CN105998280A - Anti-haze medical and edible dual-purpose cordyceps militaris and snow lotus herb composition and preparation method and application thereof - Google Patents
Anti-haze medical and edible dual-purpose cordyceps militaris and snow lotus herb composition and preparation method and application thereof Download PDFInfo
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- CN105998280A CN105998280A CN201610288489.6A CN201610288489A CN105998280A CN 105998280 A CN105998280 A CN 105998280A CN 201610288489 A CN201610288489 A CN 201610288489A CN 105998280 A CN105998280 A CN 105998280A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an anti-haze medical and edible dual-purpose cordyceps militaris and snow lotus herb composition and a preparation method and application thereof. The composition is prepared from 10-55 parts of cordyceps militaris, 10-40 parts of fresh loquat fruit pulp, 13-37 parts of fructus cannabis, 6-18 parts of platycodon roots, 5-33 parts of fresh dandelions, 4-13 parts of pummelo peel and 0.05-8 parts of snow lotus herb culturing substances. Fresh ingredients and dry ingredients are separated, mixing extracting, concentrating and drying are conducted, acceptable auxiliary materials are added, and then all the materials can be prepared into beverages, tablets, capsules, granules and oral solutions which can prevent and treat haze damage and can be used for preparing compositions for removing acne and chloasma and treating a lung cancer.
Description
Technical field
The present invention relates to medicine, field of health care food, be specifically related to a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions and its system
Preparation Method, relates to a kind of anti-haze medicine-food two-purpose Cordyceps anti-haze of Herba Saussureae Involueratae compositions and dispels acne, functions of removing chloasma, treatment pulmonary carcinoma in preparation
Compositions in application.
Background technology
Haze, also referred to as gray haze (smog), the particle such as dust in air, sulphuric acid, nitric acid, organic hydrocarbon compounds also can make greatly
Gas is muddy.The horizontal visibility of object is referred to as mist or mist in this phenomenon of 1000~ten thousand metres.Air when forming mist
Humidity should be saturated (in the presence of a large amount of nuclei of condensation, relative humidity not necessarily reaches 100% it is possible to occur saturated).By
The light of the mist scattering formed in aqueous water or ice crystal is little with wavelength relationship, thus mist seems to be creamy white or Bluish white and Lycoperdon polymorphum Vitt.
Along with Development of Urbanization and the acceleration of process of industrialization, industrial waste gas, vehicle exhaust, building building cement dirt, coal smoke dirt, rubbish
The unordered discharge of the pollutant such as rubbish burning, causes the pollutant such as the dust in air, antibacterial, virus and pellet serious
Exceeding standard, they combine with fog, allow sky moment become the most gloomy, formation haze weather, the most in recent years,
Along with air quality runs down, haze weather phenomenon occur frequency more and more higher, under this weather, when people trip or
During routine work life, molecule in air (refer mainly to the diameter particulate matter less than or equal to 2.5 microns, i.e. PM2.5,
Also referred to as can enter lung particulate matter) will be directly entered and stick in human respiratory tract and alveolar.Especially submicron particle can divide
It is not deposited in upper and lower respiratory tract and alveolar, causes the disease such as acute rhinitis and acute bronchitis.For bronchial asthma,
The chronic respiratory system diseases patients such as chronic bronchitis, obstructive emphysema and chronic obstructive pulmonary disease, haze weather can make
State of an illness acute attack or acute exacerbation.If being chronically at this environment also can induce pulmonary carcinoma.
The radical cure of haze requires time for, at present when by the efficacy of a drug, moistening the lung and resolving phlegm, to help the self-cleaning ability of lung, makes harmful particulate matter
Discharge with expectorant.Medicine-food two-purpose composition not only has that drug resistance is low, side effect and the advantage such as untoward reaction is few, is suitable for long-term taking,
But also there is many comprehensive effects, it sucks infringing party mask at preventing and treating haze advantage and the vast potential for future development of uniqueness.
Summary of the invention
Present invention seek to address that the problems referred to above, the first purpose is to provide one that multiple medicine-food two-purpose composition is carried out reasonable formula,
Can substantially effectively play and utilize effect of raw material ingredient, integrate the anti-haze medicine-food two-purpose worm for the treatment of and health care
Grass Herba Saussureae Involueratae compositions, the second purpose is to provide the preparation method of a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, the 3rd purpose
It is to provide a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions in the compositions preparing dispel acne, functions of removing chloasma, treatment pulmonary carcinoma
Application.
For achieving the above object, the present invention provides a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, said composition contain following
The raw material of weight portion: Cordyceps militaris (L.) Link. 10~55 parts, fresh loquat fruit 10~40 parts, Fructus Cannabis 13~37 parts, Radix Platycodonis 6~18 parts,
Fresh Herba Taraxaci 5~33 parts, Exocarpium Citri Grandis 4~13 parts, Saussurea involucrata culture 0.05~8 parts.
Preferably, the present invention provides a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, said composition contain following weight portion
Raw material: Cordyceps militaris (L.) Link. 14~52 parts, fresh loquat fruit 14~33 parts, Fructus Cannabis 17~31 parts, Radix Platycodonis 8~15 parts, fresh Pu is public
English 11~25 parts, Exocarpium Citri Grandis 6~9 parts, Saussurea involucrata culture 0.1~5 parts.
A kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions of the present invention, can add acceptable adjuvant, make tablet, capsule,
Granule, oral liquid, beverage.
The present invention provides the preparation method of a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, carries out as follows: (1) is by joining
Side weighs the fresh loquat fruit of weight portion, Fructus Cannabis, fresh Herba Taraxaci, smashed 60~150 mesh sieves, and added 2~5 times of water, stir
Mix 30~90 minutes, filter, collect filtrate, standby;
(2) filtering residue in above-mentioned (1) is added Cordyceps militaris (L.) Link., Radix Platycodonis, Exocarpium Citri Grandis, add 6~15 times of water, decoct extraction 2 times, often
Secondary 1~3 hour, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, dry, pulverize into
80~120 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture and proper auxiliary materials, make tablet, capsule, granule, oral liquid,
Beverage.
On the other hand, it is an object of the invention to provide a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, in preparation, there is acne of dispelling
Application in the compositions of effect.
Furthermore, it is an object of the invention to provide a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, in preparation, there is functions of removing chloasma work
Compositions in application.
Make it is further an object that provide a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions to have treatment pulmonary carcinoma in preparation
Compositions in application.
Detailed description of the invention
The present invention is further illustrated, the raw material used by following embodiment, test example, reagent material below by detailed description of the invention
Material etc., if no special instructions, all buy commercially available prod, raw material such as: Cordyceps militaris (L.) Link., Fructus Cannabis, Radix Platycodonis, Exocarpium Citri Grandis are from medical material
Market;Fresh loquat fruit be the clean sarcocarp after fresh Folium Eriobotryae enucleation, fresh Herba Taraxaci be the fresh aerial parts of Herba Taraxaci, be all from
Market is criticized in agriculture;Saussurea involucrata culture is from Puri health bio tech ltd, Dalian.Following example are merely to illustrate the present invention,
Wherein said experimental technique, as without specifically defined, being conventional method.
Embodiment 1
Raw material: Cordyceps militaris (L.) Link. 10 parts, fresh loquat fruit 10 parts, Fructus Cannabis 13 parts, Radix Platycodonis 6 parts, fresh Herba Taraxaci 33 parts, Exocarpium Citri Grandis
4 parts, Saussurea involucrata culture 8 parts.
Preparation method: (1) weighs the fresh loquat fruit 10 parts of weight portion, Fructus Cannabis 13 parts, fresh Herba Taraxaci 33 parts, smashes 150
Mesh sieve, adds 5 times of water, stirs 90 minutes, filters, and collects filtrate, standby;
(2) filtering residue in above-mentioned (1) is added Cordyceps militaris (L.) Link. 10 parts, Radix Platycodonis 6 parts, Exocarpium Citri Grandis 4 parts, add 6 times of water, decoct and extract
2 times, each 1 hour, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, be dried, powder
It is broken into 100 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture 8 parts and polyvinylpolypyrrolidone 1 part, silicified microcrystalline cellulose 0.8 part,
Magnesium stearate 0.01 part, makes tablet.
Embodiment 2
Raw material: Cordyceps militaris (L.) Link. 31 parts, fresh loquat fruit 26 parts, Fructus Cannabis 24 parts, Radix Platycodonis 12 parts, fresh Herba Taraxaci 5 parts, Exocarpium Citri Grandis
9 parts, Saussurea involucrata culture 0.05 part.
Preparation method: (1) weighs the fresh loquat fruit 26 parts of weight portion, Fructus Cannabis 24 parts, fresh Herba Taraxaci 5 parts, smashes 60
Mesh sieve, adds 2 times of water, stirs 30 minutes, filters, and collects filtrate, standby;
(2) filtering residue in above-mentioned (1) being added Cordyceps militaris (L.) Link. 31 parts, Radix Platycodonis 12 parts, Exocarpium Citri Grandis 9 parts, add 10 times of water, decoction carries
Take 2 times, each 2 hours, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, be dried,
It is ground into 80 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture 0.05 part and silicon dioxide 0.08 part, make capsule.
Embodiment 3
Raw material: Cordyceps militaris (L.) Link. 55 parts, fresh loquat fruit 40 parts, Fructus Cannabis 37 parts, Radix Platycodonis 18 parts, fresh Herba Taraxaci 19 parts, Exocarpium Citri Grandis
13 parts, Saussurea involucrata culture 3.9 parts.
Preparation method: (1) weighs the fresh loquat fruit 40 parts of weight portion, Fructus Cannabis 37 parts, fresh Herba Taraxaci 19 parts, smashes 100
Mesh sieve, adds 3.5 times of water, stirs 60 minutes, filters, and collects filtrate, standby;
(2) filtering residue in above-mentioned (1) is added Cordyceps militaris (L.) Link. 55 parts, Radix Platycodonis 18 parts, Exocarpium Citri Grandis 13 parts, add 15 times of water, decoct
Extract 2 times, each 3 hours, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, be dried,
It is ground into 120 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture 3.9 parts and mannitol 50 parts, sucralose 0.001 part, 70%
Ethanol 15 parts, makes granule.
Embodiment 4
Raw material: Cordyceps militaris (L.) Link. 52 parts, fresh loquat fruit 14 parts, Fructus Cannabis 31 parts, Radix Platycodonis 15 parts, fresh Herba Taraxaci 25 parts, Exocarpium Citri Grandis
9 parts, Saussurea involucrata culture 2.6 parts.
Preparation method: (1) weighs the fresh loquat fruit 14 parts of weight portion, Fructus Cannabis 31 parts, fresh Herba Taraxaci 25 parts, smashes 120
Mesh sieve, adds 4 times of water, stirs 70 minutes, filters, and collects filtrate, standby;
(2) filtering residue in above-mentioned (1) being added Cordyceps militaris (L.) Link. 52 parts, Radix Platycodonis 15 parts, Exocarpium Citri Grandis 9 parts, add 8 times of water, decoction carries
Take 2 times, each 2.5 hours, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, be dried,
It is ground into 100 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture 2.6 parts and erythritol 80 parts, fructose 5 parts, make solid
Beverage.
Embodiment 5
Raw material: Cordyceps militaris (L.) Link. 14 parts, fresh loquat fruit 33 parts, Fructus Cannabis 17 parts, Radix Platycodonis 8 parts, fresh Herba Taraxaci 11 parts, Exocarpium Citri Grandis
6 parts, Saussurea involucrata culture 0.1 part.
Preparation method: (1) weighs the fresh loquat fruit 33 parts of weight portion, Fructus Cannabis 17 parts, fresh Herba Taraxaci 11 parts, smashes 70
Mesh sieve, adds 3 times of water, stirs 50 minutes, filters, and collects filtrate, standby;
(2) filtering residue in above-mentioned (1) being added Cordyceps militaris (L.) Link. 14 parts, Radix Platycodonis 8 parts, Exocarpium Citri Grandis 6 parts, add 11 times of water, decoction carries
Take 2 times, each 1.5 hours, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, be dried,
It is ground into 120 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture 0.1 part and Mel 5 parts, oligofructose 2 parts, really glucose 25 parts,
Purified water 95 parts, makes oral liquid.
Embodiment 6
Raw material: Cordyceps militaris (L.) Link. 28 parts, fresh loquat fruit 22 parts, Fructus Cannabis 23 parts, Radix Platycodonis 11 parts, fresh Herba Taraxaci 18 parts, Exocarpium Citri Grandis
7.5 parts, Saussurea involucrata culture 5 parts.
Preparation method: (1) weighs the fresh loquat fruit 22 parts of weight portion, Fructus Cannabis 23 parts, fresh Herba Taraxaci 18 parts, smashes 80
Mesh sieve, adds 4.5 times of water, stirs 85 minutes, filters, and collects filtrate, standby;
(2) filtering residue in above-mentioned (1) is added Cordyceps militaris (L.) Link. 28 parts, Radix Platycodonis 11 parts, Exocarpium Citri Grandis 7.5 parts, add 13 times of water, decoct
Extract 2 times, each 1 hour, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, be dried,
It is ground into 80 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture 5 parts and Momordia grosvenori aglycone 0.001 part, fructose 10 parts, L-I
0.1 part of primary glue, purified water 1000 parts, make liquid beverage.
Test example
Test example 1, antiinflammatory action
Taking SD rat 50, male and female do not limit, and are randomly divided into 5 groups, often group 10, i.e. model group, Cefixime granule pair
According to group, the embodiment of the present invention 6 high, medium and low dosage group.Ig is administered, and every day 1 time, continuous 28 days, the 14th day, ig gave
Prepare model while medicine, i.e. under shallow fiber crops, in the dorsal sc injection 30ml air of every Mus to form air bag, then to
Inject genuine turpentine oil 1ml in air bag, after 20h, extract air in capsule out.After last is administered, 2h puts to death rat, and peels off meat in wall
Bud swells, and after normal saline rinses, claims dry weight after putting 60 DEG C of oven cooking cycle 48h.Result shows, the present invention can substantially suppress
The rat air bag granuloma hypertrophy of Oleum Terebinthinae induction, antiphlogistic effects is obvious.
The table 1 impact (x ± s) on Oleum Terebinthinae induced rat air bag granulation hyperplasia model
Compare with model group*P < 0.01,*P<0.05
Test example 2, impact on chloasma model mice
Take female KM mice, be randomly divided into 7 groups, often group 10 respectively: normal, model control group, glutathion compare
Group, Saussurea involucrata culture matched group, the embodiment of the present invention 4 high, medium and low dosage group.Normal group presses body weight intramuscular injection sterilization drug
Use level vegetable oil;Remaining 5 groups with Progesterone intramuscular injection, dosage is 30mg/kg.Every morning once, two lower limb alternate injection,
Continuous 28 days.Animal every morning ultraviolet irradiates 3 hours simultaneously.Modeling starts to gavage corresponding medicine every afternoon simultaneously,
Continuous 30 days.After last is administered, the skin that ultraviolet of learning from else's experience irradiates measures its liver lipofuscin.Result shows, the present invention is favourable
In reducing liver lipofuscin, eliminating chloasma.
The table 2 impact (x ± s) on chloasma model mice
Compare with model group*P < 0.05,*P<0.01
Test example 3, the lymphopoiesis of lotus Lewis lung cancer rat is affected
Take SD rat, male and female half and half, the Lewis lung cancer suspension 0.30ml/ Mus (about 2 × l0 of the aseptic preparation of abdominal cavity subcutaneous injection6
Individual tumor cell).Next day random packet, often group gavages corresponding medicine, and blank group gives corresponding distilled water, and last is administered
Within latter 48 hours, aseptically take Rats Spleen, make single splenocyte suspension with 150 eye mesh screens, with containing 20% inactivation calf
Serum free culture system liquid regulation cell concentration is l × l07Individual cell/ml, adds 96 porocyte culture plates, every hole 200ul (1 × 106Individual carefully
Born of the same parents/hole), add the culture fluid 100ul containing ConA (8ug, ml), put 37 DEG C, 10%CO2CMC model 72h.Inhale gently
Take supernatant l00ul, add MTT solution (6mg/m1) 20ul.Place 37 DEG C, 10%CO2Add after CMC model 24h and disappear
Change liquid 150ul, then place to survey each hole OD value next day and calculate stimulation index with formula.Stimulation index=experimental group OD value/right
According to group OD value.The division growth ability of lymphocyte reflects the power of Immune Function, lymph to a certain extent
Cell transformation test is the test method that testing machine body immunity function is conventional.Result shows that the present composition can be obviously promoted greatly
Mouse lymphotactin is bred and promotes Lewis lung cancer apoptosis.
The table 3 lymphopoietic impact (x ± s) on lotus Lewis lung cancer rat
Compare with blank group※※P<0.01
Test example 4, to treatment acne clinical observation
1, crowd and inclusive criteria
Collection volunteer, 18 years old age~32 years old, includes totally 47 people in, is randomly divided into treatment group 27 example and matched group 20 example.
There is following symptom: take place mostly in face and thoracic dorsal etc., show as blackhead, inflamed papules, secondary pustule or tuberosity,
Cyst etc..Tcm diagnosis: 1. wind-heat syndrome primary symptom: acne (blackhead, hoary hair) are in the majority, with red pimple.Secondary disease: face
Flushing, skin warms or scorching hot, breath gas heat, pain of itching.Tongue tip side of red, yellow and thin fur, rapid pulse.2. damp-heat syndrome primary symptom: skin
Greasy, based on painful pimple, pustule.Secondary disease a: nodosity, or with halitosis.Constipation, yellowish urine, red tongue, tongue
Yellow greasy, slippery and rapid pulse.3. heat toxin and blood stasis primary symptom: skin lesion is tuberosity and cyst, color is dark, and recurrent exerbation easily forms cicatrix.
Secondary disease: tuberosity and cyst matter are harder, dark tongue quality has petechia or ecchymosis, hesitant pulse.
2, Therapeutic Method
Matched group: FUFANG ZHENZHU ANCHUANG PIAN (0.33g/ sheet), 1 time 4,3 times on the 1st, take 28 days.
Treatment group: present composition embodiment 2, oral, three times a day, each consumption is equivalent to raw material 15g, takes 28 days.
3, criterion of therapeutical effect: effectively: acne count reduces > 30%, skin lesion degree alleviates;Invalid: acne count minimizing < 30%, skin lesion
Degree is unchanged.
4, therapeutic effect: the present composition has good therapeutic effect to acne.Concrete two groups of therapeutic effect are shown in Table 4, table 5.
The change (x ± s) of acne total quantity before and after the group treatment of 4 liang of table
The change (x ± s) of skin lesion degree integration before and after the group treatment of 5 liang of table
Test example 5, the clinical observation that treatment haze is damaged
1, crowd and inclusive criteria
Collection volunteer, 24 years old age~58 years old, includes totally 37 people in, is randomly divided into treatment group 19 example and matched group 18 example.
Western medicine diagnose: 1. have haze weather to go out operation history;With cough, expectoration, watery nasal discharge, shed tears, have a stuffy nose, sneeze, dry pharynx etc.
Disease;2. pharyngeal congestion or redness, tonsil inflammation, enlargement, two pulmonary respiration sounds are the most coarse or the most coarse, accompany or without dry and wet
Rale;3. peripheral blood conventional white cell calculates and is sorted between normal range or numeration of leukocyte is higher;4.X line chest film inspection
Normal.
2, Therapeutic Method
Matched group: Cefdinir dispersible tablet (50mg/ sheet), 1 time 2,3 times on the 1st, take 10 days.
Treatment group: present composition embodiment 3, oral, three times a day, each consumption is equivalent to raw material total amount 15g, takes 10
My god.
3, criterion of therapeutical effect: recovery from illness: the Clinical symptom and sign such as cough, expectoration, watery nasal discharge, nasal obstruction, sneeze, dry pharynx disappearance in treat five days;
Effective: in treating five days, the Clinical symptom and sign such as cough, expectoration, watery nasal discharge, nasal obstruction, sneeze, dry pharynx alleviates more than 2/3;
Effective: in treating five days, the Clinical symptom and sign such as cough, expectoration, watery nasal discharge, nasal obstruction, sneeze, dry pharynx alleviates 2/3~1/3;
Invalid: in treating five days, conscious or other symptoms are all not improved or increase the weight of.
4, therapeutic effect: the human body infringement that haze is caused by the present composition has good therapeutic effect.Concrete two groups of therapeutic effect are shown in
Table 6.
The result (x ± s) of 6 liang of table group therapeutic effect
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and former
Any amendment, equivalent and the improvement etc. made within then, should be included within the scope of the present invention.
Claims (7)
1. an anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions, it is characterised in that be made up of the raw material of following weight portion: Cordyceps militaris (L.) Link. 10~55
Part, fresh loquat fruit 10~40 parts, Fructus Cannabis 13~37 parts, Radix Platycodonis 6~18 parts, fresh Herba Taraxaci 5~33 parts, Exocarpium Citri Grandis
4~13 parts, Saussurea involucrata culture 0.05~8 parts.
A kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions the most as claimed in claim 1, it is characterised in that by the raw material of following weight portion
Composition: Cordyceps militaris (L.) Link. 14~52 parts, fresh loquat fruit 14~33 parts, Fructus Cannabis 17~31 parts, Radix Platycodonis 8~15 parts, fresh Pu is public
English 11~25 parts, Exocarpium Citri Grandis 6~9 parts, Saussurea involucrata culture 0.1~5 parts.
3. the one anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions as described in claim 1 to 2 is arbitrary, it is characterised in that add acceptable
Adjuvant, make tablet, capsule, granule, oral liquid, beverage.
4. the preparation method of a kind of anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions as described in claims 1 to 3 is arbitrary, it is characterised in that
Comprise the steps:
(1) weigh the fresh loquat fruit of weight portion, Fructus Cannabis, fresh Herba Taraxaci by formula, smashed 60~150 mesh sieves, add 2~
5 times of water, stir 30~90 minutes, filter, and collect filtrate, standby;
(2) filtering residue in above-mentioned (1) is added Cordyceps militaris (L.) Link., Radix Platycodonis, Exocarpium Citri Grandis, add 6~15 times of water, decoct extraction 2 times, often
Secondary 1~3 hour, filter, collect filtrate, merge filtrate in above-mentioned (1) and (2), concentrating under reduced pressure, dry, pulverize into
80~120 mesh powder, standby;
(3) powder in above-mentioned (2) is added Saussurea involucrata culture and proper auxiliary materials, make tablet, capsule, granule, oral liquid,
Beverage.
5. the answering in the compositions preparing acne of dispelling of the anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions as described in Claims 1-4 is arbitrary
With.
6. the anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions as described in Claims 1-4 is arbitrary has the group of functions of removing chloasma effect in preparation
Application in compound.
7. the anti-haze medicine-food two-purpose Cordyceps Herba Saussureae Involueratae compositions as described in Claims 1-4 is arbitrary has the group for the treatment of pulmonary carcinoma effect in preparation
Application in compound.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107837355A (en) * | 2017-12-19 | 2018-03-27 | 北京昆达中医医学研究院 | A kind of medicine of the anti-haze of clearing lung-heat |
CN108157972A (en) * | 2017-08-01 | 2018-06-15 | 楼良水 | With the cordyceps sinensis compound and solid beverage for improving immunity |
CN108477457A (en) * | 2018-04-06 | 2018-09-04 | 张奉明 | A kind of dendrobium candidum composition and preparation method thereof of clear haze benefit lung |
CN110693999A (en) * | 2019-10-10 | 2020-01-17 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition for treating lung injury, relieving cough, reducing phlegm and improving skin moisture, preparation and application |
CN112998265A (en) * | 2021-05-13 | 2021-06-22 | 广东南粤药业有限公司 | Exocarpium citri grandis composition with cough relieving and phlegm reducing effects and preparation method thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101926842A (en) * | 2010-09-07 | 2010-12-29 | 郭景龙 | Medicinal composition prepared from raw materials containing snow lotus and fermented cordyceps fungal powder |
CN103750339A (en) * | 2014-01-08 | 2014-04-30 | 大连普瑞康生物技术有限公司 | Saussurea involucrate culture health-care food and application thereof |
CN104825970A (en) * | 2015-05-19 | 2015-08-12 | 贵州广济堂药业有限公司 | Health care product containing Noni juice |
CN104839665A (en) * | 2015-04-10 | 2015-08-19 | 劲膳美生物科技股份有限公司 | Chloasma conditioning medical formula food |
CN104906358A (en) * | 2015-05-19 | 2015-09-16 | 贵州广济堂药业有限公司 | Health care product for nourishing yin, clearing away lung-heat and removing haze |
CN105028836A (en) * | 2015-08-24 | 2015-11-11 | 青海高原红绿色保健制品有限公司 | Cordyceps militaris and Chinese wolfberry-containing tea capable of preventing haze and clearing away lung-heat and preparation method thereof |
-
2016
- 2016-04-28 CN CN201610288489.6A patent/CN105998280A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101926842A (en) * | 2010-09-07 | 2010-12-29 | 郭景龙 | Medicinal composition prepared from raw materials containing snow lotus and fermented cordyceps fungal powder |
CN103750339A (en) * | 2014-01-08 | 2014-04-30 | 大连普瑞康生物技术有限公司 | Saussurea involucrate culture health-care food and application thereof |
CN104839665A (en) * | 2015-04-10 | 2015-08-19 | 劲膳美生物科技股份有限公司 | Chloasma conditioning medical formula food |
CN104825970A (en) * | 2015-05-19 | 2015-08-12 | 贵州广济堂药业有限公司 | Health care product containing Noni juice |
CN104906358A (en) * | 2015-05-19 | 2015-09-16 | 贵州广济堂药业有限公司 | Health care product for nourishing yin, clearing away lung-heat and removing haze |
CN105028836A (en) * | 2015-08-24 | 2015-11-11 | 青海高原红绿色保健制品有限公司 | Cordyceps militaris and Chinese wolfberry-containing tea capable of preventing haze and clearing away lung-heat and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
沈爱明等: "《中医护理学》", 30 June 2015, 东南大学出版社 * |
Cited By (5)
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CN108157972A (en) * | 2017-08-01 | 2018-06-15 | 楼良水 | With the cordyceps sinensis compound and solid beverage for improving immunity |
CN107837355A (en) * | 2017-12-19 | 2018-03-27 | 北京昆达中医医学研究院 | A kind of medicine of the anti-haze of clearing lung-heat |
CN108477457A (en) * | 2018-04-06 | 2018-09-04 | 张奉明 | A kind of dendrobium candidum composition and preparation method thereof of clear haze benefit lung |
CN110693999A (en) * | 2019-10-10 | 2020-01-17 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition for treating lung injury, relieving cough, reducing phlegm and improving skin moisture, preparation and application |
CN112998265A (en) * | 2021-05-13 | 2021-06-22 | 广东南粤药业有限公司 | Exocarpium citri grandis composition with cough relieving and phlegm reducing effects and preparation method thereof |
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