CN108477457A - A kind of dendrobium candidum composition and preparation method thereof of clear haze benefit lung - Google Patents
A kind of dendrobium candidum composition and preparation method thereof of clear haze benefit lung Download PDFInfo
- Publication number
- CN108477457A CN108477457A CN201810302837.XA CN201810302837A CN108477457A CN 108477457 A CN108477457 A CN 108477457A CN 201810302837 A CN201810302837 A CN 201810302837A CN 108477457 A CN108477457 A CN 108477457A
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- parts
- dendrobium candidum
- filtrate
- fresh
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Classifications
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention provides a kind of dendrobium candidum composition and preparation method thereof of clear haze benefit lung, 0.1~90 part of grass, 0.5~150 part of peach kernel, 0.01~50 part of whitewood spiceleaf, 5~800 parts of fresh broccoli sprouting including 5~850 parts of fresh dendrobium candidum leaf, 0.3~660 part of loquat flower, 0.1~180 part of Qingqian Willow leaf, 3~480 parts of lily, sorrow are escaped.Its extracted, concentration, dry, crushing, mixing and molding etc. are made, and have the function of preventing haze infringement, rhinitis and asthma etc..
Description
Technical field
The present invention relates to medicine, functional food fields, and in particular to a kind of dendrobium candidum composition of clear haze benefit lung and its
Preparation method.
Background technology
With the deterioration of air quality, haze weather significantly increases, caused by endanger it is also more serious.Haze is air dirt
A kind of state of dye, the reason of being formed with the natural conditions such as weather, meteorology, but be more mainly artificial factor, such as industry
Discharge, motor-vehicle tail-gas, winter is coal-fired, building airborne dust etc..In this condition, it is empty when people's trip or routine work are lived
Molecule (PM2.5) in gas will be directly entered and be adhered in human respiratory tract and alveolar.Especially submicron particle
It can be deposited in upper and lower respiratory tract and alveolar, cause the illnesss such as acute rhinitis and acute bronchitis.It roars for bronchus
The chronic respiratory disease patients such as asthma, chronic bronchitis, obstructive emphysema and Chronic Obstructive Pulmonary Disease, haze weather
It can make state of an illness acute attack or acute exacerbation.If lung cancer can also be induced by being chronically at this environment.Therefore, exploitation has clear haze
The product mask of beneficial lung has vast potential for future development.It is a kind of by a variety of natural originals such as dendrobium candidum leaf present invention aims at providing
Material carries out reasonable formula processing, the effect of substantially effectively capable of playing and utilize raw material ingredient, collection alleviate malaise symptoms with
Long-term care function is in the dendrobium candidum composition and preparation method thereof of one.
Invention content
An object of the present disclosure is to provide a kind of dendrobium candidum composition of clear haze benefit lung, and second is designed to provide one
The preparation for processing of the dendrobium candidum composition of the clear haze benefit lung of kind.
To achieve the above object, the dendrobium candidum composition of a kind of clear haze benefit lung provided by the invention, it includes fresh iron sheets
Stem of noble dendrobium leaf, loquat flower, Qingqian Willow leaf, lily, sorrow are escaped grass, peach kernel, whitewood spiceleaf, fresh broccoli sprouting.
Wherein, it counts in parts by weight, the dendrobium candidum composition of the clear haze benefit lung includes fresh dendrobium candidum leaf 5~850
Part, 0.3~660 part of loquat flower, 0.1~180 part of Qingqian Willow leaf, 3~480 parts of lily, sorrow escape 0.1~90 part of grass, peach kernel 0.5~
150 parts, 0.01~50 part of whitewood spiceleaf, 5~800 parts of fresh broccoli sprouting.
The dendrobium candidum composition of clear haze benefit lung of the present invention, can be added acceptable auxiliary material or food additives,
Tablet, solid beverage is made.
The present invention also provides a kind of preparation method of the dendrobium candidum composition of clear haze benefit lung of the present invention, the preparations
Method includes the following steps：
(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, is set in homogenate extraction equipment, 6~26 times of water, homogenate is added
2500~30000 turns/min of rotating speed, homogenate 10~90min of extraction, homogenate extraction 1~4 time, the filtration of 40~250 mesh screens merge
Filtrate, 35~60 DEG C are concentrated under reduced pressure into 1.05~1.36g/ml of density, and 35~55 DEG C are dried under reduced pressure, and control moisture ＜ 4% is crushed
80~200 mesh sieve is crossed, it is spare；
(2) by loquat flower, Qingqian Willow leaf, lily, sorrow escape grass, peach kernel, whitewood spiceleaf be added 10~30 times amount water decoct
Extraction 3 times is extracted 1~3 hour every time, collects filtrate, filtrate, 200 mesh sievings are spare three times for merging；
(3) 40~88% ethyl alcohol that filter residue in (2) is added to 8~16 times of amounts decoct extraction 2 times, and it is small to extract 1~3 every time
When, it is spare to merge filtrate, 250 mesh sievings twice；
(4) filtrate in (2), (3) is merged, standing 1~12 hour, 200 mesh sievings, filtrate is dense in 40~86 DEG C of decompressions
It is reduced to 1.05~1.35g/ml of density, 40~86 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 60~300 mesh sieve, standby
With；
(5) proper auxiliary materials or food additives are added in material in (1), (4), tablet, solid beverage is made.
The invention has the advantages that：The dendrobium candidum composition of the clear haze benefit lung of the present invention have prevention haze infringement,
Rhinitis, asthma, delay skin aging reduce the effect of ulcerative colitis.
Specific implementation mode
It is further illustrated the present invention below by specific implementation mode, raw material used in following embodiments, test example, examination
Agent material etc. buys commercial product unless otherwise specified.Following embodiment is merely to illustrate the present invention, wherein the reality
Proved recipe method is conventional method such as without specifically defined.
Embodiment 1
Raw material：850 parts of fresh dendrobium candidum leaf, 660 parts of loquat flower, 180 parts of Qingqian Willow leaf, 480 parts of lily, sorrow escape grass 90
Part, 150 parts of peach kernel, 50 parts of whitewood spiceleaf, 5 parts of fresh broccoli sprouting.
Preparation method：(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, is added 26 times
Water is homogenized 30000 turns/min of rotating speed, homogenate extraction 90min, and homogenate extracts 4 times, the filtration of 250 mesh screens, merging filtrate, 60 DEG C
It is concentrated under reduced pressure into density 1.36g/ml, 55 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 200 mesh sieve, spare；
(2) by loquat flower, Qingqian Willow leaf, lily, sorrow escape grass, peach kernel, whitewood spiceleaf be added 30 times amount water boiling and extractions 3
Secondary, extraction 3 hours, collect filtrate, filtrate, 200 mesh sievings are spare three times for merging every time；
(3) 88% ethyl alcohol that filter residue in (2) is added to 16 times of amounts decocts extraction 2 times, and extraction 3 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 12 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into close in 86 DEG C
1.35g/ml is spent, 86 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 300 mesh sieve, spare；
(5) 0.01 part of Sucralose, 0.03 part of steviol glycoside, 80 parts of white granulated sugar is added in material in (1), (4), be made solid
Body beverage.
Embodiment 2
Raw material：5 parts of fresh dendrobium candidum leaf, 0.3 part of loquat flower, 0.1 part of Qingqian Willow leaf, 3 parts of lily, sorrow are escaped careless 0.1 part, peach
0.5 part of benevolence, 0.01 part of whitewood spiceleaf, 800 parts of fresh broccoli sprouting.
Preparation method：(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, set in homogenate extraction equipment, 6 times of water is added,
It is homogenized 2500 turns/min of rotating speed, homogenate extraction 10min, homogenate extracts 1 time, the filtration of 40 mesh screens, merging filtrate, and 35 DEG C of decompressions are dense
It is reduced to density 1.05g/ml, 35 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 80 mesh sieve, spare；
(2) by loquat flower, Qingqian Willow leaf, lily, sorrow escape grass, peach kernel, whitewood spiceleaf be added 10 times amount water boiling and extractions 3
Secondary, extraction 1 hour, collects filtrate, filtrate, 200 mesh sievings are spare three times for merging every time；
(3) 40% ethyl alcohol that filter residue in (2) is added to 8 times of amounts decocts extraction 2 times, and extraction 1 hour, merging every time is filtered twice
Liquid, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 1 hour, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 40 DEG C
1.05g/ml, 40 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 60 mesh sieve, spare；
(5) 5 parts of sodium carboxymethyl starch, 2 parts of silicified microcrystalline cellulose, 0.05 part of talcum powder is added in material in (1), (4),
Tablet is made.
Embodiment 3
Raw material：450 parts of fresh dendrobium candidum leaf, 360 parts of loquat flower, 90 parts of Qingqian Willow leaf, 280 parts of lily, sorrow escape grass 50 parts,
70 parts of peach kernel, 25 parts of whitewood spiceleaf, 400 parts of fresh broccoli sprouting.
Preparation method：(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, is added 16 times
Water is homogenized 16000 turns/min of rotating speed, homogenate extraction 40min, and homogenate extracts 3 times, the filtration of 150 mesh screens, merging filtrate, 50 DEG C
It is concentrated under reduced pressure into density 1.22g/ml, 45 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 120 mesh sieve, spare；
(2) by loquat flower, Qingqian Willow leaf, lily, sorrow escape grass, peach kernel, whitewood spiceleaf be added 18 times amount water boiling and extractions 3
Secondary, extraction 2 hours, collect filtrate, filtrate, 200 mesh sievings are spare three times for merging every time；
(3) 60% ethyl alcohol that filter residue in (2) is added to 10 times of amounts decocts extraction 2 times, and extraction 2 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 4 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 60 DEG C
1.18g/ml, 56 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 150 mesh sieve, spare；
(5) 50 parts of crystal diabetin, 30 parts of mannitol, 100 parts of lactose is added in material in (1), (4), solid drink is made
Material.
Embodiment 4
Raw material：250 parts of fresh dendrobium candidum leaf, 160 parts of loquat flower, 80 parts of Qingqian Willow leaf, 80 parts of lily, sorrow are escaped careless 1 part, peach
2 parts of benevolence, 0.1 part of whitewood spiceleaf, 100 parts of fresh broccoli sprouting.
Preparation method：
(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, 10 times of water are added, is homogenized rotating speed
5000 turns/min, homogenate extraction 30min, homogenate extraction 2 times, 120 mesh screens filtration, merging filtrate, 45 DEG C be concentrated under reduced pressure into it is close
1.19g/ml is spent, 45 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 150 mesh sieve, spare；
(2) by loquat flower, Qingqian Willow leaf, lily, sorrow escape grass, peach kernel, whitewood spiceleaf be added 20 times amount water boiling and extractions 3
Secondary, extraction 2 hours, collect filtrate, filtrate, 200 mesh sievings are spare three times for merging every time；
(3) 68% ethyl alcohol that filter residue in (2) is added to 12 times of amounts decocts extraction 2 times, and extraction 2 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 6 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 66 DEG C
1.20g/ml, 66 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 200 mesh sieve, spare；
(5) 0.5 part of Aspartame, 200 parts of xylitol is added in material in (1), (4), solid beverage is made.
Embodiment 5
Raw material：It is 450 parts of fresh dendrobium candidum leaf, 360 parts of loquat flower, 90 parts of Qingqian Willow leaf, 280 parts of lily, 70 parts of peach kernel, white
25 parts of root of Aucklandia lappa Decne leaf, 400 parts of fresh broccoli sprouting.
Preparation method：(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, is added 16 times
Water is homogenized 16000 turns/min of rotating speed, homogenate extraction 40min, and homogenate extracts 3 times, the filtration of 150 mesh screens, merging filtrate, 50 DEG C
It is concentrated under reduced pressure into density 1.22g/ml, 45 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 120 mesh sieve, spare；
(2) by loquat flower, Qingqian Willow leaf, lily, peach kernel, 18 times of the whitewood spiceleaf addition water boiling and extraction measured 3 times, every time
Filtrate is collected in extraction 2 hours, and filtrate, 200 mesh sievings are spare three times for merging；
(3) 60% ethyl alcohol that filter residue in (2) is added to 10 times of amounts decocts extraction 2 times, and extraction 2 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 4 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 60 DEG C
1.18g/ml, 56 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 150 mesh sieve, spare；
(5) 50 parts of crystal diabetin, 30 parts of mannitol, 100 parts of lactose is added in material in (1), (4), solid drink is made
Material.
Embodiment 6
Raw material：450 parts of fresh dendrobium candidum leaf, 360 parts of loquat flower, 280 parts of lily, sorrow escape grass 50 parts, 70 parts of peach kernel, fresh west
400 parts of orchid bud.
Preparation method：(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, is added 16 times
Water is homogenized 16000 turns/min of rotating speed, homogenate extraction 40min, and homogenate extracts 3 times, the filtration of 150 mesh screens, merging filtrate, 50 DEG C
It is concentrated under reduced pressure into density 1.22g/ml, 45 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 120 mesh sieve, spare；
(2) water boiling and extractions 3 times of 18 times of amounts is added in escape grass, peach kernel of loquat flower, lily, sorrow, every time extraction 2 hours,
Filtrate is collected, filtrate, 200 mesh sievings are spare three times for merging；
(3) 60% ethyl alcohol that filter residue in (2) is added to 10 times of amounts decocts extraction 2 times, and extraction 2 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 4 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 60 DEG C
1.18g/ml, 56 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 150 mesh sieve, spare；
(5) 50 parts of crystal diabetin, 30 parts of mannitol, 100 parts of lactose is added in material in (1), (4), solid drink is made
Material.
Embodiment 7
Raw material：450 parts of fresh dendrobium candidum leaf, 360 parts of loquat flower, 280 parts of lily, 400 parts of fresh broccoli sprouting.
Preparation method：(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, is added 16 times
Water is homogenized 16000 turns/min of rotating speed, homogenate extraction 40min, and homogenate extracts 3 times, the filtration of 150 mesh screens, merging filtrate, 50 DEG C
It is concentrated under reduced pressure into density 1.22g/ml, 45 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 120 mesh sieve, spare；
(2) by loquat flower, 18 times of the lily addition water boiling and extraction measured 3 times, extraction 2 hours, collect filtrate, merging every time
Filtrate three times, 200 mesh sievings are spare；
(3) 60% ethyl alcohol that filter residue in (2) is added to 10 times of amounts decocts extraction 2 times, and extraction 2 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 4 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 60 DEG C
1.18g/ml, 56 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 150 mesh sieve, spare；
(5) 50 parts of crystal diabetin, 30 parts of mannitol, 100 parts of lactose is added in material in (1), (4), solid drink is made
Material.
Embodiment 8
Raw material：450 parts of fresh dendrobium candidum leaf, 90 parts of Qingqian Willow leaf, 280 parts of lily, sorrow are escaped 50 parts of grass, 70 parts of peach kernel, white
25 parts of root of Aucklandia lappa Decne leaf.
Preparation method：(1) fresh dendrobium candidum leaf is cleaned, sets in homogenate extraction equipment, 16 times of water are added, is homogenized rotating speed
16000 turns/min, homogenate extraction 40min, homogenate extraction 3 times, 150 mesh screens filtration, merging filtrate, 50 DEG C be concentrated under reduced pressure into it is close
1.22g/ml is spent, 45 DEG C are dried under reduced pressure, control moisture ＜ 4%, crushed 120 mesh sieve, spare；
(2) water boiling and extractions 3 times of 18 times of amounts is added in escape grass, peach kernel, whitewood spiceleaf of Qingqian Willow leaf, lily, sorrow, every time
Filtrate is collected in extraction 2 hours, and filtrate, 200 mesh sievings are spare three times for merging；
(3) 60% ethyl alcohol that filter residue in (2) is added to 10 times of amounts decocts extraction 2 times, and extraction 2 hours, merge twice every time
Filtrate, 250 mesh sievings are spare；
(4) filtrate in (2), (3) is merged, stands 4 hours, 200 mesh sievings, filtrate is concentrated under reduced pressure into density in 60 DEG C
1.18g/ml, 56 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 150 mesh sieve, spare；
(5) 50 parts of crystal diabetin, 30 parts of mannitol, 100 parts of lactose is added in material in (1), (4), solid drink is made
Material.
Test example 1, the observation to haze damage
1, crowd and inclusion criteria
Volunteer 46 is encroached on by haze, age 18-46 Sui is divided into tonifying lung ball group and group of the embodiment of the present invention at random.
All volunteers have the experience such as haze environment work, exercise, the diseases such as cough, runny nose, nasal obstruction, sneeze, dry throat occur, without other
Major disease.
2, therapy
Tonifying lung ball group：Tonifying lung ball (9g/ balls), 11 ball are taken 15 days twice a day.
Group of the embodiment of the present invention：3 sample of the embodiment of the present invention takes orally, and 2 times a day, each 9g takes 15 days.
3, criterion of therapeutical effect：Recovery from illness：Rear self-evaluation cough, runny nose, nasal obstruction, sneeze, dry throat etc. is taken to disappear substantially；
It is effective：It takes rear self-evaluation cough, runny nose, nasal obstruction, sneeze, dry throat etc. and mitigates 2/3 or more；
Effectively：It takes rear self-evaluation cough, runny nose, nasal obstruction, sneeze, dry throat etc. and mitigates 2/3~1/3；
In vain：Rear self-evaluation is taken without improvement or is aggravated.
4, therapeutic effect：The present composition encroaches on to have to haze prevents effect well.Specific two groups of therapeutic effects are shown in
Table 1.
1 two groups of effects of table
Effect observation of the test example 2 to rat asthma
1, experimental animal and method
Healthy SD rat 100 is selected, 10 groups is randomly divided into, is divided into blank control group, model group, embodiment 1-8 groups.It is empty
Daily Neulized inhalation purified water 60min, the ovalbumin of model group and daily 1% concentration of Neulized inhalation of embodiment 1-8 groups are organized in vain
And 0.08% silica suspension solution 60min, continued stimulus 7 days.Blank control group and model group continued to eat since the 8th day
With normal diet, embodiment 1-8 groups add the corresponding embodiment samples of 1.2g daily in feed, continuous 20 days.
2, assay method
After test period, rat is put to death, in strict accordance with the operating method of ELISA kit, detects each group rat branch
The content of interleukin-6, interleukin-17, interferon-γ in bronchoalveolar lavage fluid.
3, result：The present invention has good therapeutic effect to rat asthma.Concrete outcome is shown in Table 2.
Influence (x ± s) of the table 2 to rat asthma
Effect observation of the test example 3 to rat rhinitis
1, experimental animal and method
Healthy SD rat 100 is selected, 10 groups is randomly divided into, is divided into blank control group, model group, embodiment 1-8 groups.It is empty
Daily purified water 1.5mL collunariums are organized in vain, and model group and embodiment 1-8 groups are daily with the ovalbumin solution 1.5mL drops of 2% concentration
Nose, continued stimulus 10 days.Blank control group and model group continued edible normal diet since the 11st day, and embodiment 1-8 groups exist
Add the corresponding embodiment samples of 1.5g in feed daily, continuous 15 days.
2, assay method
After test period in last time collunarium 45min, statistics rat sneeze grabs nose, runny nose situation, using superposition
Quantify point-score scoring.(1) sneeze：1 3-9 1 point of meter, 10-14 is counted 2 points, is more than or equal to 15 and is counted 3 points.(2) nose is grabbed：
Grab nose 2-3 times and count 1 point, count 2 points 3-5 time, more than or equal to 6 times 3 points.(3) runny nose：It is less than nostril and counts 1 point, be more than that nostril counts 2
Point, it is covered with entire face and counts 3 points.
3, result：The present invention has good therapeutic effect to rat rhinitis.Concrete outcome is shown in Table 3.
Influence (x ± s) of the table 3 to rat rhinitis
Effect observation of the test example 4 to skin under mouse hormone disturbance and ultraviolet irradiation
1, experimental animal and method
The healthy kunming mice 90 of selection, is randomly divided into 10 groups, is divided into blank control group, model group, embodiment 1-8 groups.
Blank control group presses the isometric physiological saline of weight intramuscular injection, remaining each group is with the progesterone of progesterone intramuscular injection 15mg/kg.Daily 1
It is secondary, continuous 20 days, while irradiation ultraviolet light 4h daily.Blank control group and model group continue edible normal diet, embodiment 1-8
Group adds the corresponding embodiment samples of 0.5g daily in feed, continuous 60 days.
2, assay method
After experiment, the skin of ultraviolet light of learning from else's experience irradiation is added in the phosphate buffer of pH7.4, organizes homogenizer
Homogenate 5 minutes, 3000rpm centrifuge 10min, supernatant are taken, using Fe3+Reduction method measures antioxidative activities.
3, result：The present composition improves skin total antioxidant capacity under mouse hormone disturbance and ultraviolet irradiation, effectively
Delay skin aging.Concrete outcome is shown in Table 4.
Influence (x ± s) of the table 4 to skin model under mouse hormone disturbance and ultraviolet irradiation
Effect observation of the test example 5 to ulcerative colitis in rats
1, experimental animal and method
Healthy SD rat 72 is selected, model group, embodiment 4-8 groups are divided into.Every intraperitoneal injection 2mg antigens of each group (take
The mucous layer of the fresh colon of pig is homogenized, and 3000rpm is centrifuged 15 minutes, and isometric physiological saline is added, and freezing is spare, face with plus
Enter equivalent Freund's adjuvant), 1 time a day, continuous injection 45 days.From 46 days, model group continued edible normal diet, embodiment 4-
8 groups are added the corresponding embodiment samples of 1.0g daily in feed, continuous 30 days.
2, assay method
After experiment, each group rat etherization, solution takes colon 0.5cm, and formalin is fixed, and pathology is done in HE dyeing
Slice, light microscopic observation colon pathological change and classification.1 grade：There are cell infiltration, submucosa that can take a favourable turn in mucosa lamina propria
Oedema is spent, mucous membrane upper layer is without apparent degeneration necrosis.2 grades：Mucous membrane upper layer is denaturalized, accidental necrosis, a large amount of inflammatory cell leachings of submucosa
Profit, forms apparent inflammatory cell lesion, it is seen that apparent congestion and edema；3 grades：Submucosa inflammatory cell forms the infiltration of stove shape, mucous membrane
Upper layer necrosis falls off, and forms large stretch of ulcer.
3, result：The present composition can be substantially reduced the pathological change of rats with ulcerative colitis colon.Specifically
It the results are shown in Table 5.
Influence (x ± s) of the table 5 to ulcerative colitis in rats
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (4)
1. a kind of dendrobium candidum composition of clear haze benefit lung, it includes fresh dendrobium candidum leaf, loquat flower, Qingqian Willow leaf, lily, sorrows
It escapes grass, peach kernel, whitewood spiceleaf, fresh broccoli sprouting.
2. the dendrobium candidum composition of clear haze benefit lung according to claim 1, which is characterized in that count in parts by weight, institute
The dendrobium candidum composition for stating clear haze benefit lung includes 5~850 parts of fresh dendrobium candidum leaf, 0.3~660 part of loquat flower, Qingqian Willow leaf
0.1~180 part, 3~480 parts of lily, sorrow escape 0.1~90 part of grass, 0.5~150 part of peach kernel, 0.01~50 part of whitewood spiceleaf, fresh
5~800 parts of broccoli sprouting.
3. the dendrobium candidum composition of clear haze benefit lung according to any one of claims 1 to 2, it is characterised in that be added acceptable
Auxiliary material or food additives, tablet, solid beverage is made.
4. a kind of preparation method of the dendrobium candidum composition of clear haze benefit lung according to any one of claims 1 to 3, the system
Preparation Method includes the following steps：
(1) fresh dendrobium candidum leaf, fresh broccoli sprouting are cleaned, sets in homogenate extraction equipment, 6~26 times of water are added, is homogenized rotating speed
2500~30000 turns/min, homogenate 10~90min of extraction, homogenate extraction 1~4 time, 40~250 mesh screens filtration merges filter
Liquid, 35~60 DEG C are concentrated under reduced pressure into 1.05~1.36g/ml of density, and 35~55 DEG C are dried under reduced pressure, and control moisture ＜ 4% crushed
80~200 mesh sieve, spare；
(2) by loquat flower, Qingqian Willow leaf, lily, sorrow escape grass, peach kernel, whitewood spiceleaf be added 10~30 times amount water boiling and extractions 3
It is secondary, it extracts 1~3 hour every time, collects filtrate, filtrate, 200 mesh sievings are spare three times for merging；
(3) 40~88% ethyl alcohol that filter residue in (2) is added to 8~16 times of amounts decoct extraction 2 times, extract 1~3 hour, close every time
And filtrate, 250 mesh sievings are spare twice；
(4) filtrate in (2), (3) is merged, stands 1~12 hour, 200 mesh sievings, filtrate is concentrated under reduced pressure into 40~86 DEG C
1.05~1.35g/ml of density, 40~86 DEG C are dried under reduced pressure, control moisture content ＜ 3.0%, crushed 60~300 mesh sieve, spare；
(5) proper auxiliary materials or food additives are added in material in (1), (4), tablet, solid beverage is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810302837.XA CN108477457A (en) | 2018-04-06 | 2018-04-06 | A kind of dendrobium candidum composition and preparation method thereof of clear haze benefit lung |
Applications Claiming Priority (1)
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