acids: arginine, glutamic acid, tyrosine, proline, valine, γ-aminobutyric acid.Also containing potassium myronate, indigo glycoside, couroupitine A, 1-Hydrogen thiocyanate-2-hydroxyl fourth-3-alkene, sucrose and containing 12% amino acid whose proteoglycan.[effect] heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.[curing mainly] maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.

Flos Lonicerae: [meridian distribution of property and flavor] sweet in the mouth; Cold.Return lung; Stomach warp.[effect] heat-clearing and toxic substances removing.Epidemic febrile disease is generated heat; Toxic-heat and blood stasis; Carbuncle furuncle; Sore throat and multi-infection disease.

Herba Taraxaci: [nature,taste and action]: sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.[curing mainly]: upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder assists inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.Containing taraxasterol (Taraxasterol), choline (Choline), inulin (Inulin), pectin (Pectin); Taraxol (Taraxol), stigmasterol (Stigmasterol), β-Amyrin (β-Amyrin), cupreol (β-Sitosterol), taraxerol (taraxerol), taraxacin (Taraxacerin), taraxacin (Taraxacin) and vitamin A, B, C etc.

Herba Violae: cold in nature, bitter in the mouth, mild toxicity [return through]: " plateau Chinese herbal treatment handbook ": " enter the heart, spleen channel." [curative effect of medication] has the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence.There is heat-clearing toxin-expelling functions.Cure mainly: influenza; Upper respiratory tract infection, tonsillitis; The high heat of epidemic febrile disease is irritated, influenza, infectious hepatitis, and intestinal is scorching; Nephritis, dysentery; Scrofula, conjunctivitis; Parotitis, acute appendicitis; Furuncle and other pyogenic infection; [chemical composition]: containing more than 10 kinds of alkaloids.From wherein obtaining Herba Corydalis Bungeanae A prime, B prime, C prime and D prime (temporary name) 4 kinds of different alkaloids.Another containing Coumarins lactone, steroid saponin, phenolic substance, resinene and volatilization wet goods;

Herba Scutellariae Barbatae: nature and flavor: pungent, flat.Function cures mainly: have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, the diseases such as treating swelling and pain by traumatic injury.

The Radix Pulsatillae: [nature and flavor]: bitter in the mouth, cold in nature; [return through]: return stomach through, large intestine channel; [function]: there is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effect of removing dampness and killing parasites.[curing mainly]: pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula.Chemical composition: Radix Pulsatillae root is containing anemoside (pulchinenoside) A, B, C, D, 3-O-α-L-rhamnopyranose-(1 → 2)-α-L-arabopyranose-3 β, 23-dihydroxy-△ 20 (29)-lupene-28-acid (3-O-α-L-rhamnopyranosyl-(1 → 2) α-L-arabinopyranosyl-3 β, 23-dihydroxylup △-20 (29)-en-28-oicacid), anemoside (pulchinenoside) A3, B4, Saponin (saponin) 1, 2, betulic acid-3-O-α-L arabopyranose glycoside (betulinicacid 3-O-α-L-arabinopyranoside), betulic acid (betulinic acid), 3-oxo betulic acid (3-oxobetulinic acid), daucosterol (daucosterol), Anemonin (anemonin), protoanemonin (protoanemonin).

Herba Hedyotidis Diffusae: chemical composition: herb is containing rubichloric acid., rubichloric acid. acid, remove acetic acid, the acid of base rubichloric acid., all square rafter glycoside acid, Herba Paederiae time glycoside, Herba Paederiae time glycoside methyl ester, 6-O-p-hydroxyl cinnamyl Herba Paederiae time glycoside methyl ester, 6-O-p-methoxyl group cinnamyl Herba Paederiae time glycoside methyl ester, 6-O-Resina Ferulae acyl Herba Paederiae time glycoside methyl ester, 2-methyl-3-hydroxyanthraquinone, 2-methyl-3-methoxy anthraquinone, 2-methyl-3-hydroxyl-4-methoxy anthraquinone etc., and ursolic acid, cupreol, hentriacontane, stigmasterol, oleanolic acid, cupreol-β-glycoside, p-coumaric acid etc.Cure mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at the multiple cancerous protuberance for the treatment of.Nature and flavor: bitter in the mouth, light, cold in nature.

Radix Scrophulariae: [meridian distribution of property and flavor]: sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.[effect]: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Cure mainly: epidemic febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency not awake, Tianjin hinder constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore.

Radix Angelicae Sinensis: [chemical composition] is containing basic lactone, n-butene acyl lactone, ferulic acid, nicotinic acid, sucrose and several amino acids, and sesquiterpenoids etc.[meridian distribution of property and flavor] is warm in nature, sweet in the mouth, pungent.Return liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Paeoniae Rubra: function, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.

Myrrha: nature and flavor: bitter, pungent is flat.Enter liver, spleen, the heart, kidney channel.[effect]: loose blood blood stasis removing, subduing swelling and relieving pain.Cure mainly: raw property or lymphatic temperament disease, as raw property arthralgia, sciatica, oral cavity pain, has sore throat, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, dysuria.

Radix Glycyrrhizae: property is put down, sweet in the mouth.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, in the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines.

Rhizoma Dioscoreae: have and nourish strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, road essence, women's leukorrhagia and dyspeptic chronic enteritis.Nature and flavor: sweet, flat, nontoxic.Gui Jing: return spleen, lung, kidney channel.Function: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Complementary with the raw medicinal material property of medicine effect selected by top, evade the choosing of the mutual inhibition of compatibility between medicine, mutual restraint between two drugs, the mutual-detoxication, made medicine mutual reinforcement between, mutual-assistance effect significantly, there is effect of heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, bactericidal antiphlogistic, be used for the treatment of osteomyelitis, there is definite curative effect.Clinical practice has good precise effects:

The model case of clinical practice of the present invention:

King XX, man, 47 years old.October 21 2011 first visit date.

Patient was on July 15th, 2010, and the nameless Section 1 of left hand is damaged by machine, and soft tissue was that irregular shape is torn at that time, and tendon rupture exposes, and finger tip is livid purple, and blood is for bad.In certain hospital through debridement and suturing.Postoperative 9th day, local swelling, blackout, pain was abnormal.In row middle finger Section 1 excision on October 7, latter 2nd day of excision, patient Gao Re, shiver with cold, the thorough back of the body of middle finger severe pain, wound surface blackening, flows a little pus.X-ray takes the photograph sheet, is diagnosed as acute digital osteomyelitis.Through with high dose penicillin treatment 1 week, fail to control.Came to go to a doctor October 21.Patient's red tongue, yellow and greasy fur, wiry and frequent pulse.This is scorchingly hot flourishing, stays in muscles and bones, and rotten muscle erosion bone, pents up into pus.Control suitable heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, after clothes we 10 doses, body temperature is down to normally, and pain subtracts greatly, and local inflammation controls to some extent.After continuing to take we 15 doses, local is red, swollen, hot, pain disappears substantially, and wound granulation is fresh.Continue to take we after 1 month, wound healing, transference cure, recovers.

Method and effective dose: Radix Isatidis 30 parts, Flos Lonicerae 30 parts, Herba Taraxaci 30 parts, Herba Violae 30 parts, Herba Scutellariae Barbatae 20 parts, the Radix Pulsatillae 20 parts, Herba Hedyotidis Diffusae 20 parts, Radix Scrophulariae 30 parts, Radix Angelicae Sinensis 30 parts, Radix Paeoniae Rubra 15 parts, Myrrha 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Dioscoreae 30 parts; Get prescription ormal weight tcm and herbal slice, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.

Decoction oral is main, and every day takes orally for 2 times sooner or later, each 150ml decoction being taken warmly.Decoction then acts on fast and power is high, is adapted to the more anxious severe one of the state of an illness.As lighter in the state of an illness or slow person, is preferably that pill is for oral administration asks its merit.

Detailed description of the invention

Describedly be used for the treatment of myelitic Chinese medicine preparation, it is characterized in that, the raw material of Chinese medicine of selection and weight portion respectively: Radix Isatidis 30 parts, Flos Lonicerae 30 parts, Herba Taraxaci 30 parts, Herba Violae 30 parts, Herba Scutellariae Barbatae 20 parts, the Radix Pulsatillae 20 parts, Herba Hedyotidis Diffusae 20 parts, Radix Scrophulariae 30 parts, Radix Angelicae Sinensis 30 parts, Radix Paeoniae Rubra 15 parts, Myrrha 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Dioscoreae 30 parts;

Preparation method: get Radix Isatidis 30 parts, Flos Lonicerae 30 parts, Herba Taraxaci 30 parts, Herba Violae 30 parts, Herba Scutellariae Barbatae 20 parts, the Radix Pulsatillae 20 parts, Herba Hedyotidis Diffusae 20 parts, Radix Scrophulariae 30 parts, Radix Angelicae Sinensis 30 parts, Radix Paeoniae Rubra 15 parts, Myrrha 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Dioscoreae 30 parts; Ormal weight Chinese crude drug makes decoction pieces, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.

Claims (1)

1. the myelitic Chinese medicine preparation for the treatment of, it is characterized in that, the raw material of Chinese medicine of selection and weight portion respectively: Radix Isatidis 30 parts, Flos Lonicerae 30 parts, Herba Taraxaci 30 parts, Herba Violae 30 parts, Herba Scutellariae Barbatae 20 parts, the Radix Pulsatillae 20 parts, Herba Hedyotidis Diffusae 20 parts, Radix Scrophulariae 30 parts, Radix Angelicae Sinensis 30 parts, Radix Paeoniae Rubra 15 parts, Myrrha 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Dioscoreae 30 parts;

Preparation method: get Radix Isatidis 30 parts, Flos Lonicerae 30 parts, Herba Taraxaci 30 parts, Herba Violae 30 parts, Herba Scutellariae Barbatae 20 parts, the Radix Pulsatillae 20 parts, Herba Hedyotidis Diffusae 20 parts, Radix Scrophulariae 30 parts, Radix Angelicae Sinensis 30 parts, Radix Paeoniae Rubra 15 parts, Myrrha 12 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Dioscoreae 30 parts; Ormal weight Chinese crude drug makes decoction pieces, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.