CN103656361B - Medicine used for treating herpes zoster, and preparation method thereof - Google Patents
Medicine used for treating herpes zoster, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine used for treating herpes zoster, and a preparation method thereof. The medicine is prepared from medical ingredients, such as herba portulacae, semen plantaginis, oldenlandia diffusa, radix gentianae, rheum officinale, herba violae, rulvis glycyrrhizae extractionis sedilis, radix salviae miltiorrhizae, yam rhizome and complete scorpion, according to a certain weight ratio. The medicine is capable of clearing away heat and toxic materials, dispersing blood and diminishing swelling, and diminishing inflammation and killing parasite; and can be used for treating herpes zoster with rapidly realized effects and excellent curative effects; and relapse of herpes zoster is seldom caused.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of herpes zoster and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Herpes zoster is the actute infection dermatoses caused by varicella zoster virus.After infected to this viral child without immunity, there is chickenpox.Become carrier after some patients is infected and symptom do not occur.Because virus has neurotropism, can hide for a long time in the neuron of spinal nerves posterior root ganglion after infection, when lower for the resistance or tired, infection, flu, virus can regrow breeding, and move to skin along nerve fiber, make the nerve of being invaded and skin produce strong inflammation.Erythra generally has feature that is Unilateral and that distribute by nerve segment, is made up of the herpes of collection bunch property, and with pain; Age is larger, and neuralgia is heavier.Primary disease is apt to occur in adult, and season in spring and autumn is common.Sickness rate increases with the age and rises in remarkable.At present, because Western medicine effectively cannot treat herpes zoster, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating herpes zoster.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment herpes zoster, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating herpes zoster.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Portulacae, Semen Plantaginis, Herba Hedyotidis Diffusae, Radix Gentianae, Radix Et Rhizoma Rhei, Herba Violae, Preparatum Glycyrrhizae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Septemlobae, Scorpio, Radix Rhapontici, Folium Isatidis, Squama Manis, Flos Lonicerae, Radix et Caulis Opuntiae Dillenii, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Semen Plantaginis, Fructus Hordei Germinatus, Os Draconis, Herba Lophatheri, the Rhizoma Atractylodis Macrocephalae, Haematitum, Semen Trichosanthis, Herba Cayatiae Japonicae, Indigo Naturalis, Rhizoma Alismatis, Caulis Piperis Kadsurae, Caulis Akebiae, Fructus Crataegi, Rhizoma Corydalis, arnebia medicinal to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of herpes zoster.Wherein select Herba Portulacae to be because its nature and flavor acid, cold, enter large intestine, liver, spleen channel, have heat-clearing and toxic substances removing, the function of loose blood detumescence, controls hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Select Herba Hedyotidis Diffusae to be because its property bitter but sweet flavor, cold, enter the heart, liver, spleen three warp, have heat clearing away, dampness removing, the function of removing toxic substances, controls dyspnea and cough due to lung-heat, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Herba Violae to be that GUIXIN, Liver Channel, have heat-clearing and toxic substances removing because its nature and flavor bitter, acrid, cold, the function of removing heat from blood detumescence, controls furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Preparatum Glycyrrhizae is selected to be that cold, enter the heart, stomach warp, have heat clearing away, removing heat from blood, the function of removing toxic substances, cure the wound cold and heat disease, large hot excessive thirst, maculopapulae due to toxic heat, erysipelas, skin infection because its nature and flavor are sweet.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Rhizoma Dioscoreae Septemlobae is selected to be because its nature and flavor are bitter, flat, enter liver, stomach, urinary bladder channel, dispel the wind, the function of dampness removing, dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, damp and hot sore.Select Scorpio to be because its nature and flavor are salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, dredging collateral, the function of removing toxic substances, control convulsion with spasms ， epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer swells.Select Radix Rhapontici to be because its nature and flavor hardship is salty-cold, enter stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of stimulating milk secretion, control the swollen pain of breast, galactostasis, toxic-heat and blood stasis, arthralgia.Folium Isatidis is selected to be because its nature and flavor are bitter, cold, enter liver, the heart, stomach warp, have heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of stimulating milk secretion of stimulating the menstrual flow, control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external is stopped blooding.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Radix et Caulis Opuntiae Dillenii is selected to be because its nature and flavor are bitter, cold, enter the heart, lung, stomach three warp, have promoting flow of QI and blood, the function of heat-clearing and toxic substances removing, control heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.Select Rhizoma Osmundae to be because its nature and flavor are bitter, cool, enter liver, stomach warp, kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls anemopyretic cold, damp and hot skin eruption, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Fructus Hordei Germinatus is selected to be that tepor, enters spleen, stomach warp, have and help digestion because its nature and flavor are sweet, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, controls food stagnation and does not disappear, swollen distention and fullness in the abdomen, inappetence, and vomiting is had loose bowels, and mammary swelling does not disappear.Select Os Draconis to be because its property sweet-puckery flavor, flat, be included into the heart, liver, kidney, large intestine channel, have tranquillizing the mind by relieving convulsion, the function of arresting sweating controlling nocturnal emission with astringent drugs, control frightened Epilepsy demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.Select Herba Lophatheri to be because its property slightly sweet flavor, cold, enter heart kidney two warp, have clearing away heart-fire, heat clearing away and restlessness relieving, the function of diuresis, controls calentura thirsty, vexed, hot urination, stranguria with turbid discharge, erosion of the oral mucosa tongue boil, gingival swelling and pain.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Haematitum to be because its property bitter but sweet flavor, flat, enter liver, stomach, heart born of the same parents warp, have suppressing the hyperactive liver town inverse, the function of cooling blood for hemostasis, control eructation vomiting, dysphagia and regurgitation, asthma, frightened Epilepsy, spits blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid flaccidity, bleeding not during menses.Semen Trichosanthis is selected to be because its nature and flavor are sweet, cold, return lung, stomach, large intestine channel, have moistening the lung and resolving phlegm, the function of laxation relieving constipation, control cough caused by dryness expectorant and stick, dryness of the intestine constipation.Select Herba Cayatiae Japonicae to be because its nature and flavor picric acid, cold, enter the heart, liver, stomach three warp, have clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls carbuncle, furuncle, mumps, erysipelas, rheumatalgia, jaundice, dysentery, hematuria, nebulousurine.Select Indigo Naturalis to be because its nature and flavor are salty, cold, enter liver, lung, stomach warp, have heat clearing away, removing heat from blood, the function of removing toxic substances, control epidemic febrile disease intenseness of heat, macule, spit blood, spit blood, little Jing Epilepsy, skin ulcer swells, erysipelas, snake bite and insect sting.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Caulis Piperis Kadsurae is selected to be that tepor, enter the heart, kidney two warp, have wind-damp dispelling, the meridian dredging, the function of regulating the flow of vital energy, controls anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough because its nature and flavor are worked hard.Caulis Akebiae is selected to be that cool, enter the heart, small intestinal, urinary bladder channel, have pathogenic fire purging row water, the function of promoting blood circulation, controls hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis because its nature and flavor are bitter.Select Fructus Crataegi to be that tepor, enters spleen, stomach, Liver Channel because its nature and flavor acid is sweet, have and help digestion long-pending, dissipating blood stasis blood, drives the function of edge worm, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's also eats stagnation.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Radix Arnebiae (Radix Lithospermi) is selected to be because its nature and flavor earnestly, are trembled with fear, entered percardium, Liver Channel, have removing heat from blood, invigorate blood circulation, the function of heat-clearing and toxic substances removing, control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Herba Portulacae 15-25 gram of Semen Plantaginis 15-25 gram of Herba Hedyotidis Diffusae 10-20 gram
Radix Gentianae 10-20 gram of Radix Et Rhizoma Rhei 10-20 gram of Herba Violae 10-20 gram
Preparatum Glycyrrhizae 10-20 gram of Radix Salviae Miltiorrhizae 10-20 Ke Rhizoma Dioscoreae Septemlobae 10-20 gram
Scorpio 5-15 gram of Radix Rhapontici 5-15 gram of Folium Isatidis 5-15 gram
Squama Manis 5-15 gram of Flos Lonicerae 5-15 gram of Radix et Caulis Opuntiae Dillenii 5-15 gram
Rhizoma Osmundae 15-25 gram of Radix Glycyrrhizae 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Semen Plantaginis 15-25 gram of Fructus Hordei Germinatus 15-25 cron bone 15-25 gram
Herba Lophatheri 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram of Haematitum 15-25 gram
Semen Trichosanthis 10-20 gram of Herba Cayatiae Japonicae 10-20 gram Indigo Naturalis 10-20 gram
Rhizoma Alismatis 15-25 gram of Caulis Piperis Kadsurae 15-25 gram of Caulis Akebiae 15-25 gram
Fructus Crataegi 10-20 gram of Rhizoma Corydalis 10-20 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram
Preferable amount is
Herba Portulacae 20 grams of Semen Plantaginiss 20 grams of Herba Hedyotidis Diffusaes 15 grams
Radix Gentianae 15 grams of Radix Et Rhizoma Rhei 15 grams of Herba Violaes 15 grams
Preparatum Glycyrrhizae's 15 grams of Radix Salviae Miltiorrhizae 15 Ke Rhizoma Dioscoreae Septemlobae 15 grams
Scorpio 10 grams of Radix Rhapontici 10 grams of Folium Isatidiss 10 grams
Squama Manis 10 grams of Flos Loniceraes 10 grams of Radix et Caulis Opuntiae Dilleniis 10 grams
Rhizoma Osmundae 20 grams of Radix Glycyrrhizaes 20 grams of Rhizoma Polygoni Cuspidati 20 grams
20 grams, Semen Plantaginis 20 grams of Fructus Hordei Germinatus 20 cron bones
Herba Lophatheri 20 grams of Rhizoma Atractylodis Macrocephalaes 20 grams of Haematitums 20 grams
Semen Trichosanthis 15 grams of Herba Cayatiae Japonicaes 15 grams of Indigo Naturaliss 15 grams
Rhizoma Alismatis 20 grams of Caulis Piperis Kadsuraes 20 grams of Caulis Akebiaes 20 grams
Fructus Crataegi 15 grams of Rhizoma Corydalis 15 grams of Radix Arnebiae (Radix Lithospermi)s 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Portulacae: pick clean impurity, removing undesirable root, slightly moisten with water, cutting is dried;
2, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
3, Herba Hedyotidis Diffusae: get crude drug, removing impurity, wash quickly is clean, slightly dries in the air, cutting, dry, sieve dedust bits;
4, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
5, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
6, Herba Violae: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry;
7, Preparatum Glycyrrhizae: pick decontamination, selects dry not mould Preparatum Glycyrrhizae;
8, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
9, Rhizoma Dioscoreae Septemlobae: removing impurity, section, cleans, and soaks, runs through, dry, and sieve removes chip;
10, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
11, Radix Rhapontici: pick clean impurity, unhairing is cleaned, and runs through, and section, dries;
12, Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;
13, Squama Manis: get the Squama Manis sheet picking clean, separately size, separately put sand in pot and fry to easily, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;
14, Flos Lonicerae: sieve removes silt, picks clean impurity;
15, Radix et Caulis Opuntiae Dillenii: extract fresh Radix et Caulis Opuntiae Dillenii according to quantity;
16, Rhizoma Osmundae: slightly soak with clear water, takes out, and each watering sooner or later once, softens, and section, dries;
17, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
18, Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
19, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
20, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;
21, Os Draconis: outwash earth, smash;
22, Herba Lophatheri: pick decontamination and root, cutting, dry;
23, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
24, Haematitum: removing impurity, smashes, sieves;
25, Semen Trichosanthis: get crude drug, removing impurity and fruit stem, clean, and flattens, shredding or fritter, dry;
26, Herba Cayatiae Japonicae: summer, autumn gather, and dry;
27, Indigo Naturalis: pick decontamination, sieves;
28, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
29, Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, take out and put profit 16-24 hour in square-bottomed bamboo basket, section, dries;
30, Caulis Akebiae: slightly soak with water, moistening, to thoroughly, is cut into slices, is dried;
31, Fructus Crataegi: get and pick clean Fructus Crataegi, putting the interior slow fire stir-fry of pot is faint yellow taking-up to outside, cools;
32, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
33, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries.
Two, prepare
1, by the Herba Portulacae of described weight, Semen Plantaginis, Herba Hedyotidis Diffusae, Radix Gentianae, Radix Et Rhizoma Rhei, Herba Violae, Preparatum Glycyrrhizae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Septemlobae, Scorpio, Radix Rhapontici, Folium Isatidis, Squama Manis, Flos Lonicerae, Radix et Caulis Opuntiae Dillenii, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Semen Plantaginis, Fructus Hordei Germinatus, Os Draconis, Herba Lophatheri, the Rhizoma Atractylodis Macrocephalae, Haematitum, Semen Trichosanthis, Herba Cayatiae Japonicae, Indigo Naturalis, Rhizoma Alismatis, Caulis Piperis Kadsurae, Caulis Akebiae, Fructus Crataegi, Rhizoma Corydalis, arnebia medicinal decocts with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues after first time filtration 5 times amount, decocts boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.
3, by twice decoction liquor mixing, 6 doses are divided into take.
Medicine of the present invention has heat-clearing and toxic substances removing, loose blood detumescence, blood circulation and promoting silt, anti-inflammatory anti-itch, effect of parasite killing, and treatment herpes zoster instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 173 example for medical treatment.
2, diagnostic criteria
Clinical manifestation
Can have the slightly General Symptoms such as weak, low grade fever, poor appetite before dermexanthesis, the conscious burning sensation of illing skin or neuralgia, that touches has obvious Hyperalgesia, continues 1 ~ 3 day, also can absence of prodrome and dermexanthesis.Predilection site is followed successively by intercostal nerves, cervical nerves, nervi trigeminus and waist sacral nerves domination region.There is flushing speckle in affected part Chang Shouxian, occurs the pimple of foxtail millet grain to Semen Glycines size very soon, tufted distribution and not merging, and then become rapidly vesicle, tonic vesicle wall is shinny, limpid vesicle fluid, and periphery is around with blush, and between each bunch of vesicle group, skin is normal; Skin lesion is zonation along a certain peripheral nerve, mostly occurs in the side of health, is generally no more than median line.Neuralgia is one of primary disease feature, and can occur at premorbid or with skin lesion, gerontal patient is often comparatively violent.General 2 ~ 3 weeks of the course of disease, vesicle is dry, incrustation leaves temporary light red speckle or pigmentation after coming off.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 5 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: herpes zoster is eliminated, without recurring after observing half a year;
Take a turn for the better: shingles symptoms is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by banded herpes patient 173 example of Drug therapy of the present invention, effective 161 examples of result, obvious effective rate is 93.06%, and take a turn for the better 10 examples, and improvement rate is 5.78%, and invalid 2 examples, total effective rate is 98.84%.
Claims (3)
1. treat a medicine for herpes zoster, it is characterized in that: it is made up of the crude drug in following weight range:
Herba Portulacae 15-25 gram of Semen Plantaginis 15-25 gram of Herba Hedyotidis Diffusae 10-20 gram
Radix Gentianae 10-20 gram of Radix Et Rhizoma Rhei 10-20 gram of Herba Violae 10-20 gram
Preparatum Glycyrrhizae 10-20 gram of Radix Salviae Miltiorrhizae 10-20 Ke Rhizoma Dioscoreae Septemlobae 10-20 gram
Scorpio 5-15 gram of Radix Rhapontici 5-15 gram of Folium Isatidis 5-15 gram
Squama Manis 5-15 gram of Flos Lonicerae 5-15 gram of Radix et Caulis Opuntiae Dillenii 5-15 gram
Rhizoma Osmundae 15-25 gram of Radix Glycyrrhizae 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Semen Plantaginis 15-25 gram of Fructus Hordei Germinatus 15-25 cron bone 15-25 gram
Herba Lophatheri 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram of Haematitum 15-25 gram
Semen Trichosanthis 10-20 gram of Herba Cayatiae Japonicae 10-20 gram Indigo Naturalis 10-20 gram
Rhizoma Alismatis 15-25 gram of Caulis Piperis Kadsurae 15-25 gram of Caulis Akebiae 15-25 gram
Fructus Crataegi 10-20 gram of Rhizoma Corydalis 10-20 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Herba Portulacae 20 grams of Semen Plantaginiss 20 grams of Herba Hedyotidis Diffusaes 15 grams
Radix Gentianae 15 grams of Radix Et Rhizoma Rhei 15 grams of Herba Violaes 15 grams
Preparatum Glycyrrhizae's 15 grams of Radix Salviae Miltiorrhizae 15 Ke Rhizoma Dioscoreae Septemlobae 15 grams
Scorpio 10 grams of Radix Rhapontici 10 grams of Folium Isatidiss 10 grams
Squama Manis 10 grams of Flos Loniceraes 10 grams of Radix et Caulis Opuntiae Dilleniis 10 grams
Rhizoma Osmundae 20 grams of Radix Glycyrrhizaes 20 grams of Rhizoma Polygoni Cuspidati 20 grams
20 grams, Semen Plantaginis 20 grams of Fructus Hordei Germinatus 20 cron bones
Herba Lophatheri 20 grams of Rhizoma Atractylodis Macrocephalaes 20 grams of Haematitums 20 grams
Semen Trichosanthis 15 grams of Herba Cayatiae Japonicaes 15 grams of Indigo Naturaliss 15 grams
Rhizoma Alismatis 20 grams of Caulis Piperis Kadsuraes 20 grams of Caulis Akebiaes 20 grams
Fructus Crataegi 15 grams of Rhizoma Corydalis 15 grams of Radix Arnebiae (Radix Lithospermi)s 15 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Herba Portulacae: pick clean impurity, removing undesirable root, slightly moisten with water, cutting is dried;
(2) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
(3) Herba Hedyotidis Diffusae: get crude drug, removing impurity, wash quickly is clean, slightly dries in the air, cutting, dry, sieve dedust bits;
(4) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
(5) Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
(6) Herba Violae: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry;
(7) Preparatum Glycyrrhizae: pick decontamination, selects dry not mould Preparatum Glycyrrhizae;
(8) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
(9) Rhizoma Dioscoreae Septemlobae: removing impurity, section, cleans, and soaks, runs through, dry, and sieve removes chip;
(10) Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
(11) Radix Rhapontici: pick clean impurity, unhairing is cleaned, and runs through, and section, dries;
(12) Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;
(13) Squama Manis: get the Squama Manis sheet picking clean, separately size, separately put sand in pot and fry to easily, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;
(14) Flos Lonicerae: sieve removes silt, picks clean impurity;
(15) Radix et Caulis Opuntiae Dillenii: extract fresh Radix et Caulis Opuntiae Dillenii according to quantity;
(16) Rhizoma Osmundae: slightly soak with clear water, takes out, and each watering sooner or later once, softens, and section, dries;
(17) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(18) Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
(19) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
(20) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;
(21) Os Draconis: outwash earth, smash;
(22) Herba Lophatheri: pick decontamination and root, cutting, dry;
(23) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(24) Haematitum: removing impurity, smashes, sieves;
(25) Semen Trichosanthis: get crude drug, removing impurity and fruit stem, clean, and flattens, shredding or fritter, dry;
(26) Herba Cayatiae Japonicae: summer, autumn gather, and dry;
(27) Indigo Naturalis: pick decontamination, sieves;
(28) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
(29) Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, take out and put profit 16-24 hour in square-bottomed bamboo basket, section, dries;
(30) Caulis Akebiae: slightly soak with water, moistening, to thoroughly, is cut into slices, is dried;
(31) Fructus Crataegi: get and pick clean Fructus Crataegi, putting the interior slow fire stir-fry of pot is faint yellow taking-up to outside, cools;
(32) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(33) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;
(2) prepare
(1) by the Herba Portulacae of described weight, Semen Plantaginis, Herba Hedyotidis Diffusae, Radix Gentianae, Radix Et Rhizoma Rhei, Herba Violae, Preparatum Glycyrrhizae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Septemlobae, Scorpio, Radix Rhapontici, Folium Isatidis, Squama Manis, Flos Lonicerae, Radix et Caulis Opuntiae Dillenii, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Semen Plantaginis, Fructus Hordei Germinatus, Os Draconis, Herba Lophatheri, the Rhizoma Atractylodis Macrocephalae, Haematitum, Semen Trichosanthis, Herba Cayatiae Japonicae, Indigo Naturalis, Rhizoma Alismatis, Caulis Piperis Kadsurae, Caulis Akebiae, Fructus Crataegi, Rhizoma Corydalis, arnebia medicinal decocts with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,
(2) add water the medicinal residues after first time filtration 5 times amount, decocts boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor;
(3) by twice decoction liquor mixing, 6 doses are divided into take.
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| CN102552492A (en) * | 2012-01-12 | 2012-07-11 | 山东省千佛山医院 | Traditional Chinese medicinal composition for treating herpes zoster and preparation method thereof |
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| Title |
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| 张立军,等.中医药治疗带状疱疹的研究进展.《现代中西医结合杂志》.2013,第22卷(第6期),682-684. * |
| 杨洋,等.带状疱疹中医治疗的研究进展.《环球中医药》.2013,第6卷(第2期),155-158. * |
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