CN110333117A - Cytological stains machine - Google Patents
Cytological stains machine Download PDFInfo
- Publication number
- CN110333117A CN110333117A CN201910562233.3A CN201910562233A CN110333117A CN 110333117 A CN110333117 A CN 110333117A CN 201910562233 A CN201910562233 A CN 201910562233A CN 110333117 A CN110333117 A CN 110333117A
- Authority
- CN
- China
- Prior art keywords
- seat
- incubation
- glass slide
- heat
- manipulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002380 cytological effect Effects 0.000 title claims abstract description 40
- 239000011521 glass Substances 0.000 claims abstract description 82
- 238000011534 incubation Methods 0.000 claims abstract description 71
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 61
- 230000007246 mechanism Effects 0.000 claims abstract description 51
- 238000010438 heat treatment Methods 0.000 claims abstract description 23
- 238000009413 insulation Methods 0.000 claims abstract description 3
- 238000000889 atomisation Methods 0.000 claims description 84
- 239000007788 liquid Substances 0.000 claims description 47
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 37
- 238000005057 refrigeration Methods 0.000 claims description 29
- 239000004065 semiconductor Substances 0.000 claims description 18
- 238000009833 condensation Methods 0.000 claims description 17
- 230000005494 condensation Effects 0.000 claims description 17
- 238000001816 cooling Methods 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 239000002699 waste material Substances 0.000 claims description 7
- 230000004308 accommodation Effects 0.000 claims description 5
- 239000007769 metal material Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 2
- 238000004043 dyeing Methods 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 16
- 238000010186 staining Methods 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
- 238000010586 diagram Methods 0.000 description 8
- 239000011148 porous material Substances 0.000 description 7
- 230000010355 oscillation Effects 0.000 description 6
- 238000005192 partition Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000021170 buffet Nutrition 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000012128 staining reagent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of cytological stains machines, including reagent storage unit, incubation device, atomising device, the first manipulator and Multi-shaft movement mechanism, and reagent storage unit is to place reagent；Incubating device has one to incubate chamber, and the incubation chamber is suitable for accommodating glass slide, and carries out heating and thermal insulation to the glass slide；Atomising device is connected to the incubation chamber, to provide atomized drop to the incubation chamber, incubates intracavitary humidity to keep described；First manipulator includes the first driving mechanism that sample needle and driving sample needle move up and down, to be added to the reagent on the glass slide by the sample needle；Multi-shaft movement mechanism is connected with first manipulator, to drive first robot movement.The cytological stains machine provided according to embodiments of the present invention is, it can be achieved that automatic staining operates, and the consistency of operation is high, and dyeing effect is reliable and stable and consistency is good, also, dyeing efficiency is also higher.
Description
Technical field
The present invention relates to cell analysis technical field more particularly to a kind of cytological stains machines.
Background technique
Cell dyeing is to be dyed using staining reagent to cell, makes a kind of method of cell change color, purpose
It is preferably to observe and analyze cell pathology character, and then the diagnosing and treating of aided disease.In the related technology, cell contaminates
Color generally uses hand dyeing, and since the experience of operator is different, the consistency of operation can not ensure hand dyeing, cause to contaminate
Having differences property of color effect, in addition, dyeing effect is poor, low efficiency.
Summary of the invention
The present invention is directed to solve at least some of the technical problems in related technologies.For this purpose, of the invention
Purpose is to propose a kind of cytological stains machine.
To achieve the above object, cytological stains machine according to an embodiment of the present invention, comprising:
Reagent storage unit, to place reagent；
Device is incubated, the incubation device has one to incubate chamber, and the incubation chamber is suitable for accommodating glass slide, and to the load
Slide carries out heating and thermal insulation；
Atomising device, the atomising device are connected to the incubation chamber, to provide atomized drop to the incubation chamber, with
It keeps described and incubates intracavitary humidity；
First manipulator, first manipulator include the first driving machine that sample needle and driving sample needle move up and down
Structure, to be added to the reagent on the glass slide by the sample needle；
Multi-shaft movement mechanism, the Multi-shaft movement mechanism are connected with first manipulator, to drive first machine
Tool hands movement.
The cytological stains machine provided according to embodiments of the present invention, multiaxial motion, which is recorded a demerit, drives the first robot movement, benefit
The reagent in reagent storage unit is added on glass slide with the sample needle on the first manipulator, in this way, realizing automatic staining behaviour
Make, the consistency of operation is high, and dyeing effect is reliable and stable and consistency is good, also, dyeing efficiency is also higher.In addition, utilizing
It incubates device to keep the temperature the sample on glass slide, provides atomization dropping liquid using atomising device, atomized drop is passed into temperature
Educate it is intracavitary, on glass slide sample carry out moisturizing, so, it can be ensured that sample is in certain temperature and humidity environment,
The activity of sample is improved, and then reaches better dyeing effect.
In addition, cytological stains machine according to the above embodiment of the present invention can also have the following additional technical features:
According to one embodiment of present invention, the incubation device includes:
Seat is incubated, the incubation seat is suitable for heating glass slide；
Removable hood, the removable hood lid are located on the incubation seat, and limit incubation between the incubation seat
Chamber, the incubation chamber are suitable for accommodating the glass slide；
It is atomized interface, the atomising device is connected to by the atomization interface with the incubation chamber, to by the atomized liquid
Drop is passed through intracavitary to the incubation.
According to one embodiment of present invention, further includes:
Second manipulator, second manipulator are connected with the multiaxial motion manipulator, to by the removable hood
Lid sets to the incubation seat or opens the removable hood from the incubation seat and be transferred to predetermined position.
According to one embodiment of present invention, the incubation seat includes:
Pedestal, the top surface of the substrate are equipped with groove, the removable hood be covered on the top surface of the pedestal and with it is described
The incubation chamber is limited between pedestal, it is intracavitary that the groove is located at the incubation；
Heat-conducting plate, the heat-conducting plate are embedded in the groove, and are suitable for glass slide described in placing；
Heating member, the heating member are located at the bottom of the heat-conducting plate, to heat to the heat-conducting plate, to pass through
The heat-conducting plate conducts heat to the glass slide.
According to one embodiment of present invention, atomization runner is equipped in the pedestal, the top surface of the pedestal is equipped at least
One atomisation outlet communicated with the atomization runner, the bottom surface or side of the pedestal, which are equipped with, is atomized what runner communicated with described
Be atomized entrance, the atomization entrance and the atomization orifice, the atomisation outlet be located at the incubation it is intracavitary and with it is described
Chamber is incubated to communicate.
According to one embodiment of present invention, the incubation seat further includes locating rack, and the locating rack is equipped with multiple glass
Piece location hole, multiple slide location holes are successively spaced setting along the length direction of the locating rack；
The locating rack is detachably located on the heat-conducting plate, and the slide location hole is suitable for described thermally conductive to being placed on
The glass slide is positioned on plate.
According to one embodiment of present invention, first manipulator further includes fluid suction head, the second driving mechanism, scanner
And third driving mechanism；
The fluid suction head is connect with second driving mechanism, and under second driving mechanism driving along the vertical direction
Movement, to draw the waste liquid on the glass slide；
The scanner is connect with the third driving mechanism, and along upper and lower under the driving of the third driving mechanism
To movement, to be scanned to the information code on reagent storage unit and glass slide.
According to one embodiment of present invention, the removable hood is equipped with multiple extension stop members, the described second mechanical handbag
It includes:
Fixing seat, the fixing seat vertically extend to form bar shaped；
Handgrip is slided, the sliding handgrip includes linking arm, handgrip seat and multiple hook pawls, and the linking arm is along the vertical direction
Extend, for the upper end slidable connection of the linking arm to the fixing seat, the handgrip seat is located at the lower end of the linking arm, more
A hook pawl is located on the handgrip seat and corresponds with multiple extension stops, each hooks pawl suitable for it is corresponding
The extension stop hooks；
4th driving mechanism, the 4th driving mechanism set on the fixing seat and are connected with the linking arm, to
The linking arm is driven to slide up and down.
According to one embodiment of present invention, the reagent storage unit includes cold storage shelf, with for being loaded with the first examination
The reagent cup of agent inserts, and refrigerates to the reagent cup.
According to one embodiment of present invention, the cold storage shelf includes:
Shell, the shell have heat-barrier material to be made, and the shell is equipped with the accommodation groove of open upper end；
Seat is refrigerated, the refrigeration seat has metal material to be made, and the refrigeration seat is embedded in the accommodation groove, and described cold
It hides seat and is equipped with multiple refrigeration holes for reagent cup inserting；
Semi-conductor condensation piece, the semi-conductor condensation piece be located at it is described refrigeration seat bottom, to the refrigeration seat into
Row refrigeration；
Water-cooling head, the water-cooling head are bonded with the semi-conductor condensation piece, scattered to carry out to the semi-conductor condensation piece
Heat.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
The structure shown according to these attached drawings obtains other attached drawings.
Fig. 1 is the structural schematic diagram of cytological stains machine of the embodiment of the present invention；
Fig. 2 is the structure that device, atomising device and reagent storage unit are incubated in cytological stains machine of the embodiment of the present invention
Schematic diagram；
Fig. 3 is the structural schematic diagram that device is incubated in cytological stains machine of the embodiment of the present invention；
Fig. 4 is the exploded view that device is incubated in cytological stains machine of the embodiment of the present invention；
Fig. 5 is another exploded view that device is incubated in cytological stains machine of the embodiment of the present invention；
Fig. 6 is the structural schematic diagram that the pedestal of device is incubated in cytological stains machine of the embodiment of the present invention；
Fig. 7 is the exploded view that the pedestal of device is incubated in cytological stains machine of the embodiment of the present invention；
Fig. 8 is the bottom view that the pedestal of device is incubated in cytological stains machine of the embodiment of the present invention；
Fig. 9 is the exploded view that the oscillating table of device is incubated in cytological stains machine of the embodiment of the present invention；
Figure 10 is the structural schematic diagram of atomising device in cytological stains machine of the embodiment of the present invention；
Figure 11 is the cross-sectional view of atomising device in cytological stains machine of the embodiment of the present invention；
Figure 12 is the exploded view of atomising device in cytological stains machine of the embodiment of the present invention；
Figure 13 is the structural schematic diagram of the first manipulator in cytological stains machine of the embodiment of the present invention；
Figure 14 is the front view of the first manipulator in cytological stains machine of the embodiment of the present invention；
Figure 15 is the structural schematic diagram of the second manipulator in cytological stains machine of the embodiment of the present invention；
Figure 16 is the structural schematic diagram of cold storage shelf in cytological stains machine of the embodiment of the present invention；
Figure 17 is the exploded view of cold storage shelf in cytological stains machine of the embodiment of the present invention；
Figure 18 is the cross-sectional view of cold storage shelf in cytological stains machine of the embodiment of the present invention.
Appended drawing reference:
Reagent storage unit 100；
Universal kit 10；
Cold storage shelf 11；
Shell 111；
Refrigerate seat 112；
Refrigerate hole 1121；
Semi-conductor condensation piece 113；
Water-cooling head 114；
Top plate 115；
Via hole 1151；
Reagent cup 116；
Incubate device 200；
Incubate seat 20；
Pedestal 201；
Ontology 2011；
Groove H201；
Annular groove H202；
Locating slot H203；
Atomisation outlet H204；
It is atomized runner H206；
Bottom cover 2012；
It is atomized entrance H205；
Heat-conducting plate 202；
Boss 2021；
Heating member 203；
Locating rack 204；
Slide location hole 2041；
Positioning protrusion 2042；
Removable hood 21；
Hang stop member 211；
Week is along 212；
It is atomized interface 22；
Rocking platform 23；
Platform board 231；
Oscillation component 232；
Driving motor 2321；
Eccentric wheel 2322；
Universal driving shaft 2323；
Atomising device 300；
Liquid storage box 30；
Back box 301；
Partition 3011；
Cover 302；
Add water cavity P301；
Atomization chamber P302；
First intercommunicating pore H301；
Second intercommunicating pore H302；
Heating rod 31；
Atomizer 32；
Conducting element 33；
Fan 34；
Liquid level sensor 35；
Temperature sensor 36；
First manipulator 400；
Sample needle 40；
First driving mechanism 41；
Fluid suction head 42；
Second driving mechanism 43；
Scanner 44；
Third driving mechanism 45；
Multi-shaft movement mechanism 500；
Second manipulator 600；
Fixing seat 60；
Slide handgrip 61；
Linking arm 611；
Handgrip seat 612；
Hook pawl 613；
4th driving mechanism 62.
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific embodiment
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to is used to explain the present invention, and is not considered as limiting the invention, based on this
Embodiment in invention, every other reality obtained by those of ordinary skill in the art without making creative efforts
Example is applied, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise " " axial direction ", " circumferential direction ", " radial direction " be orientation based on the figure or
Positional relationship is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning must
There must be specific orientation, be constructed and operated in a specific orientation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more of the features.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can be machine
Tool connection, is also possible to be electrically connected；It can be directly connected, two members can also be can be indirectly connected through an intermediary
Connection inside part.For the ordinary skill in the art, above-mentioned term can be understood in this hair as the case may be
Concrete meaning in bright.
In the present invention unless specifically defined or limited otherwise, fisrt feature second feature "upper" or "lower"
It may include that the first and second features directly contact, also may include that the first and second features are not direct contacts but pass through it
Between other characterisation contact.Moreover, fisrt feature includes the first spy above the second feature " above ", " above " and " above "
Sign is right above second feature and oblique upper, or is merely representative of first feature horizontal height higher than second feature.Fisrt feature exists
Second feature " under ", " lower section " and " following " include that fisrt feature is directly below and diagonally below the second feature, or is merely representative of
First feature horizontal height is less than second feature.
The cytological stains machine of the present invention is described in detail embodiment with reference to the accompanying drawings.
Referring to figs. 1 to the cytological stains machine shown in Figure 18, provided according to embodiments of the present invention, including reagent storage unit
100, device 200, atomising device 300, the first manipulator 400 and Multi-shaft movement mechanism 500 are incubated.
Specifically, reagent storage unit 100 is to place reagent.
Incubating device 200 has one to incubate chamber, and the incubation chamber is suitable for accommodating glass slide, and adds to the glass slide
Heat heat preservation, that is to say, that glass slide is the sheet glass for placing color card, and glass slide, which can be placed in, incubates intracavitary, benefit
It is heated with 200 pairs of the device intracavitary glass slides of incubation are incubated, in this way, incubation can be played to the color card on glass slide
Effect.
Atomising device 300 is connected to the incubation chamber, to provide atomized drop to the incubation chamber, to keep the temperature
Educate intracavitary humidity.That is, atomising device 300 can atomize the liquid into form atomized liquid, and atomized liquid is passed through
It is intracavitary to incubating, so that incubating the certain humidity of intracavitary holding.
First manipulator 400 includes the first driving mechanism 41 that sample needle 40 and driving sample needle 40 move up and down, to
The reagent is added on the glass slide by the sample needle 40.It that is to say, under the driving of the first driving mechanism 41, add
Sample needle 40 can move along the vertical direction, which is used to the reagent in reagent storage unit 100 being added to glass slide
On, so that reagent is contacted with the color card on glass slide, to dye to color card.
Multi-shaft movement mechanism 500 is connected with first manipulator 400, to drive first manipulator 400 to move,
Such as the Multi-shaft movement mechanism 500 can be moved in X-axis, Y direction, the first manipulator 400 is connected to Multi-shaft movement mechanism 500
On, in this way, the first manipulator 400 can be driven to move along X-axis, Y-axis using Multi-shaft movement mechanism 500, and the first manipulator 400
On sample needle 40 can along the vertical direction (Z axis) move, sample needle 40 can be realized as a result, and moved along X-axis, Y-axis and Z axis.
The cytological stains machine provided according to embodiments of the present invention, multiaxial motion, which is recorded a demerit, drives the movement of the first manipulator 400,
The reagent in reagent storage unit 100 is added on glass slide using the sample needle 40 on the first manipulator 400, in this way, realizing
The consistency of automatic staining operation, operation is high, and dyeing effect is reliable and stable and consistency is good, also, dyeing efficiency is also higher.
In addition, keeping the temperature using device 200 is incubated to the sample on glass slide, atomization dropping liquid, atomization are provided using atomising device 300
Drop be passed into incubate it is intracavitary, on glass slide sample carry out moisturizing, so, it can be ensured that sample is in certain temperature
In humidity environment, the activity of sample is improved, and then reaches better dyeing effect.
It should be noted that cell when being dyed, is easy to be influenced by temperature and humidity, dyeing effect is in turn resulted in
Fruit is bad, influences the analysis of pathological trait.In the application, using incubate device 200 to glass slide and thereon color card into
Row heat preservation, and using atomising device 300 to incubate it is intracavitary be passed through atomized drop and color card to glass slide and thereon into
Row moisturizing in this way, color card can be made to be in suitable temperature and humidity environment, and then improves the work of sample
Property, reach better dyeing effect.
Referring to shown in Fig. 3 to Fig. 9, in some embodiments of the invention, incubating device 200 includes incubating seat 20, removable
Dynamic lid 21 and atomization interface 22, wherein incubate seat 20 and be suitable for heating glass slide；The lid of removable hood 21 is located at the incubation
On seat 20, and incubation chamber is limited between the incubation seat 20, the incubation chamber is suitable for accommodating the glass slide；It is atomized interface
22 are connected to the atomising device 300 with the incubation chamber, intracavitary to the incubation being passed through the atomized drop.
That is, the lid of removable hood 21 is located at and incubates on seat 20, and when the lid of removable hood 21 is located at and incubates on seat 20,
Above-mentioned incubation chamber is limited between removable hood 21 and incubation seat 20, it is intracavitary that glass slide is located at the incubation, in this way, incubating seat 20
When heating to glass slide, it is intracavitary that color card due to glass slide and thereon is in incubation, and incubating chamber is closed state,
So it is relatively stable to incubate intracavitary temperature, reaches and preferably incubate effect.Atomization interface 22 is connected to 300 He of atomising device
It incubates between device 200, the atomized drop that the atomization of atomising device 300 is formed is passed through by the atomization interface 22 to incubation device
200 incubation is intracavitary, so that incubating intracavitary holding predetermined moisture.
In the present embodiment, incubation chamber is limited jointly using removable hood 21 and incubation seat 20, can make dyeing course
Middle operation is more convenient, such as opens removable hood 21 from incubation seat 20 before dyeing, then glass slide is placed in incubation
On seat 20 and load color card, addition reagent etc., removable hood 21 is finally covered, atomized drop is passed through, and dyed
Cheng Hou opens removable hood 21, glass slide is taken out, easy to operate simple.
Referring to Figure 5, in one embodiment of the invention, seat 20 is incubated to include pedestal 201, heat-conducting plate 202 and add
Warmware 203, wherein the top surface of pedestal 201 is equipped with groove H201, and the removable hood 21 is covered on the top surface of the pedestal 201
And the incubation chamber is limited between the pedestal 201, it is intracavitary that the groove H201 is located at the incubation.
Heat-conducting plate 202 is embedded in the groove H201, and is suitable for glass slide described in placing.Preferably, on heat-conducting plate 202
Multiple glass slides can be spaced apart, the metal material which can be good using thermal conductivity, such as aluminum alloy material
Deng.
Heating member 203 is located at the bottom of the heat-conducting plate 202, to heat to the heat-conducting plate 202, to pass through
It states heat-conducting plate 202 and conducts heat to the glass slide.
That is, heating member 203 is located at the bottom of heat-conducting plate 202, it can be to heat-conducting plate 202 using the heating member 203
It is heated, preferably, heating member 203 can be Electric radiant Heating Film, and heat-conducting plate 202 is embedded the groove in the top surface of pedestal 201
In H201, glass slide can be placed on heat-conducting plate 202, in this way, the heat that heating member 203 generates can be conducted to heat-conducting plate
202, heat-conducting plate 202 is conducted heat to again on each glass slide.
It in the present embodiment, is carried out using heat-conducting plate 202 thermally conductive, can heat be uniformly distributed, and conducted to leading
On hot plate 202 on each glass slide, so that each glass slide is heated evenly.
Referring to shown in Fig. 3 to Fig. 5, in one embodiment of the invention, removable hood 21 has week along 212, pedestal 201
The annular groove H202 that is equipped with of top surface, be matched in annular groove H202 along 212 in week, in this way, using week along 212 and annular groove H202
Cooperation, realize positioning of the removable hood 21 on pedestal 201, the lid of removable hood 21 facilitated to close.
Advantageously, groove H201 is located inside annular groove H202, that is to say, annular groove H202 is looped around outside groove H201
It encloses, in this way, layout is more compact, and when the lid of removable hood 21 is set to the top surface of pedestal 201, heat-conducting plate 202 can be provide with,
So that heat-conducting plate 202 is intracavitary positioned at incubating, stablized with keeping incubating cavity temperature.
Referring to shown in Fig. 6 to Fig. 8, it is equipped with atomization runner H206, institute in one embodiment of the invention, in pedestal 201
The top surface for stating pedestal 201 is equipped at least one atomisation outlet H204 communicated with the atomization runner H206, the pedestal 201
Bottom surface or side are equipped with the atomization entrance H205, the atomization entrance H205 that communicate with the atomization runner H206 and the atomization
Interface 22 is connected to, and the atomisation outlet H204 is intracavitary positioned at the incubation and communicates with the incubation chamber.
That is, atomization interface 22, atomization entrance H205, atomization runner H206 and atomisation outlet H204 are sequentially communicated,
Atomization interface 22 is connected to atomising device 300, and atomisation outlet H204 is intracavitary positioned at incubation and communicates with chamber is incubated, in this way, mist
Makeup set the atomized drop that 300 are passed through can pass sequentially through atomization interface 22, atomization entrance H205, atomization runner H206 after, from
Atomisation outlet H204 spray into it is intracavitary to incubating so that atomized drop full of incubate chamber, and then using atomized drop keep incubate chamber
Interior humidity.
In the present embodiment, the setting atomization runner H206 in pedestal 201, then in the setting of the top surface of pedestal 201 and atomized flow
The atomisation outlet H204 that road H206 is communicated enters in the side of pedestal 201 or bottom surface setting with the atomization runner H206 atomization communicated
Mouth H205 is passed through atomized drop in this way, can be convenient to incubation is intracavitary, also, its structure is simple, it is ensured that aerosolizable outlet H204
It is connected to reliably with chamber is incubated.
More specifically, pedestal 201 includes ontology 2011 and bottom cover 2012, and the bottom surface of ontology 2011 is equipped with drop slot, bottom
Lid 2012 is fixed on the bottom surface of ontology 2011, and the 2012 sealing fluid drip trays of bottom cover by fastener, and then forms above-mentioned atomization
Runner H206, atomization entrance H205 are located on bottom cover 2012, and atomisation outlet H204 is located at the top surface of ontology 2011.In addition, annular
Slot H202, groove H201 are each provided at the top surface of ontology 2011.In this way, it is convenient to the machine-shaping of atomization runner H206, in addition, its
Structure is simple, easy to assembly.
Referring to shown in Fig. 4 to Fig. 5, in one embodiment of the invention, incubating seat 20 further includes locating rack 204, described
Locating rack 204 is equipped with multiple slide location holes 2041, length of multiple slide location holes 2041 along the locating rack 204
Direction is successively spaced setting.Locating rack 204 is detachably located on the heat-conducting plate 202, and the slide location hole 2041 is suitable for
It is positioned to the glass slide on the heat-conducting plate 202 is placed on.
That is, the shape and size of the slide location hole 2041 on locating rack 204 are adapted with glass slide, locating rack
204 can install to heat-conducting plate 202, can also remove from heat-conducting plate 202.When in the installation to heat-conducting plate 202 of locating rack 204
When, glass slide level can be put into slide location hole 2041, then glass slide is located in slide location hole 2041 and places
On heat-conducting plate 202, glass slide is positioned using glass slide, glass slide is heated using heat-conducting plate 202.
In specific dyeing course, first locating rack 204 can be installed to heat-conducting plate 202, then glass slide is put into fixed
Then slide location hole 2041 on the frame 204 of position carries out dying operation so that glass slide is placed on to heat-conducting plate 202.It is dyeing
After the completion, locating rack 204 can be removed from heat-conducting plate 202, then glass slide is taken out.
In the present embodiment, it may be implemented to determine the multiple glass slides placed on heat-conducting plate 202 using locating rack 204
Position, is convenient to the fixation of glass slide, it is ensured that each glass slide is sequentially arranged at intervals on heat-conducting plate 202, advantageous batch dyeing behaviour
Make, it is ensured that the order and reliability of batch dyeing.
Optionally, the top surface of pedestal 201 is set there are two locating slot H203, and two locating slot H203 are located at described
The two sides of groove H201；The both ends of the locating rack 204 are respectively provided with downwardly projecting positioning protrusion 2042, two positioning
Protrusion 2042 and two locating slot H203 are corresponded, and each positioning protrusion 2042 is matched with the accordingly positioning
In slot H203.
In the installation of locating rack 204, the positioning protrusion 2042 at 204 both ends of locating rack and two positioning on pedestal 201
Slot H203 is accurate, so that two positioning protrusion 2042 are located in two locating slot H203, in this way, utilizing two positioning protrusion
The cooperation of 2042 and two locating slot H203 are convenient to install locating rack 204 to 202 top of heat-conducting plate.In addition, having dyed
Cheng Hou is also convenient to remove locating rack 204 from heat-conducting plate 202, easy to use and operate.
More advantageously, the top surface of heat-conducting plate 202 has multiple boss 2021, and multiple boss 2021 are along described thermally conductive
The length direction interval of plate 202 is arranged, and multiple boss 2021 are corresponded with multiple slide location holes 2041, each
The boss 2021 is located at the lower section of the corresponding one slide location hole 2041 and is suitable for glass slide described in placing.Work as positioning
When frame 204 is mounted on heat-conducting plate 202, glass slide is put into the slide location hole 2041 on locating rack 204, then glass slide position
In on boss 2021, glass slide is conducted heat to using boss 2021, realizes and glass slide is heated.
In the present embodiment, by the way that boss 2021 is arranged, assemble heat using boss 2021, and conduct heat to load glass
Piece, so, it can be ensured that heat can concentrate conduction to each glass slide, and heating effect is more preferable.
Referring to shown in Fig. 3 to Fig. 5 and Fig. 9, in some embodiments of the invention, incubating device 200 further includes that oscillation is flat
Platform 23, the pedestal 201 are located on rocking platform 23, to drive the pedestal 201 by the rocking platform 23 to make a reservation for frequency
Rate oscillation.In this way, using rocking platform 23 drive pedestal 201 vibrate so that incubate 20 upper slide of seat on color card and by
The reagent on color card being added to can come into full contact with, and reach better dyeing effect.
More specifically, rocking platform 23 may include platform board 231 and multiple oscillation components 232, multiple oscillation components
232 are located at the lower section of the platform board 231, and each oscillation component 232 includes driving motor 2321, eccentric wheel 2322 and universal driving shaft
2323, eccentric wheel 2322 is connected to the output shaft of driving motor 2321, and one end of universal driving shaft 2323 is eccentrically set on eccentric wheel
On 2322, the other end of universal driving shaft 2323 is connected to platform board 231, in this way, passing through eccentric wheel when driving motor 2321 works
2322 driving universal driving shafts 2323 rotate, and then platform board 231 is driven to vibrate, and pedestal 201 is located on platform board 231, can be with flat
Platen 231 vibrates, and structure is simple, vibrates soft and reliable and stable.
0 to shown in Figure 12 referring to Fig.1, and in some embodiments of the invention, atomising device 300 includes liquid storage box 30, adds
Hot pin 31, atomizer 32, conducting element 33 and fan 34, liquid storage box 30 has plus water cavity P301 and atomization chamber P302, described plus water
Chamber P301 is arranged side by side and connects with described plus water cavity P301 to store liquid, the atomization chamber P302 and described plus water cavity P301
It is logical, to receive the liquid of described plus water cavity P301 outflow.That is, plus water cavity P301 for storing liquid, can Xiang Jiashui
Adding liquid in chamber P301, liquid generally can for water etc., in addition, atomization chamber P302 with add water cavity P301 be it is interconnected, add
Liquid in water cavity P301 can flow into atomization chamber P302.
Heating rod 31 is located in described plus water cavity P301, to heat to the liquid in described plus water cavity P301, that is to say, that
Add the heating member 203 in water cavity P301 can be to adding the liquid in water cavity P301 to heat, so that plus the liquid in water cavity P301
Body is heated to predetermined temperature, and atomization chamber P302 is connected to water cavity P301 is added, so, the liquid of heating can flow into atomization chamber
In P302, so that the liquid in atomization chamber P302 has certain temperature.
Atomizer 32 is located in the atomization chamber P302, is atomized the liquid in the atomization chamber P302 to form atomized liquid
Drop, the atomizer 32 are contacted with liquid in atomization chamber P302, are acted on by vibratory atomizer, can be made in atomization chamber P302
Liquid is atomized.Wherein, atomizer 32 can use ultrasonic ultrasonic delay line memory 32.
Conducting element 33 is connected to the atomization chamber P302, to guide the atomization drop outflow of the atomization chamber P302, water conservancy diversion
Part 33 is connect with atomization interface 22.Fan 34 is connected to the atomization chamber P302, to dry into the atomization chamber P302, so that
The atomization drop of atomization chamber P302 enters to the conducting element 33, and flows out to atomization by the conducting element 33 guidance and connect
Mouthfuls 22, and by be atomized interface 22 be passed through it is intracavitary to incubating.
That is, the air outlet of fan 34 is connected to atomization chamber P302, for drying into atomization chamber P302, it is blown into
Wind and atomized drop form air-flow in atomization chamber P302, and flow into conducting element 33, then (such as by the guidance of conducting element 33 outflow
In Figure 11 shown in arrow) it extremely incubates in the incubation chamber of device 200, and then heat and moisture preserving is carried out to chamber is incubated using atomized drop,
So that inside is maintained at certain temperature and humidity.
More specifically, liquid storage box 30 includes back box 301 and cover 302, and the open upper end of the back box 301 forms spacious
Mouthful, the cover 302 is connected to the upper end of the back box 301 by fastener, to close the opening.Fan 34 and conducting element
33 are located on cover 302, and structure is simple, easy to process, and assembly is simple.
The inner space of back box 301 is separated out by multiple partitions 3011 adds water cavity P301 and multiple atomization chamber P302, is adding
Partition 3011 between water cavity P301 and the atomization chamber P302 adjacent thereto is equipped with the first intercommunicating pore H301, passes through first
Through-hole communicates with each other the described plus water cavity P301 and atomization chamber P302 adjacent thereto, then plus the liquid in water cavity P301 is
Atomization chamber P302 adjacent thereto can be flowed by first intercommunicating pore H301.Between the atomization chamber P302 of adjacent two
Partition 3011 be equipped with the second intercommunicating pore H302, by the second intercommunicating pore H302 by two adjacent atomization chamber P302 that
This connection, then the liquid in an atomization chamber P302 can flow into another mist adjacent thereto by the second intercommunicating pore H302
Change in chamber P302, in this way, can to all have liquid in each atomization chamber P302, and is kept in each atomization chamber P302 opposite
Consistent liquid level.Add water cavity P301 and multiple atomization chamber P302 in addition, being formed using the isolation of partition 3011, structure letter
It is single, it is easy to process.
Advantageously, add in water cavity P301 and be equipped with to detect the liquid level sensor 35 of liquid level and to detect liquid temperature
The temperature sensor 36 of degree.In this way, using liquid level sensor 35 can detecte plus water cavity P301 in liquid level, in order to and
When supplement liquid or prevent liquid level excessively high, and then can detecte using temperature sensor 36 plus water cavity P301 in liquid temperature
Degree, and then ensure that the temperature of liquid maintains predetermined temperature.
3 to shown in Figure 14 referring to Fig.1, and in one embodiment of the invention, the first manipulator 400 further includes fluid suction head
42, the second driving mechanism 43, scanner 44 and third driving mechanism 45.
Wherein, fluid suction head 42 is connect with second driving mechanism 43, and drives lower edge in second driving mechanism 43
Up and down direction movement, to draw the waste liquid on the glass slide.
Scanner 44 is connect with the third driving mechanism 45, and under the driving of the third driving mechanism 45 vertically
Direction movement, to be scanned to the information code on reagent storage unit 100 and glass slide.
After the completion of dyeing, after removable hood 21 is opened, it is mechanical to can use the driving of Multi-shaft movement mechanism 500 first
Hand 400 moves, using the fluid suction head 42 on the first manipulator 400 by waste liquid (remaining reagent and other liquid on wave carrier piece
Deng) draw, then glass slide is taken out again, in this way, the absorption of waste liquid may be implemented, it is ensured that after the completion of dyeing on glass slide
Waste liquid be removed, in order to glass slide taking-up when waste liquid pollute the problems such as.
In addition, scanner 44 can scan information code on the reagent container in reagent storage unit 100 when adding reagent
(such as two dimensional code or bar code etc.) obtains the information of reagent in reagent container.Meanwhile scanner 44 scans the information on glass slide
Code, to obtain the information of the color card on glass slide, in this way, can be related to the information of reagent by the information of color card
Connection, in order to be associated record to dyeing relevant information.
It further include the second manipulator 600 in some embodiments of the invention referring to Fig.1 and shown in Figure 15, described second
Manipulator 600 is connected with the multiaxial motion manipulator, to set to the incubation seat 20 or incite somebody to action the removable hood 21 lid
The removable hood 21 is opened from the incubation seat 20 and is transferred to predetermined position.
That is, Multi-shaft movement mechanism 500 can drive the second manipulator 600 to move, it can using the second manipulator 600
It is set with shifting and covering by removable hood 21 to incubation seat 20, or removable hood 21 on seat 20 will be incubated and open and be transferred to pre-
Positioning is set, in this way, the automatic transfer of removable hood 21 may be implemented, improves dyeing efficiency.
Referring to Fig.1 shown in 5, in one embodiment of the invention, the removable hood 21 is equipped with multiple extension stop members
211, second manipulator 600 includes fixing seat 60, sliding handgrip 61 and the 4th driving mechanism 62, wherein 60 edge of fixing seat
Up and down direction extends to form bar shaped.The fixing seat 60 is fixed on Multi-shaft movement mechanism 500, can by Multi-shaft movement mechanism 500
To drive fixing seat 60 to move along X-axis and Y direction.
Sliding handgrip 61 includes linking arm 611, handgrip seat 612 and multiple hook pawls 613, and the linking arm 611 is vertically square
To extension, for the upper end slidable connection of the linking arm 611 to the fixing seat 60, the handgrip seat 612 is located at the connection
The lower end of arm 611, multiple hook pawls 613 are located on the handgrip seat 612 and correspond with multiple extension stops, each
The hook pawl 613 is suitable for hooking with the corresponding extension stop.
That is, linking arm 611 is slidably connected in fixing seat 60, handgrip seat 612 is located on linking arm 611, and more
A hook pawl 613 is located on handgrip seat 612, when (Z-direction) moves linking arm 611 along the vertical direction, handgrip seat 612 and hook pawl
613 move along the vertical direction together with linking arm 611, and work as fixing seat 60 under the driving of Multi-shaft movement mechanism 500 along X-axis, Y
When axis direction moves, then linking arm 611, handgrip seat 612 and hook pawl 613 are moved along X-axis, Y direction together with fixing seat 60, such as
This, can be realized and hook pawl 613 in X-axis, Y-axis and Z-direction free movement.It is adapted, uses with stop member 211 is hung in addition, hooking pawl 613
It is hooked in extension 211 phase of stop member, and then facilitates using the hook pawl 613 and hang the hook of stop member 211 and grab removable hood 21.
4th driving mechanism 62 is located in the fixing seat 60 and is connected with the linking arm 611, to drive the company
Arm 611 is connect to slide up and down.It that is to say, arm 611 can be drivingly connected using the 4th driving mechanism 62 and moved along Z-direction, in turn
It realizes and hooks the driving of pawl 613 in the Z-axis direction.
In the present embodiment, using above-mentioned second manipulator, 600 structure, cooperates with Multi-shaft movement mechanism 500, may be implemented to hook
For pawl 613 in X-axis, Y-axis and Z-direction free movement, structure is simple, also, grabs removable hood 21 using pawl 613 is hooked,
It grabs relatively reliable.
Advantageously, multiple hook pawls 613 are arranged in polygon, due to more on multiple hook pawls 613 and removable hood 21
A extension stop member 211 is one-to-one, so, multiple extension stop members 211 on removable hood 21 are also to arrange in polygon, such as
This, when multiple hook pawls 613 are hooked with multiple 211 phases of extension stop member, it can be ensured that the crawl of removable hood 21 is more steady reliable, and
Removable hood 21 is shifted and is covered and is set to when incubating on seat 20, removable hood 21 is also more preferable with the fitness for incubating seat 20, subtracts
The problems such as few lid coincidence sets inaccuracy.
6 to shown in Figure 18 referring to Fig.1, and in some embodiments of the invention, reagent storage unit 100 includes cold storage shelf
11, it is inserted with for the reagent cup 116 for being loaded with the first reagent, and the reagent cup 116 is refrigerated.
That is, on the one hand, can erect to place by reagent cup 116 using cold storage shelf 11 and fix, be convenient to the first machine
The sample needle 40 of tool hand 400 is added on glass slide after sampling in the reagent cup 116, and on the other hand, which can be with
Freeze to reagent cup 116, so that the first reagent in reagent cup 116 keeps lower temperature, and then reliably preservation the
One reagent.
It is understood that reagent storage unit 100 can also include universal kit 10, for containing the second reagent,
Universal kit 10 can be to be multiple, and multiple universal kits 10 are arranged successively.
In one embodiment of the invention, cold storage shelf 11 includes shell 111, refrigeration seat 112, semi-conductor condensation piece 113
And water-cooling head 114, shell 111 has heat-barrier material to be made, such as plastic cement material, and the shell 111 is equipped with the accommodating of open upper end
Slot；Refrigeration seat 112 has metal material to be made, such as aluminium or copper material, the refrigeration seat 112 are embedded in the accommodation groove, and
The refrigeration seat 112 is equipped with multiple refrigeration holes 1121 for the reagent cup 116 inserting；Semi-conductor condensation piece 113 is located at
The bottom of the refrigeration seat 112, to freeze to the refrigeration seat 112；Water-cooling head 114 and the semi-conductor condensation piece
113 fittings, to radiate to the semi-conductor condensation piece 113.
That is, refrigeration seat 112 is located in shell 111, reagent cup 116 can insert the refrigeration sky in refrigeration seat 112
Interior, the huyashi-chuuka (cold chinese-style noodles) of semi-conductor condensation piece 113 is sticked in the bottom of refrigeration seat 112, and water-cooling head 114 is sticked in semi-conductor condensation piece 113
Hot face, in this way, 113 pairs of refrigeration seats 112 of semi-conductor condensation piece freeze, so that the reagent cup 116 in buffet seat reaches cold
The purpose of hiding, in addition, water-cooling head 114 carries out heat exchange, the heat of semi-conductor condensation piece 113 to the hot face of semiconductor condensate film 113
The heat in face is conducted to water-cooling head 114, is absorbed by the recirculated water of water-cooling head 114, and then reach lasting refrigeration purpose, structure
Simply, cold storage effect is good.
Optionally, cold storage shelf 11 further includes top plate 115, the setting of top plate 115 above refrigeration seat 112, the use of top plate 115 every
Hot material, such as plastic cement material, top plate 115 is equipped with via hole 1151 corresponding with refrigeration hole 1121, in order to reagent cup 116
It is inserted into refrigeration hole 1121 by via hole 1151, seat 112 will be refrigerated by top plate 115 and be isolated with external environment, refrigeration is reduced
The cold energy loss of seat 112.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
The above description is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, all at this
Under the inventive concept of invention, using equivalent structure transformation made by description of the invention and accompanying drawing content, or directly/use indirectly
It is included in other related technical areas in scope of patent protection of the invention.
Claims (10)
1. a kind of cytological stains machine characterized by comprising
Reagent storage unit, to place reagent；
Device is incubated, the incubation device has one to incubate chamber, and the incubation chamber is suitable for accommodating glass slide, and to the glass slide
Carry out heating and thermal insulation；
Atomising device, the atomising device are connected to the incubation chamber, to provide atomized drop to the incubation chamber, to keep
It is described to incubate intracavitary humidity；
First manipulator, first manipulator include the first driving mechanism that sample needle and driving sample needle move up and down, and are used
The reagent to be added on the glass slide by the sample needle；
Multi-shaft movement mechanism, the Multi-shaft movement mechanism are connected with first manipulator, to drive first manipulator
Movement.
2. cytological stains machine according to claim 1, which is characterized in that the incubation device includes:
Seat is incubated, the incubation seat is suitable for heating glass slide；
Removable hood, the removable hood lid are located on the incubation seat, and limit incubation chamber, institute between the incubation seat
It states and incubates chamber suitable for accommodating the glass slide；
It is atomized interface, the atomising device is connected to by the atomization interface with the incubation chamber, to lead to the atomized drop
Enter intracavitary to the incubation.
3. cytological stains machine according to claim 1, which is characterized in that further include:
Second manipulator, second manipulator are connected with the multiaxial motion manipulator, to set the removable hood lid
The removable hood is opened to the incubation seat or from the incubation seat and is transferred to predetermined position.
4. cytological stains machine according to claim 2, which is characterized in that the incubation seat includes:
Pedestal, the top surface of the substrate are equipped with groove, the removable hood be covered on the top surface of the pedestal and with the pedestal
Between limit the incubation chamber, the groove be located at it is described incubate it is intracavitary；
Heat-conducting plate, the heat-conducting plate are embedded in the groove, and are suitable for glass slide described in placing；
Heating member, the heating member are located at the bottom of the heat-conducting plate, to heat to the heat-conducting plate, by described
Heat-conducting plate conducts heat to the glass slide.
5. cytological stains machine according to claim 4, which is characterized in that atomization runner is equipped in the pedestal, it is described
The top surface of pedestal is equipped at least one and described atomisation outlet for communicating of atomization runner, the bottom surface or side of the pedestal be equipped with
The atomization entrance that the atomization runner communicates, the atomization entrance and the atomization orifice, the atomisation outlet are located at institute
It states and incubates intracavitary and communicated with the incubation chamber.
6. cytological stains machine according to claim 4, which is characterized in that the incubation seat further includes locating rack, described
Locating rack is equipped with multiple slide location holes, and multiple slide location holes are successively spaced along the length direction of the locating rack and set
It sets；
The locating rack is detachably located on the heat-conducting plate, and the slide location hole is suitable for being placed on the heat-conducting plate
The glass slide is positioned.
7. cytological stains machine according to claim 1, which is characterized in that first manipulator further include fluid suction head,
Second driving mechanism, scanner and third driving mechanism；
The fluid suction head is connect with second driving mechanism, and is transported along the vertical direction under second driving mechanism driving
It is dynamic, to draw the waste liquid on the glass slide；
The scanner is connect with the third driving mechanism, and is transported along the vertical direction under the driving of the third driving mechanism
It is dynamic, to be scanned to the information code on reagent storage unit and glass slide.
8. cytological stains machine according to claim 3, which is characterized in that the removable hood, which is equipped with multiple extensions, to be stopped
Part, second manipulator include:
Fixing seat, the fixing seat vertically extend to form bar shaped；
Handgrip is slided, the sliding handgrip includes that linking arm, handgrip seat and multiple hook pawls, the linking arm prolong along the vertical direction
It stretches, for the upper end slidable connection of the linking arm to the fixing seat, the handgrip seat is located at the lower end of the linking arm, multiple
The hook pawl is located on the handgrip seat and corresponds with multiple extension stops, and each hook pawl is suitable for and corresponding institute
It states and hangs stop hook；
4th driving mechanism, the 4th driving mechanism sets on the fixing seat and is connected with the linking arm, to drive
The linking arm slides up and down.
9. cytological stains machine according to claim 1, which is characterized in that the reagent storage unit includes cold storage shelf,
It is inserted with for the reagent cup for being loaded with the first reagent, and the reagent cup is refrigerated.
10. cytological stains machine according to claim 9, which is characterized in that the cold storage shelf includes:
Shell, the shell have heat-barrier material to be made, and the shell is equipped with the accommodation groove of open upper end；
Seat is refrigerated, the refrigeration seat has metal material to be made, and the refrigeration seat is embedded in the accommodation groove, and the refrigeration seat
It is equipped with multiple refrigeration holes for reagent cup inserting；
Semi-conductor condensation piece, the semi-conductor condensation piece is located at the bottom of the refrigeration seat, to the refrigeration seat system
It is cold；
Water-cooling head, the water-cooling head are bonded with the semi-conductor condensation piece, to radiate to the semi-conductor condensation piece.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910562233.3A CN110333117A (en) | 2019-06-26 | 2019-06-26 | Cytological stains machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910562233.3A CN110333117A (en) | 2019-06-26 | 2019-06-26 | Cytological stains machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110333117A true CN110333117A (en) | 2019-10-15 |
Family
ID=68142881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910562233.3A Pending CN110333117A (en) | 2019-06-26 | 2019-06-26 | Cytological stains machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110333117A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110849695A (en) * | 2019-11-26 | 2020-02-28 | 苏州百道医疗科技有限公司 | Full-automatic immunohistochemical system |
| CN112781962A (en) * | 2020-12-29 | 2021-05-11 | 广东金泉医疗科技有限公司 | Automatic dropping dyeing mounting equipment with all-in-one machine structure |
| CN114657736A (en) * | 2022-04-11 | 2022-06-24 | 广州市鸿通机械有限公司 | Integrated machine |
| CN116793796A (en) * | 2022-11-07 | 2023-09-22 | 广州泰立生物科技有限公司 | Automatic immunohistochemical dyeing machine and immunohistochemical dyeing process |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110136135A1 (en) * | 2009-12-09 | 2011-06-09 | Larsen Soeren Damgaard | Apparatus and method for processing biological samples |
| CN203083237U (en) * | 2013-01-27 | 2013-07-24 | 江苏江航医疗设备有限公司 | Insulin refrigeration box |
| CN103675315A (en) * | 2013-12-20 | 2014-03-26 | 深圳徳夏生物医学工程有限公司 | Sample-injection and transferring device for microporous plate |
| CN103901221A (en) * | 2014-04-11 | 2014-07-02 | 深圳德夏生物医学工程有限公司 | Fully-automatic chemiluminescence enzyme immunity analyzer |
| CN204507708U (en) * | 2015-02-13 | 2015-07-29 | 温州松浦电器有限公司 | Two warm area quartz conductor insulin cold storage box |
| KR20160037720A (en) * | 2014-09-29 | 2016-04-06 | 주식회사 싸이토젠 | Apparatus for controlling humidity for staining equipment |
| CN105699156A (en) * | 2016-02-24 | 2016-06-22 | 福州迈新生物技术开发有限公司 | Full-automatic staining instrument for staining tissue samples on glass slides and method for applying full-automatic staining instrument |
| CN206172205U (en) * | 2016-07-28 | 2017-05-17 | 中国农业科学院蜜蜂研究所 | Cold -stored box of miniature sample |
| CN206670186U (en) * | 2017-01-17 | 2017-11-24 | 深圳市帝迈生物技术有限公司 | Blood analyser and its reagent bottle cold storage plant |
| CN109580595A (en) * | 2017-09-29 | 2019-04-05 | 深圳市新产业生物医学工程股份有限公司 | Chemiluminescence detector incubates device and reaction disc mechanism |
| CN208751104U (en) * | 2018-08-21 | 2019-04-16 | 厦门七智厨房科技有限公司 | A kind of water-cooling semiconductor refrigeration air duct refrigerates rice bin |
| CN210690188U (en) * | 2019-06-26 | 2020-06-05 | 万兆 | Pathology dyeing machine |
-
2019
- 2019-06-26 CN CN201910562233.3A patent/CN110333117A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110136135A1 (en) * | 2009-12-09 | 2011-06-09 | Larsen Soeren Damgaard | Apparatus and method for processing biological samples |
| CN203083237U (en) * | 2013-01-27 | 2013-07-24 | 江苏江航医疗设备有限公司 | Insulin refrigeration box |
| CN103675315A (en) * | 2013-12-20 | 2014-03-26 | 深圳徳夏生物医学工程有限公司 | Sample-injection and transferring device for microporous plate |
| CN103901221A (en) * | 2014-04-11 | 2014-07-02 | 深圳德夏生物医学工程有限公司 | Fully-automatic chemiluminescence enzyme immunity analyzer |
| KR20160037720A (en) * | 2014-09-29 | 2016-04-06 | 주식회사 싸이토젠 | Apparatus for controlling humidity for staining equipment |
| CN204507708U (en) * | 2015-02-13 | 2015-07-29 | 温州松浦电器有限公司 | Two warm area quartz conductor insulin cold storage box |
| CN105699156A (en) * | 2016-02-24 | 2016-06-22 | 福州迈新生物技术开发有限公司 | Full-automatic staining instrument for staining tissue samples on glass slides and method for applying full-automatic staining instrument |
| CN206172205U (en) * | 2016-07-28 | 2017-05-17 | 中国农业科学院蜜蜂研究所 | Cold -stored box of miniature sample |
| CN206670186U (en) * | 2017-01-17 | 2017-11-24 | 深圳市帝迈生物技术有限公司 | Blood analyser and its reagent bottle cold storage plant |
| CN109580595A (en) * | 2017-09-29 | 2019-04-05 | 深圳市新产业生物医学工程股份有限公司 | Chemiluminescence detector incubates device and reaction disc mechanism |
| CN208751104U (en) * | 2018-08-21 | 2019-04-16 | 厦门七智厨房科技有限公司 | A kind of water-cooling semiconductor refrigeration air duct refrigerates rice bin |
| CN210690188U (en) * | 2019-06-26 | 2020-06-05 | 万兆 | Pathology dyeing machine |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110849695A (en) * | 2019-11-26 | 2020-02-28 | 苏州百道医疗科技有限公司 | Full-automatic immunohistochemical system |
| CN112781962A (en) * | 2020-12-29 | 2021-05-11 | 广东金泉医疗科技有限公司 | Automatic dropping dyeing mounting equipment with all-in-one machine structure |
| CN114657736A (en) * | 2022-04-11 | 2022-06-24 | 广州市鸿通机械有限公司 | Integrated machine |
| CN114657736B (en) * | 2022-04-11 | 2024-04-26 | 广州市鸿通机械有限公司 | Integrated machine |
| CN116793796A (en) * | 2022-11-07 | 2023-09-22 | 广州泰立生物科技有限公司 | Automatic immunohistochemical dyeing machine and immunohistochemical dyeing process |
| CN116793796B (en) * | 2022-11-07 | 2024-01-23 | 广州泰立生物科技有限公司 | Automatic immunohistochemical dyeing machine and immunohistochemical dyeing process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110333117A (en) | Cytological stains machine | |
| CN207457256U (en) | Automatic clinical chemistry analyzer | |
| US5595707A (en) | Automated biological reaction apparatus | |
| US4919887A (en) | Automatic analyzer | |
| CN105628687B (en) | A kind of Full-automatic chemiluminescence analyzer | |
| JPS60241884A (en) | Automation cycling reaction apparatus and automatic analyzer using same | |
| US20030032191A1 (en) | Sample processing apparatus and methods | |
| CN1963527A (en) | Full-automatic biochemical analyzer and analysis method thereof | |
| CN102192992A (en) | Sample analyzer and non-transitory storage medium | |
| US20210108996A1 (en) | Automatic slide staining and cooling systems | |
| CN207423982U (en) | Small-sized automatic biochemistry analyzer | |
| CN210604107U (en) | Immunohistochemical dyeing machine | |
| CN110411810A (en) | A kind of immunohistochemical staining machine and immunohistochemical staining method | |
| CN109613285A (en) | Biochemical immunity one analyzer and method of sample analysis | |
| CN210690188U (en) | Pathology dyeing machine | |
| CN114152496A (en) | Automatic immunohistochemical dyeing machine | |
| CN207764227U (en) | A kind of automatic incubation heating oscillating uniform device | |
| CN215953379U (en) | Cold air circulation system, bearing assembly and analyzer | |
| CN214251985U (en) | Liquid path system of full-automatic biochemical analyzer and full-automatic biochemical analyzer | |
| CN206347776U (en) | The agent bin of Electrogenerated chemiluminescent immunoassay instrument | |
| CN110333118A (en) | Incubate device and the cytological stains machine with it | |
| CN208194440U (en) | A kind of constant temperature water bath apparatus | |
| CN207259496U (en) | Nucleic acid hybridization oven | |
| CN107132345B (en) | A kind of biological chip reading apparatus | |
| JP3983872B2 (en) | Automatic analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |