CN103747790A - 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法 - Google Patents

制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法 Download PDF

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Publication number
CN103747790A
CN103747790A CN201280011166.2A CN201280011166A CN103747790A CN 103747790 A CN103747790 A CN 103747790A CN 201280011166 A CN201280011166 A CN 201280011166A CN 103747790 A CN103747790 A CN 103747790A
Authority
CN
China
Prior art keywords
buffer agent
local anesthetic
heparinoid
buffer
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280011166.2A
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English (en)
Chinese (zh)
Inventor
C·洛维尔·帕森斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201910485483.1A priority Critical patent/CN110292639A/zh
Publication of CN103747790A publication Critical patent/CN103747790A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201280011166.2A 2011-01-06 2012-01-05 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法 Pending CN103747790A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910485483.1A CN110292639A (zh) 2011-01-06 2012-01-05 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430468P 2011-01-06 2011-01-06
US61/430,468 2011-01-06
PCT/US2012/020357 WO2012094515A1 (en) 2011-01-06 2012-01-05 Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910485483.1A Division CN110292639A (zh) 2011-01-06 2012-01-05 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法

Publications (1)

Publication Number Publication Date
CN103747790A true CN103747790A (zh) 2014-04-23

Family

ID=46457713

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910485483.1A Pending CN110292639A (zh) 2011-01-06 2012-01-05 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法
CN201280011166.2A Pending CN103747790A (zh) 2011-01-06 2012-01-05 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201910485483.1A Pending CN110292639A (zh) 2011-01-06 2012-01-05 制造包含局部麻醉剂、类肝素和缓冲剂的组合物的方法

Country Status (15)

Country Link
US (1) US20140194380A1 (ja)
EP (2) EP2661271B1 (ja)
JP (2) JP6474193B2 (ja)
KR (2) KR20140049964A (ja)
CN (2) CN110292639A (ja)
AU (1) AU2012204311B2 (ja)
CA (1) CA2823949C (ja)
EA (1) EA201391014A1 (ja)
ES (1) ES2813498T3 (ja)
HU (1) HUE051630T2 (ja)
IL (1) IL227324A (ja)
MX (1) MX359125B (ja)
SG (3) SG10201402682RA (ja)
WO (1) WO2012094515A1 (ja)
ZA (1) ZA201305873B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105263503A (zh) * 2013-01-28 2016-01-20 奥利金制药公司 含有类肝素、急效麻醉剂及缓冲液的稳定组合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105963244A (zh) * 2016-01-15 2016-09-28 赵鸣 注射用青蒿琥酯制剂及其应用
CA3061891A1 (en) * 2017-04-12 2018-10-18 Urigen Pharmaceuticals, Inc. Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability
KR102385760B1 (ko) * 2019-04-26 2022-04-11 티씨엠 바이오테크 인터내셔널 코포레이션 재발성 요로 감염의 예방을 위한 약학 조성물
US20220273587A1 (en) * 2019-07-18 2022-09-01 C. Lowell Parsons Alkalization of urinary bladder wall prior to treatment with intravesical heparin and alkalinized lidocaine to enhance relief of bladder pain symptoms
CN118121624B (zh) * 2024-05-10 2024-09-13 成都青山利康药业股份有限公司 一种心脏停搏液的基础液溶液产品、制备方法、联合产品及其联合用输液包

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593672A (zh) * 2004-07-05 2005-03-16 暨南大学 可注射型胶原基软组织填充材料及其制备方法
US20050234013A1 (en) * 2004-01-28 2005-10-20 The Regents Of The University Of California Novel interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis
WO2006076663A2 (en) * 2005-01-14 2006-07-20 Urigen, Inc. Kits and improved compositions for treating lower urinary tract
WO2007072147A2 (en) * 2005-12-19 2007-06-28 Ernst, Johanna, Catarina Composition for diagnosing and treating circulatory system diseases
CN102170856A (zh) * 2008-08-04 2011-08-31 阿勒根工业有限公司 包含麻醉剂的透明质酸基凝胶

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040037896A1 (en) * 2000-12-08 2004-02-26 Ernst Pieter Theo Therapeutic treatment
US7379623B2 (en) * 2004-04-30 2008-05-27 Microsoft Corporation Method to quickly warp a 2-D image using only integer math
NZ552486A (en) 2004-07-22 2009-11-27 Era Environmental Refrigeratio Refrigeration system
WO2007073397A1 (en) 2005-12-19 2007-06-28 Urigen, Inc. Kits and improved compositions for treating lower urinary tract discorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050234013A1 (en) * 2004-01-28 2005-10-20 The Regents Of The University Of California Novel interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis
CN1593672A (zh) * 2004-07-05 2005-03-16 暨南大学 可注射型胶原基软组织填充材料及其制备方法
WO2006076663A2 (en) * 2005-01-14 2006-07-20 Urigen, Inc. Kits and improved compositions for treating lower urinary tract
WO2007072147A2 (en) * 2005-12-19 2007-06-28 Ernst, Johanna, Catarina Composition for diagnosing and treating circulatory system diseases
CN102170856A (zh) * 2008-08-04 2011-08-31 阿勒根工业有限公司 包含麻醉剂的透明质酸基凝胶

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105263503A (zh) * 2013-01-28 2016-01-20 奥利金制药公司 含有类肝素、急效麻醉剂及缓冲液的稳定组合物

Also Published As

Publication number Publication date
HUE051630T2 (hu) 2021-03-01
EP2661271A4 (en) 2014-09-24
EP2661271B1 (en) 2020-07-08
CA2823949A1 (en) 2012-07-12
IL227324A (en) 2017-12-31
WO2012094515A1 (en) 2012-07-12
KR20140049964A (ko) 2014-04-28
EP3744334A1 (en) 2020-12-02
IL227324A0 (en) 2013-09-30
KR20190049767A (ko) 2019-05-09
ZA201305873B (en) 2015-08-26
AU2012204311B2 (en) 2017-05-04
JP6474193B2 (ja) 2019-02-27
SG10201402682RA (en) 2014-08-28
SG10201809955SA (en) 2018-12-28
US20140194380A1 (en) 2014-07-10
EP2661271A1 (en) 2013-11-13
MX2013007975A (es) 2014-02-27
ES2813498T3 (es) 2021-03-24
CA2823949C (en) 2020-09-22
SG191889A1 (en) 2013-08-30
EA201391014A1 (ru) 2014-01-30
JP2014501782A (ja) 2014-01-23
MX359125B (es) 2018-09-13
AU2012204311A1 (en) 2013-08-22
CN110292639A (zh) 2019-10-01
JP2017061503A (ja) 2017-03-30

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Application publication date: 20140423