CN103735905A - Yening capsule and preparation method thereof - Google Patents
Yening capsule and preparation method thereof Download PDFInfo
- Publication number
- CN103735905A CN103735905A CN201310747204.7A CN201310747204A CN103735905A CN 103735905 A CN103735905 A CN 103735905A CN 201310747204 A CN201310747204 A CN 201310747204A CN 103735905 A CN103735905 A CN 103735905A
- Authority
- CN
- China
- Prior art keywords
- night
- fructus
- preparation
- yiganning capsule
- ganoderma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Yening capsule and a preparation method thereof. The adopted method is to carry out superfine grinding on lucid ganoderma and blighted wheat, thereby avoiding single extraction of the two medicines in the traditional process, shortening the process time and better playing efficacy; dry granulation is adopted to avoid the defect that a large amount of excipients are added in the granulation process and greatly decrease the taking dosage, so as to ensure easier acceptance and convenience in taking of patients; furthermore, the powder fluidity is improved, the resistance to moisture absorption is increased, the storage is easy, bad smell can be hidden, taking is more convenient, the property is more stable, storage, carrying and transportation are easy, and meanwhile, taking requirements of diabetic patients are satisfied.
Description
Technical field
The present invention relates to Chinese medicine formulation art, be specifically related to Yiganning capsule at a kind of night and preparation method thereof.
Background technology
Peaceful preparation generally be take Cortex Albiziae, Caulis Polygoni Multiflori, Ganoderma, Fructus Jujubae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, Fructus Tritici Levis seven taste Chinese medicines and was made as raw material existing night, major function is to calm the nerves to nourish heart, for neurasthenia, dizzy insomnia, the treatment of the sleep disorder that the factors such as blood deficiency dreaminess cause, its determined curative effect is reliable.
The preparation method of the Yening Tangjiang of recording in one of < < Chinese Pharmacopoeia > > version in 2000 is: Fructus Tritici Levis adds after water boil, in 80～90 ℃ of warm macerating 2 times, each 2 hours, merge warm macerating liquid; Ganoderma powder is broken into coarse powder, with appropriate one week of soak with ethanol, filters and collects soak, reclaims ethanol standby; Its medicinal residues and Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae, Fructus Ligustri Lucidi decoct with water twice, and each 3 hours, collecting decoction, filter, the immersion of filtrate and above-mentioned Fructus Tritici Levis and Ganoderma merges, standing, filtration, and filtrate is concentrated into appropriate amount, adds certain adjuvant to make syrup.This preparation method Shortcomings part: one, long to the extracting cycle of ganoderol extract, and concentration of alcohol and consumption indefinite; Two, the warm macerating process conditions of Fructus Tritici Levis, still have indefinite part.
A kind of nano Medicine ' Yening ' and preparation method thereof is disclosed in Chinese patent application CN01102093.8, the method is first made respectively after nano-scale particle by each taste medicine, by the original prescription proportioning of < < Chinese Pharmacopoeia > > Yening Tangjiang, make various preparations again, but there is no definite drug effect in this application, record, be withdrawn at present.
In China Patent No. 200410041958.1, disclose preparation method and the solid preparation thereof of peaceful medicine at a kind of night, the method, when the warm macerating of Fructus Tritici Levis, limits the consumption of water; During ganoderol extract, the consumption of ethanol and concentration have also been done to corresponding restriction; The independent spraying of ganoderol extract is dry, avoid in concentration process alcohol dissolubility position and water soluble part at extractum skewness, thereby affected drug quality, there is certain science, but also there is deficiency: 1. the warm macerating technique of Fructus Tritici Levis is large to the consumption of water, increase the time of heating up; When 2. ganoderol extracts, the concentration of ethanol is low, and alcohol extract content is not high; 3. Fructus Tritici Levis and (Ganoderma medicinal residues and all the other Chinese medicine extract) are merged to the concentrated and dry uncertain part that still has of spraying; 4. the dried powder body of spraying is had to uncertain part in the processing of making solid preparation; 5. n-butanol extract is low.
Night, peaceful former dosage form was syrup, and taste is bad, takes inconvenience, and especially crowd to taste sensitivity with respect to those, is more unfavorable for taking; Adding a large amount of sucrose is adjuvant, affects taking of diabetics; Dose is inaccurate, and in storage process vulnerable to pollution.
Summary of the invention
The invention provides the preparation method of Yiganning capsule at a kind of night, this preparation method operation is easier, and the good fluidity of the medicated powder obtaining, is convenient to large-scale production.
The present invention also provides a kind of Yiganning capsule at night being made by described preparation method, and this, Yiganning capsule stable in properties, was easy to store at night, and water content is few, and has shorter disintegration.
Night Yiganning capsule a preparation method, comprise the steps:
(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, obtain nanometer medicated powder;
(2) Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi are added to the water, the extracting solution obtaining in 70～80 ℃ of decoctions, the concentrated rear spraying of described extracting solution is dry, obtain extract medicated powder;
(3) the extract medicated powder mix homogeneously that nanometer medicated powder step (1) being obtained and step (2) obtain, through granulating, sieve and encapsulated, obtain described Yiganning capsule at night (1) by Ganoderma, Fructus Tritici Levis nano-pulverization, sieve, obtain nanometer medicated powder;
Wherein, the weight portion of raw material is as follows: 0.7～1 part of Cortex Albiziae, 0.3～0.5 part of Ganoderma, 0.7～1 part of Caulis Polygoni Multiflori, 0.6～0.8 part, Fructus Jujubae, 0.7～1 part of Fructus Ligustri Lucidi, 0.2～0.3 part, Radix Glycyrrhizae, 1.5～2.0 parts of Fructus Tritici Levis.
In the present invention, adopt the method for nano-pulverization to process Ganoderma, Fructus Tritici Levis, the nanometer medicated powder obtaining is directly used as medicine, avoided the step of lixiviate in pharmacopeia, operate easier, and the good fluidity of the medicated powder that employing the method obtains, is convenient to follow-up encapsulated operation, is convenient to carry out suitability for industrialized production.Method with lixiviate is compared, nano-pulverization can retain some helper components that are difficult to be extracted in Ganoderma and Fructus Tritici Levis, the existence of these components can not only improve obtain night Yiganning capsule physical property, and medical effect experiment shows, the existence of these components does not produce adverse influence to drug effect.
As preferably, in step (1), the order number of the sieve used that sieves is 120～200 orders, directly pulverize to be used as medicine and can accelerate digesting and assimilating of Ganoderma, and Fructus Tritici Levis more can fully discharge the effective ingredient of medicine.Nano-pulverization not only improves drug effect, steady quality, and shorten the process time, energy savings.
As preferably, in step (2), the consumption of described water is Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi weight sum 6～10 times, owing to not comprising in thing to be extracted that ganoderol extracts rear medicinal residues, can use the water of less amount to extract, both save water consumption, made again follow-up concentrated power consumption still less.The process of extracting generally repeats twice.
In addition, due in thing to be extracted, do not comprise ganoderol extract after medicinal residues, the temperature of decoction can suitably reduce, as preferably, in step (2), the temperature of described decoction is 70～80 ℃, the reduction of temperature can further prevent the destruction of effective ingredient.
As preferably, under described being concentrated in-0.084MPa～-0.088MPa pressure, at 65～69 ℃ of temperature, carry out;
Concentrated proceed to extracting solution density and be 1.06～1.09g/cm3 after, carry out described spraying dry.
As preferably, in step (2), described spray-dired inlet temperature is 130～160 ℃, 90～120 ℃ of leaving air temps.Now, can make greatly shorten drying time on the one hand, improve work efficiency, the more important thing is and shortened medicinal liquid heated time, favourable to preserving effective component; Spraying is dried and has simplified technical process on the other hand.
As preferably, in step (3), the method for described granulation is dry granulation, has avoided traditional granulation need add the disadvantage of a large amount of excipient, and taking dose is greatly reduced, thereby makes patient Geng Yi accept, take more convenient; And improved the mobility of medicated powder, and increased resistance to water soak, easily preserve.
The present invention also provide a kind of night Yiganning capsule, by said method, prepared.
Crude drug of the present invention specifically describes as follows:
Cortex Albiziae is fabaceous dry bark, has resolving stagnation for tranquilization, promoting blood circulation and detumescence.At present clinical in irritability, melancholy insomnia, lung abscess.
Ganoderma is the dry sporophore of On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma, has invigorating QI and tranquilization, relieving cough and asthma.For malaise, insomnia cardiopalmus, cough and asthma due to lung deficiency, asthenia is losed heart, anorexia.
Caulis Polygoni Multiflori is the dry rattan of polygonum multiflorum thunb, has nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia, skin pruritus.
Fructus Jujubae is the dry mature fruit of Rhamnaceae plant Fructus Jujubae, has invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, married woman is dirty dry.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi, has nourishing the liver and kidney, improving eyesight black hair.For the hepatic and renal YIN deficiency, vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision, interior-heat is quenched one's thirst, osteopyrexia and fever.
Radix Glycyrrhizae is glycyrrhizic legume, Glycyrrhiza inflata Bat. or the dry root of Glycyrrhiza glabra L. and rhizome, and for invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, wrist abdomen, the anxious pain of extremity contraction, too fat to move sore, cushion toxicity, strong.
Fructus Tritici Levis is the shrivelled frivolous caryopsis of grass Semen Tritici aestivi, has except deficiency-heat, hidroschesis, main only fever due to yin deficiency, night sweat, spontaneous perspiration.
Compared with the existing technology, the present invention has following characteristics: the inventive method, Ganoderma and Fructus Tritici Levis are carried out to micronizing, and avoided the independent extraction to its two tastes medicine in traditional handicraft, performance drug effect that can also be larger when shortening the process time.With dry granulation, having avoided granulates need add the disadvantage of a large amount of excipient, and taking dose is greatly reduced again, thereby makes patient Geng Yi accept, take more convenient; And improved the mobility of medicated powder, and increased resistance to water soak, easily preserve, can cover its bad smell, take more conveniently, character is more stable, is easy to store, carry and transport, and also meets the requirement that diabetics is taken simultaneously.
The specific embodiment
Embodiment 1
Take Cortex Albiziae 0.84kg, Ganoderma 0.4kg, Caulis Polygoni Multiflori 0.84kg, Fructus Jujubae 0.6kg, Fructus Ligustri Lucidi 0.84kg, Radix Glycyrrhizae 0.24kg, Fructus Tritici Levis 1.4kg.
(1), by Ganoderma, Fructus Tritici Levis nano-pulverization, cross 120 mesh sieves standby.
(2) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add 6 times of water gagings of medical material weight, in 70 ℃, decoct twice (each 6 times of water gagings), each 3 hours, merge extractive liquid, was standby, and medicinal residues discard, filter, filtrate, in 65 ℃ of temperature, is evaporated to the extractum of relative density 1.08 under vacuum-0.084MPa condition, by 130 ℃ of extractum inlet temperature, under the condition that leaving air temp is 90 ℃, spraying is dried, and makes extract medicated powder.
(3) Ganoderma, Fructus Tritici Levis are mixed homogeneously with extract medicated powder, dry granulation, sieves, and packs granule into capsule No. 0, obtains Yiganning capsule at night.
Embodiment 2
Take Cortex Albiziae 1.68kg, Ganoderma 0.8kg, Caulis Polygoni Multiflori 1.68g, Fructus Jujubae 1.2kg, Fructus Ligustri Lucidi 1.68kg, Radix Glycyrrhizae 0.48kg, Fructus Tritici Levis 3.8kg.
(1), by Ganoderma, Fructus Tritici Levis nano-pulverization, cross 120 mesh sieves standby.
(2) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add 8 times of water gagings of medical material weight, in 73 ℃, decoct twice, each 3 hours, merge extractive liquid, was standby, and medicinal residues discard, filter, filtrate, in 67 ℃ of temperature, is evaporated to the extractum of relative density 1.08 under vacuum-0.084MPa condition, by 150 ℃ of extractum inlet temperature, under the condition that leaving air temp is 100 ℃, spraying is dried, and makes extract medicated powder.
(3) Ganoderma, Fructus Tritici Levis are mixed homogeneously with extract medicated powder, dry granulation, sieves, and packs granule into capsule No. 0, obtains Yiganning capsule at night.
Embodiment 3
Take Cortex Albiziae 2.52kg, Ganoderma 1.2kg, Caulis Polygoni Multiflori 2.52g, Fructus Jujubae 1.8kg, Fructus Ligustri Lucidi 2.52kg, Radix Glycyrrhizae 0.72kg, Fructus Tritici Levis 6.2kg.
(1), by Ganoderma, Fructus Tritici Levis nano-pulverization, cross 120 mesh sieves standby.
(2) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add 10 times of water gagings of medical material weight, in 80 ℃, decoct twice, each 3 hours, merge extractive liquid, was standby, and medicinal residues discard, filter, filtrate, in 69 ℃ of temperature, is evaporated to the extractum of relative density 1.08 under vacuum-0.088MPa condition, by 160 ℃ of extractum inlet temperature, under the condition that leaving air temp is 110 ℃, spraying is dried, and makes extract medicated powder.
(3) Ganoderma, Fructus Tritici Levis are mixed homogeneously with extract medicated powder, dry granulation, sieves, and packs granule into capsule No. 0, obtains Yiganning capsule at night.
Comparative example 1
(1) take Cortex Albiziae 21kg, Ganoderma 10kg, Caulis Polygoni Multiflori 21kg, Fructus Jujubae 15kg, Fructus Ligustri Lucidi 21kg, Radix Glycyrrhizae 6kg, Fructus Tritici Levis 60kg is standby;
(2) prepare ganoderol and promote extract powder
Get and be crushed to 10 object Ganoderma 10kg, put into extraction pot, add 60% ethanol of 20 times of Ganoderma volumes, in 80 ℃ of reflux, extract, 2 hours, after filtering after filtrate recycling ethanol, concentrating under reduced pressure, the spray-dried ganoderol that obtains is promoted extract powder 0.6kg, standby; Filter the preservation of gained Ganoderma medicinal residues and treat further processing;
(3) prepare Fructus Tritici Levis water solubility extract
In extraction pot, add Fructus Tritici Levis 60kg, then add the water boil of 20 times of Fructus Tritici Levis volumes after 10 minutes, 85 ± 5 ℃ of insulations, extract 2 hours, filter and retain warm filtrate, medicinal residues are pressed aforesaid operations again and are repeated 1 time, and after filtration, merging filtrate is standby, and medicinal residues discard;
(4) prepare the mixing water solubility extract that Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae and ganoderol extract rear medicinal residues
In extraction pot, add above-mentioned Chinese medicine of the five flavours material and add ganoderol to extract rear medicinal residues, then add the water of 20 times of medical material volumes, in 70 ℃ of extractions 3 hours, after filtering, filtrate retained, and filtering residue is pressed aforesaid operations repetition 1 time again, merges filtrate for later use each time, and medicinal residues discard;
(5) preparation mixes the dry extract of water solubility extract
The filtrate of (3) and (4) is merged, in concentration tank, in 70 ℃ of decompressions, be condensed into thick extractum, 45 ℃ of dry dry extracts that obtain 28kg mixing water solubility extract of spraying in spray dryer
(6) prepare peaceful medicine at night
(2) and (5) gained dry extract mix homogeneously is obtained to peaceful medicine at night, through pulverizing, cross sieve No. 4, adopt fully-automatic capsule racking machine to be divided in capsule shells, make the peaceful hard capsule at night of 0.1～1g different size.
Comparative example 2
(1) take Cortex Albiziae 21kg, Ganoderma 10kg, Caulis Polygoni Multiflori 21kg, Fructus Jujubae 15kg, Fructus Ligustri Lucidi 21kg, Radix Glycyrrhizae 6kg, Fructus Tritici Levis 35kg is standby;
(2), by Ganoderma, Fructus Tritici Levis nano-pulverization, cross 120 mesh sieves standby.
(3) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add 20 times of water gagings of medical material weight, in 70 ℃, decoct twice, each 3 hours, merge extractive liquid, is standby, medicinal residues discard, in concentration tank, in 70 ℃ of decompressions, be condensed into thick extractum, 45 ℃ of dry dry extracts that obtain 28kg mixing water solubility extract of spraying in spray dryer.
(4) dry extract was pulverized No. 4 mesh sieves and was mixed homogeneously with step (1), adopted fully-automatic capsule racking machine to be divided in capsule shells, obtained Yiganning capsule at night.
Comparative example 3
(1) take Cortex Albiziae 21kg, Ganoderma 10kg, Caulis Polygoni Multiflori 21kg, Fructus Jujubae 15kg, Fructus Ligustri Lucidi 21kg, Radix Glycyrrhizae 6kg, Fructus Tritici Levis 60kg is standby;
(2) prepare ganoderol and promote extract powder
Get and be crushed to 10 object Ganoderma 10kg, put into extraction pot, add 60% ethanol of 20 times of Ganoderma volumes, in 80 ℃ of reflux, extract, 2 hours, after filtering after filtrate recycling ethanol, concentrating under reduced pressure, the spray-dried ganoderol that obtains is promoted extract powder 0.6kg, standby; Filter the preservation of gained Ganoderma medicinal residues and treat further processing;
(3) prepare Fructus Tritici Levis water solubility extract
In extraction pot, add Fructus Tritici Levis 60kg, then add the water boil of 20 times of Fructus Tritici Levis volumes after 10 minutes, 85 ± 5 ℃ of insulations, extract 2 hours, filter and retain warm filtrate, medicinal residues are pressed aforesaid operations again and are repeated 1 time, and after filtration, merging filtrate is standby, and medicinal residues discard;
(4) all the other Chinese crude drugs (Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Fructus Ligustri Lucidi, Radix Glycyrrhizae) add 6 times of water gagings of medical material weight, in 70 ℃, decoct twice (each 6 times of water gagings), each 3 hours, merge extractive liquid, is standby, medicinal residues discard, filter, filtrate, in 65 ℃ of temperature, is evaporated to the extractum of relative density 1.08 under vacuum-0.084MPa condition.
(5) by 130 ℃ of step (3) and step (4) extractum inlet temperature, under the condition that leaving air temp is 90 ℃ spraying dry, make extract medicated powder.
(6) Ganoderma is mixed homogeneously with extract medicated powder, dry granulation, sieves, and packs granule into capsule No. 0, obtains Yiganning capsule at night.
The embodiment of the present invention 1 is made night Yiganning capsule and the Yiganning capsule at night of comparative example 1 preparation carry out stability test, adopt the method for accelerated test to carry out study on the stability to it, 28 ℃～32 ℃ of temperature, relative humidity 55%～65% condition is accelerated to place 6 months, the results are shown in Table 1
Table 1 stability test result
| Sample | Content after January | Content after February | Content after March | Content after June | Meansigma methods |
| Embodiment 1 | 99.3% | 99.26% | 99.2% | 99.08% | 99.21% |
| Comparative example 1 | 93.60% | 92.86% | 92.68% | 91.46% | 92.65% |
Visible, preparation method of the present invention prepare night Yiganning capsule stability be better than Yiganning capsule at night prepared by prior art.
To embodiment 1～3 prepared night Yiganning capsule and the Yiganning capsule at night of comparative example 1～3 preparation carry out respectively quality testing, concrete detection method all, according to second of < < Pharmacopoeia of People's Republic of China > > version in 2005, the results are shown in Table 2:
The mensuration of table 2 mobility, moisture, disintegration
Visible, the present invention makes night, the indices of Yiganning capsule was up to specification, and wherein content and moisture are all better than prior art.
The therapeutic effect of compound preparation of the present invention is described by some experimental datas below:
Test exercise question: following data by our company, entrust that Xianyang central hospital organizes and implements night Yiganning capsule clinical trial, evaluate Yiganning capsule treatment at night neurasthenia's (insufficiency of vital energy and blood and neurasthenia's deficiency syndrome), evident in efficacy, existing report is as follows:
1, clinical data
Meet Western medicine diagnose, Standards of Chinese Medical Syndrome Differentiation; Age was at 18～70 years old; The course of disease is more than 3 months person.Adopt multicenter, random, single blind, parallel check experiment research method, it is 120 examples that qualified experimenter be take the pro rate treatment group of 3:1, and matched group is 40 examples, totally 160 examples.Before two groups of sexes, ages and treatment, the vital sign such as heart rate, pulse, breathing, systolic pressure, diastolic pressure all has comparability (P > 0.05).State of an illness total mark, the length of one's sleep, lassitude, tongue fur, the more equal no statistical significance of body of the tongue (P > 0.05) before two groups of courses of disease, medication history, treatment are harmonious good.
2, Therapeutic Method
Test group: night Yiganning capsule, oral, one time 5,2 times on the one; Nourishing blood to tranquillize the mind sheet simulant, oral, one time 5,3 times on the one.
Matched group: night Yiganning capsule simulant, oral, one time 5,2 times on the one; Nourishing blood to tranquillize the mind sheet, oral, one time 5,3 times on the one.
The course for the treatment of: 28 days.
3, test performance
This clinical trial shows that Yiganning capsule had and calmed the nerves night, the effect nourishing heart, the neurasthenia who causes for hyperactivity of fire caused by deficiency of YIN has good therapeutical effect, particularly can better improve soreness of the waist and knees, dreaming often and waking easily, dry mouth and throat, dizziness and tinnitus, the hyperactivity of fire caused by deficiency of YIN tcm symptom such as forgetful.
Claims (8)
- Night Yiganning capsule a preparation method, it is characterized in that, comprise the steps:(1) by Ganoderma, Fructus Tritici Levis nano-pulverization, sieve, obtain nanometer medicated powder;(2) Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi are added to the water, the extracting solution obtaining in 70～80 ℃ of decoctions, the concentrated rear spraying of described extracting solution is dry, obtain extract medicated powder;(3) the extract medicated powder mix homogeneously that nanometer medicated powder step (1) being obtained and step (2) obtain, process is granulated, is sieved and be encapsulated, obtains described Yiganning capsule at night;Wherein, the weight portion of raw material is as follows: 0.7～1 part of Cortex Albiziae, 0.3～0.5 part of Ganoderma, 0.7～1 part of Caulis Polygoni Multiflori, 0.6～0.8 part, Fructus Jujubae, 0.7～1 part of Fructus Ligustri Lucidi, 0.2～0.3 part, Radix Glycyrrhizae, 1.5～2.0 parts of Fructus Tritici Levis.
- Night according to claim 1 Yiganning capsule preparation method, it is characterized in that, in step (1), the order number of the sieve used that sieves is 120～200 orders.
- Night according to claim 1 Yiganning capsule preparation method, it is characterized in that, in step (2), the consumption of described water is Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Jujubae, Radix Glycyrrhizae and Fructus Ligustri Lucidi weight sum 6～10 times.
- Night according to claim 1 Yiganning capsule preparation method, it is characterized in that, in step (2), the temperature of described decoction is 70～80 ℃.
- Night according to claim 1 Yiganning capsule preparation method, it is characterized in that, under described being concentrated in-0.084MPa～-0.088MPa pressure, at 65～69 ℃ of temperature, carry out;Concentrated proceed to extracting solution density and be 1.06～1.09g/cm3 after, carry out described spraying dry.
- Night according to claim 1 Yiganning capsule preparation method, it is characterized in that, in step (2), described spray-dired inlet temperature is 130～160 ℃, 90～120 ℃ of leaving air temps.
- Night according to claim 1 Yiganning capsule preparation method, it is characterized in that, in step (3), the method for described granulation is dry granulation.
- Night a Yiganning capsule, it is characterized in that, by the preparation method described in claim 1～8 any one, prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310747204.7A CN103735905B (en) | 2013-12-30 | 2013-12-30 | A kind of Yening capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310747204.7A CN103735905B (en) | 2013-12-30 | 2013-12-30 | A kind of Yening capsule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103735905A true CN103735905A (en) | 2014-04-23 |
| CN103735905B CN103735905B (en) | 2015-12-30 |
Family
ID=50493021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310747204.7A Active CN103735905B (en) | 2013-12-30 | 2013-12-30 | A kind of Yening capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103735905B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796968A (en) * | 2016-04-19 | 2016-07-27 | 湖北午时药业股份有限公司 | Nerve-soothing granules for treating neurasthenia and insomnia and preparation method thereof |
| CN108721477A (en) * | 2018-09-05 | 2018-11-02 | 陕西省万寿制药有限责任公司 | A kind of pharmaceutical preparation and preparation method thereof for treating internal organs spasm |
| CN109045222A (en) * | 2018-11-01 | 2018-12-21 | 苏州卫生职业技术学院 | Improve the oral solution and its preparation process of sleep quality |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368111A (en) * | 2001-01-31 | 2002-09-11 | 杨孟君 | Nano Medicine 'Yening' and its preparing process |
| CN1615962A (en) * | 2004-09-08 | 2005-05-18 | 丁青龙 | Method for preparing night rest medicine and its solid preparation |
-
2013
- 2013-12-30 CN CN201310747204.7A patent/CN103735905B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368111A (en) * | 2001-01-31 | 2002-09-11 | 杨孟君 | Nano Medicine 'Yening' and its preparing process |
| CN1615962A (en) * | 2004-09-08 | 2005-05-18 | 丁青龙 | Method for preparing night rest medicine and its solid preparation |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796968A (en) * | 2016-04-19 | 2016-07-27 | 湖北午时药业股份有限公司 | Nerve-soothing granules for treating neurasthenia and insomnia and preparation method thereof |
| CN108721477A (en) * | 2018-09-05 | 2018-11-02 | 陕西省万寿制药有限责任公司 | A kind of pharmaceutical preparation and preparation method thereof for treating internal organs spasm |
| CN108721477B (en) * | 2018-09-05 | 2021-03-23 | 陕西省万寿制药有限责任公司 | Pharmaceutical preparation for treating organ spasm and preparation method thereof |
| CN109045222A (en) * | 2018-11-01 | 2018-12-21 | 苏州卫生职业技术学院 | Improve the oral solution and its preparation process of sleep quality |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103735905B (en) | 2015-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101972395B (en) | Calming and decompressing traditional Chinese medicine composition and preparation method thereof | |
| CN110038085A (en) | A kind of preparation method and purposes of compound Semen Ziziphi Spinosae combined extracts | |
| CN103735905B (en) | A kind of Yening capsule and preparation method thereof | |
| CN104887747A (en) | Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method therefor | |
| CN103272136B (en) | Traditional Chinese medicine for treating climacteric syndrome of women | |
| CN104984296A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof | |
| CN104436145A (en) | Pharmaceutical composition for preventing and/or treating allergic rhinitis and allergic asthma | |
| CN104435567A (en) | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout | |
| CN103690780A (en) | Heart-invigorating and sedative pill and preparation method thereof | |
| CN113599471A (en) | Traditional Chinese medicine granules for primary lung cancer and production process thereof | |
| CN105343313A (en) | Traditional Chinese medicinal composition for treating senile skin pruritus and preparation method of traditional Chinese medicinal composition | |
| CN102120000B (en) | Composition of effective parts of traditional Chinese medicine preparation for resisting Coxsackie virus B and preparation method thereof | |
| CN111329966A (en) | Traditional Chinese medicine composition for treating skin itch and extract and preparation thereof | |
| CN104189833A (en) | Process for preparing xiaoyao pills | |
| CN105232923A (en) | Foot bath medicine for treating specific endowment constitution and preparation method and application thereof | |
| CN104491318A (en) | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation | |
| CN105770815A (en) | Folium artemisiae argyi-containing traditional Chinese medicine composition for treating postpartum collapse and preparation method thereof | |
| CN106692698B (en) | Bletilla striata cough relieving granule and preparation method thereof | |
| CN105194299A (en) | Application of traditional Chinese medicine composition in preparation of medicines for treating cerebral thrombosis | |
| CN105412673A (en) | Drug for treating Hashimoto disease and preparing method thereof | |
| CN104096078A (en) | Traditional Chinese medicine medicament for treating diabetes insipidus | |
| CN105362849A (en) | Method for preparing traditional Chinese medicine composition for treating infertility | |
| CN104888080A (en) | Traditional Chinese medicine composition for treating insomnia | |
| CN114224975A (en) | Composition and medicine for strengthening brain and tonifying kidney as well as preparation method and application of composition and medicine | |
| CN104083734A (en) | Traditional Chinese medicine preparation for treating hypotension |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Haikou national high tech Zone Industrial Park two trough trough four road 570311 Hainan city of Haikou province No. 8 Patentee after: HAINAN HULUWA PHARMACEUTICAL GROUP CO., LTD. Address before: Haikou national high tech Zone Industrial Park two trough trough four road 570311 Hainan city of Haikou province No. 8 Patentee before: Hainan Gourd Doll Pharmaceutical Co., Ltd. |