CN103675315B - Microwell plate application of sample and transporter - Google Patents
Microwell plate application of sample and transporter Download PDFInfo
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- CN103675315B CN103675315B CN201310706440.4A CN201310706440A CN103675315B CN 103675315 B CN103675315 B CN 103675315B CN 201310706440 A CN201310706440 A CN 201310706440A CN 103675315 B CN103675315 B CN 103675315B
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Abstract
The invention discloses a kind of microwell plate application of sample and transporter, comprise worktable, handgrip placement mechanism, micropore plate hand grab mechanism, three-axis moving mechanism and control system, wherein, handgrip placement mechanism is configured at the side of worktable, and micropore plate hand grab mechanism is provided with hanging structure and butt-joint fixing structure; Three-axis moving organization establishes is in the top of described worktable, this three-axis moving mechanism comprises X-axis motion, Y-axis motion and Z axis motion, Z axis motion is provided with a transfer arm, transfer arm is provided with in order to be added to the sample needle in microwell plate and the handgrip seat in order to install fixing described micropore plate hand grab mechanism after sampling from specimen holder.Present invention employs a set of three-axis moving mechanism and a set of micropore plate hand grab mechanism and achieve the function such as application of sample, microwell plate crawl, transfer in process of the test, relative to two cover three axle systems and a set of mechanical finger systems in prior art, its structure is more simple, greatly reduces production cost and controls difficulty.
Description
Technical field
The present invention relates to technical field of medical equipment, particularly relate to and a kind ofly apply microwell plate application of sample in ELISA Auto Analyze System, Chemiluminescence Apparatus and molecular diagnosis instrument and transporter.
Background technology
Microwell plate is an important component part in enzyme non-analysis meter, Chemiluminescence Apparatus and molecular diagnosis instrument, is mainly used in carrying out application of sample, dilution, incubation and enzyme to sample and exempts from chemical test and the detections such as reaction.
In above-mentioned chemical test and testing process, need to be transferred to by the microwell plate being added with sample in enzyme non-analysis meter, Chemiluminescence Apparatus and/or molecular diagnosis instrument and carry out detection analysis, therefore, this process just relates to the transhipment of microwell plate.In the prior art, the transhipment of microwell plate generally adopts man-handling of materials or mechanical arm transhipment, for man-handling of materials, needs manually on duty, inefficiency, and for mechanical arm transhipment, general a set of independently three axle systems and a set of mechanical finger system of needing; And in whole process of the test, application of sample operation also needs a set of independently three axle systems, therefore, existing in the industry situation to complete application of sample and transport function, then at least need two cover three axle systems and a set of mechanical finger system, simultaneously, need to configure multiple kinematic system and movement arm, also have multiple auto-induction apparatus, so, cause system architecture and Automated condtrol complexity, also cause production cost higher simultaneously.In addition, two cover three axle systems, easily occur the problems such as mechanical collision, the reagent after an impact in microwell plate and sample are easily scattered and cause cross pollution etc.
Summary of the invention
The object of the invention is to overcome deficiency of the prior art and a kind of microwell plate application of sample provided and transporter.
The present invention solves the technical scheme that prior art problem adopts: a kind of microwell plate application of sample and transporter, and it comprises worktable, handgrip placement mechanism, micropore plate hand grab mechanism, three-axis moving mechanism and control system, wherein,
Described worktable is placed with specimen holder and microwell plate, described handgrip placement mechanism is configured at the side of described worktable, and described micropore plate hand grab mechanism is provided with hanging structure and butt-joint fixing structure;
Described three-axis moving organization establishes is in the top of described worktable, and this three-axis moving mechanism comprises X-axis motion, Y-axis motion and Z axis motion; Described X-axis motion is arranged along the length direction of described worktable, and described Y-axis motion is arranged on X-axis motion, can move under the driving of described X-axis motion along X-direction; Described Z axis motion is arranged on described Y-axis motion, can move under the driving of described Y-axis motion along Y direction;
Described Z axis motion is provided with a transfer arm, and described transfer arm is provided with in order to be added to the sample needle in microwell plate and the handgrip seat in order to install fixing described micropore plate hand grab mechanism after sampling from specimen holder; Under the driving of described Z axis motion, described transfer arm can drive described sample needle and handgrip seat to move along Z-direction;
Described control system and described X-axis motion, Y-axis motion, Z axis motion are electrically connected, in order under application of sample duty, first controlling X-axis motion, Y-axis motion and Z axis motion drives described transfer arm micropore plate hand grab mechanism to be transferred to described handgrip placement mechanism position, and by hanging structure, this micropore plate hand grab mechanism is placed on described handgrip placement mechanism, controlling X-axis motion, Y-axis motion and Z axis motion again drives described transfer arm to move, and carries out application of sample operation by sample needle;
Under transhipment duty, first controlling X-axis motion, Y-axis motion and Z axis motion drives described transfer arm to move to described handgrip placement mechanism position, and to be mated with butt-joint fixing structure by handgrip seat described micropore plate hand grab mechanism is fixed on described transfer arm, controlling X-axis motion, Y-axis motion and Z axis motion again drives described transfer arm to move, and carries out microwell plate transhipment operation by micropore plate hand grab mechanism.
Below technique scheme is further elaborated:
Further, described micropore plate hand grab mechanism comprises link plate, and the both sides of described link plate lower end are respectively equipped with the upper arm that protrudes from described link plate front surface, and downward in each described upper arm convexly have the hook capturing microwell plate;
The upper end of described link plate is provided with described butt-joint fixing structure, described butt-joint fixing structure comprises one in order to this micropore plate hand grab mechanism to be mounted the hollow out hanging hole on described handgrip seat, and the first adsorption piece in order to adsorb mutually with described handgrip seat, the upper edge of described hollow out hanging hole is provided with semicircular indentations portion; The side of described hollow out hanging hole is installed with an optocoupler catch.
Further, in upper arm described in two, wherein a upper arm is provided with a described hook, another upper arm is provided with two described hooks, and these three hooks are isosceles triangle arrangement; The end of each described hook comprises a step, and described step is provided with location structure, and described location structure has the inversion conical surface.
Further, described handgrip seat comprises pedestal and optoelectronic switch, and described pedestal is provided with suspender member in order to plug with described hollow out hanging hole and the second adsorption piece in order to adsorb mutually with the first adsorption piece in micropore plate hand grab mechanism; Described optoelectronic switch is arranged on described pedestal, and when described handgrip mechanism is mounted on described handgrip seat, described optoelectronic switch is relative with the optocoupler catch in described handgrip mechanism.
Further, described pedestal comprises substrate and is convexly equipped in the flange of described substrate bottom; Described suspender member is convexly equipped in described substrate front surface, and described second adsorption piece is attached at the front surface of described substrate, and one end of described flange is provided with the mounting groove suitable with described optoelectronic switch, and described optoelectronic switch is installed in described mounting groove.
Further, described handgrip placement mechanism comprises support and vertically flat, and described support is fixedly installed in the side of described worktable, and described vertically flat is arranged at the side near worktable on described support, and described vertically flat is provided with buckling of protrusion.
Further, described hanging structure comprises and is arranged at both sides, described link plate upper end, can buckle the mouth hanging mounted mutually with described.
Further, the rear side of described worktable is provided with a fixed mount, and described X-axis motion is arranged on described fixed mount;
Described X-axis motion comprise X direction guiding rail, X to screw mandrel, X-axis nut and drive described X to rotate to screw mandrel X to drive motor, described X direction guiding rail is fixedly installed in the bottom of fixed mount, described X is connected to drive motor to screw mandrel with described X, and described X is connected to wire rod thread to nut with X.
Further, the Y-direction drive motor that described Y-axis motion comprises Y-direction guide rail, Y-direction screw mandrel, Y-axis nut and drives described Y-direction screw mandrel to rotate, one end of described Y-direction guide rail is connected to described X direction guiding rail slidably by one first slide block, described first slide block is fixedly connected with to nut with described X, the other end is free end, described Y-direction screw mandrel is connected with described Y-direction drive motor, and described Y-direction nut is connected with Y-direction wire rod thread.
Further, the Z-direction drive motor that described Z axis motion comprises Z-direction guide rail, Z-direction screw mandrel, Z axis nut and drives described Z-direction screw mandrel to rotate, the lower end of described Z-direction guide rail is slidably connected to Y-direction guide rail by one second slide block, described second slide block is fixedly connected with described Y-direction nut, described Z-direction screw mandrel is connected with described Z-direction drive motor, described Z-direction nut is connected with Z-direction wire rod thread, and described transfer arm is fixedly connected with described Z-direction nut.
The invention has the beneficial effects as follows: one, microwell plate application of sample provided by the invention and transporter, have employed a set of three-axis moving mechanism and a set of micropore plate hand grab mechanism and achieve the function such as application of sample, microwell plate crawl, transfer in process of the test, relative to two cover three axle systems and a set of mechanical finger systems in prior art, its structure is more simple, greatly reduces production cost and controls difficulty.Concrete, under application of sample duty, first controlling X-axis motion, Y-axis motion and Z axis motion drives described transfer arm micropore plate hand grab mechanism to be transferred to described handgrip placement mechanism position, and by hanging structure, this micropore plate hand grab mechanism is placed on described handgrip placement mechanism, controlling X-axis motion, Y-axis motion and Z axis motion again drives described transfer arm to move, and carries out application of sample operation by sample needle; Under transhipment duty, first controlling X-axis motion, Y-axis motion and Z axis motion drives described transfer arm to move to described handgrip placement mechanism position, and to be mated with butt-joint fixing structure by handgrip seat described micropore plate hand grab mechanism is fixed on described transfer arm, controlling X-axis motion, Y-axis motion and Z axis motion again drives described transfer arm to move, and carries out transhipment operation after capturing microwell plate by micropore plate hand grab mechanism.They are two years old, micropore plate hand grab mechanism adopts said structure design, be convenient to the handgrip seat mounted on transfer arm, the optocoupler catch that it is arranged is relative with the optoelectronic switch on handgrip seat, when collide process time, optocoupler catch generation certain deviation, now, optoelectronic switch on handgrip seat can go to on-state by off-state, send signal immediately, control system is shut down, transfer arm stops action, stop collision, available protecting micropore plate hand grab mechanism, mechanical collision is avoided to damage, simultaneously, can also effectively avoid rotating the generation that in collision, microwell plate drops, and reagent and sample are scattered problems such as causing cross pollution in the microwell plate caused.They are three years old, adopt the automatic transhipment of micropore plate hand grab mechanism realization to microwell plate, the hook with the location structure being inverted the conical surface is utilized to realize the location with microwell plate, not only registration, and the guiding mechanism that make use of circular arc realizes linking up with and the coordinating of microwell plate, larger to the tolerance of handgrip mechanism, after hook and microwell plate carry out preliminary contraposition, the location structure of circular arc can coordinate with the corresponding site on microwell plate automatically, realize locating fast and accurately of microwell plate, thus the transport efficacy accelerated microwell plate, also improve enzyme non-analysis meter, the checkability of Chemiluminescence Apparatus and molecular diagnosis instrument.
Accompanying drawing explanation
Fig. 1 is the structural representation one under application of sample duty of the present invention;
Fig. 2 is the structural representation two under application of sample duty of the present invention;
Fig. 3 is the partial enlarged drawing at A place in Fig. 2;
Fig. 4 is the structural representation one under the present invention transports duty;
Fig. 5 is the partial enlarged drawing at B place in Fig. 4;
Fig. 6 is the structural representation two under the present invention transports duty;
Fig. 7 is the system architecture schematic diagram being configured with testing equipment in apparatus of the present invention side;
Fig. 8 is the structural representation of micropore plate hand grab mechanism in the present invention;
Fig. 9 is the structural representation of handgrip seat in the present invention;
Figure 10 is the structural representation that in the present invention, micropore plate hand grab mechanism is connected with handgrip seat;
In figure: worktable 10; Microwell plate 101; Specimen holder 102,102 '; Handgrip placement mechanism 20; Support 201; Vertically flat 202; Raised line 203; Recess 204; Keeper 205; Locating slot 206; Micropore plate hand grab mechanism 30; Link plate 310; Hollow out hanging hole 3101; Semicircular indentations portion 3102; Mouth hanging 3103; Upper arm 320; Hook 330; Step 3301; Location structure 3302; First adsorption piece 340; Back up pad 350; Optocoupler catch 360; Card 370; X-axis motion 40; Y-axis motion 50; Z axis motion 60; Fixed mount 70; Testing equipment 80; Handgrip seat 90; Substrate 911; Flange 912; Suspender member 913; Second adsorption piece 914; Mounting groove 915; Optoelectronic switch 916; Sample needle 100; Sheet frame 110.
The realization of the object of the invention, functional characteristics and advantage will in conjunction with the embodiments, are described further with reference to accompanying drawing.
Embodiment
Describe technical scheme of the present invention in detail below with reference to drawings and the specific embodiments, so as clearer, understand invention essence of the present invention intuitively.
As shown in Figures 1 to 7, the invention provides a kind of microwell plate application of sample and transporter, it comprises worktable 10, handgrip placement mechanism 20, micropore plate hand grab mechanism 30, three-axis moving mechanism and control system, wherein, worktable 10 is placed with specimen holder 102, 102 ' and microwell plate 101, specimen holder 102, the solution of various sample or other tests is housed in 102 ', microwell plate 101 has multiple hole, by sample needle 100 by specimen holder 102, the solution of the sample in 102 ' and/or other tests is added in the hole on microwell plate 101, again microwell plate 101 is transferred to testing equipment 80(enzyme non-analysis meter, Chemiluminescence Apparatus and/or molecular diagnosis instrument) in carry out detection analyze.
Handgrip placement mechanism 20 is configured at the side of described worktable 10, for placing micropore plate hand grab mechanism 30, and micropore plate hand grab mechanism 30 is provided with hanging structure and butt-joint fixing structure, hanging structure is used for coordinating with handgrip placement mechanism 20, so that be hung on handgrip placement mechanism 20 by micropore plate hand grab mechanism 30, butt-joint fixing structure is then for being fixed on three-axis moving mechanism by micropore plate hand grab mechanism 30.
Three-axis moving organization establishes is in the top of described worktable 10, and this three-axis moving mechanism comprises X-axis motion 40, Y-axis motion 50 and Z axis motion 60; X-axis motion 40 is arranged along the length direction of described worktable 10, and Y-axis motion 50 is arranged on X-axis motion 40, can move under the driving of described X-axis motion 40 along X-direction; Z axis motion 60 is arranged on described Y-axis motion 50, can move under the driving of described Y-axis motion 50 along Y direction; Simultaneously, Z axis motion 60 is provided with a transfer arm, transfer arm is provided with in order to be added to the sample needle 100 in microwell plate 101 and the handgrip seat 90 in order to install fixing described micropore plate hand grab mechanism 30 after sampling from specimen holder 102,102 ', handgrip seat 90 can dock with the butt-joint fixing structure in micropore plate hand grab mechanism 30, can be fixed on transfer arm to make micropore plate hand grab mechanism 30, under the driving of described Z axis motion 60, described transfer arm can drive described sample needle 100 and handgrip seat 90 to move along Z-direction.
In the present embodiment, the rear side of worktable 10 is provided with a fixed mount 70, and X-axis motion 40 is arranged on described fixed mount 70; X-axis motion 40 comprise X direction guiding rail, X to screw mandrel, X-axis nut and drive described X to rotate to screw mandrel X to drive motor, described X direction guiding rail is fixedly installed in the bottom of fixed mount 70, described X is connected to drive motor to screw mandrel with described X, and described X is connected to wire rod thread to nut with X.The Y-direction drive motor that Y-axis motion 50 comprises Y-direction guide rail, Y-direction screw mandrel, Y-axis nut and drives described Y-direction screw mandrel to rotate, one end of described Y-direction guide rail is connected to described X direction guiding rail slidably by one first slide block, described first slide block is fixedly connected with to nut with described X, the other end is free end, described Y-direction screw mandrel is connected with described Y-direction drive motor, and described Y-direction nut is connected with Y-direction wire rod thread.The Z-direction drive motor that Z axis motion 60 comprises Z-direction guide rail, Z-direction screw mandrel, Z axis nut and drives described Z-direction screw mandrel to rotate, the lower end of described Z-direction guide rail is slidably connected to Y-direction guide rail by one second slide block, described second slide block is fixedly connected with described Y-direction nut, described Z-direction screw mandrel is connected with described Z-direction drive motor, described Z-direction nut is connected with Z-direction wire rod thread, and described transfer arm is fixedly connected with described Z-direction nut.
Control system and described X-axis motion 40, Y-axis motion 50, Z axis motion 60 are electrically connected, under control of the control system, X-axis motion 40, Y-axis motion 50 and Z axis motion 60 can drive transfer arm free movement on X, Y, Z tri-directions.When application of sample, need by sample needle 100 application of sample, and sample needle 100 is mounted on transfer arm, therefore, micropore plate hand grab mechanism 30 during application of sample on transfer arm should be transferred on handgrip placement mechanism 20 and lie over, and when the microwell plate 101 after application of sample completes is transported, needs to capture microwell plate 101 by micropore plate hand grab mechanism 30, therefore, during transhipment, transfer arm needs again to load onto micropore plate hand grab mechanism 30.
By this, under application of sample duty, control system first controls X-axis motion 40, Y-axis motion 50 and Z axis motion 60 and drives described transfer arm micropore plate hand grab mechanism 30 to be transferred to described handgrip placement mechanism 20 position, and by hanging structure, this micropore plate hand grab mechanism 30 is placed on described handgrip placement mechanism 20, controlling X-axis motion 40, Y-axis motion 50 and Z axis motion 60 again drives described transfer arm to move, and carries out application of sample operation by sample needle 100; Under transhipment duty, control system first controls X-axis motion 40, Y-axis motion 50 and Z axis motion 60 and drives described transfer arm to move to described handgrip placement mechanism 20 position, and dock to mate with butt-joint fixing structure by handgrip seat 90 described micropore plate hand grab mechanism 30 is fixed on described transfer arm, controlling X-axis motion 40, Y-axis motion 50 and Z axis motion 60 again drives described transfer arm to move, and carries out microwell plate 101 transport operation by micropore plate hand grab mechanism 30.
With reference to shown in Fig. 8 and Figure 10, in the present embodiment, micropore plate hand grab mechanism 30 comprises link plate 310, the both sides of described link plate 310 lower end are respectively equipped with the upper arm 320 that protrudes from described link plate 310 front surface, and downward in each described upper arm 320 convexly have the hook 330 capturing microwell plate 101; The upper end of link plate 310 is provided with above-mentioned butt-joint fixing structure, this butt-joint fixing structure comprises a hollow out hanging hole 3101 in order to this micropore plate hand grab mechanism 30 to be mounted on handgrip seat 90, and the first adsorption piece 340 in order to adsorb with handgrip seat 90 phase, the upper edge of hollow out hanging hole 3101 is provided with semicircular indentations portion 3102, this semicircular indentations portion 3102 for coordinating with the corresponding suspension member on handgrip seat 90, to realize mounting of micropore plate hand grab mechanism and handgrip seat 90; The side of hollow out hanging hole 3101 is installed with one in order to block the optocoupler catch 360 of optoelectronic switch 916 on described handgrip seat 90.
Because microwell plate 101 is standard component, so, generally microwell plate 101 is placed on a sheet frame 110, then captures sheet frame 110 by the hook 330 of micropore plate hand grab mechanism 30, to realize the crawl of microwell plate 101.In the present embodiment, in upper arm 320 described in two, wherein a upper arm 320 is provided with a described hook 330, another upper arm 320 is provided with two described hooks 330, and these three hooks 330 are isosceles triangle arrangement, so, when capturing sheet frame 110 and microwell plate 101, more solid and reliable.In addition, the end of each described hook 330 comprises a step 3301, described step 3301 is provided with location structure 3302, location structure 3302 has the inversion conical surface, this structural design, the hook 330 with the location structure 3302 being inverted the conical surface is utilized to realize the location with microwell plate 101, not only registration, and the guiding mechanism that make use of circular arc realizes coordinating of hook 330 and microwell plate 101, larger to the tolerance of micropore plate hand grab mechanism 30, after hook 330 and microwell plate 101 carry out preliminary contraposition, the location structure 3302 of circular arc can coordinate with the corresponding site on sheet frame 110 automatically, realize locating fast and accurately of microwell plate 101, thus the transport efficacy accelerated microwell plate 101, also improve enzyme non-analysis meter, the checkability of Chemiluminescence Apparatus and molecular diagnosis instrument.
As preferably, semicircular indentations portion 3102 is two, and described in two, semicircular indentations portion 3102 is symmetricly set in link plate 310, and so, this micropore plate hand grab mechanism 30 is more firm when mounting with handgrip seat 90; First adsorption piece 340 can adopt magnet or metalwork, and as preferably, the first adsorption piece 340 is three, and three described adsorption pieces are triangular in shape is distributed in described hollow out hanging hole 3101 around, and micropore plate hand grab mechanism can be made to be close to handgrip seat 90.For strengthening rigidity, preventing from affecting the quick effective location to microwell plate 101 because of distortion, between two described upper arms 320, being provided with the back up pad 350 for strengthening rigidity.
Corresponding, with reference to shown in Fig. 9 and Figure 10, handgrip seat 90 comprises pedestal and optoelectronic switch 916, described pedestal is provided with suspender member 913 in order to plug with described hollow out hanging hole 3101 and the second adsorption piece 914 in order to adsorb with the first adsorption piece 340 phase in micropore plate hand grab mechanism 30, and this second adsorption piece 914 can adopt magnet or metalwork; Described optoelectronic switch 916 is arranged on described pedestal, and when micropore plate hand grab mechanism 30 is mounted on described handgrip seat 90, described optoelectronic switch 916 is relative with the optocoupler catch 360 in described handgrip mechanism, is in off-state to make optoelectronic switch 916.
Concrete, the pedestal in this handgrip seat 90 comprises substrate 911 and is convexly equipped in the flange 912 of described substrate 911 bottom; Described suspender member 913 is convexly equipped in described substrate 911 front surface, described second adsorption piece 914 is attached at the front surface of described substrate 911, one end of described flange 912 is provided with the mounting groove 915 suitable with described optoelectronic switch 916, and described optoelectronic switch 916 is installed in described mounting groove 915.So, structure can be made more simply compact on the one hand, on the other hand, because optoelectronic switch 916 is hidden in mounting groove 915, can avoid in use procedure, especially collide in process, avoid damaging this optoelectronic switch 916.
When micropore plate hand grab mechanism 30 collides in the process of transporting microwell plate 101, the acting force that micropore plate hand grab mechanism 30 is collided, be moved, optocoupler catch 360 and optoelectronic switch 916 are misplaced, now optoelectronic switch 916 transfers on-state to by off-state, send signal immediately, control system is shut down, micropore plate hand grab mechanism stops action, stop collision, the mechanical collision of available protecting micropore plate hand grab mechanism damages, simultaneously, can also effectively avoid rotating the generation that in collision, microwell plate 101 drops, and reagent and sample are scattered problems such as causing cross pollution in the microwell plate 101 caused.
Handgrip placement mechanism 20 comprises support 201 and vertically flat 202, support 201 is fixedly installed in the side of described worktable 10, described vertically flat 202 is arranged at the side near worktable 10 on described support 201, described vertically flat 202 is provided with buckling of protrusion, preferably, buckle is two, two raised lines 203 buckled as protruding from vertically flat 202 surface, raised line 203 is provided with for fixing recess 204, two buckle the keeper 205 that top is provided with a protrusion, locating slot 206 on keeper 205.Corresponding, the hanging structure in micropore plate hand grab mechanism 30 comprises and is arranged at both sides, described link plate 310 upper end, and can buckle with described the mouth hanging 3103 mounted mutually, the top of link plate 310 is provided with card 370.When three-axis moving mechanism drives transfer arm (now it being fixed with micropore plate hand grab mechanism 30) to move to handgrip placement mechanism 20 position, mouth hanging 3103 in micropore plate hand grab mechanism 30 just hangs in the recess 204 that handgrip placement mechanism 20 buckles, the card 370 on link plate 310 top then just snaps in the locating slot 206 on described keeper 205, so, achieve between micropore plate hand grab mechanism 30 and handgrip placement mechanism 20 mount fixing.
In sum, microwell plate application of sample provided by the invention and transporter, have employed the functions such as a set of three-axis moving mechanism and a set of micropore plate hand grab mechanism 30 achieve application of sample in process of the test, microwell plate 101 captures, transfer, relative to two cover three axle systems and a set of mechanical finger systems in prior art, its structure is more simple, greatly reduces production cost and controls difficulty.
In the concrete course of work, first carry out application of sample work, namely by sample needle 100, the sample in specimen holder 102,102 ' and other testing liquids are added in the hole of microwell plate 101, then microwell plate 101 are transported to the testing equipment 80(enzyme non-analysis meter of handgrip placement mechanism 20 side, Chemiluminescence Apparatus and/or molecular diagnosis instrument) in carry out detection and analyze.Concrete, in application of sample process, control system first controls X-axis motion 40, Y-axis motion 50 and Z axis motion 60 and drives described transfer arm micropore plate hand grab mechanism 30 to be transferred to described handgrip placement mechanism 20 position, mouth hanging 3103 in micropore plate hand grab mechanism 30 just hangs in the recess 204 that handgrip placement mechanism 20 buckles, the card 370 on link plate 310 top then just snaps in the locating slot 206 on described keeper 205, so, micropore plate hand grab mechanism 30 is temporarily mounted on handgrip placement mechanism 20, controlling X-axis motion 40, Y-axis motion 50 and Z axis motion 60 again drives described transfer arm to move, and is added in the hole of microwell plate 101, completes application of sample operation by sample needle 100 from specimen holder 102,102 ' after being sampled, in transport process, after application of sample completes, control system first controls X-axis motion 40, Y-axis motion 50 and Z axis motion 60 drive described transfer arm to move to described handgrip placement mechanism 20 position, suspender member 913 on handgrip seat 90 is inserted in the semicircular indentations portion 3102 on link plate 310, first adsorption piece 340 adsorbs with the second adsorption piece 914 phase, so, described micropore plate hand grab mechanism 30 is fixed on described transfer arm, control X-axis motion 40 again, Y-axis motion 50 and Z axis motion 60 drive described transfer arm to move, transfer arm drives the hook 330 for micropore plate hand grab mechanism 30 lower end to move downward, step 3301 on hook 330 and location structure 3302 are interlocked with the catching groove of sheet frame 110 both sides, to complete the crawl of microwell plate 101, after capturing microwell plate 101, control transfer arm microwell plate 101 is moved in side testing equipment 80 to carry out detection and analyze.
The foregoing is only the preferred embodiments of the present invention; not thereby the scope of the claims of the present invention is limited; every utilize instructions of the present invention and accompanying drawing content to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (9)
1. microwell plate application of sample and a transporter, is characterized in that: it comprises worktable, handgrip placement mechanism, micropore plate hand grab mechanism, three-axis moving mechanism and control system, wherein,
Described worktable is placed with specimen holder and microwell plate, described handgrip placement mechanism is configured at the side of described worktable, and described micropore plate hand grab mechanism is provided with hanging structure and butt-joint fixing structure;
Described three-axis moving organization establishes is in the top of described worktable, and this three-axis moving mechanism comprises X-axis motion, Y-axis motion and Z axis motion; Described X-axis motion is arranged along the length direction of described worktable, and described Y-axis motion is arranged on X-axis motion, can move under the driving of described X-axis motion along X-direction; Described Z axis motion is arranged on described Y-axis motion, can move under the driving of described Y-axis motion along Y direction;
Described Z axis motion is provided with a transfer arm, and described transfer arm is provided with in order to be added to the sample needle in microwell plate and the handgrip seat in order to install fixing described micropore plate hand grab mechanism after sampling from specimen holder; Under the driving of described Z axis motion, described transfer arm can drive described sample needle and handgrip seat to move along Z-direction;
Described control system and described X-axis motion, Y-axis motion, Z axis motion are electrically connected, in order under application of sample duty, first controlling X-axis motion, Y-axis motion and Z axis motion drives described transfer arm micropore plate hand grab mechanism to be transferred to described handgrip placement mechanism position, and by hanging structure, this micropore plate hand grab mechanism is placed on described handgrip placement mechanism, controlling X-axis motion, Y-axis motion and Z axis motion again drives described transfer arm to move, and carries out application of sample operation by sample needle;
Under transhipment duty, first controlling X-axis motion, Y-axis motion and Z axis motion drives described transfer arm to move to described handgrip placement mechanism position, and to be mated with butt-joint fixing structure by handgrip seat described micropore plate hand grab mechanism is fixed on described transfer arm, controlling X-axis motion, Y-axis motion and Z axis motion again drives described transfer arm to move, and carries out microwell plate transhipment operation by micropore plate hand grab mechanism;
Described micropore plate hand grab mechanism comprises link plate, and the both sides of described link plate lower end are respectively equipped with the upper arm that protrudes from described link plate front surface, and downward in each described upper arm convexly have the hook capturing microwell plate; The upper end of described link plate is provided with described butt-joint fixing structure, described butt-joint fixing structure comprises one in order to this micropore plate hand grab mechanism to be mounted the hollow out hanging hole on described handgrip seat, and the first adsorption piece in order to adsorb mutually with described handgrip seat, the upper edge of described hollow out hanging hole is provided with semicircular indentations portion; The side of described hollow out hanging hole is installed with an optocoupler catch.
2. microwell plate application of sample and transporter according to claim 1, is characterized in that: in upper arm described in two, wherein a upper arm is provided with a described hook, another upper arm is provided with two described hooks, and these three hooks arrange for isosceles triangle; The end of each described hook comprises a step, and described step is provided with location structure, and described location structure has the inversion conical surface.
3. microwell plate application of sample and transporter according to claim 1, it is characterized in that: described handgrip seat comprises pedestal and optoelectronic switch, described pedestal is provided with suspender member in order to plug with described hollow out hanging hole and the second adsorption piece in order to adsorb mutually with the first adsorption piece in micropore plate hand grab mechanism; Described optoelectronic switch is arranged on described pedestal, and when described handgrip mechanism is mounted on described handgrip seat, described optoelectronic switch is relative with the optocoupler catch in described handgrip mechanism.
4. microwell plate application of sample and transporter according to claim 3, is characterized in that: described pedestal comprises substrate and is convexly equipped in the flange of described substrate bottom; Described suspender member is convexly equipped in described substrate front surface, and described second adsorption piece is attached at the front surface of described substrate, and one end of described flange is provided with the mounting groove suitable with described optoelectronic switch, and described optoelectronic switch is installed in described mounting groove.
5. microwell plate application of sample and transporter according to claim 1, it is characterized in that: described handgrip placement mechanism comprises support and vertically flat, described support is fixedly installed in the side of described worktable, described vertically flat is arranged at the side near worktable on described support, and described vertically flat is provided with buckling of protrusion.
6. microwell plate application of sample and transporter according to claim 5, is characterized in that: described hanging structure comprises and is arranged at both sides, described link plate upper end, can buckle the mouth hanging mounted mutually with described.
7. microwell plate application of sample and transporter according to claim 1, it is characterized in that: the rear side of described worktable is provided with a fixed mount, described X-axis motion is arranged on described fixed mount;
Described X-axis motion comprise X direction guiding rail, X to screw mandrel, X-axis nut and drive described X to rotate to screw mandrel X to drive motor, described X direction guiding rail is fixedly installed in the bottom of fixed mount, described X is connected to drive motor to screw mandrel with described X, and described X is connected to wire rod thread to nut with X.
8. microwell plate application of sample and transporter according to claim 7, it is characterized in that: the Y-direction drive motor that described Y-axis motion comprises Y-direction guide rail, Y-direction screw mandrel, Y-axis nut and drives described Y-direction screw mandrel to rotate, one end of described Y-direction guide rail is connected to described X direction guiding rail slidably by one first slide block, described first slide block is fixedly connected with to nut with described X, the other end is free end, described Y-direction screw mandrel is connected with described Y-direction drive motor, and described Y-direction nut is connected with Y-direction wire rod thread.
9. microwell plate application of sample and transporter according to claim 8, it is characterized in that: the Z-direction drive motor that described Z axis motion comprises Z-direction guide rail, Z-direction screw mandrel, Z axis nut and drives described Z-direction screw mandrel to rotate, the lower end of described Z-direction guide rail is slidably connected to Y-direction guide rail by one second slide block, described second slide block is fixedly connected with described Y-direction nut, described Z-direction screw mandrel is connected with described Z-direction drive motor, described Z-direction nut is connected with Z-direction wire rod thread, and described transfer arm is fixedly connected with described Z-direction nut.
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| CN201310706440.4A CN103675315B (en) | 2013-12-20 | 2013-12-20 | Microwell plate application of sample and transporter |
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| CN201310706440.4A CN103675315B (en) | 2013-12-20 | 2013-12-20 | Microwell plate application of sample and transporter |
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| CN103675315B true CN103675315B (en) | 2015-12-16 |
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| CN104360089B (en) * | 2014-11-05 | 2016-04-20 | 合肥天一生物技术研究所 | A kind of automatic microcolumn gel card detector |
| CN104634984B (en) * | 2015-02-10 | 2016-06-22 | 中国科学院苏州生物医学工程技术研究所 | A kind of full-automatic fluorescence immunoassay system |
| KR101767336B1 (en) * | 2015-07-09 | 2017-08-10 | 사회복지법인 삼성생명공익재단 | The device for automatic cell culture and operating method thereof |
| CN106443040B (en) * | 2016-08-31 | 2018-02-13 | 江苏拜明生物技术有限公司 | Inter-plate liquid transfer device suitable for automatic immunoassay instrument |
| CN108295914A (en) * | 2017-01-11 | 2018-07-20 | 广州康昕瑞基因健康科技有限公司 | Liquid-transfering needle positioning device |
| CN107807249B (en) * | 2017-10-26 | 2024-05-24 | 迈克医疗电子有限公司 | Unlocking assembly, sample transferring device and control method thereof |
| CN108315243B (en) * | 2017-12-29 | 2021-08-17 | 广州市金圻睿生物科技有限责任公司 | Automatic sample adding system |
| CN110333117A (en) * | 2019-06-26 | 2019-10-15 | 万兆 | Cytological stains machine |
| CN110333119A (en) * | 2019-06-26 | 2019-10-15 | 万兆 | Lid-moving machine structure and cytological stains machine with it |
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