CN103656046A - Lemai pellet composition - Google Patents
Lemai pellet composition Download PDFInfo
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- CN103656046A CN103656046A CN201310704037.8A CN201310704037A CN103656046A CN 103656046 A CN103656046 A CN 103656046A CN 201310704037 A CN201310704037 A CN 201310704037A CN 103656046 A CN103656046 A CN 103656046A
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Abstract
The invention discloses a Lemai pellet composition which is prepared by the following steps: weighing roots of red-rooted salvia, ligusticum wallichii, roots of common peony, safflower carthamus, rhizoma cyperi, costustoot and hawthorn according to a recipe; adding the seven medicinal materials into an extraction pot, adding water, performing reflux extraction for multiple times, collecting filter liquor every time, combining the filter liquor, concentrating to thick paste with the relative density of 1.25-1.30 at 60 DEG C, drying the thick paste, grinding, and performing micro-powder treatment to obtain extract micro-powder; adding starch and a bonder as well as soybean oil into the extract micro-powder, uniformly mixing, extruding to form strip-shaped materials, putting the extruded strip-shaped materials into a centrifugal rounder, cutting the strip-shaped materials into cylindrical materials through a ladder-shaped cutter in the centrifugal rounder, and enabling the cylindrical materials to collide with each other under the high-speed motion of the centrifugal rounder. According to the Lemai pellet composition, the preparation time of Lemai pellets is shortened, the yield of the Lemai pellets is increased, and the cost is reduced.
Description
Technical field:
The present invention relates to Lemaiwan pill compositions, particularly a kind of Lemaiwan pill pellet composition.
Background technology:
Lemaiwan pill is a kind of cardiovascular and cerebrovascular vessel medication, has promoting flow of QI and blood, the blood stasis dispelling effect of promoting blood circulation, for the headache of caused by energy stagnation and blood stasis, dizzy, chest pain, cardiopalmus, coronary heart diseases and angina pectoris, multiple cerebral infarction prevention and treatment.Its main component is Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Flos Carthami, Rhizoma Cyperi, the Radix Aucklandiae, Fructus Crataegi.
The medical mechanism of Lemaiwan pill is as follows:
1, increase blood flow, reduce myocardial oxygen consumption, improve microcirculation, effectively prevent the formation of anginal generation and cerebral thrombosis;
2, cardiac nutrition, strengthens blood supply of cardiac muscle and myocardium power;
3, improve dense, sticky, the poly-state of blood, adjust blood physicochemical property, protection vascular endothelial cell;
4, the formation of prevention thromboxane, effectively removes the speckle of coronary atherosclerosis, the thrombosis particle in lysed blood;
5, accelerate the metabolism of lipid material (cholesterol, triglyceride etc.) and suppress the absorption to lipid material in body, reducing lipid material at the deposition of blood vessel wall, blood fat reducing, blood pressure, atherosclerosis;
6, repair impaired atherosis coronary artery and myocardial cell, improve the metabolic rate of damaged cell, strengthen coronary artery cardiomyocyte viability, increase cardiac output, heart tonifying and anti-arrhythmia.
7, improve dysmnesia, activate dormancy brain cell.
If, all there is different shortcomings in former conventional preparation method for Lemaiwan pill micropill.
General method for making: require material very thin, at least cross 120 orders, like this, material is prepared with regard to consuming time, power consumption; Speed of production is slow in process of production, and production efficiency is lower.
Dropping preparation method: require equally material very thin, must cross 120 orders, like this, material is prepared or consuming time, power consumption, also have, by the method, produce, in composition production process, follow-up drying equipment is had relatively high expectations, drop into larger, production cycle is longer, in preparation process, must add partial supplementary material, and this has and conflict with this product approval standards.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of employing to mould the Lemaiwan pill pellet composition that method for making pill principle is made for the deficiencies in the prior art.
Technical problem to be solved by this invention can be achieved through the following technical solutions:
A kind of Lemaiwan pill pellet composition, it is characterized in that, this Lemaiwan pill compositions obtains according to following method: by formula, take Radix Salviae Miltiorrhizae 79.84 weight portions, Rhizoma Chuanxiong 39.92 weight portions, Radix Paeoniae Rubra 39.92 weight portions, Flos Carthami 39.92 weight portions, Rhizoma Cyperi 19.96 weight portions, the Radix Aucklandiae 19.96 weight portions, Fructus Crataegi 9.98 weight portions, above seven flavor medicine material 249.504 weight portions are added in extraction pot, add water reflux, extract, repeatedly, collect each filtrate and merge, merging filtrate is concentrated into the thick paste that 60 ℃ of relative densities are 1.25～1.30, thick paste crushed after being dried, sieves and obtain extract micropowder after micropowder is processed with 80 eye mesh screens, to starch and the binding agent of 30wt%～60wt% of extract micropowder quality and the soybean oil of the 2wt%～3wt% of extract micropowder quality processed through micropowder that add the 50wt%～70wt% of extract micropowder quality in extract micropowder, after mixing, pass through extruding shaping, the strip-shaped materials of extruding is put into centrifugal spheronizator, by the trapezoidal cutting knife in centrifugal spheronizator, strip-shaped materials is cut into the cylindrical material that length is 0.8～1.2mm, adjust centrifugal spheronizator and turn 600～700 revs/min, air quantity adjustment is by regulating air blast agent frequency and air-introduced machine frequency to control, under centrifugal spheronizator high-speed motion, cylindrical material is made Lemaiwan pill pellet composition by mutual collision.
In a preferred embodiment of the invention, the number of times that adds water reflux, extract, is three times, wherein adds for the first time the water of 10 times of medical material amounts, reflux, extract, 1h, collects filtrate, adds for the second time the water of 8 times of medical material amounts again, reflux, extract, 1h, adds the water of 8 times of medical material amounts, reflux, extract, 1h for the third time again.
It is that dried extractum is pulverized by 120 object pulverizers that described micropowder is processed, then sieves and get final product with 100 eye mesh screens.
In a preferred embodiment of the invention, described binding agent is that mass percent concentration is 95% ethanol.
In a preferred embodiment of the invention, the frequency-tuning range of described aerator is 20～25Hz; The frequency-tuning range of described air-introduced machine is 15～20Hz.
The present invention is alleged moulds method for making pill principle and refers to fine drug powder, adjuvant and suitable binding agent are mixed and made into the plasticity soft material that soft or hard is suitable, and then by relevant device, be squeezed into the strip of suitable size, then by high speed centrifugation and cutting knife by the round as a ball pill of making of the strong thing cutting of bar.
Lemaiwan pill pellet composition prepared by the present invention, the yield that it has shortened the preparation time of Lemaiwan pill and has improved Lemaiwan pill, reduces costs.
The specific embodiment
By specific embodiments of the invention given below, can further be well understood to the present invention, but they not limitation of the invention.
Concrete technical scheme is as follows:
The preparation method of the Lemaiwan pill extractum fine powder that the specific embodiment is used is below as follows:
By formula, take Radix Salviae Miltiorrhizae 79.84kg, Rhizoma Chuanxiong 39.92kg, Radix Paeoniae Rubra 39.92kg, Flos Carthami 39.92kg, Rhizoma Cyperi 19.96kg, Radix Aucklandiae 19.96kg, Fructus Crataegi 9.98kg; Above seven flavor medicine material 249.504kg is added in extraction pot, add for the first time the water of 10 times of medical material amounts, reflux, extract, 1h, collects filtrate, adds for the second time the water of 8 times of medical material amounts again, and reflux, extract, 1h adds the water of 8 times of medical material amounts, reflux, extract, 1h for the third time again.Collect each filtrate and merge, merging filtrate is concentrated into the thick paste that 60 ℃ of relative densities are 1.25～1.30, and thick paste crushed after being dried is sieved and obtain Lemaiwan pill extractum micropowder after micropowder is processed with 80 eye mesh screens; The method that micropowder is processed is that dried extractum is pulverized by 120 object pulverizers, then sieves and get final product with 100 eye mesh screens.
Test 1: general method for making:
1.1 lot numbers: 20101001.
1.2 inventorys: 5000g
1.3 October 10 2010 time started
1.4 sample preparations:
1.4.1 taking Lemaiwan pill extractum 4000g must mix to such an extent that mixed powder is standby with the starch 1500g after micropowder is processed by Lemaiwan pill extractum micropowder 3500g after micropowder is processed.
1.4.2 will mix rear mixed powder 2000g adds in general ball machine, adjusts 50 hertz of general ball unit frequencies, with spray gun, spray the ethanol that mass percent concentration is 75% and carry out pill as binding agent, in pelletizing process, constantly add mixed powder to carry out pill, and sieve with 60 eye mesh screens, by mistake 60 orders with can not cross 60 order semi-finished product and separate, by crossing 60 object fine powders, pour in general ball machine that with same method, to add mass percent concentration be that 75% ethanol is made binding agent and amplified production again into again, the mistake of collecting 60 object pillers are amplified to production again.After finally 5000g medicated powder according to said method being machined, be dried.
1.4.3 with 14 orders and 30 object screen clothes, sieve, crossing 30 orders and can not crossing the defective semi-finished product of 10 object has 3400g, and crossing 14 orders and can not crossing the qualified semi-finished product of 30 object has 750g, and loss has 850g.This batch of Lemaiwan pill 4 hours 30 minutes used time of test, one time yield is 9.8%, and the proportion of goods damageds are 17.0%.
With same method, produce 20101002.With 14 orders and 30 object screen clothes, sieve, cross 30 orders and can not cross 10 orders and defective semi-finished product have 3260g, crossing 14 orders and can not crossing the qualified semi-finished product of 30 object has 980g, and loss has 760g.4 hours 30 minutes used time, one time yield is 19.6%, and the proportion of goods damageds are 15.2%.
With same method, produce 20101003.With 14 orders and 30 object screen clothes, sieve, cross 30 orders and can not cross 10 orders and defective semi-finished product have 3120g, crossing 14 orders and can not crossing the qualified semi-finished product of 30 object has 1120g, and loss has 760g.4 hours 10 minutes used time, one time yield is 22.4%, and the proportion of goods damageds are 15.2%.
Test 2: mould method for making:
2.1 lot numbers: 20101101.
2.2 inventorys: 5000g
2.3 November 5 2010 time started
2.4 sample preparations:
2.4.1 the preparation of binding agent
Mass percent concentration is the preparation of 30% ethanol binding agent: measure 95% ethanol 2000ml, add purified water 4333ml, stirring and evenly mixing is standby.
Mass percent concentration is the preparation of 45% ethanol binding agent: measure 95% ethanol 2000ml, add purified water 2222ml, stirring and evenly mixing is standby.
Mass percent concentration is the preparation of 60% ethanol binding agent: measure 95% ethanol 2000ml, add purified water 1166ml, stirring and evenly mixing is standby.
2.4.2 take the starch 2500g after Lemaiwan pill extract powder micropowder 2500g, micropowder processing, after mix homogeneously, obtain mixed powder standby.
2.4.3 soft material preparation: be 30% ethanol 4300ml and soybean oil 20ml to adding mass percent concentration in above-mentioned mixed powder, stir soft material processed.Make soft material reach " hold agglomerating, pinch loose " degree standby.
2.4.4 ball bar preparation: the extrusion cavities mould of 0.8mm is arranged on extruder; the wet stock of being made by wet mixing pelletizer; put in extruder feed appliance hopper; by screw rod motion for the relative rotation; by wet stock equably along with the hand of spiral is continuously pushed the longitudinal end that is advanced into squeezer by feed end; at mesh plate, place is hampered; the pressure of mesh plate inner side is raise; formation is to the extruding force in mesh plate outside; material is just evenly closely extruded by aperture, forms micro-shape cylinder bar.And above-mentioned soft material is put into extruder charge door by extruding, and soft material is in the situation that gravity pushes, and by extrusion cavities, extruding length is that 1.0～1.2mm becomes uniform bar.
2.4.5 micropill preparation: the above-mentioned bar of extruding is added in spheronizator, cylinder strip-shaped materials drops on centrifugal turntable, the disrumpent feelings tooth being centrifuged on rotating disk cuts into short cylindrical shape granule equal in length, and cut-out is automatically to be completed by the disrumpent feelings tooth on the centrifugal turntable of high speed rotating.Adjust centrifugal spheronizator rotating speed extremely? 600～700 revs/min; air quantity is controlled by adjusting air blast frequency (20～25Hz) air-introduced machine frequency (15～20Hz); cylindrical particles after disrumpent feelings is in granulator for spherical particulate; under the effect at resultant forces such as centrifugal force, rotatory force, self gravitation, thrust gas, frictional force; speed difference between centrifugal turntable and material cylindrical shell is delivered between pill; cause uniform rubbing effect; make it be rolled onto rapidly ball, and the ball after round as a ball is dried.
2.4.6 with 14 orders and 30 object screen clothes, sieve, crossing 30 orders and can not crossing the defective semi-finished product of 10 object has 1390g, and crossing 14 orders and can not crossing the qualified semi-finished product of 30 object has 3190g, and loss has 420g.This batch of golden pheasant micropill 1 hour 30 minutes used time of test, one time yield is 63.8%, and the proportion of goods damageds are 8.4%.
With the ethanol that mass percent concentration is 45%, make binding agent, the extrusion cavities mould of 1.0mm is arranged on extruder and adopts the preparation method in the of same 20101101 to produce 20101102.With 14 orders and 30 object screen clothes, sieve, cross 30 orders and can not cross 10 orders and defective semi-finished product have 1425g, crossing 14 orders and can not crossing the qualified semi-finished product of 30 object has 3150g, and loss has 425g.1 hour 20 minutes used time, one time yield is 63.0%, and the proportion of goods damageds are 8.5%.
With the ethanol that mass percent concentration is 60%, make binding agent, the extrusion cavities mould of 1.2mm is arranged on extruder and adopts the preparation method in the of same 20101101 to produce 20101103.With 14 orders and 30 object screen clothes, sieve, cross 30 orders and can not cross 10 orders and defective semi-finished product have 1380g, crossing 14 orders and can not crossing the qualified semi-finished product of 30 object has 3320g, and loss has 300g.1 hour 20 minutes used time, one time yield is 66.4%, and the proportion of goods damageds are 6.0%.
Result of the test:
Six groups of Experimental Comparisons of above two kinds of production methods the results are shown in following table:
According to above-mentioned analysis of experimental data, in the present invention, adopt 3 groups of data moulding method for making test not only in product yield, the proportion of goods damageds, be all greatly improved than general method for making on process time.Adopt this method to produce, not only improved production efficiency, also reduced production cost.
Claims (5)
1. a Lemaiwan pill pellet composition, it is characterized in that, this Lemaiwan pill compositions obtains according to following method: by formula, take Radix Salviae Miltiorrhizae 79.84 weight portions, Rhizoma Chuanxiong 39.92 weight portions, Radix Paeoniae Rubra 39.92 weight portions, Flos Carthami 39.92 weight portions, Rhizoma Cyperi 19.96 weight portions, the Radix Aucklandiae 19.96 weight portions, Fructus Crataegi 9.98 weight portions, above seven flavor medicine material 249.504 weight portions are added in extraction pot, add water reflux, extract, repeatedly, collect each filtrate and merge, merging filtrate is concentrated into the thick paste that 60 ℃ of relative densities are 1.25～1.30, thick paste crushed after being dried, sieves and obtain extract micropowder after micropowder is processed with 80 eye mesh screens, to starch and the binding agent of 30wt%～60wt% of extract micropowder quality and the soybean oil of the 2wt%～3wt% of extract micropowder quality processed through micropowder that add the 50wt%～70wt% of extract micropowder quality in extract micropowder, after mixing, pass through extruding shaping, the strip-shaped materials of extruding is put into centrifugal spheronizator, by the trapezoidal cutting knife in centrifugal spheronizator, strip-shaped materials is cut into the cylindrical material that length is 0.8～1.2mm, adjust centrifugal spheronizator and turn 600～700 revs/min, air quantity adjustment is by regulating air blast agent frequency and air-introduced machine frequency to control, under centrifugal spheronizator high-speed motion, cylindrical material is made Lemaiwan pill pellet composition by mutual collision.
2. Lemaiwan pill pellet composition as claimed in claim 1, it is characterized in that, the number of times that adds water reflux, extract, is three times, the water that wherein adds for the first time 10 times of medical material amounts, reflux, extract, 1h, collects filtrate, the water that adds again for the second time 8 times of medical material amounts, reflux, extract, 1h, adds the water of 8 times of medical material amounts, reflux, extract, 1h for the third time again.
3. Lemaiwan pill pellet composition as claimed in claim 1, is characterized in that, it is that dried extractum is pulverized by 120 object pulverizers that described micropowder is processed, then sieves and get final product with 100 eye mesh screens.
4. Lemaiwan pill pellet composition as claimed in claim 1, is characterized in that, described binding agent is that mass percent concentration is 95% ethanol.
5. Lemaiwan pill pellet composition as claimed in claim 1, is characterized in that, the frequency-tuning range of described aerator is 20～25Hz; The frequency-tuning range of described air-introduced machine is 15～20Hz.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310704037.8A CN103656046A (en) | 2013-12-19 | 2013-12-19 | Lemai pellet composition |
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| CN201310704037.8A CN103656046A (en) | 2013-12-19 | 2013-12-19 | Lemai pellet composition |
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| CN103656046A true CN103656046A (en) | 2014-03-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191279A (en) * | 2013-04-12 | 2013-07-10 | 康美药业股份有限公司 | Application of traditional Chinese medicine compound in preparation of medicament used for treating or preventing diseases caused by platelet aggregation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191279A (en) * | 2013-04-12 | 2013-07-10 | 康美药业股份有限公司 | Application of traditional Chinese medicine compound in preparation of medicament used for treating or preventing diseases caused by platelet aggregation |
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Application publication date: 20140326 |
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