CN103732213A - 治疗方法 - Google Patents

治疗方法 Download PDF

Info

Publication number
CN103732213A
CN103732213A CN201280035731.9A CN201280035731A CN103732213A CN 103732213 A CN103732213 A CN 103732213A CN 201280035731 A CN201280035731 A CN 201280035731A CN 103732213 A CN103732213 A CN 103732213A
Authority
CN
China
Prior art keywords
aerosol
lung
activating agent
dosing step
airway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280035731.9A
Other languages
English (en)
Chinese (zh)
Inventor
R·鲍彻
M·R·约翰逊
W·R·西林
B·巴顿
T·纳夫拉蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parion Sciences Inc
Original Assignee
Parion Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parion Sciences Inc filed Critical Parion Sciences Inc
Publication of CN103732213A publication Critical patent/CN103732213A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001Particle size control
    • A61M11/003Particle size control by passing the aerosol trough sieves or filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001Particle size control
    • A61M11/002Particle size control by flow deviation causing inertial separation of transported particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0086Inhalation chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0666Nasal cannulas or tubing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/12Preparation of respiratory gases or vapours by mixing different gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/14Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/14Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/16Devices to humidify the respiration air
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/12Mucolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0085Inhalators using ultrasonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/02Gases
    • A61M2202/0266Nitrogen (N)
    • A61M2202/0275Nitric oxide [NO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/14Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280035731.9A 2011-06-07 2012-06-07 治疗方法 Pending CN103732213A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161494198P 2011-06-07 2011-06-07
US61/494,198 2011-06-07
US201161496317P 2011-06-13 2011-06-13
US61/496,317 2011-06-13
US201261639619P 2012-04-27 2012-04-27
US61/639,619 2012-04-27
PCT/US2012/041333 WO2012170677A1 (en) 2011-06-07 2012-06-07 Methods of treatment

Publications (1)

Publication Number Publication Date
CN103732213A true CN103732213A (zh) 2014-04-16

Family

ID=47296441

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280035731.9A Pending CN103732213A (zh) 2011-06-07 2012-06-07 治疗方法

Country Status (7)

Country Link
US (2) US8778383B2 (https=)
EP (1) EP2717855A4 (https=)
JP (2) JP6219271B2 (https=)
CN (1) CN103732213A (https=)
AU (2) AU2012267938B2 (https=)
CA (1) CA2838529C (https=)
WO (1) WO2012170677A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8551534B2 (en) 2007-10-10 2013-10-08 Parion Sciences, Inc. Inhaled hypertonic saline delivered by a heated nasal cannula
US8945605B2 (en) * 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
EP3216475B1 (en) * 2012-01-24 2020-07-22 Vapotherm, Inc. Systems for providing respiratory therapy
US9326547B2 (en) 2012-01-31 2016-05-03 Altria Client Services Llc Electronic vaping article
US9669172B2 (en) * 2012-07-05 2017-06-06 Resmed Limited Discreet respiratory therapy system
WO2014158201A1 (en) * 2013-03-28 2014-10-02 Pharmacaribe, Llc Compositions, formulations and methods of bio-balancing the ph of sterile isotonic saline and hypertonic saline solutions
US12290631B2 (en) 2013-07-19 2025-05-06 Altria Client Services Llc Electronic smoking article
CN110447963B (zh) * 2013-07-25 2023-01-10 奥驰亚客户服务有限责任公司 电子吸烟器具
MX2016002968A (es) * 2013-09-10 2016-12-02 P Glynn Kenneth Dispositivos y metodos de suministros nasal de solucion salina y dioxido de carbono.
EP3412327A1 (en) * 2014-06-06 2018-12-12 Vapotherm, Inc. Heated nebulizer adapter for respiratory therapy
MY196072A (en) * 2014-09-15 2023-03-13 Verona Pharma Plc Liquid Inhalation Formulation Comprising RPL554
WO2016089981A1 (en) * 2014-12-04 2016-06-09 Carefusion 2200, Inc. Breath-actuated nebulizer for medicine inhalation
US10518288B2 (en) * 2015-06-10 2019-12-31 Stamford Devices Limited Aerosol generation
US10661283B1 (en) * 2015-06-18 2020-05-26 Elemental Scientific, Inc. Treated nebulizer tip and spray chamber
US11058842B2 (en) * 2015-08-23 2021-07-13 Pivotal Biotech LLC Adapter with moisture trap assembly for respiratory circuit
LT3487571T (lt) 2016-07-21 2024-06-25 Fisher & Paykel Healthcare Limited Medicininiai vamzdeliai kvėpavimo grandinei
US9937303B1 (en) * 2016-10-11 2018-04-10 Kaer Biotherapeutics Corporation Two-stage apparatus and method for generating and concentrating fine particle aerosols
US10207064B2 (en) * 2017-07-11 2019-02-19 Glen McCants Dual chamber nebulizer apparatus
USD855795S1 (en) * 2018-03-27 2019-08-06 Mercury Enterprises, Inc. Reusable t-piece resuscitator
CN112368040A (zh) 2018-05-31 2021-02-12 蒸汽热能公司 近机器侧雾化器
US12102755B2 (en) 2018-05-31 2024-10-01 Vapotherm, Inc. Cannula-based vibrating mesh nebulizer
EP3976143B1 (en) * 2019-05-24 2024-07-17 Stamford Devices Ltd Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device
US11878115B2 (en) 2019-09-26 2024-01-23 Vapotherm, Inc. Internal cannula mounted nebulizer
US20210315849A1 (en) * 2020-04-10 2021-10-14 Pacific Sinus Solutions LLC Compositions and methods for treating one or more ailments with a nasal rinse comprising n-acetylcysteine
US20210319865A1 (en) * 2020-04-13 2021-10-14 Cornell University Computable Phenotypes to Identify Patients with Preventable High Cost
EP4208237B1 (en) * 2020-09-01 2024-11-06 Stamford Devices Limited Aerosol high flow therapy apparatus
US11253670B1 (en) 2020-12-09 2022-02-22 Apogee Innovations Respiratory isolation and/or treatment devices and methods of using the same
WO2023164030A1 (en) * 2022-02-24 2023-08-31 Data Sciences International Inc. System and method for inhalation exposure
US20230321683A1 (en) * 2022-04-09 2023-10-12 Abdulilah M. Mayet Method And Apparatus For Atomizing And Vaporizing Liquid
WO2025265075A1 (en) * 2024-06-21 2025-12-26 Parion Sciences, Inc. Methods of clearing mucus from the lungs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268460A (en) * 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US6223745B1 (en) * 1996-10-16 2001-05-01 Aga Aktiebolag Method and a device for producing a fine homogeneous aerosol

Family Cites Families (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US548953A (en) 1895-10-29 Harness-tug
US2534636A (en) * 1949-02-12 1950-12-19 American Cyanamid Co Powder dispenser
BE758814A (fr) 1970-05-11 1971-04-16 Respiratory Care Atomiseur
US4159803A (en) 1977-03-31 1979-07-03 MistO2 Gen Equipment Company Chamber for ultrasonic aerosol generation
US4312860A (en) 1980-10-24 1982-01-26 Regents Of The University Of California Lung surfactant compositions
US4479932A (en) 1982-05-18 1984-10-30 University Of Florida Brain-specific drug delivery
US4540564A (en) 1982-05-18 1985-09-10 University Of Florida Brain-specific drug delivery
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
GB2152819B (en) * 1983-12-08 1988-05-11 Anthony John Dyson Improved nebuliser
US4906476A (en) 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5100806A (en) 1989-03-24 1992-03-31 Macri James N Method for detecting Edwards syndrome
CA2063273C (en) 1989-07-11 2002-09-24 Bradley J. Benson Surfactant compositions and methods
US5007419A (en) 1989-09-25 1991-04-16 Allan Weinstein Inhaler device
US5002048A (en) 1989-12-12 1991-03-26 Makiej Jr Walter J Inhalation device utilizing two or more aerosol containers
US5614216A (en) 1990-10-17 1997-03-25 The Liposome Company, Inc. Synthetic lung surfactant
US5292498A (en) 1991-06-19 1994-03-08 The University Of North Carolina At Chapel Hill Method of treating lung disease with uridine triphosphates
US5687715A (en) 1991-10-29 1997-11-18 Airways Ltd Inc Nasal positive airway pressure apparatus and method
US5477852A (en) 1991-10-29 1995-12-26 Airways Ltd., Inc. Nasal positive airway pressure apparatus and method
US5388574A (en) 1993-07-29 1995-02-14 Ingebrethsen; Bradley J. Aerosol delivery article
US5437267A (en) 1993-08-03 1995-08-01 Weinstein; Allan Device for delivering aerosol to the nasal membranes and method of use
AUPM411494A0 (en) 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
US5656256A (en) 1994-12-14 1997-08-12 The University Of North Carolina At Chapel Hill Methods of treating lung disease by an aerosol containing benzamil or phenamil
US5533506A (en) 1995-01-13 1996-07-09 Medlife, Inc. Nasal tube assembly
KR100424934B1 (ko) 1995-03-29 2004-07-27 다이호야쿠힌고교 가부시키가이샤 우라실유도체및이를함유하는항종양효과증강제및항종양제
US5483953A (en) * 1995-04-08 1996-01-16 The United States Of America As Represented By The Secretary Of The Navy Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
US5628984A (en) * 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US6015828A (en) 1996-05-31 2000-01-18 Cuppoletti; John Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
AU5701498A (en) 1996-12-12 1998-07-03 Johns Hopkins University School Of Medicine, The Method and apparatus for providing ventilatory support to a patient
CN1262556C (zh) 1997-02-06 2006-07-05 印斯拜尔药品股份有限公司 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
IL123122A0 (en) 1998-01-29 1998-09-24 Oridion Medical Ltd Oral/nasal cannula
US6550476B1 (en) 1998-05-21 2003-04-22 Steven L. Ryder Heat-moisture exchanger and nebulization device
EP1143896B1 (en) 1998-10-20 2006-12-13 The University of North Carolina at Chapel Hill Methods of hydrating the nasal mucosal surface
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US7074388B2 (en) * 1998-12-10 2006-07-11 Kos Life Science, Inc. Water stabilized medicinal aerosol formulation
US6387886B1 (en) 1998-12-17 2002-05-14 Chiron Corporation Method for the treatment of severe chronic bronchitis (bronchietasis) with an aerosolized antibiotic
US6926911B1 (en) 1998-12-22 2005-08-09 The University Of North Carolina At Chapel Hill Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
US20070137653A1 (en) 2000-03-13 2007-06-21 Wood Thomas J Ventilation interface for sleep apnea therapy
HK1049621A1 (zh) 1999-06-09 2003-05-23 罗伯特‧E‧希弗斯 超临界流体辅助的喷雾和鼓泡乾燥
WO2001038002A1 (en) * 1999-09-13 2001-05-31 Sheffield Pharmaceuticals, Inc. Aerosol airflow control system and method
US6530370B1 (en) 1999-09-16 2003-03-11 Instrumentation Corp. Nebulizer apparatus
NZ518401A (en) 1999-10-29 2004-01-30 Nektar Therapeutics Dry powder compositions having improved dispersivity
EP1237614B1 (en) 1999-12-10 2005-10-19 Vapotherm, Inc. Apparatus for respiratory tract therapy
US7345051B2 (en) 2000-01-31 2008-03-18 Genaera Corporation Mucin synthesis inhibitors
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US20030171332A1 (en) 2001-05-23 2003-09-11 Abraham William M. Treatment of respiratory conditions associated with bronchoconstriction with aerosolized hyaluronic acid
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
EP1420794B1 (en) 2001-08-31 2017-12-27 Sucampo AG Prostaglandin analogs as chloride channel openers
CA2370995C (en) 2001-09-13 2010-08-17 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
US6679265B2 (en) 2001-10-25 2004-01-20 Worldwide Medical Technologies Nasal cannula
AU2003207984A1 (en) 2002-02-15 2003-09-04 Oridion Medical 1987 Ltd. Dual function nasal cannula
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
EP1340492A1 (en) 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Aerosol formulations for pulmonary administration of medicaments having systemic effects
US7607436B2 (en) 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
US8245708B2 (en) 2002-05-07 2012-08-21 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
AU2003256755A1 (en) 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
AU2004202274B2 (en) 2003-05-30 2006-10-26 Fisher & Paykel Healthcare Limited Breathing Assistance Apparatus
US7375107B2 (en) 2003-08-18 2008-05-20 Parion Sciences, Inc. Alaphatic pyrazinoylguanidine sodium channel blockers
JP2007502829A (ja) 2003-08-18 2007-02-15 パリオン・サイエンシィズ・インコーポレーテッド 環状ピラジノイルグアニジンナトリウムチャネルブロッカー
US20050090505A1 (en) 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
AU2004266704B2 (en) 2003-08-18 2012-02-23 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
EP1673123A2 (en) 2003-09-05 2006-06-28 Kurve Technology, Inc. Integrated nebulizer and particle dispersing chamber for delivery of medicament
US7499570B2 (en) 2004-03-02 2009-03-03 Siemens Corporate Research, Inc. Illumination invariant change detection
DE102004012093A1 (de) * 2004-03-05 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Merkanaldüse
GB0407627D0 (en) 2004-04-02 2004-05-05 Vectura Ltd Corkscrew pump
US7267121B2 (en) 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
WO2005115520A1 (en) 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CA2575670A1 (en) 2004-08-18 2006-03-02 Michael R. Johnson Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers
US7399766B2 (en) 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
WO2006023617A2 (en) 2004-08-18 2006-03-02 Johnson Michael R Cyclic amide & ester pyrazinoylguanidine sodium channel blockers
US20090324724A1 (en) 2004-08-18 2009-12-31 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
EP2402323A3 (en) 2004-10-13 2012-05-30 PTC Therapeutics, Inc. Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases
US8757150B2 (en) 2004-12-17 2014-06-24 Ric Investments, Llc Condensation reduction and management systems in a gas flow delivery system
JP2009221164A (ja) 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
CN102600480B (zh) 2005-01-07 2015-07-22 阿尔尼拉姆医药品有限公司 RSV的RNAi调节及其治疗应用
DE102005000922A1 (de) 2005-01-07 2006-07-20 Seleon Gmbh Luftbrille, Nasenstück, Y-Stück sowie Verfahren
DE102005016100B3 (de) 2005-04-08 2006-10-26 Altana Pharma Ag Vorrichtung zur Dosierung und Trockenvernebelung
US20070157931A1 (en) 2005-07-11 2007-07-12 Richard Parker System and method for optimized delivery of an aerosol to the respiratory tract
US7807834B2 (en) 2005-08-03 2010-10-05 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7900625B2 (en) 2005-08-26 2011-03-08 North Carolina State University Inhaler system for targeted maximum drug-aerosol delivery
US8105572B2 (en) 2007-05-18 2012-01-31 New York University Method of treating tuberculosis with interferons
WO2007041156A2 (en) 2005-09-29 2007-04-12 Nektar Therapeutics Antibiotic formulations, unit doses, kits, and methods
US8701668B2 (en) 2005-10-14 2014-04-22 Resmed Limited Nasal assembly
EP2036567A3 (en) 2005-12-06 2009-12-09 P2-Science APS Modulation of the P2Y2 receptor pathway
AU2006331565A1 (en) 2005-12-27 2007-07-05 Vertex Pharmaceuticals Incorporated Compounds useful in CFTR assays and methods therewith
US20080000473A1 (en) 2005-12-29 2008-01-03 Hugo Stephenson pH-Based Methods and Devices for Preventing Hemagglutinin Cell Membrane Fusion
JP2007195838A (ja) * 2006-01-30 2007-08-09 Blue Cross Kk ネブライザ
US20070202055A1 (en) 2006-02-09 2007-08-30 Julianne Berry Pharmaceutical Formulations
EP1981572B1 (en) 2006-02-09 2012-11-21 Kamada Ltd. Pulmonary delivery of alpha-i proteinase inhibitor
US20070202051A1 (en) 2006-02-10 2007-08-30 Pari Gmbh Aerosols for sinunasal drug delivery
MX2008010222A (es) 2006-02-10 2008-10-17 Pari Pharma Gmbh Antibioticos nebulizados para terapia de inhalacion.
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
EP2021797B1 (en) 2006-05-12 2011-11-23 Vertex Pharmaceuticals, Inc. Compositions of n-ý2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl¨-1,4-dihydro-4-oxoquinoline-3-carboxamide
US7861713B2 (en) 2006-06-08 2011-01-04 Sunil Kumar Dhuper Adapter for use in an aerosol delivery system
US20110195973A1 (en) 2006-06-09 2011-08-11 Parion Sciences, Inc. Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
US8324218B2 (en) 2006-06-09 2012-12-04 Parion Sciences, Inc. Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity
PT2035004E (pt) 2006-06-09 2012-11-21 Parion Sciences Inc Bloqueadores dos canais de sódio de pirazinoilguanidona substituída com fenilo que possuem actividade agonista beta
US20080035141A1 (en) 2006-06-16 2008-02-14 Warner W R Aerosolized therapy kit
US8161971B2 (en) 2006-08-04 2012-04-24 Ric Investments, Llc Nasal and oral patient interface
HUE048024T2 (hu) 2006-08-10 2020-05-28 Roy C Levitt Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra
EP2106268B1 (en) 2006-08-30 2018-12-12 Kurve Technology, Inc. Aerosol generating and delivery device
TW200819430A (en) 2006-09-07 2008-05-01 Michael R Johnson Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
AU2007294547A1 (en) * 2006-09-07 2008-03-13 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
WO2008030592A2 (en) 2006-09-08 2008-03-13 Vapotherm, Inc. System and method for delivering medications
EP2063903A1 (en) * 2006-09-19 2009-06-03 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US20080078382A1 (en) 2006-09-20 2008-04-03 Lemahieu Edward Methods and Systems of Delivering Medication Via Inhalation
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
US20080223375A1 (en) 2006-11-15 2008-09-18 Vapotherm, Inc. Single nasal prong nasal cannula
US20080243050A1 (en) 2007-03-28 2008-10-02 John Sylvester Power Insufflation of Body Cavities
US20080293740A1 (en) 2007-04-03 2008-11-27 Parion Sciences, Inc. Method of treating acid-sensing ion channel mediated pain, cough suppression, and central nervous system disorders
US8288391B2 (en) 2007-04-03 2012-10-16 Parion Sciences, Inc. Pyrazinoylguanidine compounds for use as taste modulators
JP2010527914A (ja) 2007-04-26 2010-08-19 クォーク ファーマシューティカルズ インコーポレーティッド 呼吸器系への抑制性核酸分子の治療的送達
JP4963084B2 (ja) * 2007-05-31 2012-06-27 株式会社吉野工業所 吸引式投薬器
EP1997502A1 (en) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
US8822409B2 (en) 2007-06-20 2014-09-02 Phylogica Limited Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
US8551534B2 (en) 2007-10-10 2013-10-08 Parion Sciences, Inc. Inhaled hypertonic saline delivered by a heated nasal cannula
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20090263495A1 (en) 2007-10-25 2009-10-22 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
EP2217249A4 (en) 2007-11-06 2011-10-12 Benaroya Res Inst INHIBITION OF VERSICAN WITH SIRNA AND OTHER MOLECULES
WO2009105445A1 (en) 2008-02-18 2009-08-27 Virginia Commonwealth University Effective delivery of nanoparticles and micrometer-sized pharmaceutical aerosols to the lung through enhanced condensational growth
WO2009139948A1 (en) 2008-02-26 2009-11-19 Johnson Michael R Poly aromatic sodium channel blockers
CA2716936C (en) 2008-02-26 2018-06-05 Elevation Pharmaceuticals, Inc. Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
NZ720282A (en) 2008-02-28 2017-12-22 Vertex Pharma Heteroaryl derivatives as cftr modulators
NZ747465A (en) 2008-03-04 2020-05-29 ResMed Pty Ltd Unobtrusive interface systems
EP2271621B1 (en) 2008-03-31 2013-11-20 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators
US20110214673A1 (en) 2008-05-08 2011-09-08 Edward Masionis Portable Life Support Apparatus Ventilator
US20100074881A1 (en) 2008-07-11 2010-03-25 Parion Sciences, Inc. Multiple nebulizer systems
US8418690B2 (en) 2008-09-26 2013-04-16 Stamford Devices Limited Supplemental oxygen delivery system
US20100081956A1 (en) 2008-09-30 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, composition, and system to control pH in pulmonary tissue of a subject
PT2358680E (pt) 2008-10-23 2013-05-14 Vertex Pharma Formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2- (trifluorometil)fenil)-4-oxo- 5-(trifluorometil)-1,4- dihidroquinolina-3-carboxamida
WO2010054083A2 (en) 2008-11-05 2010-05-14 Pharmacaribe Inhalation formulation for treating and prophylatic use in bacteria, mycobacterial and fungal respiratory infections
DE102009047246A1 (de) 2008-12-01 2010-06-10 Fisher & Paykel Healthcare Ltd., East Tamaki Nasenkanüle
US20100316628A1 (en) 2008-12-09 2010-12-16 The General Hospital Corporation Agents and methods for treating respiratory disorders
EP2382197B1 (en) 2008-12-30 2016-10-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2010088191A1 (en) 2009-01-27 2010-08-05 Teleflex Medical Incorporated Sputum dissolving suctioning solution for endotracheal and tracheostomy tubes
WO2010091259A2 (en) 2009-02-06 2010-08-12 Vapotherm, Inc. Heated nebulizer devices, nebulizer systems, and methods for inhalation therapy
DK2315580T3 (da) * 2009-03-26 2012-04-10 Pulmatrix Inc Farmaceutiske formuleringer og fremgangsmåder til behandling af luftvejsinfektioner
WO2010151804A1 (en) 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
WO2011057235A2 (en) * 2009-11-09 2011-05-12 Virginia Commonwealth University Improved delivery of submicrometer and nonometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery
EP4389182A3 (en) 2009-11-18 2024-07-31 Fisher & Paykel Healthcare Limited Nasal interface
US10532177B2 (en) 2009-12-22 2020-01-14 Fisher & Paykel Healthcare Limited Components for medical circuits
US20120125332A1 (en) 2010-11-19 2012-05-24 Vapotherm, Inc. Apparatus, systems, and methods for respiratory therapy
US8893720B2 (en) 2011-02-15 2014-11-25 Binyomin A. Cohen Inhalation apparatus
US20120304992A1 (en) 2011-06-06 2012-12-06 Ratto David R Breathing treatment system and method
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
EP2928532A4 (en) 2012-12-07 2016-06-29 Parion Sciences Inc NOSE CANNULA FOR THE ADMINISTRATION OF MEDICAMENTS IN AEROSOL FORM

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268460A (en) * 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US6223745B1 (en) * 1996-10-16 2001-05-01 Aga Aktiebolag Method and a device for producing a fine homogeneous aerosol

Also Published As

Publication number Publication date
WO2012170677A1 (en) 2012-12-13
US20130074842A1 (en) 2013-03-28
JP6219271B2 (ja) 2017-10-25
EP2717855A4 (en) 2014-11-12
AU2017210594A1 (en) 2017-08-24
CA2838529A1 (en) 2012-12-13
US8778383B2 (en) 2014-07-15
US10335558B2 (en) 2019-07-02
AU2012267938A1 (en) 2014-01-23
CA2838529C (en) 2020-03-24
JP2014516081A (ja) 2014-07-07
AU2012267938B2 (en) 2017-05-04
EP2717855A1 (en) 2014-04-16
JP2017222717A (ja) 2017-12-21
US20150101597A1 (en) 2015-04-16

Similar Documents

Publication Publication Date Title
AU2012267938B2 (en) Methods of treatment
JP2014516081A5 (https=)
AU2017261520B2 (en) Aerosol delivery systems, compositions and methods
US10835512B2 (en) Methods of treating respiratory syncytial virus infections
US8387895B2 (en) Inhalation nebulizer
JP5863641B2 (ja) 濃縮肥満細胞安定化用薬学的調合物
JP2008536546A5 (https=)
AU2008310734A1 (en) Delivering osmolytes by nasal cannula
CO2021007141A2 (es) Composiciones inhalables para usarse en el tratamiento de enfermedades pulmonares
CN115190793A (zh) 5-胺基-2,3-二氢-1,4-酞嗪二酮用于吸入性治疗发炎性肺疾病的应用
CN115209872A (zh) 含有酒石酸左旋沙丁胺醇的可吸入制剂
HK40082788A (en) Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the inhalatory treatment of inflammatory pulmonary diseases
TW202602487A (zh) 呼吸系統疾病的治療與預防

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20140416