CN103735905B - A kind of Yening capsule and preparation method thereof - Google Patents
A kind of Yening capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Yening capsule and preparation method thereof, the method for employing, for carry out micronizing to Ganoderma and Fructus Tritici Levis, avoids the independent extraction to its two tastes medicine in traditional handicraft, performance drug effect that can also be larger while shortening the process time.Again with dry granulation, avoiding granulates need add the disadvantage of a large amount of excipient, and taking dose is greatly reduced, thus patient Geng Yi is accepted, take more convenient; And improve the mobility of medicated powder, increase resistance to water soak, easily preserve, can cover its bad smell, take more convenient, character is more stable, is easy to storage, carries and transport, and also meets the requirement that diabetics is taken simultaneously.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field, be specifically related to a kind of Yening capsule and preparation method thereof.
Background technology
Existing night, peaceful preparation was generally made for raw material with Cortex Albiziae, Caulis Polygoni Multiflori, Ganoderma, Fructus Jujubae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, Fructus Tritici Levis seven taste Chinese medicine, major function calms the nerves to nourish heart, for neurasthenia, dizzy insomnia, the treatment of the sleep disorder that the factors such as blood deficiency dreaminess cause, its determined curative effect is reliable.
The preparation method of Yening Tangjiang recorded in " Chinese Pharmacopoeia " version one in 2000 is: after Fructus Tritici Levis adds water boil, in 80 ~ 90 DEG C of warm macerating 2 times, each 2 hours, merges warm macerating liquid; Ganoderma powder is broken into coarse powder, soaks a week by ethanol in proper amount, collecting by filtration soak, reclaims ethanol for subsequent use; Its medicinal residues and Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae, Fructus Ligustri Lucidi decoct with water twice, each 3 hours, collecting decoction, filter, the immersion of filtrate and above-mentioned Fructus Tritici Levis and Ganoderma merges, leaves standstill, filters, and filtrate is concentrated into appropriate amount, adds certain adjuvant and makes syrup.This preparation method Shortcomings part: one, long to the extracting cycle of ganoderol extract, and concentration of alcohol and consumption indefinite; Two, the warm macerating process conditions of Fructus Tritici Levis, still have indefinite part.
A kind of nano Medicine ' Yening ' and preparation method thereof is disclosed in Chinese patent application CN01102093.8, after each taste medicine is first made nano-scale particle by the method respectively, various preparation is made again by the original prescription proportioning of " Chinese Pharmacopoeia " Yening Tangjiang, but there is no definite drug effect in this application to record, be withdrawn at present.
Disclose preparation method and the solid preparation thereof of peaceful medicine at a kind of night in China Patent No. 200410041958.1, the method, when the warm macerating of Fructus Tritici Levis, limits the consumption of water; During ganoderol extract, corresponding restriction be have also been made to the consumption of ethanol and concentration; The independent spraying dry of ganoderol extract, to avoid in concentration process alcohol dissolubility position and water soluble part at extractum skewness, thus affect drug quality, there is certain science, but also there is deficiency: 1. the warm macerating technique of Fructus Tritici Levis is large to the consumption of water, increases the time of heating up; 2., when ganoderol extracts, the concentration of ethanol is low, and alcohol extract content is not high; 3. Fructus Tritici Levis and (Ganoderma medicinal residues and all the other Chinese medicine extract) are merged and to concentrate and spraying dry still has uncertain part; 4. uncertain part is had to the powder body after spraying dry in the process of making solid preparation; 5. n-butanol extract is low.
Night, peaceful former dosage form was syrup, and taste is bad, takes inconvenience, especially relative to those crowds to taste sensitivity, was more unfavorable for taking; Adding a large amount of sucrose is adjuvant, affects taking of diabetics; Dose is inaccurate, and in storage process vulnerable to pollution.
Summary of the invention
The invention provides a kind of preparation method of Yening capsule, the operation of this preparation method is easier, and the good fluidity of the medicated powder obtained, is convenient to large-scale production.
Present invention also offers a kind of Yening capsule obtained by described preparation method, this Yening capsule stable in properties, be easy to store, water content is few, and has shorter disintegration.
A preparation method for Yening capsule, comprises the steps:
(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, nanometer medicated powder is obtained;
(2) Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi are added to the water, in the extracting solution that 70 ~ 80 DEG C of decoctions obtain, spraying dry after described extracting solution is concentrated, obtains extract medicated powder;
(3) the extract medicated powder mix homogeneously that nanometer medicated powder step (1) obtained and step (2) obtain, through granulating, sieving and encapsulated, obtain described Yening capsule (1) by Ganoderma, Fructus Tritici Levis nano-pulverization, sieve, obtain nanometer medicated powder;
Wherein, the weight portion of raw material is as follows: Cortex Albiziae 0.7 ~ 1 part, Ganoderma 0.3 ~ 0.5 part, Caulis Polygoni Multiflori 0.7 ~ 1 part, 0.6 ~ 0.8 part, Fructus Jujubae, Fructus Ligustri Lucidi 0.7 ~ 1 part, 0.2 ~ 0.3 part, Radix Glycyrrhizae, Fructus Tritici Levis 1.5 ~ 2.0 parts.
In the present invention, the method of nano-pulverization is adopted to process Ganoderma, Fructus Tritici Levis, the nanometer medicated powder obtained directly is used as medicine, avoid the step of lixiviate in pharmacopeia, operate easier, and the good fluidity of the medicated powder adopting the method to obtain, is convenient to follow-up encapsulated operation, is convenient to carry out suitability for industrialized production.Method with lixiviate is compared, nano-pulverization can retain in Ganoderma and Fructus Tritici Levis that some are difficult to the helper component be extracted, the existence of these components can not only improve the physical property of the Yening capsule obtained, and effect experiment display, and the existence of these components does not produce adverse influence to drug effect.
As preferably, in step (1), the order number of the sieve used that sieves is 120 ~ 200 orders, directly pulverize to be used as medicine and can accelerate digesting and assimilating of Ganoderma, and Fructus Tritici Levis more fully can discharge the effective ingredient of medicine.Nano-pulverization not only improves drug effect, steady quality, and shortens the process time, energy savings.
As preferably, in step (2), the consumption of described water be Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi weight sum 6 ~ 10 times, rear medicinal residues are extracted owing to not comprising ganoderol in thing to be extracted, the water of less amount can be used to extract, both save water consumption, and make again subsequent concentration consume energy less.The process extracted generally repeats twice.
In addition, due to do not comprise in thing to be extracted ganoderol extract after medicinal residues, the temperature of decoction can suitably reduce, and as preferably, in step (2), the temperature of described decoction is 70 ~ 80 DEG C, and the reduction of temperature can prevent the destruction of effective ingredient further.
As preferably, described be concentrated in-0.084MPa ~-0.088MPa pressure under, carry out at 65 ~ 69 DEG C of temperature;
Concentrating and proceeding to extracting solution density is after 1.06 ~ 1.09g/cm3, carries out described spraying dry.
As preferably, in step (2), described spray-dired inlet temperature is 130 ~ 160 DEG C, leaving air temp 90 ~ 120 DEG C.Now, can make greatly shorten drying time on the one hand, improve work efficiency, the more important thing is and shorten medicinal liquid heated time, favourable to preservation effective component; Spraying dry has simplified technical process on the other hand.
As preferably, in step (3), the method for described granulation is dry granulation, avoids tradition and granulates and need add the disadvantage of a large amount of excipient, taking dose is greatly reduced, thus patient Geng Yi is accepted, take more convenient; And improve the mobility of medicated powder, increase resistance to water soak, easily preserve.
Present invention also offers a kind of Yening capsule, prepared by said method.
Crude drug of the present invention specifically describes as follows:
Cortex Albiziae is fabaceous dry bark, has resolving stagnation for tranquilization, promoting blood circulation and detumescence.Clinical in irritability at present, melancholy insomnia, lung abscess.
Ganoderma is the dry sporophore of On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma, has invigorating QI and tranquilization, relieving cough and asthma.For malaise, insomnia cardiopalmus, cough and asthma due to lung deficiency, asthenia is losed heart, anorexia.
Caulis Polygoni Multiflori is the dry rattan of polygonum multiflorum thunb, has nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia, skin pruritus.
Fructus Jujubae is the dry mature fruit of Rhamnaceae plant Fructus Jujubae, has invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, married woman is dirty dry.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi, has nourishing the liver and kidney, improving eyesight black hair.For the hepatic and renal YIN deficiency, vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision, interior-heat is quenched one's thirst, osteopyrexia and fever.
Radix Glycyrrhizae is glycyrrhizic legume, Glycyrrhiza inflata Bat. or the dry root welding technology of Glycyrrhiza glabra L., for invigorating the spleen and replenishing QI, and heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, wrist abdomen, the anxious pain of extremity contraction, too fat to move sore, cushion toxicity, strong.
Fructus Tritici Levis is the shrivelled frivolous caryopsis of grass Semen Tritici aestivi, has except deficiency-heat, hidroschesis, main only fever due to yin deficiency, night sweat, spontaneous perspiration.
Compared with the existing technology, the present invention has following characteristics: the inventive method, carries out micronizing to Ganoderma and Fructus Tritici Levis, avoids the independent extraction to its two tastes medicine in traditional handicraft, performance drug effect that can also be larger while shortening the process time.Again with dry granulation, avoiding granulates need add the disadvantage of a large amount of excipient, and taking dose is greatly reduced, thus patient Geng Yi is accepted, take more convenient; And improve the mobility of medicated powder, increase resistance to water soak, easily preserve, can cover its bad smell, take more convenient, character is more stable, is easy to storage, carries and transport, and also meets the requirement that diabetics is taken simultaneously.
Detailed description of the invention
Embodiment 1
Take Cortex Albiziae 0.84kg, Ganoderma 0.4kg, Caulis Polygoni Multiflori 0.84kg, Fructus Jujubae 0.6kg, Fructus Ligustri Lucidi 0.84kg, Radix Glycyrrhizae 0.24kg, Fructus Tritici Levis 1.4kg.
(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, 120 mesh sieves are crossed for subsequent use.
(2) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add medical material weight 6 times of water gagings, twice (each 6 times of water gagings) are decocted in 70 DEG C, each 3 hours, merge extractive liquid, was for subsequent use, and medicinal residues discard, filter, filtrate, in temperature 65 DEG C, is evaporated to the extractum of relative density 1.08 under vacuum-0.084MPa condition, by extractum inlet temperature 130 DEG C, spraying dry under the condition that leaving air temp is 90 DEG C, obtained extract medicated powder.
(3) Ganoderma, Fructus Tritici Levis are mixed homogeneously with extract medicated powder, dry granulation, sieves, and granule is loaded No. 0 capsule, obtains Yening capsule.
Embodiment 2
Take Cortex Albiziae 1.68kg, Ganoderma 0.8kg, Caulis Polygoni Multiflori 1.68g, Fructus Jujubae 1.2kg, Fructus Ligustri Lucidi 1.68kg, Radix Glycyrrhizae 0.48kg, Fructus Tritici Levis 3.8kg.
(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, 120 mesh sieves are crossed for subsequent use.
(2) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add medical material weight 8 times of water gagings, decoct twice in 73 DEG C, each 3 hours, merge extractive liquid, was for subsequent use, and medicinal residues discard, filter, filtrate, in temperature 67 DEG C, is evaporated to the extractum of relative density 1.08 under vacuum-0.084MPa condition, by extractum inlet temperature 150 DEG C, spraying dry under the condition that leaving air temp is 100 DEG C, obtained extract medicated powder.
(3) Ganoderma, Fructus Tritici Levis are mixed homogeneously with extract medicated powder, dry granulation, sieves, and granule is loaded No. 0 capsule, obtains Yening capsule.
Embodiment 3
Take Cortex Albiziae 2.52kg, Ganoderma 1.2kg, Caulis Polygoni Multiflori 2.52g, Fructus Jujubae 1.8kg, Fructus Ligustri Lucidi 2.52kg, Radix Glycyrrhizae 0.72kg, Fructus Tritici Levis 6.2kg.
(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, 120 mesh sieves are crossed for subsequent use.
(2) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add medical material weight 10 times of water gagings, decoct twice in 80 DEG C, each 3 hours, merge extractive liquid, was for subsequent use, and medicinal residues discard, filter, filtrate, in temperature 69 DEG C, is evaporated to the extractum of relative density 1.08 under vacuum-0.088MPa condition, by extractum inlet temperature 160 DEG C, spraying dry under the condition that leaving air temp is 110 DEG C, obtained extract medicated powder.
(3) Ganoderma, Fructus Tritici Levis are mixed homogeneously with extract medicated powder, dry granulation, sieves, and granule is loaded No. 0 capsule, obtains Yening capsule.
Comparative example 1
(1) take Cortex Albiziae 21kg, Ganoderma 10kg, Caulis Polygoni Multiflori 21kg, Fructus Jujubae 15kg, Fructus Ligustri Lucidi 21kg, Radix Glycyrrhizae 6kg, Fructus Tritici Levis 60kg are for subsequent use;
(2) prepare ganoderol and promote extract powder
Get and be crushed to 10 object Ganoderma 10kg, put into extraction pot, add 60% ethanol of Ganoderma volume 20 times, in 80 DEG C of reflux, extract, 2 hours, after filtering after filtrate recycling ethanol, concentrating under reduced pressure, the spray-dried ganoderol that obtains promotes extract powder 0.6kg, for subsequent use; Filter the preservation of gained Ganoderma medicinal residues and treat further process;
(3) Fructus Tritici Levis water solubility extract is prepared
In extraction pot, add Fructus Tritici Levis 60kg, then the water boil adding Fructus Tritici Levis volume 20 times is after 10 minutes, 85 ± 5 DEG C of insulation extractions 2 hours, filter and retain warm filtrate, medicinal residues repeated 1 time, after filtration by aforesaid operations again, and merging filtrate is for subsequent use, and medicinal residues discard;
(4) the mixing water soluble extract that Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae and ganoderol extract rear medicinal residues is prepared
In extraction pot, add above-mentioned Chinese medicine of the five flavours material and add ganoderol and extract rear medicinal residues, then add the water of 20 times of medical material volumes, extract 3 hours in 70 DEG C, after filtering, filtrate retains, and filtering residue repeats 1 time by aforesaid operations again, and merge each filtrate for subsequent use, medicinal residues discard;
(5) dry extract of mixing water soluble extract is prepared
The filtrate of (3) and (4) merged, in concentration tank, be condensed into thick extractum in decompression 70 DEG C, in spray dryer, 45 DEG C of spraying dry obtain the dry extract of 28kg mixing water soluble extract
(6) peaceful medicine at night is prepared
Namely (2) and (5) gained dry extract mix homogeneously being obtained peaceful medicine at night, through pulverizing, crossing No. 4 sieves, adopt fully-automatic capsule racking machine to be divided in capsule shells, make the peaceful hard capsule at night of 0.1 ~ 1g different size.
Comparative example 2
(1) take Cortex Albiziae 21kg, Ganoderma 10kg, Caulis Polygoni Multiflori 21kg, Fructus Jujubae 15kg, Fructus Ligustri Lucidi 21kg, Radix Glycyrrhizae 6kg, Fructus Tritici Levis 35kg are for subsequent use;
(2) by Ganoderma, Fructus Tritici Levis nano-pulverization, 120 mesh sieves are crossed for subsequent use.
(3) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add medical material weight 20 times of water gagings, decoct twice in 70 DEG C, each 3 hours, merge extractive liquid, is for subsequent use, medicinal residues discard, in concentration tank, be condensed into thick extractum in decompression 70 DEG C, in spray dryer, 45 DEG C of spraying dry obtain the dry extract of 28kg mixing water soluble extract.
(4) dry extract was pulverized No. 4 mesh sieves and was mixed homogeneously with step (1), adopted fully-automatic capsule racking machine to be divided in capsule shells, obtained Yening capsule.
Comparative example 3
(1) take Cortex Albiziae 21kg, Ganoderma 10kg, Caulis Polygoni Multiflori 21kg, Fructus Jujubae 15kg, Fructus Ligustri Lucidi 21kg, Radix Glycyrrhizae 6kg, Fructus Tritici Levis 60kg are for subsequent use;
(2) prepare ganoderol and promote extract powder
Get and be crushed to 10 object Ganoderma 10kg, put into extraction pot, add 60% ethanol of Ganoderma volume 20 times, in 80 DEG C of reflux, extract, 2 hours, after filtering after filtrate recycling ethanol, concentrating under reduced pressure, the spray-dried ganoderol that obtains promotes extract powder 0.6kg, for subsequent use; Filter the preservation of gained Ganoderma medicinal residues and treat further process;
(3) Fructus Tritici Levis water solubility extract is prepared
In extraction pot, add Fructus Tritici Levis 60kg, then the water boil adding Fructus Tritici Levis volume 20 times is after 10 minutes, 85 ± 5 DEG C of insulation extractions 2 hours, filter and retain warm filtrate, medicinal residues repeated 1 time, after filtration by aforesaid operations again, and merging filtrate is for subsequent use, and medicinal residues discard;
(4) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add medical material weight 6 times of water gagings, twice (each 6 times of water gagings) are decocted in 70 DEG C, each 3 hours, merge extractive liquid, is for subsequent use, medicinal residues discard, filter, filtrate, in temperature 65 DEG C, is evaporated to the extractum of relative density 1.08 under vacuum-0.084MPa condition.
(5) by step (3) and step (4) extractum inlet temperature 130 DEG C, spraying dry under the condition that leaving air temp is 90 DEG C, obtained extract medicated powder.
(6) mixed homogeneously with extract medicated powder by Ganoderma, dry granulation, sieves, and granule is loaded No. 0 capsule, obtains Yening capsule.
Yening capsule prepared by Yening capsule obtained for the embodiment of the present invention 1 and comparative example 1 is carried out stability test, adopt the method for accelerated test to carry out study on the stability to it, temperature 28 DEG C ~ 32 DEG C, relative humidity 55% ~ 65% condition accelerates placement 6 months, the results are shown in Table 1
Table 1 stability test result
| Sample | Content after January | Content after February | Content after March | Content after June | Meansigma methods |
| Embodiment 1 | 99.3% | 99.26% | 99.2% | 99.08% | 99.21% |
| Comparative example 1 | 93.60% | 92.86% | 92.68% | 91.46% | 92.65% |
Visible, the stability of Yening capsule prepared by preparation method of the present invention is better than Yening capsule prepared by prior art.
Carry out quality testing respectively to Yening capsule prepared by the Yening capsule prepared by embodiment 1 ~ 3 and comparative example 1 ~ 3, concrete detection method all according to Pharmacopoeia of the People's Republic of China version in 2005 second, the results are shown in Table 2:
The mensuration of table 2 mobility, moisture, disintegration
Visible, the indices of the Yening capsule that the present invention obtains conforms with the regulations, and wherein content and moisture are all better than prior art.
The therapeutic effect of compound preparation of the present invention is described below by way of some experimental datas:
Test exercise question: the clinical trial of the Yening capsule that following data entrust Xianyang central hospital to organize and implement by our company, evaluates Yening capsule treatment neurasthenia (insufficiency of vital energy and blood and neurasthenia's deficiency syndrome), and evident in efficacy, existing report is as follows:
1, clinical data
Meet Western medicine diagnose, Standards of Chinese Medical Syndrome Differentiation; Age was at 18 ~ 70 years old; The course of disease is person more than 3 months.Adopt multicenter, random, single blind, parallel check experiment research method, Eligible subjects is 120 examples with the pro rate treatment group of 3:1, and matched group is 40 examples, totally 160 examples.The vital signs such as two groups of sexes, age and treatment front heart rate, pulse, breathing, systolic pressure, diastolic pressures all have comparability (P > 0.05).State of an illness total mark, the length of one's sleep, lassitude, tongue fur, the more equal no statistical significance of body of the tongue (P > 0.05) before two groups of courses of disease, medication history, treatment are harmonious good.
2, Therapeutic Method
Test group: Yening capsule, oral, one time 5,2 times on the one; Nourishing blood to tranquillize the mind sheet simulant, oral, one time 5,3 times on the one.
Matched group: Yening capsule simulant, oral, one time 5,2 times on the one; Nourishing blood to tranquillize the mind sheet, oral, one time 5,3 times on the one.
The course for the treatment of: 28 days.
3, performance is tested
This clinical trial shows that Yening capsule has and calms the nerves, the effect nourished heart, the neurasthenia caused for hyperactivity of fire caused by deficiency of YIN has good therapeutical effect, particularly better can improve soreness of the waist and knees, dreaming often and waking easily, dry mouth and throat, dizziness and tinnitus, the hyperactivity of fire caused by deficiency of YIN tcm symptom such as forgetful.
Claims (8)
1. a preparation method for Yening capsule, is characterized in that, comprises the steps:
(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, sieve, obtain nanometer medicated powder;
(2) Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi are added to the water, in the extracting solution that 70 ~ 80 DEG C of decoctions obtain, spraying dry after described extracting solution is concentrated, obtains extract medicated powder;
(3) the extract medicated powder mix homogeneously that nanometer medicated powder step (1) obtained and step (2) obtain, through granulating, sieving and encapsulated, obtains described Yening capsule;
Wherein, the weight portion of raw material is as follows: Cortex Albiziae 0.7 ~ 1 part, Ganoderma 0.3 ~ 0.5 part, Caulis Polygoni Multiflori 0.7 ~ 1 part, 0.6 ~ 0.8 part, Fructus Jujubae, Fructus Ligustri Lucidi 0.7 ~ 1 part, 0.2 ~ 0.3 part, Radix Glycyrrhizae, Fructus Tritici Levis 1.5 ~ 2.0 parts.
2. the preparation method of Yening capsule according to claim 1, is characterized in that, in step (1), the order number of the sieve used that sieves is 120 ~ 200 orders.
3. the preparation method of Yening capsule according to claim 1, is characterized in that, in step (2), the consumption of described water be Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi weight sum 6 ~ 10 times.
4. the preparation method of Yening capsule according to claim 1, is characterized in that, in step (2), the temperature of described decoction is 70 ~ 80 DEG C.
5. the preparation method of Yening capsule according to claim 1, is characterized in that, described be concentrated in-0.084MPa ~-0.088MPa pressure under, carry out at 65 ~ 69 DEG C of temperature;
Concentrating and proceeding to extracting solution density is 1.06 ~ 1.09g/cm
3after, carry out described spraying dry.
6. the preparation method of Yening capsule according to claim 1, is characterized in that, in step (2), described spray-dired inlet temperature is 130 ~ 160 DEG C, leaving air temp 90 ~ 120 DEG C.
7. the preparation method of Yening capsule according to claim 1, is characterized in that, in step (3), the method for described granulation is dry granulation.
8. a Yening capsule, is characterized in that, is prepared by the preparation method described in any one of claim 1 ~ 7.
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| CN1368111A (en) * | 2001-01-31 | 2002-09-11 | 杨孟君 | Nano Medicine 'Yening' and its preparing process |
| CN1615962A (en) * | 2004-09-08 | 2005-05-18 | 丁青龙 | Method for preparing night rest medicine and its solid preparation |
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| CN1368111A (en) * | 2001-01-31 | 2002-09-11 | 杨孟君 | Nano Medicine 'Yening' and its preparing process |
| CN1615962A (en) * | 2004-09-08 | 2005-05-18 | 丁青龙 | Method for preparing night rest medicine and its solid preparation |
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Address after: Haikou national high tech Zone Industrial Park two trough trough four road 570311 Hainan city of Haikou province No. 8 Patentee after: HAINAN HULUWA PHARMACEUTICAL GROUP CO., LTD. Address before: Haikou national high tech Zone Industrial Park two trough trough four road 570311 Hainan city of Haikou province No. 8 Patentee before: Hainan Gourd Doll Pharmaceutical Co., Ltd. |