CN103732216A - 无机基质和有机聚合物组合用于制备稳定的无定形分散体的用途 - Google Patents
无机基质和有机聚合物组合用于制备稳定的无定形分散体的用途 Download PDFInfo
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- CN103732216A CN103732216A CN201280039578.7A CN201280039578A CN103732216A CN 103732216 A CN103732216 A CN 103732216A CN 201280039578 A CN201280039578 A CN 201280039578A CN 103732216 A CN103732216 A CN 103732216A
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
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- Inorganic Chemistry (AREA)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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PCT/US2012/050221 WO2013025449A1 (en) | 2011-08-16 | 2012-08-10 | Use of inorganic matrix and organic polymer combinations for preparing stable amorphous dispersions |
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EP (1) | EP2744481A4 (hr) |
JP (1) | JP2014521745A (hr) |
CN (1) | CN103732216A (hr) |
AU (1) | AU2012295397A1 (hr) |
CA (1) | CA2844827A1 (hr) |
IN (1) | IN2014CN00827A (hr) |
WO (1) | WO2013025449A1 (hr) |
Cited By (7)
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CN105943536A (zh) * | 2016-05-06 | 2016-09-21 | 杭州容立医药科技有限公司 | 一种固体分散体的制备方法及其应用 |
CN108883190A (zh) * | 2016-03-31 | 2018-11-23 | 宝丽制药股份有限公司 | 无定形化剂、包含无定形化剂而成的无定形的组合物及其使用 |
CN109152842A (zh) * | 2016-04-29 | 2019-01-04 | 罗赛洛公司 | 用于活性药物成分的基于蛋白质的赋形剂 |
CN112023124A (zh) * | 2019-06-03 | 2020-12-04 | 上海微创医疗器械(集团)有限公司 | 结晶型涂层及其制备方法和应用 |
CN112300086A (zh) * | 2019-08-02 | 2021-02-02 | 江苏恩华药业股份有限公司 | 氯氮平与富马酸喹硫平共无定型物及其制备方法 |
CN113271978A (zh) * | 2018-11-07 | 2021-08-17 | 创新材料制药公司 | 包括基本上无定形的介孔碳酸镁的新型无定形活性药物成分 |
CN113490492A (zh) * | 2019-03-04 | 2021-10-08 | 日本烟草产业株式会社 | 吡唑酰胺化合物的非晶质固体分散体 |
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US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
KR101747156B1 (ko) | 2009-07-22 | 2017-06-27 | 그뤼넨탈 게엠베하 | 산화-안정화된 탬퍼-내성 용량형 |
MX2013002377A (es) | 2010-09-02 | 2013-04-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica. |
EA201400172A1 (ru) | 2011-07-29 | 2014-06-30 | Грюненталь Гмбх | Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства |
EA201400173A1 (ru) | 2011-07-29 | 2014-06-30 | Грюненталь Гмбх | Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
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JP6282261B2 (ja) | 2012-04-18 | 2018-02-21 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 不正使用防止および過量放出防止医薬剤形 |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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JP6480936B2 (ja) * | 2013-11-26 | 2019-03-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | クライオミリングによる粉末状医薬組成物の調製 |
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CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
BR112018070199A2 (pt) | 2016-04-01 | 2019-01-29 | Therapeuticsmd Inc | composição farmacêutica de hormônio esteroide |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US20230173073A1 (en) | 2020-06-25 | 2023-06-08 | Omya International Ag | Co-ground active(s) comprising product comprising surface-reacted calcium carbonate |
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2012
- 2012-08-10 WO PCT/US2012/050221 patent/WO2013025449A1/en active Application Filing
- 2012-08-10 JP JP2014526085A patent/JP2014521745A/ja not_active Withdrawn
- 2012-08-10 US US14/238,874 patent/US20140206717A1/en not_active Abandoned
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- 2012-08-10 IN IN827CHN2014 patent/IN2014CN00827A/en unknown
- 2012-08-10 CN CN201280039578.7A patent/CN103732216A/zh active Pending
- 2012-08-10 EP EP12823625.4A patent/EP2744481A4/en not_active Withdrawn
- 2012-08-10 CA CA2844827A patent/CA2844827A1/en not_active Abandoned
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US20060153913A1 (en) * | 2004-10-25 | 2006-07-13 | Shogo Yamane | Solid formulation with improved solubility and stability, and method for producing said formulation |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108883190A (zh) * | 2016-03-31 | 2018-11-23 | 宝丽制药股份有限公司 | 无定形化剂、包含无定形化剂而成的无定形的组合物及其使用 |
CN108883190B (zh) * | 2016-03-31 | 2022-07-01 | 宝丽制药股份有限公司 | 无定形化剂、包含无定形化剂而成的无定形的组合物及其使用 |
CN109152842A (zh) * | 2016-04-29 | 2019-01-04 | 罗赛洛公司 | 用于活性药物成分的基于蛋白质的赋形剂 |
CN109152842B (zh) * | 2016-04-29 | 2022-10-28 | 罗赛洛公司 | 用于活性药物成分的基于蛋白质的赋形剂 |
CN105943536A (zh) * | 2016-05-06 | 2016-09-21 | 杭州容立医药科技有限公司 | 一种固体分散体的制备方法及其应用 |
CN113271978A (zh) * | 2018-11-07 | 2021-08-17 | 创新材料制药公司 | 包括基本上无定形的介孔碳酸镁的新型无定形活性药物成分 |
CN113490492A (zh) * | 2019-03-04 | 2021-10-08 | 日本烟草产业株式会社 | 吡唑酰胺化合物的非晶质固体分散体 |
CN112023124A (zh) * | 2019-06-03 | 2020-12-04 | 上海微创医疗器械(集团)有限公司 | 结晶型涂层及其制备方法和应用 |
CN112300086A (zh) * | 2019-08-02 | 2021-02-02 | 江苏恩华药业股份有限公司 | 氯氮平与富马酸喹硫平共无定型物及其制备方法 |
CN112300086B (zh) * | 2019-08-02 | 2022-03-15 | 苏州恩华生物医药科技有限公司 | 氯氮平与富马酸喹硫平共无定型物及其制备方法 |
Also Published As
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IN2014CN00827A (hr) | 2015-04-03 |
EP2744481A4 (en) | 2015-07-01 |
AU2012295397A1 (en) | 2014-02-20 |
EP2744481A1 (en) | 2014-06-25 |
US20140206717A1 (en) | 2014-07-24 |
WO2013025449A1 (en) | 2013-02-21 |
JP2014521745A (ja) | 2014-08-28 |
CA2844827A1 (en) | 2013-02-21 |
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