CN103751194B - 用于治疗病症的方法和组合物 - Google Patents

用于治疗病症的方法和组合物 Download PDF

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Publication number
CN103751194B
CN103751194B CN201310718872.7A CN201310718872A CN103751194B CN 103751194 B CN103751194 B CN 103751194B CN 201310718872 A CN201310718872 A CN 201310718872A CN 103751194 B CN103751194 B CN 103751194B
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CN
China
Prior art keywords
pain
trpa1
substituted
halo
compound
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Expired - Fee Related
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CN201310718872.7A
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English (en)
Chinese (zh)
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CN103751194A (zh
Inventor
H.恩格
M.魏格勒
M.莫兰
J.郑
C.方格尔
G.R.拉尔森
D.德尔卡米诺
N.海沃德
S.P.亚当斯
A.里普卡
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Eli Lilly and Co
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Hydra Biosciences LLC
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Expired - Fee Related legal-status Critical Current
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105Persulfides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/11Aldehydes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201310718872.7A 2007-06-22 2008-06-23 用于治疗病症的方法和组合物 Expired - Fee Related CN103751194B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94586607P 2007-06-22 2007-06-22
US94584007P 2007-06-22 2007-06-22
US60/945,840 2007-06-22
US60/945,866 2007-06-22
CN200880103802.8A CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Related Parent Applications (1)

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CN200880103802.8A Division CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Publications (2)

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CN103751194A CN103751194A (zh) 2014-04-30
CN103751194B true CN103751194B (zh) 2018-01-05

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Family Applications (4)

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CN201510111699.3A Expired - Fee Related CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN200880103802.8A Expired - Fee Related CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201310718872.7A Expired - Fee Related CN103751194B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201711272327.4A Pending CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

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CN201510111699.3A Expired - Fee Related CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN200880103802.8A Expired - Fee Related CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

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CN201711272327.4A Pending CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

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US (3) US8163761B2 (enExample)
EP (3) EP2170309B1 (enExample)
JP (5) JP2010530901A (enExample)
CN (4) CN104825457B (enExample)
AU (1) AU2008268463B2 (enExample)
CA (2) CA2691468C (enExample)
DK (1) DK2170309T3 (enExample)
ES (1) ES2609912T3 (enExample)
HR (1) HRP20200357T1 (enExample)
SI (1) SI3184527T1 (enExample)
WO (1) WO2009002933A1 (enExample)

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JP2017165790A (ja) 2017-09-21
US8163761B2 (en) 2012-04-24
JP2014141535A (ja) 2014-08-07
EP3184527A1 (en) 2017-06-28
CN104825457A (zh) 2015-08-12
ES2609912T3 (es) 2017-04-25
EP2170309A1 (en) 2010-04-07
AU2008268463A1 (en) 2008-12-31
CA2691468C (en) 2017-05-09
AU2008268463B2 (en) 2015-03-05
CA2962043A1 (en) 2008-12-31
JP2010530901A (ja) 2010-09-16
AU2008268463A2 (en) 2010-02-25
CN108042542A (zh) 2018-05-18
JP2019147808A (ja) 2019-09-05
DK2170309T3 (en) 2017-01-09
EP3663295A1 (en) 2020-06-10
JP5932883B2 (ja) 2016-06-08
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US20130059869A1 (en) 2013-03-07
CN101801362B (zh) 2014-01-22
EP3184527B1 (en) 2020-01-29
CA2691468A1 (en) 2008-12-31
US20180133170A1 (en) 2018-05-17
EP2170309A4 (en) 2010-11-03
CN103751194A (zh) 2014-04-30
CN101801362A (zh) 2010-08-11
US20090143377A1 (en) 2009-06-04
JP2015180700A (ja) 2015-10-15
EP2170309B1 (en) 2016-10-26
CN104825457B (zh) 2019-11-19
HRP20200357T1 (hr) 2020-06-12
WO2009002933A1 (en) 2008-12-31
SI3184527T1 (sl) 2020-03-31

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