CN103750339A - Saussurea involucrate culture health-care food and application thereof - Google Patents
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- CN103750339A CN103750339A CN201410008936.9A CN201410008936A CN103750339A CN 103750339 A CN103750339 A CN 103750339A CN 201410008936 A CN201410008936 A CN 201410008936A CN 103750339 A CN103750339 A CN 103750339A
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- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000025366 tissue development Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a saussurea involucrate culture health-care food and application thereof. The saussurea involucrate culture health-care food comprises the following components in parts by weight: 10-50 parts of saussurea involucrate culture and 50-500 parts of rhodiola rosea extract. The saussurea involucrate culture is a novel functional food ingredient and appears for the first time in an anti-fatigue anti-radiation health-care food formula serves as a medical plant cell product. The saussurea involucrate culture and the rhodiola rosea extract are taken as main raw materials; according to reasonable experimental study, a health-care food with the effects of relieving physical fatigue and protecting the radiation hazards in an assisted mode is prepared, the health-care effects of relieving physical fatigue and protecting the radiation hazards can be well exerted by the combination of the two materials, the requirements of consumers troubled by the two health problems are met, and the economic cost of the consumers is saved, so that people can have more healthy body to cope with life, work and study. Therefore, the health-care food has wide market prospects.
Description
Technical field
The present invention relates to a kind of Saussurea involucrata culture health food and uses thereof.
Background technology
In the face of the society of modern competition fierceness, people, in order to strive for larger value of survival, in order to pursue higher quality of life, need high concentration energy, all the time to meet the challenge of competition.And the pressure that the rhythm of life that consequent high speed changes is born people is also increasing, add habits and customs irregular, dietary structure is the various reasons such as science not, causes more and more from the people of each post stratum, being all subject to some extent tired puzzlement.These cause the important background of modern society people " fatigue " symptom, " chronic fatigue syndrome " exactly, can say that the whole world is all in popular " fatigue ".
When the physiological function of body can not remain on its function one specified level or each organ and can not maintain its predetermined exercise intensity, be called " fatigue ".Fatigue is to prevent that body from a kind of aversion response that life-threatening excessive failure function produces occurring, and reminds and should reduce working strength or stop motion, in order to avoid body injury while producing fatigue.Excessive fatigue can be accelerated death, when human body is for a long time under fatigue state, can produce prematurely senile and burnout syndrome.The symptom that may occur has be difficult for eliminating tired out, is weary of, color spot, apocleisis, sexuality decline, hypertension, high fat of blood and fatty liver etc. appear in the finding it hard to concentrate of absent minded, unknown cause, dizziness, headache, constipation or diarrhoea, skin.
According to investigations: 41.1% white collars are being faced with larger operating pressure; In student, tired person accounts for 38.71% once in a while, and frequent tired person accounts for 33.87%, and tired person accounts for 11.29% always.In entire society, tired person reaches 70% more than unexpectedly, had a strong impact on people's study and work efficiency, endangered the healthy of people, alleviating physical fatigue is very urgent.
In the modern life, another healthy hidden danger is also perplexing people deeply, and that is exactly the harm that Radiation On Human body causes.Entered today of cyberage, electronic product has served as more and more important role in life.And we are enjoying when modern high technology offers convenience, also start frightened its adverse effect to health.Radiation is almost all-pervasive: nearby, from the mobile phone of carry-on use, to computer, the duplicator of working environment indispensability, then the TV of putting to family, refrigerator, air-conditioning, micro-wave oven, even often the make a move marble, the composite floor board that touch of people; At a distance, from surrounding enviroment such as periphery high-voltage line, transformer stations, to natural environments such as sunspots; Various radiation all let us keep away and can not keep away.
Radiation refers to a kind of state that the materials such as heat, light, sound, electromagnetic wave are propagated to surrounding, and in life, the radiation of Cucumber may bring harm to human body.The people who works, learns, lives in the concentrated environment of radiation source, easily weak, the hypoimmunity of insomnia and dreamful sleep, failure of memory, body void etc., and also than normal person fast 24 times of the speeds of growth of its cancer cell.
The harm of Radiation On Human body is great: it is the main inducing of angiocardiopathy, diabetes; It can be to human reproductive system, and nervous system and immune system cause direct injury; It is the risk factor that causes the pathologies such as pregnant woman miscarries, sterile, monster; It can directly affect children's tissue development, skeleton development, and visual impairment, liver hematopoiesis are declined; It can make Male sexual decline, female incretion disorder, menstrual disorder etc.
China's Indoor Environment Detection center has also been sent electromagnetic radiation and has been had the six large warnings that endanger: it is to cause one of leukemic reason of children most probably; It can bring out cancer and accelerate the cancer cell multiplication of human body; It affects people's reproductive system; It can cause children's intelligence incompleteness; It affects people's cardiovascular system; It has harmful effect to people's vision system.These harm ought to cause everybody attention, and actively took measures to safeguard that our healthy do not encroached on by it.
Visible, physical fatigue and radiation hazradial bundle are slowly corroding the healthy of people, and these problems ought to be subject to everybody attention.
Thus; antifatigue and radioresistance have become safeguards the healthy requisite link of people; have alleviating physical fatigue and have the health food of assistant protection function on market, to have very large demand to radiation hazradial bundle, the product of studying and develop this function becomes very important.
Prior art research is as follows:
Zhang Baiqing etc. (Herba Saussureae Involueratae culture on mouse movement after the impact of blood lactic acid and hepatic glycogen content. Chinese Medicine guide, 2012,10(7): 94-95) to the Saussurea involucrata culture capsule of mouse stomach various dose continuous 30 days every day, survey its swimming with a load attached to the body time, Serum lactic acid content and hepatic glycogen content, experimental result shows that Saussurea involucrata culture can extend the mice burden swimming time, reduces Serum lactic acid content, improve hepatic glycogen content, shows that Saussurea involucrata culture has the effect of alleviating physical fatigue.
Zhao Xiaomei etc. (research of Herba Saussureae Involueratae culture antifatigue effect. China and foreign countries' medical treatment, 2012,7:30) take Saussurea involucrata culture as research object, by mice burden swimming, test, take serum urea mensuration, hepatic glycogen content mensuration and blood Plasma lactate as index, research Saussurea involucrata culture is to mouse anti-reflecting fatigue activity.Result of the test shows: Saussurea involucrata culture can extend the mice burden swimming time, the increase of serum urea while reducing mouse swimming, and while reducing swimming, the level of serum lactic acid, significantly increases hepatic glycogen storage level, has good antifatigue physiologically active.
Radiation is mainly manifested in hematological system, immune infringement and inducing cell canceration aspect, particularly hemopoietic system radiation height sensitivity the damage of body.Liu Yaping etc. (the defencive function research of Herba Saussureae Involueratae culture to radiation injury. magazine is learned on Chinese traditional Chinese medicine basis; 2011; 17(9): 968-970), from hematological system, chromosome and 3 aspects of oxidation-reduction system, investigated respectively the protective effect of Herba Saussureae Involueratae culture to radiation injury.Result shows that giving Saussurea involucrata culture can significantly improve the 3rd day radiation damage model mice peripheral white blood cell after radiation; significantly improve the 14th day radiation damage model mice peripheral leukocytes after irradiation; significantly reduce radiation damage model mice bone marrow cell micronucleus rate; significantly improve superoxide dismutase activity in radiation damage model mice blood, illustrate that Saussurea involucrata culture has good defencive function to radiation injury.
Jia Jingming etc. (radiation resistance of Xinjiang Saussurea involucrate tissue culture. Shenyang Pharmaceutical University's journal, 2005,22(6): 444-448,462) in order to inquire into the radiation resistance of Saussurea involucrata culture ethanol extract, to mouse stomach, give various dose Saussurea involucrata culture ethanol extract, every day, gavage was total to 30d 1 time, and within the 20th day after gavage, by control group and 60Co γ-ray irradiation for test group, be total to 10d 1 every day.Observe the variation of Mice Body quality, peripheral cells number, superoxide dismutase activity, Micronucleus and mean survival time.Result shows that Saussurea involucrata culture alcohol extract can make that peripheral leukocytes, superoxide dismutase activity and the mean survival time of Irradiated Mice significantly increase, Micronucleus significantly reduces, and has illustrated that Saussurea involucrata culture ethanol extract has radiation resistance.
In the radiation resistance of the Herba Saussureae Involueratae culture " research " literary composition (. China and foreign countries' medical treatment, 2012,6:26), experimenter is divided into 4 groups of control group and high, medium and low dosage groups by mouse and carries out experimental study.Research is found and control group comparison; give the reduction of PCEMNR micronuclear rates, the increase of mouse peripheral blood leukocyte count, superoxide dismutase activity increase, mean survival time increase that Saussurea involucrata culture can make raying, illustrate that Saussurea involucrata culture has defencive function to radiation injury.
Ancient book is early on the books to it: tetra-doctor's allusion quotation > > of Tibetan medicine < < record rhodiola root " cool in nature, heat-clearing, nourishing vigour "; It is " draft is top grade " that the < < Compendium of Materia Medica-careless > > of portion the 20th volume indicates rhodiola root, has effects such as " strengthening the body resistance to consolidate the constitution, benefiting qi and nourishing blood ".In modern medicine study, rhodiola root is also listed in primary study object.Research in recent years show (the Microwave Extraction preliminary experiment of volatile oil in rhodiola root leaf. Guangdong pharmacy, 2002,12(6): 21-22) rhodiola root has strong, anti-anoxic, cold resistance, antifatigue, radioresistance and excited brain and spinal cord effect, the operating efficiency that can improve muscle power and mental labour, delays body aging.
Hao Zhaolin etc. (research of gadol extract antifatigue effect. food and pharmaceutical, 2007,9(11A): 28-31) healthy rat is divided into 4 groups at random, be respectively rhodiola root low dose group (0.01g/kg), middle dosage group (0.1g/kg), high dose group (0.3g/kg) and blank group (distilled water), continuously after gastric infusion 15d, carry out swimming with a load attached to the body experiment, record doing one's utmost property of rat swimming time, measure subsequently blood lactic acid, serum urea nitrogen, muscle glycogen and hepatic glycogen.Experimental result shows: rhodiola root has good antifatigue effect, and may be deposit and the realization of inhibition serum urea nitrogen by increasing hepatic glycogen, muscle glycogen.
Dai Chunmin etc. (research of sachalin rhodiola rhizome to Kunming mouse antifatigue effect. Agriculture of Anhui science, 2010,38(30): 16850-16852,16859) select 40 kunming mices, be divided at random high, medium and low 3 test group and blank group, gavage concentration is respectively 1.0g(crude drug) rhodiola root decoction 10.0g/ (kg.bw), the 5.0g/(kg.bw of/ml) and 2.5g/(kg.bw), blank group gavage equivalent distilled water, continuously gavage 3 weeks.After 10d, measure the mouse pole-climbing time; After 3 weeks, measure respectively each group of mouse swimming time, hepatic glycogen, muscle glycogen content.Pole-climbing time, swimming with a load attached to the body time and hepatic glycogen content and blank group that result records high, medium and low dosage group more all have utmost point significant difference, and height, middle dosage group hepatic glycogen content and low dose group relatively have significant difference; The muscle glycogen of gavage high dose group and control group relatively have utmost point significant difference, and the muscle glycogen of middle dosage group and control group relatively have significant difference, illustrate that rhodiola root has the effect of alleviating physical fatigue.
Yang Xiaoyan etc. (Tibetan medicine Rhodiola rosea capsules antifatigue effect research [J]. Natural products research exploitation, 2009,21:480-482) in the experiment of research Tibetan medicine Rhodiola rosea capsules antifatigue effect, breakdown test and biochemical indicator have been measured respectively, result shows that experimental mice significantly increased compared with the control group mice swimming with a load attached to the body time, after experimental mice motion, serum urea nitrogen and Serum lactic acid content significantly reduce than control group mice under the same terms, and the content of hepatic glycogen obviously increases than control group mice under the same terms.Thereby show, Rhodiola rosea capsules has obvious antifatigue effect.
Miao Yanbo etc. (radiation resistance [J] of sachalin rhodiola rhizome. Pharmacology and Clinics of Chinese Materia Medica, 2004,20(3): 21-22), by observing the generation of the survival rate of mouse and survival mice thymus gland, spleen index and the heart, hepatic tissue lipid peroxide after single-bolus high-dose (5Gy or 4Gy) deep X-ray irradiation, the radiation resistance of rhodiola root has been carried out to experimental study.Research is found that the rhodiola root gastric infusion of high dose can obviously improve and is accepted the survival rate of single-bolus high-dose deep X-ray irradiation mouse, obviously increases survival mice thymus gland, spleen index; and the heart of docking raying mouse, the generation of hepatic tissue lipid peroxide have obvious inhibitory action, show that the radical damage that rhodiola root causes radiation has significant protective effect.
Zheng Zhi wait clearly (preliminary experiment of rhodiola root radiation-resisting functional research [J]. Shanghai preventive medicine magazine; 2000; the preliminary experiment of 12(2): 69-70) having carried out rhodiola root radiation-resisting functional is studied, and experimental result shows that rhodiola root alcohol extract is subject to postradiation time-to-live of 60Co and PBL to have remarkable protective effect to mouse.Prompting rhodiola root is the extremely valuable radioresistance food plant of one.Its toxicity is little simultaneously, and without obviously cumulative effect, and there is potential plurality of health care functions, be the health food that a kind of utmost point has exploitation to be worth.
Liu Sanqiang (experimental study [J] of rhodiola root to rat radiation injury protective action. Clinical Medical Engineering, 2010,17(2): 50-51) in order to study the protective action of rhodiola root to rat radiation injury, give SD rat every day with gadol extract gavage, after irradiating with high-energy X-ray accelerator, measure indices.Result shows after rhodiola root is to rat raying that peripheral blood, myeloplast have obvious protective effect, and rat chest gland and index and spleen index are had and obviously increase effect.Therefore, rhodiola root has obvious protective action to rat radiation injury.
At present, anti-fatigue effect food mainly comprises following a few class: (1) is rich in vitamins functional food, is mainly vitamin A, Cobastab, vitamin C and vitamin E; (2) be rich in amino acid whose functional food; (3) be rich in micro-functional food; (4) proteins and peptides based food; (5) active polysaccharide food; (6) Chinese medicine of antifatigue.Radiation-resistant food mainly comprises tea, Semen sesami nigrum, spirulina, Chinese herbal medicine, sea-tangle, matrimony vine, marine alga, ginseng, glossy ganoderma, mushroom class, black fungus, purple three-coloured amaranth, propolis, fruit and vegetable etc.
Summary of the invention
The person that the present invention is directed to fatiguability with contact radiation person; selecting Saussurea involucrata culture, gadol extract is primary raw material; through rational experimental study; be processed into the health food that there is alleviating physical fatigue and radiation hazradial bundle is had to assistant protection function, to reach antifatigue and radiation-resistant object simultaneously.
One of the object of the invention is to provide a kind of Saussurea involucrata culture health food, comprises following weight part ratio:
Saussurea involucrata culture 10～50;
Gadol extract 50～500;
Saussurea involucrata culture of the present invention is the dry powder that the processing of saussurea involucrata cultured cell drying obtains.
Saussurea involucrata cultured cell of the present invention is that Herba Saussureae Involueratae is cultivated gained through cell tissue, commercially available purchasing.
Preferably, described Saussurea involucrata culture health food, comprises following weight part ratio:
Saussurea involucrata culture 10;
Gadol extract 60.
Preferably, described Saussurea involucrata culture is prepared by following technique:
1. freeze drying: saussurea involucrata cultured cell is kept 1～4 hour at-40～-60 ℃; Holding temperature, at-40～-60 ℃, is evacuated to vacuum 0.001～0.1pa, lyophilization 5～20 hours; Be warming up to-20～-35 ℃ dry 2～6 hours, 0～-15 ℃ dry 2～6 hours, 1～20 ℃ dry 5～20 hours, 25～35 ℃ dry 3～10 hours, 40～60 ℃ and be dried 3～10 hours, obtain dried frozen aquatic products;
2. pulverize and sieve: after described dried frozen aquatic products is pulverized, cross 80 mesh sieves.
The flavones content of the Saussurea involucrata culture of preparing through above-mentioned technique reaches 12%, and protein content is greater than 20%.
The flavones content of Saussurea involucrata culture of the present invention refers to the mass percent of flavones in Saussurea involucrata culture, and protein content refers to the mass percent of protein in Saussurea involucrata culture.
Preferably, described gadol extract is prepared by following technique:
1. pulverize: rhodiola root is pulverized, obtained meal;
2. extract: rhodiola root meal 70% alcohol reflux extracts 3 times, and each 1h, filters, and obtains ethanol extract and filter residue;
3. concentrated: ethanol extract, at temperature 60-70 ℃, is concentrated into relative density 1.18-1.20 under vacuum 0.07-0.08Mpa, obtain concentrate;
4. spraying is dry: by concentrate at EAT 170-180 ℃, at leaving air temp 70-80 ℃ spraying dry, obtain spray powder;
5. sieve: after spray powder is pulverized, cross 80 mesh sieves, obtain gadol extract.
In the gadol extract that above technique prepares, Determination of Salidroside is greater than 2%.
In gadol extract of the present invention, Determination of Salidroside refers to the mass percent of rhodioside in gadol extract.
Still a further object of the present invention is to provide a kind of Saussurea involucrata culture health food preparation, by above-described Saussurea involucrata culture health food, optionally by the technology of well known to a person skilled in the art, adds auxiliary material to be processed into preparation.
According to clinical need to the practice of experimental study, Saussurea involucrata culture health food of the present invention and auxiliary material are prepared to formulation conventional in this area with together with optional coating material, as tablet, granule, capsule, pill, syrup, pulvis etc.
Described auxiliary material comprises following optional:
Filler, is selected from Icing Sugar, starch, dextrin, cyclodextrin, calcium sulfate two water things, calcium phosphate, calcium carbonate or microcrystalline cellulose etc.;
Adhesive, is selected from starch, alginic acid and its esters, methylcellulose, sodium carboxymethylcellulose, ethyl cellulose or polyvinylpyrrolidone etc.;
Lubricant, is selected from dolomol, zinc stearate, talcum powder, dodecyl sodium sulfate, silica etc.
Preferably, described Saussurea involucrata culture health food preparation comprises following weight part ratio:
Another object of the present invention is to provide described Saussurea involucrata culture health food or the purposes of Saussurea involucrata culture health food preparation in the radiation-resistant health food of preparation antifatigue.
Saussurea involucrata is composite family phoenix hair Dendranthema, is the perennial rare herbaceous plant in a kind of plateau, and medical value is high.Uygur medicine is thought saussurea involucrata invigorating kidney, promoting blood circulation, strengthening the bones and muscles, trophic nerve, dysregulation body fluid.The traditional Chinese medical science is thought, saussurea involucrata bitter warm in nature, warming kidney and enhancing yang, have clearing heat and detoxicating, wines used as antirheumatic, swelling and pain relieving, the effect such as restore menstrual flow and invigorate blood circulation, for anti-inflammatory, dispel cold, menstruation regulating, hemostasis, strengthen immunity, delay senility, defaecation, radioresistance have good action effect, modern pharmacological research proves, its active ingredient is mainly flavone compound and polysaccharide.
Rhodiola root is sweet, and hardship is flat, returns lung, the heart channel of Hang-Shaoyin, has qi and activate blood circulation, an effect such as relieving asthma of promoting blood circulation, and can resist anoxic, antifatigue, antibacterial, analgesia, radioresistance, delay senility etc.
Advantage of the present invention is mainly reflected in:
(1) the present invention to fatiguability person with contact radiation person, select Saussurea involucrata culture, gadol extract is primary raw material, through rational experimental study, be processed into the health food that there is alleviating physical fatigue and radiation hazradial bundle is had to assistant protection function, the two is also used, can better bring into play alleviating physical fatigue and the health care to radiation hazradial bundle, met the consumer demand that is deeply subject to these two health problem puzzlements, saved consumer's economy expenditure, can have more healthy health and deal with life, working and learning, therefore the present invention has wide market prospects.
(2) Saussurea involucrata culture is a kind of novel functional food ingredient, as Medicinal Plant Cell series products, appears at first in antifatigue anti-radiation health care food formula.Wild saussurea involucrata natural resources had both been protected in the application of Saussurea involucrata culture, had avoided again the safety problems such as agricultural chemicals that artificial growth saussurea involucrata brings, heavy metal.
(3) Saussurea involucrata culture of preparing through the present invention, general flavone content is up to 12%, and this has established the radioresistance of Saussurea involucrata culture health food of the present invention and the material base of anti-fatigue effect.
The specific embodiment
Following non-limiting example can make the present invention of those of ordinary skill in the art's comprehend, but does not limit the present invention in any way.
Saussurea involucrata cultured cell is that Saussurea involucrata is cultivated gained through cell tissue, is aubergine, lumps, purchased from Dalian Puruikang Biotechnology Co.
Rhodiola root: sachalin rhodiola rhizome, purchased from local market, Tibet;
Gadol extract is prepared by following technique:
1. pulverize: rhodiola root is pulverized, obtained meal;
2. extract: rhodiola root meal 70% alcohol reflux extracts 3 times, and each 1h, filters, and obtains ethanol extract and filter residue;
3. concentrated: ethanol extract, at temperature 60-70 ℃, is concentrated into relative density 1.18-1.20 under vacuum 0.07-0.08Mpa, obtain concentrate;
4. spraying is dry: by concentrate at EAT 170-180 ℃, at leaving air temp 70-80 ℃ spraying dry, obtain spray powder;
5. sieve: after spray powder is pulverized, cross 80 mesh sieves, obtain gadol extract.
In the gadol extract that above technique prepares, Determination of Salidroside is greater than 2%.
Embodiment 1
Saussurea involucrata culture health food, comprises following weight part ratio:
Saussurea involucrata culture 10; Gadol extract 50.
Embodiment 2
Saussurea involucrata culture health food, comprises following weight part ratio:
Saussurea involucrata culture 50; Gadol extract 500.
Embodiment 3
Saussurea involucrata culture health food, comprises following weight part ratio:
Saussurea involucrata culture 1; Gadol extract 6.
Embodiment 4
Saussurea involucrata culture 1; Gadol extract 6.
Embodiment 5
Saussurea involucrata culture health food, comprises following weight part ratio:
The preparation of embodiment 6 Saussurea involucrata culture health-care edible capsules
By following weight portion, prepare raw material: 1 part of Saussurea involucrata culture, 6 parts of gadol extracts,
Technique: adopt the common process of capsule to produce.First Saussurea involucrata culture fine powder and dextrin fine powder are mixed, obtain mixed powder A; Again gadol extract fine powder is mixed with mixed powder A, obtain mixed powder B; Finally fine silica is mixed to the direct filled capsules of total mixed powder obtaining with mixed powder B.
Test example 1
The damage of nuclear radiation on organism is mainly manifested in aspects such as hematological system, immune infringement and inducing cell cancerations.In radiation injury, body also can produce a large amount of free radicals, and medicine, by removing these free radicals, alleviates and eliminates the damage that radiation brings and reach.This research is investigated the impact of mouse peripheral blood leukocyte count before and after radiation and bone marrow cell micronucleus rate.
Experimental studies have found that, the recovery of immune system to nuclear radiation injury mouse of Saussurea involucrata culture, gadol extract, hematopoiesis function and remove the aspects such as free radical and all have facilitation, and Saussurea involucrata culture health food of the present invention has synergy aspect opposing radiation, have more remarkable radioresistance effect.
Animal: the clean level of Kunming kind female mice, is provided by Institute of Experimental Animals, Chinese Academy of Medical Sciences's breeding field.
Experimental technique:
Adopting respectively the Saussurea involucrata culture health food of embodiment 3 and embodiment 4 is given the test agent, as experimental group, enters
Row test.
Take Saussurea involucrata culture, gadol extract as given the test agent, group is tested as a comparison respectively, and dosage is identical with experimental group.
Kunming kind female mice, 10 every group, random packet.Give 420mg/kg.BW(Mouse Weight every day) given the test agent powder, sample configures with sterilized water, and once a day, per os gives, and irradiation animal after gavage 30d, still gives given the test agent after irradiation continuously.Mouse stomach volume is 0.1ml/10g.BW.If radiation model control group, replaces given the test agent with sterilized water, every day, gavage volume was identical with experimental group.
Leukocyte count is measured: contrast groups, experimental group and radiation model control group are all with same dosage 60Co-gamma-rays full-body exposure 1 time, and exposure dose is selected 3Gy.Respectively at pre-irradiation, after irradiating, within the 14th day, get blood 20 μ L, carry out leukocyte count mensuration with MEK-6318K blood analyser.
Bone marrow cell micronucleus rate: all same dosage gamma-rays full-body exposures 1 time of contrast groups, experimental group and radiation model control group, exposure dose is selected 3Gy.The 3rd day cervical vertebra dislocation kill animals after irradiating, microscopy, obtains bone marrow cell micronucleus rate.
On the impact (n=10) of mouse peripheral blood leukocyte count after radiation
| Group and dosage | Before radiation (× 10 9/L) | 14d (× 10 after radiation 9/L) |
| Radiation control group | 12.04±2.73 | 5.55±1.29 |
| Saussurea involucrata culture contrast groups | 11.93±2.50 | 6.44±1.29 |
| Gadol extract contrast groups | 11.76±2.43 | 6.31±1.57 |
| Embodiment 3 experimental group | 11.86±2.78 | 7.61±1.31 |
| Embodiment 4 experimental group | 11.98±2.36 | 7.96±1.66 |
Found that, radiation control group leukocyte count after radiation obviously reduces, and illustrates and has successfully set up radiation injury model; And compared with control group, the leukocyte count after contrast groups, experimental group radiation is all significantly improved; And the leukocyte count of embodiment 3 and embodiment 4 experimental group is respectively compared with Saussurea involucrata culture contrast groups, gadol extract contrast groups, it is more that leukocyte count improves, and wherein embodiment 4 experimental group are maximum.
On the impact of Micronucleus after radiation
| Group and dosage | Micronucleus number (individual) | Bone marrow cell micronucleus rate (‰) |
| Radiation control group | 14.7±3.72 | 14.7 |
| Saussurea involucrata culture contrast groups | 13.4±2.32 | 13.4 |
| Gadol extract contrast groups | 13.1±3.32 | 13.1 |
| Embodiment 3 experimental group | 12.1±3.34 | 12.1 |
| Embodiment 4 experimental group | 11.5±2.64 | 11.5 |
Found that, compared with control group, the bone marrow cell micronucleus rate of contrast groups, experimental group obviously reduces, and the value of other each groups of the numeric ratio of embodiment 3 experimental group and embodiment 4 experimental group is lower, and wherein embodiment 4 experimental group are minimum.
Above two experimental results show, Saussurea involucrata culture health food of the present invention has collaborative resistant function for radiation hazradial bundle.
Test example 2
Evaluate tired method and have two kinds: the detection of breakdown test and biochemical indicator.Exercise tolerance be reflection organism fatigue the most directly, the most objective index.Biochemical indicator just changed before fatigue appears in body, can be therefore that hepatic glycogen and blood lactic acid reflect degree of fatigue with tired biochemical indicator.
Blood lactic acid, as the main metabolites of muscle activity, is the important indicator of evaluating organism fatigue.It is just more serious that lactic acid is piled up more, tired degree, and when tired, the lactic acid in muscle penetrates into blood very soon, makes Serum lactic acid content increase, until concentration reaches balance between muscle lactic acid and blood lactic acid.Therefore the Serum lactic acid content that mensuration is moved after stopping reflects the level of muscle lactic acid substantially.Glucose is stored in liver and muscle with the form of glycogen, is called muscle glycogen and hepatic glycogen.The main source of energy when muscle glycogen is muscle activity, its how many direct locomitivities that affect.It is in the flue always simultaneous with the exhaustion of muscle glycogen that motion causes.Along with the continuous increase that muscle glycogen consumes, body is for maintaining blood sugar level, will employ hepatic glycogen and causes hepatic glycogen minimizing.Therefore, hepatic glycogen content is the sensitive indicator of reflection degree of fatigue.
Animal: the clean level of Kunming kind female mice, is provided by Institute of Experimental Animals, Chinese Academy of Medical Sciences's breeding field.
Adopting respectively the Saussurea involucrata culture health food of embodiment 3 and embodiment 4 is given the test agent, as experimental group, tests.
Take Saussurea involucrata culture, gadol extract as given the test agent, group is tested as a comparison respectively, and dosage is identical with experimental group group.
Experimental technique:
Give 420mg/kg.BW given the test agent powder every day, sample configures with sterilized water, and once a day, the Hou Jingkou that weighs gives, continuously gavage 30d.Mouse stomach volume is 0.2ml/10g BW.If control group, replaces given the test agent with sterilized water, every day, gavage volume was identical with experimental group.
Mice burden swimming test: last gives after given the test agent 30min, claim weight, every mouse root of the tail portion 5% weight sheet lead of loading, is placed in the depth of water (30 ± 1) cm, water temperature (25 ± 1) ℃ swimming trunk went swimming, agitate water frequently, makes mouse four limbs keep motion.Record starts to death time (min) from swimming.
Hepatic glycogen is measured: last gives to put to death mouse after given the test agent 30min and removes liver, carries out hepatic glycogen mensuration.
Serum urea assay: last gives after given the test agent 30min, puts into mouse not swimming with a load attached to the body of the water 90min of 30 ℃ of temperature, after rest 60min, plucks eyeball and gets blood, surveys serum urea content.
Mice burden swimming test swimming time, serum urea and hepatic glycogen content measurement result (n=10)
| Group | Swimming time (min) | Serum urea (mmol/L) | Hepatic glycogen content (mg/100g hepatic tissue) |
| Control group | 32.00±9.57 | 6.38±0.76 | 6463.97±762.35 |
| Saussurea involucrata culture contrast groups | 36.21±4.56 | 6.01±0.73 | 7653.75±351.35 |
| Gadol extract contrast groups | 35.62±7.06 | 5.90±0.71 | 7490.19±289.36 |
| Embodiment 3 experimental group | 40.14±5.32 | 5.60±0.89 | 9096.07±304.55 |
| Embodiment 4 experimental group | 44.70±5.85 | 5.33±0.69 | 9686.03±2767.57 |
Found that, compared with control group, contrast groups, experimental group swimming time obviously extend, and serum urea content reduces, and hepatic glycogen content raises; And compared with Saussurea involucrata culture contrast groups, rhodiola root contrast groups, embodiment 3 experimental group and embodiment 4 experimental group more can effectively extend mouse swimming time, reduce serum urea content, increase hepatic glycogen content, i.e. antifatigue better effects if, wherein embodiment 4 experimental group antifatigue effects are best.
Thus, Saussurea involucrata culture and the rhodiola root in Saussurea involucrata culture health food of the present invention can be worked in coordination with performance antifatigue effect.
Test example 3 safety testings
(1) animal acute toxicity test of Saussurea involucrata culture health food of the present invention
Adopt respectively each 20 of Kunming mouse and SD rat, carry out animal acute toxicity test.Test is established dosage group of 15000mg/kg.BW by maximum tolerated dose method, with distilled water, mixes, and 75g embodiment 3 Saussurea involucrata culture health food adding distil waters are settled to 200ml, gavage.Experimental result demonstration, MTD value is all greater than 15000mg/kg.BW, by acute toxicity pulvis, belongs to nontoxic level.
(2) embodiment 3 Saussurea involucrata culture health foods are carried out to three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test), result has no Saussurea involucrata culture health food of the present invention mutagenesis.
Feeding trial test in (3) 30 days
SD rat, the present embodiment 3 Saussurea involucrata culture health foods are established 350mg/kg.BW, 700mg/kg.BW, tri-dosage groups of 1400mg/kg.BW, separately establish full-valence pellet feed control group, feeding 30 days.Found that, animal growth is normal, body weight sustainable growth, and figure is active, and stool and urine no abnormality seen changes; Without animal, there is poisoning symptom and death; The body weight weekly of three dosage group male and female rats, food-intake, weekly food utilization and total foodstuff utilization rate, liver ratio are compared with control group weekly, difference that there are no significant; Blood test result, latter stage Biochemistry test result and control group comparison, difference that there are no significant.Histopathological examination has no tested material high dose group and causes that animal toxic injury changes.
Test example 4: the flavones content of Saussurea involucrata culture of the present invention
Flavonoid substances is antifatigue and radiation-resistant material base.This measuring the general flavone content in the embodiment of the present invention 4 Saussurea involucrata cultures.
Method: get embodiment 4 Saussurea involucrata cultures appropriate, add methyl alcohol appropriate, be placed in apparatus,Soxhlet's, add hot reflux.According to 2005 editions two catalogue VB of Chinese pharmacopoeia, take rutin as reference substance, spectrophotometric determination flavones content.
Result: in the Saussurea involucrata culture of preparing through technique of the present invention, flavones content is up to 12%.
Test example 5: the protein content of Saussurea involucrata culture of the present invention
According to GB5009.5-2010 food security national standard, the protein content of measuring embodiment 4 Saussurea involucrata cultures is 25%.
Test example 6: in gadol extract of the present invention salidroside content
By < < health food check and the method for it " mensuration of rhodioloside in health food " of assessment technique standard > > (version in 2003) regulation, test, the content of measuring rhodioloside in gadol extract prepared by technique of the present invention is 3%.
Test example 7: the content of rhodioloside in Saussurea involucrata culture health food of the present invention
By the check of < < health food and the method for it " mensuration of rhodioloside in health food " of assessment technique standard > > (version in 2003) regulation, test, the content of measuring rhodioloside in embodiment 4 Saussurea involucrata culture health foods is 1.06%.In Saussurea involucrata culture health food of the present invention, the content of rhodioloside is the mass percent of rhodioloside in Saussurea involucrata culture health food.
Claims (10)
1. Saussurea involucrata culture health food, is characterized in that comprising following weight part ratio:
Saussurea involucrata culture 10～50;
Gadol extract 50～500.
2. Saussurea involucrata culture health food according to claim 1, is characterized in that comprising following weight part ratio:
Saussurea involucrata culture 10;
Gadol extract 60.
3. Saussurea involucrata culture health food according to claim 1 and 2, is characterized in that described Saussurea involucrata culture prepared by following technique:
1. freeze drying: saussurea involucrata cell is kept 1～4 hour at-40～-60 ℃; Holding temperature, at-40～-60 ℃, is evacuated to vacuum 0.001～0.1pa, lyophilization 5～20 hours; Be warming up to-20～-35 ℃ dry 2～6 hours, 0～-15 ℃ dry 2～6 hours, 1～20 ℃ dry 5～20 hours, 25～35 ℃ dry 3～10 hours, 40～60 ℃ and be dried 3～10 hours, obtain dried frozen aquatic products;
2. pulverize and sieve: after described dried frozen aquatic products is pulverized, cross 80 mesh sieves.
4. Saussurea involucrata culture health food according to claim 3, is characterized in that, the flavones content of described Saussurea involucrata culture reaches 12%, and protein content is greater than 20%.
5. Saussurea involucrata culture health food according to claim 1, is characterized in that described gadol extract prepared by following technique:
1. pulverize: rhodiola root is pulverized, obtained meal;
2. extract: rhodiola root meal 70% alcohol reflux extracts 3 times, and each 1h, filters, and obtains ethanol extract and filter residue;
3. concentrated: ethanol extract, at temperature 60-70 ℃, is concentrated into relative density 1.18-1.20 under vacuum 0.07-0.08Mpa, obtain concentrate;
4. spraying is dry: by concentrate at EAT 170-180 ℃, at leaving air temp 70-80 ℃ spraying dry, obtain spray powder;
5. sieve: after spray powder is pulverized, cross 80 mesh sieves, obtain gadol extract.
6. Saussurea involucrata culture health food according to claim 5, is characterized in that in described gadol extract, Determination of Salidroside is greater than 2%.
7. a Saussurea involucrata culture health food preparation, by the health food described in claim 1-6 any one, optionally adds auxiliary material to be processed into preparation by the technology of well known to a person skilled in the art.
8. Saussurea involucrata culture health food preparation according to claim 7, is characterized in that described preparation is soft capsule, hard shell capsules, tablet, tea-drinking, oral liquid, vina, granule, sweet cream, distillate medicinal water, powder or fresh juice.
9. Saussurea involucrata culture health food preparation according to claim 7, is characterized in that described preparation comprises following weight part ratio:
10. the purposes of Saussurea involucrata culture health food preparation in preparation antifatigue radiation-resistant health food described in Saussurea involucrata culture health food or claim 7-9 any one described in claim 1-5 any one.
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| CN106260359A (en) * | 2016-09-18 | 2017-01-04 | 大连普瑞康生物技术有限公司 | A kind of Saussurea involucrata culture compositions Ganoderma tea and preparation method thereof |
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| CN108813610A (en) * | 2018-05-30 | 2018-11-16 | 南京中生生物科技有限公司 | A kind of saussurea involucrata composition and its application for improving immunity |
| CN108813610B (en) * | 2018-05-30 | 2022-03-04 | 南京中生生物科技有限公司 | Saussurea involucrate composition for improving immunity and application thereof |
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| CN113052202A (en) * | 2021-01-29 | 2021-06-29 | 昆明理工大学 | Method for classifying sun black subgroup in full-sun image |
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