CN103690612B - Chinese medicine composition for the treatment of severe pneumonia of infants and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for the treatment of severe pneumonia of infants and preparation method thereof.Medicine provided by the invention with Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Moschus, Herba Peristrophes, Herba Wedeliae Prostratae for main component, reasonable recipe, craft science, convenient operation, the therapeutic effect for severe pneumonia of infants is remarkable, has rapid-action, curative effect is good, the feature such as have no side effect, and achieves important breakthrough relative to prior art, has outstanding substantive distinguishing features and significant progressive.

Description

Chinese medicine composition for the treatment of severe pneumonia of infants and preparation method thereof

Technical field

The present invention relates to biomedicine field, be specifically related to a kind of Chinese medicine composition for the treatment of severe pneumonia of infants and preparation method thereof.

Background technology

Infantile pneumonia is the modal a kind of respiratory tract disease of children's, and the four seasons all easily occur, and the infant within 3 years old suffers from an inflammation of the lungs more in winter, spring.As treatment is thorough, easy recurrent exerbation, cause multiple serious symptom complication, affect child's growth.Infantile pneumonia clinical manifestation is heating, cough, tachypnea, dyspnea and pulmonary's fine crackles, also has not fever with cough to breathe heavily severe one.Infantile pneumonia has classical symptom, and have atypical, pneumonia of newborn is not especially true to type yet.The pneumonia caused by antibacterial and virus is the most common.As long as infantile pneumonia Timeliness coverage and effective treatment, sick child can very fast rehabilitation.But have 7% ~ 13% infantile pneumonia to belong to severe pneumonia, serious symptom as there is the complication such as heart failure, respiratory failure, pyopneumothorax, hypoxic ischemic encephalopathy, toxic shock, toxical paralytic ileus, as treated not in time, prognosis mala.Severe pneumonia of infants is one of common critical illness of department of pediatrics, various complication and organ failure can be caused, platelet aggregation, Blood denseness is abnormal, the pathophysiological changes such as microvascular thrombosis formation, its onset is fast, the oncoming force is violent, complication is many, the multiple complications serious threat children's health that it causes and life.

The domestic treatment for severe pneumonia of infants, substantially still to take antibiotic and antiviral therapy, easily develops immunity to drugs, and side effect is very big, as hepatic injury, deafness etc.

Infantile pneumonia, in motherland's medical science allusion quotation mat, early has similar description, and the name recorded existing pneumonia and breath with cough is thanked in beautiful fine jade " numb section living person pandect " to by the Qing Dynasty.Because child physical endowment is delicate, shape gas does not fill, and lungs are gentle and demure.Weakened defensive QI, adaptive capacity is weak, therefore infantile pneumonia sickness rate is high, and serious symptom is many.Infantile pneumonia or evil poison is flourishing, or healthy energy is indefinite, the state of an illness transforms rapidly, closes, the serious symptom such as de-of fainting in being easy to occur.For the Coryza Treated by Syndrome Differentiation of severe pneumonia of infants, be crucial with the pass of grasping between good and evil.1. poison Sheng lung closes, and eliminating fire and detoxication is just to turn round and look at; 2. heat bright Tianjin wound, profit health preserving Tianjin is with rescuing YIN; 3. deficient and weak YANG QI, recuperating depleted YANG emergency is admittedly to take off.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of severe pneumonia of infants and preparation method thereof, this traditional Chinese medicine composition for treating severe pneumonia of infants is rapid-action, respond well, has no side effect.

The Chinese medicine composition for the treatment of severe pneumonia of infants of the present invention is prepared from by the raw material comprising following weight portion: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 80 ~ 150 parts, 1 ~ 5 part, Moschus, Herba Peristrophes 15 ~ 30 parts, Herba Wedeliae Prostratae 15 ~ 30 parts.

The Chinese medicine composition for the treatment of severe pneumonia of infants of the present invention is prepared from by the raw material comprising following weight portion: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 90 ~ 120 parts, 2 ~ 4 parts, Moschus, Herba Peristrophes 20 ~ 25 parts, Herba Wedeliae Prostratae 20 ~ 25 parts.

Crude drug source of the present invention is as follows:

Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), formal name used at school: CorydalissaxicolaBunting, is the root of bloodroot Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), adopts after autumn.Bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, dampness removing, analgesic hemostatic.

Moschus is the dry secretions in the ripe male body note capsule of animal in deer family woods Moschus moschiferous MoschusberezovskiiFlerov, horse Moschus moschiferous MoschussifanicusPrzewalski or former Moschus moschiferous MoschusmoschiferusLinnaeus.Acrid in the mouth, warm in nature.GUIXIN, spleen channel.To have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea ， WEIJIA, difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain, falls and flutter the pain of injury, and arthralgia pain is numb.

Herba Peristrophes is Acanthaceae Herba Peristrophes platymiscium Herba Peristrophes Peristrophejaponica(Thunb.) Makino [Diclipterajaponica (Thunb.) Makino; D.crinita (Thunb.) Nees] herb.The wild product four seasons can adopt.Cultivation product can be gathered in summer, autumn.Choose herb, removing impurity, dries.Pungent, micro-hardship, cool.Send out juice to induce sweat, heat-clearing and toxic substances removing, spasmolytic.For flu, laryngopharynx swelling and pain, diphtheria, infantile dyspepsia, infantile hyperpyrexia, carbuncle furuncle and phyma poison, venom.

The herb that Herba Wedeliae Prostratae (Wedeliaprostrata) is feverfew Herba Wedeliae Prostratae.Acid is sweet, flat, nontoxic.Enter liver, spleen two warp.Heat clearing away, removing toxic substances.Control throat moth, sore throat, diphtheria, pertussis, dyspnea and cough due to lung-heat, epistaxis, carbuncle, furuncle.

The Chinese medicine composition for the treatment of severe pneumonia of infants of the present invention, its active component is prepared from by following technique:

(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is 50 ~ 80% ethanol percolate extraction with the volume by volume concentration being equivalent to medical material gross weight 4 ~ 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights, decoct 10 ~ 60 minutes, and filter, filtrate and percolate merge, and are concentrated into 2 ~ 3 times of medical material gross weight, filter, and leave standstill 1 ~ 10 day, obtain solution A;

(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 ~ 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 ~ 90 times, merges distillate, obtains solution B;

(3) merge solution A and solution B, obtain inventive compound.

The Chinese medicine composition for the treatment of severe pneumonia of infants of the present invention, its active component is preferably prepared from by following technique:

(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 60% with the volume by volume concentration being equivalent to medical material gross weight 5 ~ 6 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights, decoct 20 ~ 40 minutes, and filter, filtrate and percolate merge, and are concentrated into 2 ~ 3 times of medical material gross weight, filter, and leave standstill 2 ~ 3 days, obtain solution A;

(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 92 ~ 100 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 70 ~ 80 times, merges distillate, obtains solution B;

(3) merge solution A and solution B, obtain inventive compound.

The Chinese medicine composition for the treatment of severe pneumonia of infants of the present invention, the injection of its active component is prepared from by following technique:

(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 80% with the volume by volume concentration being equivalent to medical material gross weight 4 ~ 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights again, decoct 10 ~ 60 minutes, filter, filtrate and percolate merge, regulate PH to 3 ~ 4 with dilute hydrochloric acid solution, leave standstill half an hour, elimination precipitate, PH to 6.5 ~ 7.5 are regulated again with sodium hydroxide solution, reclaim ethanol, be concentrated into 2 ~ 3 times of medical material gross weight, filter, leave standstill 3 ~ 10 days, obtain solution A;

(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 ~ 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 ~ 90 times, merges distillate, obtains solution B;

(3) merge solution A and solution B, add the surfactant of 0.5% ~ 1%, mix homogeneously, regulate PH to 8.5, filter, fill, sterilizing, to obtain final product.

The Chinese medicine composition of severe pneumonia of infants of the present invention, with pharmaceutically acceptable carrier combination, can make various preparation.

Chinese medicine composition of the present invention can make injection, treats in the mode of acupoint injection therapy, also can be prepared into various oral formulations or other dosage form use be applicable to.

Chinese medicine composition of the present invention has extraordinary effect for treatment severe pneumonia of infants, and have rapid-action, curative effect is good, and the feature such as have no side effect, and achieves important breakthrough relative to prior art, has outstanding substantive distinguishing features and significant progressive.

Embodiment 1

Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 800g Moschus 10g Herba Peristrophes 150g Herba Wedeliae Prostratae 150.

, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, being ground into coarse powder, is the ethanol percolate extraction of 50% with 4800g volume by volume concentration, to extract solution stores for subsequent use, medicinal residues add the water of 2400g again, decoct 10 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 2400g, filter, leave standstill 1 day, obtain solution A;

(2), get Moschus, pulverize, distillation twice, adds the water of 920g at every turn, and each collection 600g distillate, merges distillate, obtain solution B;

(3), merge solution A and solution B, obtain inventive compound.

Embodiment 2

Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1500g Moschus 50g Herba Peristrophes 300g Herba Wedeliae Prostratae 300g

(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 80% with 16800g volume by volume concentration, to extract solution stores for subsequent use, medicinal residues add the water of 6300g again, decoct 30 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 6300g, filter, leave standstill 2 days, obtain solution A;

(2), get Moschus, pulverize, distillation twice, adds the water of 6000g at every turn, and each collection 4500g distillate, merges distillate, obtain solution B;

(3), merge solution A and solution B, obtain inventive compound;

(4), merge solution A and solution B, add the Tween 80 of 0.5%, mix homogeneously, regulate PH to 8.5, filter, fill, sterilizing, obtains injection of the present invention.

Embodiment 3

Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1200g Moschus 40g Herba Peristrophes 250g Herba Wedeliae Prostratae 250g

(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 60% with 8500g volume by volume concentration, to extract solution stores for subsequent use, medicinal residues add the water of 5100g again, decoct 20 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 3400g, filter, leave standstill 3 days, obtain solution A;

(2), get Moschus, pulverize, distillation twice, adds the water of 4000g at every turn, and each collection 3600g distillate, merges distillate, obtain solution B;

(3), merge solution A and solution B, obtain inventive compound;

, active component is concentrated into suitable relative density after, mix with appropriate amount of starch and dextrin, granulate, dry, tabletting, obtains tablet of the present invention.

Embodiment 4

Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 900g Moschus 20g Herba Peristrophes 200g Herba Wedeliae Prostratae 200g

(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 60% with 7800g volume by volume concentration, to extract solution stores for subsequent use, medicinal residues add the water of 2600g again, decoct 20 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 3900g, filter, leave standstill 10 days, obtain solution A;

(2), get Moschus, pulverize, distillation twice, adds the water of 1200g at every turn, and each collection 1400g distillate, merges distillate, obtain solution B;

(3), merge solution A and solution B, obtain inventive compound;

(4), by active component mix with suitable amount of sucrose and antiseptic, add water to 10000g, obtain oral liquid of the present invention.

Embodiment 5

Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 950g Moschus 30g Herba Peristrophes 220g Herba Wedeliae Prostratae 220g

(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 70% with 8000g volume by volume concentration, to extract solution stores for subsequent use, medicinal residues add the water of 3000g again, decoct 20 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 4000g, filter, leave standstill 3 days, obtain solution A;

(2), get Moschus, pulverize, distillation twice, adds the water of 2760g at every turn, and each collection 2400g distillate, merges distillate, obtain solution B;

(3), merge solution A and solution B, obtain inventive compound;

(4), by active component to put in vacuum drying oven 70 DEG C and dry, pulverize 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, make granule, dry, incapsulate, obtain capsule of the present invention.

clinical efficacy

1, group standard is entered: heating, cough, rapid breathing, pulmonary hear rale, x-ray has lung marking to change.Severe pneumonia diagnosis merges 1. gastrointestinal symptom: loss of appetite, vomiting, abdominal distention etc.; 2. blood circulation: pale complexion, hear sounds low blunt, increased heart rate is unbecoming with body temperature, liver increase: 3. nervous system: dysphoria, drowsiness.

2, basic condition: 36 routine cases of selection are divided into observation group and matched group at random.Observation group is totally 18 examples, wherein male 10 example, women 8 example, 2 months ages ~ 4 month, average 1 years old 6 months, mild 8 example, serious symptom 10 example; Matched group 18 example, wherein male 11 example, women 7 example, 2 months ~ 4 years old age, average 1 years old 6 months, mild 9 example, serious symptom 9 example.Two groups of data comparing differences, without significance, have comparability.

3, Therapeutic Method:

Observation group: use the embodiment of the present invention 2 injection to be dissolved in the glucose intravenous drip of 5%, every day 1 time, and carry out suiting the medicine to the illness and Synthetic therapy, comprise infection, relieving asthma, cough-relieving, oxygen uptake etc.

Matched group: adopt and suit the medicine to the illness and above-mentioned composite treatment, two groups are 7 days was 1 course for the treatment of.

4, criterion of therapeutical effect: effective: cough with asthma, dyspnea, pale complexion disappear or obviously alleviate, pulmonary rale disappears or obviously reduces, and arrhythmia disappears or obviously alleviates; Effective: above-mentioned symptom takes a turn for the better or part takes a turn for the better: invalid: the rear state of an illness for the treatment of is unchanged or increase the weight of.

5, therapeutic outcome: in table 1.

Table 1 liang group comparitive study

	Effective	Effectively	Invalid	Total effective rate (%)
					Observation group	8	9	1	94.4
Matched group	5	10	3	83.3

Table 1 result shows: adopt medicine of the present invention to carry out severe pneumonia of infants therapeutic effect ideal, total effective rate reaches 94.4%.

model case

Zhang, female, 4 months.Rapid heating is frightened cautious, and cough with asthma is out of breath, and vomiting is tired makes a noise, and gradually know mist to god, emergency treatment is admitted to hospital.Fever of the body 40 DEG C, flaring of nares with dyspnea, the grey lip dark purple in face, convenient to both obstructed, soldier so faints from fear, and revolve and breathe more short, rale drags saw, gnathospasma, the wet sound of trembling of two fullness of the lung cloth.Have a blood test total white blood cells 48 × 109/L, and Chest X-rays two lung differs in size lamellar confusing shadows.The injection embodiment of the present invention 2 also carries out suiting the medicine to the illness and Synthetic therapy, comprises infection, relievings asthma, cough-relieving, after oxygen uptake etc., first day tonneau convenient to both, fever of the body gradually falls, and faints from fear flat, and dyspnea with rapid and short breath subtracts, continual cure, and secondary Phoebus is clear.Within 10 days, fully recover afterwards and leave hospital.

Lee, man, 2 months.With heating, cough with asthma 5 days.Complexion is greyish white, shortness of breath flaring of nares, opening mouth and lifting shoulder due to dyspnea, lethargy. and refuse newborn 4h, emergency treatment is so that " infant pneumonia merges heart failure.Respiratory failure " income is in hospital.Look into infant coma after being admitted to hospital, complexion is greyish white, lip and extremity bundle slightly cyanosis, and bregma is full, double eyeball chemosis, bilateral contracted pupil, and diameter is about 0.15cm, and light reflex disappears, and stiffness of the neck, has time-out during shortness of breath, and two lung auscultation respiratory murmur is low.Audible and tiny wet ring, heart rate 180 times/min, in gallop rhythm. and hear sounds is low blunt, 4cm under liver rib, and extremity muscular tension strengthens.Bilateral knee tendon hyperreflexia.Red tongue is dry, yellow fur, and fingerprint is purple dark, the sickly color of the superficial veins of index finger extending through the three passes toward the finger nail.Be diagnosed as after being admitted to hospital bronchopneumonia merge heart failure, exhale decline, cerebral edema.Rescue to the comprehensive platform measure such as dehydration, heart tonifying, diuresis, infection, oxygen uptake, and inject injection obtained by the embodiment of the present invention 2.Sb.'s illness took a favorable turn to rescue 2d, and l3d recovery from illness of being in hospital is left hospital.

What certain, man, 10 months.Heating, cough with asthma 3d, outpatient service is in hospital with " bronchopneumonia " income.Pneumonia conventional therapy is given after being admitted to hospital.But body temperature is kept at 39, " more than C, lasting 8d does not move back.Symptoms including cough, out of breath, breathe heavily suppress, flaring nares, three depressions sign is obvious, lip fingernail cyanosis, lethargy, frequent irritability, just thousand, yellowish urine, body of the tongue red drop, thready and rapid pulse.Obtained by the injection embodiment of the present invention 2, after injection l days, body temperature is down to 38 DEG C, and 2d body temperature is down to less than 37 DEG C, and all diseases alleviate.Front and back hospitalization 17d recovery from illness is left hospital.

Claims (7)

1. treat a Chinese medicine composition for severe pneumonia of infants, it is characterized in that being prepared from by the raw material of Chinese medicine of following weight portion: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 80 ~ 150 parts, 1 ~ 5 part, Moschus, Herba Peristrophes 15 ~ 30 parts, Herba Wedeliae Prostratae 15 ~ 30 parts.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that being prepared from by the raw material of Chinese medicine of following weight portion: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 90 ~ 120 parts, 2 ~ 4 parts, Moschus, Herba Peristrophes 20 ~ 25 parts, Herba Wedeliae Prostratae 20 ~ 25 parts.

3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that its active component adopts the ethanol extraction of 50-80% concentration expressed in percentage by volume to be prepared from.

4. Chinese medicine composition as claimed in claim 1, it is characterized in that, its active component is prepared from by following technique:

(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 80% with the volume by volume concentration being equivalent to medical material gross weight 4 ~ 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights, decoct 10 ~ 60 minutes, and filter, filtrate and percolate merge, and are concentrated into 2 ~ 3 times of medical material gross weight, filter, and leave standstill 1 ~ 10 day, obtain solution A;

(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 ~ 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 ~ 90 times, merges distillate, obtains solution B;

(3) merge solution A and solution B, obtain active component.

5. Chinese medicine composition as claimed in claim 4, it is characterized in that, its active component is prepared from by following technique:

(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 60% with the volume by volume concentration being equivalent to medical material gross weight 5 ~ 6 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights, decoct 20 ~ 40 minutes, and filter, filtrate and percolate merge, and are concentrated into 2 ~ 3 times of medical material gross weight, filter, and leave standstill 2 ~ 3 days, obtain solution A;

(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 92 ~ 100 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 70 ~ 80 times, merges distillate, obtains solution B;

(3) merge solution A and solution B, obtain active component.

6. Chinese medicine composition as claimed in claim 1, it is characterized in that, the injection of its active component is prepared from by following technique:

(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Herba Peristrophes, Herba Wedeliae Prostratae herb, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 80% with the volume by volume concentration being equivalent to medical material gross weight 4 ~ 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights again, decoct 10 ~ 60 minutes, filter, filtrate and percolate merge, regulate pH to 3 ~ 4 with dilute hydrochloric acid solution, leave standstill half an hour, elimination precipitate, pH to 6.5 ~ 7.5 are regulated again with sodium hydroxide solution, reclaim ethanol, be concentrated into 2 ~ 3 times of medical material gross weight, filter, leave standstill 3 ~ 10 days, obtain solution A;

(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 ~ 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 ~ 90 times, merges distillate, obtains solution B;

(3) merge solution A and solution B, add the surfactant of 0.5% ~ 1%, mix homogeneously, regulate pH to 8.5, filter, fill, sterilizing, to obtain final product.

7. treat a Chinese medicine composition for severe pneumonia of infants, Chinese medicine composition and the pharmaceutically acceptable carrier combination of the treatment severe pneumonia of infants any one of claim 1 or 2 are prepared from.