CN111821187A - Traditional Chinese medicine extract powder granulating system and method for treating cervical spondylosis - Google Patents
Traditional Chinese medicine extract powder granulating system and method for treating cervical spondylosis Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine granulation, and relates to a traditional Chinese medicine extract powder granulation system and method for treating cervical spondylosis. The raw materials are mixed at normal temperature and low temperature, then freeze-dried at low temperature, and then granulated by a dry method. The obtained granulated particles have better fluidity and compressibility.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine granulation, and particularly relates to a traditional Chinese medicine extract powder granulation system and method for treating cervical spondylosis.
Background
The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.
In the existing granulation method, the extract is filtered and boiled to remove large particles to obtain fine powder, and the fluidity is increased by utilizing the boiling process, and then spray granulation is carried out. However, through the process, some effective substances contained in the traditional Chinese medicine are removed, and the retention effect of the medicine effect is influenced.
However, in the complicated preparation method of the traditional Chinese medicine components, different components are required to be respectively and independently extracted, then the components are combined together for granulation, and finally, the physical states of various extracts before mixing are different, such as flowability, compressibility, powder structure characteristics and the like. And due to different Chinese medicine types, the physical properties of the extracts obtained by different methods are different.
Therefore, when the conventional spray granulation method is adopted, the obtained powder component is not uniform and is liable to agglomerate and agglomerate due to the difference in flowability of the pharmaceutical ingredient during the process of flowing. The resulting dry powder has an uneven structure and uneven particle diameters due to the uneven composition. If the complex treatment process is adopted, the fluidity of the extract is improved, the retention of the drug effect is influenced, and the quality of the traditional Chinese medicine granules is influenced.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide a traditional Chinese medicine extract powder granulating system and a traditional Chinese medicine extract powder granulating method for treating cervical spondylosis. According to the fluidity and compressibility of the traditional Chinese medicine extract, the structural characteristics of the powder and the like, a granulating system and a granulating method are provided, so that the quality of the obtained traditional Chinese medicine granules is uniform, and the retention rate of the effective ingredients of the medicine is improved.
In order to solve the technical problems, the technical scheme of the invention is as follows:
in a first aspect, a traditional chinese medicine extract powder pelletization system of treatment cervical spondylopathy, including the mixing arrangement who connects gradually, low temperature drying equipment, dry granulation equipment, mixing equipment includes mixing apparatus and lower mixing apparatus, the feed end of mixing apparatus sets up the feed inlet, the discharge end of mixing apparatus sets up the discharge gate, lower mixing apparatus is located the discharge gate below of mixing apparatus discharge end, set up discharging channel in the lower mixing apparatus, discharging channel's top and mixing apparatus's discharge gate intercommunication, set up cooling structure in the lower mixing apparatus.
A Chinese medicine extract for treating cervical spondylopathy is prepared from two clear pastes, notoginseng powder and volatile oil. By utilizing the system, the obtained product has better fluidity and certain compressibility. The mixture is relatively uniform.
The clear paste is a mixed phase dispersion and is a complex organic compound system. Miscible dispersions comprising eutectic mixtures, solid solutions, amorphous precipitates, and the like. The miscible dispersion has a large surface area and surface energy, and therefore has increased moisture absorption and blocking characteristics.
The properties of the clear paste obtained by different clear paste preparation methods are different, and the properties of the clear paste obtained by the traditional Chinese medicine with different components are also different.
The mixing device is used for reducing the surface energy of the mixture, and after the surface energy is reduced, the wettability of the mixture is better, so that the materials in the mixture are more uniform, the flowability is better, and the granulation quality is better.
In a second aspect, a method for granulating traditional Chinese medicine extract powder for treating cervical spondylosis comprises the following specific steps:
mixing the raw materials and the auxiliary materials at normal temperature and low temperature in sequence;
carrying out low-temperature freeze drying on the mixture;
and (4) carrying out dry granulation on the mixture obtained by low-temperature freeze drying.
One or more technical schemes of the invention have the following beneficial effects:
the granulation method suitable for the traditional Chinese medicine is obtained by considering the fluidity, compressibility and other aspects of the physical properties of the intermediate components of the traditional Chinese medicine extract.
After the mixing treatment of the granulating system, the difference between the fluidity and the compressibility of different extractum is met, and the fluidity of the mixture is improved from the aspect of influencing the surface energy of the fluidity of the mixture.
The raw materials and the auxiliary materials are comprehensively proportioned, so that the flowability and the compressibility of the mixture are in a proper range, the obtained granulated particles are facilitated, and the surface smoothness and the uniformity of the particles are better.
The quality and clinical curative effect of the traditional Chinese medicine granules are ensured, the granulation efficiency is improved, a reliable and rapid technical platform can be provided for the research of a traditional Chinese medicine forming process and a medicament prescription, and the traditional Chinese medicine granules have wide application prospects in the aspects of improving the research level of a traditional Chinese medicine extraction process, promoting the research of a traditional Chinese medicine preparation, promoting the modernization of a traditional Chinese medicine industry and promoting the export of the traditional Chinese medicine preparation.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description, serve to explain the invention and not to limit the invention.
Fig. 1 is a structural diagram of a traditional Chinese medicine extract powder granulating system for treating cervical spondylosis in an embodiment;
fig. 2 is a top view structural view of an up-mixing apparatus of an embodiment;
FIG. 3 is a cross-sectional structural view of a discharge passage of the embodiment;
the device comprises a mixing device 1, a low-temperature drying device 2, a dry granulation device 3, a discharge channel 4, a mixing channel 5, a feeding channel 6, a cooling cavity 7 and a cooler 8.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
In a first aspect, a traditional chinese medicine extract powder pelletization system of treatment cervical spondylopathy, including the mixing arrangement who connects gradually, low temperature drying equipment, dry granulation equipment, mixing equipment includes mixing apparatus and lower mixing apparatus, the feed end of mixing apparatus sets up the feed inlet, the discharge end of mixing apparatus sets up the discharge gate, lower mixing apparatus is located the discharge gate below of mixing apparatus discharge end, set up discharging channel in the lower mixing apparatus, discharging channel's top and mixing apparatus's discharge gate intercommunication, set up cooling structure in the lower mixing apparatus.
In some embodiments of the present invention, the discharge channel is vertically disposed, the cross section of the discharge channel is a double circle, the double circles are partially overlapped, the outer sides of the double circles have different sizes of convex structures, and the discharge channel is a hollow pipe structure.
In some embodiments of the invention, the upmixing device comprises a central mixing channel and a plurality of oppositely arranged feed channels on both sides of the mixing channel, the feed channels being located above the sides of the mixing channel and being inclined in an axial direction perpendicular to the mixing channel.
In some embodiments of the invention, several feed channels are provided independently of each other, and a screw conveyor is provided in the mixing channel.
In some embodiments of the present invention, the lower mixing device comprises a discharge channel and a cooling cavity, and the discharge channel is located in the cooling cavity and is arranged in a sealing manner with the cooling cavity.
In some embodiments of the invention, the mixing apparatus further comprises a cooler disposed below the upper mixing device on one side of the upper mixing device, the cooler being in communication with the cooling chamber via the medium conduit.
As shown in fig. 1, in the traditional Chinese medicine extract powder granulation system, the raw materials (the radix puerariae and radix paeoniae alba extract, the ligusticum chuanxiong hort and rhizoma corydalis extract and the radix notoginseng powder) are fully mixed by a mixing device 1, the mixed materials pass through a lower mixing device, the mixed materials pass through the contraction action of a discharge channel and the cooling action of a cooling device in the lower mixing device, the substances in the mixed materials have the contraction action, the surface energy is reduced, the fluidity is enhanced, the mixture with the enhanced fluidity is dried by a low-temperature drying device 2, and then is granulated by a dry granulation device 3, and in the granulation process, the mixing effect of the materials is good, and the obtained granules have better uniformity.
As shown in fig. 2, the top of the upper mixing device of the mixing apparatus is an open or closed structure. The feed inlet is arranged at the position of the feed channel opposite to the side wall of the upper mixing device, so that feeding can be carried out through the feed inlet. Or if open, so that the feed channel can be fed directly.
As shown in figure 2, the mixture is driven by the screw conveyer to move, when the mixture moves to the upper part of the discharge channel, the mixture enters the discharge channel under the action of the gravity of the mixture, and an opening is arranged at the joint between the top of the discharge channel and the upper mixing equipment.
As shown in fig. 3, the mixture passes through the discharging channel 4, which is equivalent to extruding the mixture, the upper mixing device is positioned above the lower mixing device, and the mixture passes through the discharging channel 4 downwards under the action of gravity. The material is passed through the discharge channel 4 under the constraint of gravity and the discharge channel. The outlet channel 4 is designed in the shape of a double circle, and the double circles partly overlap. Therefore, materials in each circular channel are mutually contacted at the overlapped part, the outer side edges of the double circles are provided with convex structures with different sizes, the clear paste in the mixture fully adsorbs the pseudo-ginseng powder, the pseudo-ginseng powder is fully fused in the clear paste, the shape of the discharge channel 4 through which the mixed clear paste passes is changed, the surface of the formed aggregation structure is rougher and more changeable, and the mixture tends to reduce the surface energy. And the mixture further mixes evenly after passing through the discharging channel.
As shown in figure 2, each feeding channel 6 and the mixing channel 5 are obliquely arranged, so that materials can obliquely fall into the mixing channel 5, the two opposite feeding channels 6 are mutually collided and overlapped in the mixing channel 5, the mixing effect is favorably improved, and the feeding of the adjacent or opposite feeding channels 6 is different, so that two kinds of clear paste and pseudo-ginseng powder can be mutually wrapped and mixed. Avoid a certain position to wrap too much clear paste or pseudo-ginseng powder.
The cooling cavity 7 is filled with cooling medium, so that the discharge channel 4 can be cooled, the cooler 8 is communicated with the cooling cavity 7, cooling liquid can be pumped into the cooling cavity, and then the cooling liquid is returned and then repeatedly condensed for recycling.
The mixture contributes to the reduction of surface energy at low temperature and improves fluidity.
In a second aspect, a method for granulating Chinese medicinal extract powder by using the Chinese medicinal extract powder granulation system for treating cervical spondylosis comprises the following specific steps:
mixing the raw materials and auxiliary materials at normal temperature and low temperature in sequence;
carrying out low-temperature freeze drying on the mixture;
and (4) carrying out dry granulation on the mixture obtained by low-temperature freeze drying.
In some embodiments of the invention, the raw materials are mixed successively at normal temperature and low temperature, and when the raw materials are mixed at normal temperature, the feeding of two adjacent feeding channels is different in each feeding channel of the upper mixing device, the feeding of two opposite feeding channels is different, and the temperature at low temperature is 5-18 ℃; preferably: 8-15 ℃; further preferably 10 to 12 ℃.
In some embodiments of the invention, the auxiliary materials are dextrin and carboxymethyl cellulose, and the mass ratio of the dextrin to the carboxymethyl cellulose is 10: 3-5; preferably 10: 4.
In some embodiments of the invention, the mass ratio of the total mass of each raw material to the total mass of the auxiliary materials is 10: 3-6; preferably 10: 5. The total mass of the raw materials and the mass ratio of the auxiliary materials influence the fluidity and compressibility of the mixture and indirectly influence the uniformity and surface morphology of the obtained particles.
In some embodiments of the invention, the raw materials comprise radix puerariae and radix paeoniae alba clear paste, rhizoma ligustici chuanxiong and rhizoma corydalis clear paste and pseudo-ginseng powder, and the granularity of the pseudo-ginseng powder is 100-120 meshes. Aiming at special raw materials, the raw materials are added with auxiliary materials in different proportions, and different treatment methods are set, so that a better granulation effect can be obtained.
In some embodiments of the invention, the granulated particles are mixed with volatile oil of notopterygium root and clematis root to obtain the product.
In some embodiments of the invention, the vacuum of the low temperature freeze drying is-0.1 to-0.5 MPa, and the temperature is-10 to-15 ℃; preferably, the vacuum degree of the low-temperature freeze drying is-0.2 to-0.5 MPa, and the temperature is-10 to-12 ℃.
In some embodiments of the invention, dry granulation is carried out using a dry granulator under the following conditions: the main pressure is 5-8 MPa, the side pressure is 0.5-2 MPa, the rotating speed of a roller is 10-30 r/min, and the rotating speed of a propeller is 50-80 r/min.
Each intermediate product obtained by the medicament preparation method in CN1228071C, wherein, in the step (1), the pseudo-ginseng powder is crushed into 100-120 mesh fine powder (the pseudo-ginseng powder of the invention); extracting volatile oil from notopterygium root and clematis root, collecting distilled aqueous solution in another container, decocting the residue in water for 1h, and filtering to obtain filtrate; decocting radix puerariae and radix paeoniae alba with water twice, the first time lasts for 2 hours, the second time lasts for 1 hour, mixing the filtrate with the two aqueous solutions, concentrating, precipitating with ethanol, recovering ethanol, and concentrating to obtain a fluid extract (the radix puerariae and radix paeoniae alba fluid extract of the invention) with a relative density of 1.25-1.30(50 ℃); and (4) refluxing and extracting the ligusticum wallichii and the rhizoma corydalis by using ethanol, discarding residues, recovering the ethanol from the extracting solution, and concentrating the extracting solution into clear paste (the ligusticum wallichii and the rhizoma corydalis clear paste of the invention) with the relative density of 1.25-1.30(50 ℃). 1-15 parts of pseudo-ginseng, 3-20 parts of ligusticum chuanxiong hort, 2-15 parts of rhizoma corydalis, 3-20 parts of radix paeoniae alba, 4-25 parts of radix clematidis, 3-20 parts of radix puerariae and 4-25 parts of notopterygium root. The invention will be further illustrated by the following examples
Example 1
Mixing radix Puerariae and radix Paeoniae alba fluid extract, rhizoma Ligustici Chuanxiong and rhizoma corydalis fluid extract, Notoginseng radix powder and adjuvants in a mixing device at room temperature, then mixing at 10 deg.C, and freeze drying at low temperature (-0.3MPa, -12 deg.C) to obtain mixture; and (3) performing dry granulation on the mixture obtained by low-temperature freeze drying (the main pressure is 6 MPa, the side pressure is 1 MPa, the rotating speed of a roller is 20 r/min, and the rotating speed of a propeller is 60 r/min).
The mass ratio of the total mass of the radix puerariae and radix paeoniae alba clear paste, the ligusticum chuanxiong hort rhizoma corydalis clear paste and the pseudo-ginseng powder to the auxiliary materials is 10:5, the auxiliary materials are dextrin and carboxymethyl cellulose, and the mass ratio of the dextrin to the carboxymethyl cellulose in the auxiliary materials is 10: 4.
Example 2
Mixing radix Puerariae and radix Paeoniae alba fluid extract, rhizoma Ligustici Chuanxiong and rhizoma corydalis fluid extract, Notoginseng radix powder and adjuvants in a mixing device at room temperature, then mixing at 12 deg.C, and freeze drying the obtained mixture at low temperature (-0.4 MPa-10 deg.C); and (3) performing dry granulation on the mixture obtained by low-temperature freeze drying (the main pressure is 7 MPa, the side pressure is 1.5 MPa, the rotating speed of a roller is 25 r/min, and the rotating speed of a propeller is 70 r/min).
The mass ratio of the total mass of the radix puerariae and radix paeoniae alba clear paste, the ligusticum chuanxiong hort rhizoma corydalis clear paste and the pseudo-ginseng powder to the auxiliary materials is 10:4, the auxiliary materials are dextrin and carboxymethyl cellulose, and the mass ratio of the dextrin to the carboxymethyl cellulose in the auxiliary materials is 10: 3.
Example 3
Mixing radix Puerariae and radix Paeoniae alba fluid extract, rhizoma Ligustici Chuanxiong and rhizoma corydalis fluid extract, Notoginseng radix powder and adjuvants in a mixing device at room temperature, then mixing at 11 deg.C, and freeze drying at low temperature (-0.5 MPa-11 deg.C) to obtain mixture; and (3) performing dry granulation on the mixture obtained by low-temperature freeze drying (the main pressure is 8 MPa, the side pressure is 2 MPa, the rotating speed of a roller is 30 revolutions per minute, and the rotating speed of a propeller is 75 revolutions per minute).
The mass ratio of the total mass of the radix puerariae and radix paeoniae alba clear paste, the ligusticum chuanxiong hort rhizoma corydalis clear paste and the pseudo-ginseng powder to the auxiliary materials is 10:3, the auxiliary materials are dextrin and carboxymethyl cellulose, and the mass ratio of the dextrin to the carboxymethyl cellulose in the auxiliary materials is 10: 5.
Comparative example 1
Mixing radix Puerariae and radix Paeoniae alba fluid extract, rhizoma Ligustici Chuanxiong and rhizoma corydalis fluid extract, Notoginseng radix powder and adjuvants in a mixing device at room temperature, then mixing at 10 deg.C, and freeze drying at low temperature (-0.3MPa, -12 deg.C) to obtain mixture; and (3) performing dry granulation on the mixture obtained by low-temperature freeze drying (the main pressure is 6 MPa, the side pressure is 1 MPa, the rotating speed of a roller is 20 r/min, and the rotating speed of a propeller is 60 r/min).
The mass ratio of the total mass of the radix puerariae and radix paeoniae alba clear paste, the ligusticum chuanxiong hort rhizoma corydalis clear paste and the pseudo-ginseng powder to the auxiliary materials is 10:8, the auxiliary materials are dextrin and carboxymethyl cellulose, and the mass ratio of the dextrin to the carboxymethyl cellulose in the auxiliary materials is 10: 7.
Comparative example 2
Compared with example 1, the particle size of the notoginseng powder is 150 meshes, and other granulating methods are the same as example 1.
Test example 1
Fluidity the fluidity of the fluid extract was measured according to the method specified in GB 8077. Example 1 and example 3, comparative example 1. As shown in Table 1, the results showed that the powder mixture obtained by obtaining the mixing effect of the mixing apparatus of example 1 as shown in Table 1 was uniform and had good fluidity. Comparative example 1 the flowability decreased with respect to example 1 after the addition ratio of the adjuvant was changed. The particle size of the raw material in comparative example 2 was changed, and the fluidity of the resulting mixture was deteriorated, so that the fluidity of the different raw materials was different.
In table 1, no cooling chamber was provided, and the mixture was not cooled in the mixing device in addition to example 1. The mix without cooling chamber had a slightly lower fluidity than the mix of example 1.
TABLE 1 fluidity
Test example 2
The freeze-dried materials of example 1 and comparative example 1 were tabletted using a tabletting machine, and the powder obtained by drying the raw materials by spray drying was tabletted, specifically, the two clear pastes were mixed and boiled for 5 minutes, and then the notoginseng powder and the auxiliary materials (the ratio of the raw materials to the auxiliary materials was the same as in example 1) were added, followed by spray granulation, and the results were as shown in table 2. From fig. 2, it can be seen that the freeze-dried mix of example 1 has better compressibility, better cohesive impact than spray drying, and better friability of the powder. In comparative example 1, the proportion of the auxiliary materials was changed, and although the hardness was better, the sticking property was reduced as compared with example 1.
TABLE 2 compressibility
Test example 3
Example 1, comparative example 1 and comparison of the surface morphology of the granules obtained after spray drying and dry granulation, as shown in table 3, the spray drying method was the same as that of test example 2, and the operating conditions of dry granulation were the same as those of example 1. As can be seen from table 3, the particle size after granulation in example 1 was uniform, indicating that the granulation process in example 1 improved the granulation quality. The granules obtained by the spray drying and dry granulation methods are different in size and have a small amount of agglomeration. The particle diameter obtained in comparative example 1 is regular, but the surface of the particle has some pits, so that the whole granulation effect is influenced.
TABLE 3 powder Structure
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine extract powder granulating system for treating cervical spondylosis is characterized in that: the method comprises the following specific steps: including the mixing arrangement who connects gradually, low temperature drying equipment, dry process granulation equipment, mixing apparatus includes mixing apparatus and mixing apparatus down, and the feed end of mixing apparatus sets up the feed inlet, and the discharge end of mixing apparatus sets up the discharge gate, and mixing apparatus is located the discharge gate below of mixing apparatus discharge end down, sets up discharging channel in the mixing apparatus down, and discharging channel's top and mixing apparatus's discharge gate intercommunication set up cooling structure in the mixing apparatus down.
2. The traditional Chinese medicine extract powder granulation system for treating cervical spondylosis as claimed in claim 1, wherein: the discharge passage is vertically arranged, the cross section of the discharge passage is in a double-circle shape, the double-circle part is overlapped, the outer side edges of the double-circle shape are provided with convex structures with different sizes, and the discharge passage is in a hollow pipe body structure.
3. The traditional Chinese medicine extract powder granulation system for treating cervical spondylosis as claimed in claim 1, wherein: the upper mixing equipment comprises a middle mixing channel and a plurality of oppositely arranged feeding channels at two sides of the mixing channel, and the feeding channels are positioned above the side of the mixing channel and are obliquely arranged in the axial direction vertical to the mixing channel; preferably, the feeding channels are respectively and independently arranged, and the mixing channel is internally provided with a screw conveyor.
4. The traditional Chinese medicine extract powder granulation system for treating cervical spondylosis as claimed in claim 1, wherein: the lower mixing device comprises a discharge channel and a cooling cavity, wherein the discharge channel is positioned in the cooling cavity and is arranged between the discharge channel and the cooling cavity in a sealing manner.
5. The traditional Chinese medicine extract powder granulation system for treating cervical spondylosis as claimed in claim 1, wherein: the mixing device also comprises a cooler, the cooler is arranged below the upper mixing device and on one side of the upper mixing device, and the cooler is communicated with the cooling cavity through a medium pipeline.
6. The method for granulating the traditional Chinese medicine extract powder by using the traditional Chinese medicine extract powder granulating system for treating cervical spondylosis as claimed in any one of claims 1 to 5, is characterized in that: the method comprises the following specific steps:
mixing the raw materials and auxiliary materials at normal temperature and low temperature in sequence;
carrying out low-temperature freeze drying on the mixture;
and (4) carrying out dry granulation on the mixture obtained by low-temperature freeze drying.
7. The method for granulating traditional Chinese medicine extract powder as claimed in claim 6, characterized in that: mixing the raw materials at normal temperature and low temperature in sequence, wherein the low temperature is 5-18 ℃; preferably: 8-15 ℃; further preferably 10 to 12 ℃.
8. The method for granulating traditional Chinese medicine extract powder as claimed in claim 6, characterized in that: the auxiliary materials are dextrin and carboxymethyl cellulose, and the mass ratio of the dextrin to the carboxymethyl cellulose is 10: 3-5; preferably 10: 4.
9. The method for granulating traditional Chinese medicine extract powder as claimed in claim 6, characterized in that: the mass ratio of the total mass of the raw materials to the total mass of the auxiliary materials is 10: 3-6; preferably 10: 5;
the raw materials comprise radix puerariae and radix paeoniae alba clear paste, rhizoma ligustici chuanxiong and rhizoma corydalis clear paste and pseudo-ginseng powder;
or mixing the granulated particles with volatile oil of Notopterygii rhizoma and radix Clematidis to obtain the final product.
10. The method for granulating traditional Chinese medicine extract powder as claimed in claim 6, characterized in that: the vacuum degree of low-temperature freeze drying is-0.1 to-0.5 MPa, and the temperature is-10 to-15 ℃; preferably, the vacuum degree of low-temperature freeze drying is-0.2 to-0.5 MPa, and the temperature is-10 to-12 ℃;
or, the dry granulation is carried out by a dry granulator under the following conditions: the main pressure is 5-8 MPa, the side pressure is 0.5-2 MPa, the rotating speed of a roller is 10-30 r/min, and the rotating speed of a propeller is 50-80 r/min.
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| CN202010738392.7A CN111821187A (en) | 2020-07-28 | 2020-07-28 | Traditional Chinese medicine extract powder granulating system and method for treating cervical spondylosis |
| PCT/CN2021/098702 WO2022022064A1 (en) | 2020-07-28 | 2021-06-07 | Granulation system for traditional chinese medicine extract powder for treating cervical spine disease, and method |
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| CN202010738392.7A CN111821187A (en) | 2020-07-28 | 2020-07-28 | Traditional Chinese medicine extract powder granulating system and method for treating cervical spondylosis |
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| WO2022022064A1 (en) * | 2020-07-28 | 2022-02-03 | 山东明仁福瑞达制药股份有限公司 | Granulation system for traditional chinese medicine extract powder for treating cervical spine disease, and method |
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| CN114870430B (en) * | 2022-06-20 | 2023-06-13 | 信阳农林学院 | Traditional Chinese medicine raw material continuous extraction device and extraction method |
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Inventor after: Liu Jie Inventor after: Jiang Yujuan Inventor after: Xu Min Inventor after: Gao Chao Inventor after: Pan Ruixue Inventor after: Wang Li Inventor after: Zhang Yaxin Inventor after: Chen Kexin Inventor after: Hao Honghui Inventor before: Liu Jie Inventor before: Jiang Yujuan Inventor before: Xu Min Inventor before: Gao Chao Inventor before: Pan Ruixue Inventor before: Wang Li Inventor before: Zhang Yaxin Inventor before: Chen Kexin Inventor before: Hao Honghui |