CN109045222A - Improve the oral solution and its preparation process of sleep quality - Google Patents

Improve the oral solution and its preparation process of sleep quality Download PDF

Info

Publication number
CN109045222A
CN109045222A CN201811294258.1A CN201811294258A CN109045222A CN 109045222 A CN109045222 A CN 109045222A CN 201811294258 A CN201811294258 A CN 201811294258A CN 109045222 A CN109045222 A CN 109045222A
Authority
CN
China
Prior art keywords
parts
oral solution
weight
filter residue
leaching liquor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811294258.1A
Other languages
Chinese (zh)
Inventor
张立光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Vocational Health College
Original Assignee
Suzhou Vocational Health College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Vocational Health College filed Critical Suzhou Vocational Health College
Priority to CN201811294258.1A priority Critical patent/CN109045222A/en
Publication of CN109045222A publication Critical patent/CN109045222A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of oral solution and its preparation process for improving sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 8-15 parts, 4-10 parts of Aralia mandshrica, 2-7 parts of loquat flower, 5-8 parts of the fruit of glossy privet, 3-6 parts of cattail pollen, 2-8 parts of japanese saussurea herb, 1-5 parts of peach kernel, 4-9 parts of rush, 3-6 parts of glutinous rice root, 4-10 parts of stamen nelumbini, 3-7 parts of the vine of multiflower knotweed, 2-5 parts of Radix Glycyrrhizae.Oral solution prepared by the present invention improves working well for sleep quality for treatment, change oral solution can treatment of insomnia patients and improve sleep cure rate be up to 97%-99%, without side-effects, use is safe, zero illegally adds drug and significant effect, can meet better application demand.

Description

Improve the oral solution and its preparation process of sleep quality
Technical field
The invention belongs to medicines and health protection technical fields, and in particular to improve the oral solution and its preparation process of sleep quality.
Background technique
Insomnia, which refers to, can not fall asleep or cannot keep sleep state, cause to have not enough sleep.It also known as falls asleep and sleep is maintained to hinder Hinder, causes difficulty falling asleep, Depth of sleep for a variety of causes or frequency is too short, early awakening and sleeping time are insufficient or of poor quality etc..With The quickening of modern life rhythm, the increase of life stress, more and more people face the symptoms such as anxiety, insomnia, for a long time by The puzzlement of insomnia.Since worry takes for long periods of time, sedative hypnotic adverse drug reaction is larger, and many insomniacs relatively favor Improve sleep class Chinese patent drug and health food, therefore the market demand for improving sleep class Chinese patent drug and health food also increasingly increases therewith It is long.
In order to improve the effect for improving sleep quality of Chinese patent drug and health food, illegal businessman can add thereto The drug illegally added, wherein most often hypnotic sedative agent, antalgesic and antipsychotics etc., however these are illegal The drug of addition can bring serious adverse effect to the health of consumer.
Based on this, we research and develop a kind of using safe, zero illegal addition drug and the effective sleep quality that improves Oral solution, to meet better application demand.
Summary of the invention
It is a kind of using safe, zero illegal addition drug and effect the purpose of the present invention is providing to solve existing technical problem The significant oral solution and its preparation process for improving sleep quality.
Technical solution of the present invention is come as follows:
Improve the oral solution of sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 8-15 parts, thorn Imperial 4-10 parts of bud, 2-7 parts of loquat flower, 5-8 parts of the fruit of glossy privet, 3-6 parts of cattail pollen, 2-8 parts of japanese saussurea herb, 1-5 parts of peach kernel, rush 4-9 Part, 3-6 parts of glutinous rice root, 4-10 parts of stamen nelumbini, 3-7 parts of the vine of multiflower knotweed, 2-5 parts of Radix Glycyrrhizae.
In above-mentioned technical proposal, the mass ratio of the pony bubble, Aralia mandshrica and stamen nelumbini is 1.5-2:1:1.
In above-mentioned technical proposal, the oral solution is prepared by the component of following parts by weight: pony steeps 12 parts, Aralia mandshrica 6 parts, 4 parts of loquat flower, 6 parts of the fruit of glossy privet, 4 parts of cattail pollen, 5 parts of japanese saussurea herb, 3 parts of peach kernel, 6 parts of rush, 4 parts of glutinous rice root, stamen nelumbini 6 Part, 5 parts of the vine of multiflower knotweed, 2 parts of Radix Glycyrrhizae.
In above-mentioned technical proposal, the oral solution is prepared by the component of following parts by weight: pony steeps 10 parts, Aralia mandshrica 5 parts, 6 parts of loquat flower, 5 parts of the fruit of glossy privet, 4 parts of cattail pollen, 5 parts of japanese saussurea herb, 3 parts of peach kernel, 5 parts of rush, 4 parts of glutinous rice root, stamen nelumbini 5 Part, 6 parts of the vine of multiflower knotweed, 3 parts of Radix Glycyrrhizae.
It further include the honey or xylitol of 0.5-5 parts by weight in above-mentioned technical proposal.
Another technical solution of the invention is come as follows:
The preparation process for improving the oral solution of sleep quality, includes the following steps:
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, the tuber of multiflower knotweed Rattan；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 50-120 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 20-30 times of parts by weight, then It is filtered with double gauze, obtains filter residue and filtrate, it is spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 50-65wt.% of 10-20 times of parts by weight is then added, Extraction, leaching liquor is freeze-dried, mixed powder is obtained；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, is uniformly mixed, is concentrated into original volume 1/2, through filtering, filling and sterilizing to get this product.
Another technical solution of the invention is come as follows:
The preparation process for improving the oral solution of sleep quality, includes the following steps:
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, the tuber of multiflower knotweed Rattan；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 50-120 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 3-6 times of parts by weight, are then used Double gauze filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 50-65wt.% of 5-8 times of parts by weight, leaching is then added It mentions, leaching liquor is freeze-dried, obtain mixed powder；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, calls in honey or xylitol, and mixing is equal It is even, it is concentrated into the 1/2 of original volume, through filtering, filling and sterilizing to get this product.
In above-mentioned technical proposal, the specific steps that are extracted in the step 3 are as follows: 50-80 points are first extracted at 40-60 DEG C Leaching liquor one and filter residue one is obtained by filtration in clock；Above-mentioned filter residue one is added in the ethyl alcohol of 5-10 times of parts by weight again later, in 65- Extraction 30-60 minutes is carried out at 85 DEG C, and leaching liquor two and filter residue two is obtained by filtration；8-10 times of parts by weight are added in filter residue two again Water in, carried out at 80-95 DEG C extraction 30-60 minutes, leaching liquor two and filter residue two is obtained by filtration；By leaching liquor one, extraction Liquid two and leaching liquor three merge to get leaching liquor.
In above-mentioned technical proposal, after the honey refines 20-40min at a temperature of 110-120 DEG C in advance before calling in.
Due to using above technical scheme, the invention has the benefit that
Oral solution prepared by the present invention improves sleep quality for treatment and works well, change oral solution can treatment of insomnia patients and The cure rate for improving sleep is up to 97%-99%, without side-effects, and use is safe, zero illegally adds drug and significant effect, can meet Better application demand.
Specific embodiment
Combined with specific embodiments below, present invention is further described in detail.The following examples are intended to illustrate the invention, But it is not intended to limit the scope of the invention.
Embodiment 1
Improve the oral solution of sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 8 parts, thorn dragon Luxuriant 4 parts, 2 parts of loquat flower, 5 parts of the fruit of glossy privet, 3 parts of cattail pollen, 2 parts of japanese saussurea herb, 1 part of peach kernel, 4 parts of rush, 3 parts of glutinous rice root, stamen nelumbini 4 Part, 3 parts of the vine of multiflower knotweed, 2 parts of Radix Glycyrrhizae.
The preparation process for improving the oral solution of sleep quality, includes the following steps:
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, the tuber of multiflower knotweed Rattan；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 50 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 3 times of parts by weight, then with the double-deck yarn Cloth filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 50wt.% of 5 times of parts by weight is then added, and are extracted, will Leaching liquor freeze-drying, obtains mixed powder；The specific steps wherein extracted are as follows: first extract 50 minutes, filter at 40 DEG C To leaching liquor one and filter residue one；Above-mentioned filter residue one is added in the ethyl alcohol of 5 times of parts by weight again later, extraction 30 is carried out at 65 DEG C Minute, leaching liquor two and filter residue two is obtained by filtration；Filter residue two is added in the water of 8 times of parts by weight again, is soaked at 80 DEG C It mentions 30 minutes, leaching liquor two and filter residue two is obtained by filtration；Leaching liquor one, leaching liquor two and leaching liquor three are merged to get extraction Liquid；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, is uniformly mixed, is concentrated into original volume 1/2, through filtering, filling and sterilizing to get this product.
Embodiment 2
Improve the oral solution of sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 15 parts, thorn dragon Luxuriant 10 parts, 7 parts of loquat flower, 8 parts of the fruit of glossy privet, 6 parts of cattail pollen, 8 parts of japanese saussurea herb, 5 parts of peach kernel, 9 parts of rush, 6 parts of glutinous rice root, stamen nelumbini 10 parts, 7 parts of the vine of multiflower knotweed, 5 parts of Radix Glycyrrhizae, 0.5 part of xylitol.
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, The vine of multiflower knotweed；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 120 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 6 times of parts by weight, then with the double-deck yarn Cloth filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 65wt.% of 8 times of parts by weight is then added, and are extracted, will Leaching liquor freeze-drying, obtains mixed powder；The specific steps wherein extracted are as follows: first extract 80 minutes, filter at 60 DEG C To leaching liquor one and filter residue one；Above-mentioned filter residue one is added in the ethyl alcohol of 10 times of parts by weight again later, is extracted at 85 DEG C 60 minutes, leaching liquor two and filter residue two is obtained by filtration；Filter residue two is added in the water of 10 times of parts by weight again, is carried out at 95 DEG C Extraction 60 minutes, is obtained by filtration leaching liquor two and filter residue two；Leaching liquor one, leaching liquor two and leaching liquor three are merged to get leaching Extract；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, calls in honey or xylitol, and mixing is equal It is even, it is concentrated into the 1/2 of original volume, through filtering, filling and sterilizing to get this product.
Embodiment 3
Improve the oral solution of sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 12 parts, thorn dragon Luxuriant 8 parts, 5 parts of loquat flower, 5 parts of the fruit of glossy privet, 6 parts of cattail pollen, 3 parts of japanese saussurea herb, 2 parts of peach kernel, 5 parts of rush, 4 parts of glutinous rice root, stamen nelumbini 8 Part, 4 parts of the vine of multiflower knotweed, 5 parts of Radix Glycyrrhizae, 5 parts of xylitol.
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, The vine of multiflower knotweed；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 80 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 5 times of parts by weight, then with the double-deck yarn Cloth filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 55wt.% of 6 times of parts by weight is then added, and are extracted, will Leaching liquor freeze-drying, obtains mixed powder；The specific steps wherein extracted are as follows: first extract 60 minutes, filter at 50 DEG C To leaching liquor one and filter residue one；Above-mentioned filter residue one is added in the ethyl alcohol of 7 times of parts by weight again later, extraction 50 is carried out at 75 DEG C Minute, leaching liquor two and filter residue two is obtained by filtration；Filter residue two is added in the water of 10 times of parts by weight again, is soaked at 85 DEG C It mentions 45 minutes, leaching liquor two and filter residue two is obtained by filtration；Leaching liquor one, leaching liquor two and leaching liquor three are merged to get extraction Liquid；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, calls in xylitol, is uniformly mixed, concentration To the 1/2 of original volume, through filtering, filling and sterilizing to get this product.
Embodiment 4
Improve the oral solution of sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 12 parts, thorn dragon Luxuriant 6 parts, 4 parts of loquat flower, 6 parts of the fruit of glossy privet, 4 parts of cattail pollen, 5 parts of japanese saussurea herb, 3 parts of peach kernel, 6 parts of rush, 4 parts of glutinous rice root, stamen nelumbini 6 Part, 5 parts of the vine of multiflower knotweed, 2 parts of Radix Glycyrrhizae, 2 parts of honey.
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, The vine of multiflower knotweed；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 100 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 4 times of parts by weight, then with the double-deck yarn Cloth filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 60wt.% of 7 times of parts by weight is then added, and are extracted, will Leaching liquor freeze-drying, obtains mixed powder；The specific steps wherein extracted are as follows: first extract 65 minutes, filter at 55 DEG C To leaching liquor one and filter residue one；Above-mentioned filter residue one is added in the ethyl alcohol of 8 times of parts by weight again later, extraction 50 is carried out at 75 DEG C Minute, leaching liquor two and filter residue two is obtained by filtration；Filter residue two is added in the water of 9 times of parts by weight again, is soaked at 85 DEG C It mentions 60 minutes, leaching liquor two and filter residue two is obtained by filtration；Leaching liquor one, leaching liquor two and leaching liquor three are merged to get extraction Liquid；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, calls in and refines at a temperature of 110 DEG C in advance The honey of 20min processed is uniformly mixed, is concentrated into the 1/2 of original volume, through filtering, filling and sterilizing to get this product.
Embodiment 5
Improve the oral solution of sleep quality, the oral solution is prepared by the component of following parts by weight: pony steeps 10 parts, thorn dragon Luxuriant 5 parts, 6 parts of loquat flower, 5 parts of the fruit of glossy privet, 4 parts of cattail pollen, 5 parts of japanese saussurea herb, 3 parts of peach kernel, 5 parts of rush, 4 parts of glutinous rice root, stamen nelumbini 5 Part, 6 parts of the vine of multiflower knotweed, 3 parts of Radix Glycyrrhizae, 4 parts of honey.
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, The vine of multiflower knotweed；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 120 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 5 times of parts by weight, then with the double-deck yarn Cloth filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 65wt.% of 7 times of parts by weight is then added, and are extracted, will Leaching liquor freeze-drying, obtains mixed powder；The specific steps wherein extracted are as follows: first extract 65 minutes, filter at 50 DEG C To leaching liquor one and filter residue one；Above-mentioned filter residue one is added in the ethyl alcohol of 9 times of parts by weight again later, extraction 50 is carried out at 80 DEG C Minute, leaching liquor two and filter residue two is obtained by filtration；Filter residue two is added in the water of 8 times of parts by weight again, is soaked at 90 DEG C It mentions 50 minutes, leaching liquor two and filter residue two is obtained by filtration；Leaching liquor one, leaching liquor two and leaching liquor three are merged to get extraction Liquid；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, calls in and refines at a temperature of 120 DEG C in advance The honey of 40min processed is uniformly mixed, is concentrated into the 1/2 of original volume, through filtering, filling and sterilizing to get this product.
Comparative example 1
This comparative example provides a kind of oral solution, and the oral solution is prepared by the component of following parts by weight: pony steeps 8 parts, Pi Rake spends 2 parts, 5 parts of the fruit of glossy privet, 3 parts of cattail pollen, 2 parts of japanese saussurea herb, 1 part of peach kernel, 4 parts of rush, 3 parts of the vine of multiflower knotweed, 2 parts of Radix Glycyrrhizae.
The preparation step of above-mentioned oral solution is the same as embodiment 1.
Comparative example 2
This comparative example provides a kind of oral solution, and the oral solution is prepared by the component of following parts by weight: 4 parts of Aralia mandshrica, Pi Rake spends 2 parts, 5 parts of the fruit of glossy privet, 3 parts of cattail pollen, 2 parts of japanese saussurea herb, 1 part of peach kernel, 4 parts of rush, 3 parts of glutinous rice root, 4 parts of stamen nelumbini, the tuber of multiflower knotweed 3 parts of rattan, 2 parts of Radix Glycyrrhizae.
The preparation step of above-mentioned oral solution is the same as embodiment 1.
Comparative example 3
This comparative example provides a kind of oral solution, and the oral solution is prepared by the component of following parts by weight: pony steeps 6 parts, thorn Imperial bud 3 parts, 1.5 parts of loquat flower, 4 parts of the fruit of glossy privet, 2 parts of cattail pollen, 1 part of japanese saussurea herb, 0.4 part of peach kernel, 3 parts of rush, glutinous rice root 2 Part, 2 parts of stamen nelumbini, 2 parts of the vine of multiflower knotweed, 1 part of Radix Glycyrrhizae.
The preparation step of above-mentioned oral solution is the same as embodiment 1.
Comparative example 4
This comparative example provides a kind of oral solution, and the oral solution is prepared by the component of following parts by weight: pony steeps 18 parts, thorn Imperial 12 parts of bud, 8 parts of loquat flower, 9 parts of the fruit of glossy privet, 8 parts of cattail pollen, 10 parts of japanese saussurea herb, 7 parts of peach kernel, 10 parts of rush, 7 parts of glutinous rice root, 11 parts of stamen nelumbini, 8 parts of the vine of multiflower knotweed, 7 parts of Radix Glycyrrhizae, 1 part of xylitol.
The preparation step of above-mentioned oral solution is the same as embodiment 2.
For the clinical efficacy for further proving oral solution of the invention, selects 100 patients to take orally respectively and (take orally 3 daily Secondary, 10 milliliters every time) oral solution of the various embodiments described above and comparative example 15 days and clinical observation is carried out, clinical testing data is such as Shown in following table:
It can be seen that in oral solution prepared by the present invention that embodiment 5 is most preferred embodiment from the above test result, and embodiment Oral solution prepared by 1-5 improves sleep quality for treatment and works well, change oral solution can treatment of insomnia patients and improving sleep The cure rate of dormancy is up to 97%-99%, without side-effects, and use is safe, zero illegally adds drug and significant effect, can meet preferably Application demand.

Claims (9)

1. improving the oral solution of sleep quality, which is characterized in that the oral solution is prepared by the component of following parts by weight: small Horse steeps 8-15 parts, 4-10 parts of Aralia mandshrica, 2-7 parts of loquat flower, 5-8 parts of the fruit of glossy privet, 3-6 parts of cattail pollen, 2-8 parts of japanese saussurea herb, peach kernel 1-5 Part, 4-9 parts of rush, 3-6 parts of glutinous rice root, 4-10 parts of stamen nelumbini, 3-7 parts of the vine of multiflower knotweed, 2-5 parts of Radix Glycyrrhizae.
2. the oral solution according to claim 1 for improving sleep quality, which is characterized in that pony bubble, Aralia mandshrica and The mass ratio of stamen nelumbini is 1.5-2:1:1.
3. the oral solution according to claim 1 for improving sleep quality, which is characterized in that the oral solution is by following weight Part component be prepared: pony steep 12 parts, 6 parts of Aralia mandshrica, 4 parts of loquat flower, 6 parts of the fruit of glossy privet, 4 parts of cattail pollen, 5 parts of japanese saussurea herb, 3 parts of peach kernel, 6 parts of rush, 4 parts of glutinous rice root, 6 parts of stamen nelumbini, 5 parts of the vine of multiflower knotweed, 2 parts of Radix Glycyrrhizae.
4. the oral solution according to claim 1 for improving sleep quality, which is characterized in that the oral solution is by following weight Part component be prepared: pony steep 10 parts, 5 parts of Aralia mandshrica, 6 parts of loquat flower, 5 parts of the fruit of glossy privet, 4 parts of cattail pollen, 5 parts of japanese saussurea herb, 3 parts of peach kernel, 5 parts of rush, 4 parts of glutinous rice root, 5 parts of stamen nelumbini, 6 parts of the vine of multiflower knotweed, 3 parts of Radix Glycyrrhizae.
5. the oral solution according to claim 1 to 4 for improving sleep quality, which is characterized in that further include 0.5-5 weight Measure the honey or xylitol of part.
6. improving the preparation process of the oral solution of sleep quality, which comprises the steps of:
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, the tuber of multiflower knotweed Rattan；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 50-120 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 20-30 times of parts by weight, then It is filtered with double gauze, obtains filter residue and filtrate, it is spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 50-65wt.% of 10-20 times of parts by weight is then added, Extraction, leaching liquor is freeze-dried, mixed powder is obtained；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, is uniformly mixed, is concentrated into original volume 1/2, through filtering, filling and sterilizing to get this product.
7. improving the preparation process of the oral solution of sleep quality, which comprises the steps of:
Step 1, each Chinese medicine of weighing by weight: the fruit of glossy privet, cattail pollen, japanese saussurea herb, peach kernel, rush, glutinous rice root, stamen nelumbini, the tuber of multiflower knotweed Rattan；Then above-mentioned Chinese medicine composition is dry and crush, obtain medicinal powder；
Step 2, water infusion 50-120 minutes that Aralia mandshrica, pony bubble, loquat flower and Radix Glycyrrhizae are added to 3-6 times of parts by weight, are then used Double gauze filtering, obtains filter residue and filtrate, spare；
Above-mentioned filter residue, medicinal powder are uniformly mixed by step 3, and the ethanol solution of the 50-65wt.% of 5-8 times of parts by weight, leaching is then added It mentions, leaching liquor is freeze-dried, obtain mixed powder；
Mixed powder obtained in step 3 is added in the filtrate in step 2 step 4, calls in honey or xylitol, and mixing is equal It is even, it is concentrated into the 1/2 of original volume, through filtering, filling and sterilizing to get this product.
8. the preparation process of the oral solution according to claim 6 or 7 for improving sleep quality, which is characterized in that the step The specific steps extracted in rapid 3 are as follows: first extracted 50-80 minutes at 40-60 DEG C, leaching liquor one and filter residue one is obtained by filtration；It Above-mentioned filter residue one is added in the ethyl alcohol of 5-10 times of parts by weight again afterwards, extraction 30-60 minutes is carried out at 65-85 DEG C, is filtered To leaching liquor two and filter residue two；Filter residue two is added in the water of 8-10 times of parts by weight again, extraction 30- is carried out at 80-95 DEG C 60 minutes, leaching liquor two and filter residue two is obtained by filtration；Leaching liquor one, leaching liquor two and leaching liquor three are merged to get leaching liquor.
9. the preparation process of the oral solution according to claim 7 for improving sleep quality, which is characterized in that the honey tune After refining 20-40min at a temperature of 110-120 DEG C in advance before entering.
CN201811294258.1A 2018-11-01 2018-11-01 Improve the oral solution and its preparation process of sleep quality Pending CN109045222A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811294258.1A CN109045222A (en) 2018-11-01 2018-11-01 Improve the oral solution and its preparation process of sleep quality

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811294258.1A CN109045222A (en) 2018-11-01 2018-11-01 Improve the oral solution and its preparation process of sleep quality

Publications (1)

Publication Number Publication Date
CN109045222A true CN109045222A (en) 2018-12-21

Family

ID=64788857

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811294258.1A Pending CN109045222A (en) 2018-11-01 2018-11-01 Improve the oral solution and its preparation process of sleep quality

Country Status (1)

Country Link
CN (1) CN109045222A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1615962A (en) * 2004-09-08 2005-05-18 丁青龙 Method for preparing night rest medicine and its solid preparation
CN103735905A (en) * 2013-12-30 2014-04-23 海南葫芦娃制药有限公司 Yening capsule and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1615962A (en) * 2004-09-08 2005-05-18 丁青龙 Method for preparing night rest medicine and its solid preparation
CN103735905A (en) * 2013-12-30 2014-04-23 海南葫芦娃制药有限公司 Yening capsule and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
江丽杰等: "基于复杂网络的失眠中医诊治规律研究", 《中国中医基础医学杂志》 *
陈涌波: "验方五则", 《老年人》 *

Similar Documents

Publication Publication Date Title
CN104857030A (en) Wall breaking method for ganoderma lucidum spore powder and product obtained with same
CN104274692B (en) Golden Buddhist sedative wine and its preparation technology
CN102102079A (en) Blood pressure-reducing table vinegar and preparation method thereof
CN105754817A (en) Healthcare wine with sleep improvement function and preparation method
CN104173503B (en) The Chinese herbal granules of the preparation method of a kind of Chinese herbal granules and preparation thereof and purposes
CN109045222A (en) Improve the oral solution and its preparation process of sleep quality
CN1853681A (en) Medicine for treating nervous prostration and improving sleep
CN104161850B (en) The preparation method of a kind of Chinese medicine extract and the Chinese medicine extract of preparation thereof and purposes
CN105779232B (en) A kind of kidney-nourishing macrobiosis health preserving wine containing Golden flower and preparation method thereof
CN110856530A (en) Inonotus obliquus health-care beverage
CN108607048A (en) The solid beverage and preparation method thereof of energy dispelling effects of alcohol and nourishing liver
CN108553632A (en) A kind of preparation method of the hot compound fresh bamboo juice of clearing lung-heat
CN104721508B (en) A kind of pharmaceutical composition and preparation method for treating the infection of the upper respiratory tract
CN106360716A (en) Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof
CN112690451A (en) Application of ginseng alcohol extract in sleep-promoting health-care product or food
CN105920066A (en) Applications, as well as preparation method and preparation of vernonia amygdalina extract
CN105925447B (en) Compound health wine containing abelmoschus manihot and preparation method and application thereof
CN107582898A (en) A kind of antibechic stops pharmaceutical composition of phlegm and its production and use
CN102669660B (en) Health-care food with antidiabetic effect
CN104222400A (en) Pu'er tea cream with functions of dispelling alcohol effect, protecting liver, nourishing heart and tranquilizing mind and processing method thereof
CN108478715A (en) A kind of Chinese medicine composition is preparing the application in treating children's hyperkinetic syndrome drug
CN104547285B (en) A kind of composition that containing eaglewood leaf, soothing nerves and assisting sleep is slept
KR20200027308A (en) Method for manufacturing Aquilaria agallocha Roxburgh Gongnokdan
CN108403749A (en) A kind of instant cream of rhodiola root and its preparation process
CN102772583A (en) Heat clearing tablet and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20181221

RJ01 Rejection of invention patent application after publication