CN103381193A - Rhodiola rosea micro powder tablet and preparation method thereof - Google Patents
Rhodiola rosea micro powder tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a rhodiola rosea micro powder tablet and a preparation method thereof and aims at solving the problem that existing tabletting processes need additional auxiliary materials and the content of effective constituents of prepared tablets is low. The rhodiola rosea micro powder tablet has water content 3-15%, the partical size of the tablet is 1-150mum, the rhodiola rosea micro powder tablet is prepared at the tabletting temperature of subzero 10-10 DEG C, any auxiliary material is not added in the preparation process, and rhodiola rosea micro powder is an unique constituent of the tablet. The purpose of direct tabletting and forming can be achieved by controlling moisture and the temperature or by adopting a circular tabletting process or a dry granulating and tabletting process. The process enables the tablet to be good in appearance and enables the pitted surface rate and the breakage rate to be low, the hardness, the disintegration degree and the breakage degree of the tablet meet the requirement for tablet quality, and the hardness can further ensure the tablet not to fragment in the coating and film covering treatment process of the tablet.
Description
Technical field
The invention belongs to medicine and field of health care food, be specifically related to a kind of Radix Rhodiolae micropowder sheet and preparation method thereof.
Background technology
Generally, be all first will require to select suitable adjuvant according to character and the clinical application of medicine when those skilled in the art prepare tablet, through hybrid process, make it have good mobility and compressibility.(pharmacy of Chinese materia medica, China Traditional Chinese Medicine Publishing House, in January, 2003 front page, p411, the 2nd section reciprocal), during direct compression, the selection of adjuvant is extremely important, wherein the most important thing is filler and adhesive, they are keys of tabletting.The effect in the film-making of wet grain method of acting on of excipient, the especially filler in direct compression prescription and adhesive even more important (pharmacy of Chinese materia medica, China Traditional Chinese Medicine Publishing House, in January, 2003 front page, p410, the 4th section).
Radix Rhodiolae (Herba Rhodiolae) sacc. is that China's special product is treasured Chinese crude drug, mainly originates in Tibet, northwestern Yunnan Province, western Sichuan.Be born in the patana, shrubbery of height above sea level 2800-5600 rice, in crack of stone.At present Radix Rhodiolae being made in the technique of tablet generally all needs to mix with other medical material use or adds a large amount of adjuvants in order to figuration, Radix Rhodiolae never occurred with the form of pure medical material tablet, when tabletting, no matter be for the extractum after Radix Rhodiolae powder or Radix Rhodiolae extraction process, extract powder etc., usually all can by adding adjuvant to improve some performance of powder, extractum or extract powder, make the tablet of compacting meet the correlated quality requirement.And press pharmaceutics classification, wherein so-called full powder sheet is also to have added to suppress after suitable adjuvant to form usually, is not to use the Chinese drugs powder tabletting fully.As Chinese patent application (publication number CN97107821.1) Radix Rhodiolae buccal tablet, about this patent document of granulating process, this tablet Radix Rhodiolae extractum 3-15 part is disclosed wherein, Mel 5-20 part, dextrin 20-40 part, Mentholum 1-5 part, xylitol 30-50 part, sucrose 40-60 part, magnesium stearate 0.8-1.2 part, citric acid 0.2-1 part, protein sugar 0.5-2 part is through mixing, solution processed, drying, sieve and make tablet or piece agent.As Chinese patent (CN1429622A) Radix rhodiolae double action lozenge, it is by Radix Rhodiolae extract (or superfine powder ground product) 5-30%, Cordyceps superfine powder 1.5%-18%, Radix Panacis Quinquefolii superfine powder 1.5%-18%, additive 40%-95% that this patent has been announced this buccal tablet.So far, yet there are no the report for preparing separately tablet with the pure medical material of Radix Rhodiolae.
In addition, when the inventor found that in research process Radix Rhodiolae is ground into the micropowder rank powder of particle diameter 1-150 μ m, its dissolution rate was very high, and active constituents of medicine reaches the blood drug level for the treatment of disease at short notice.But the micropowder surface tension of particle diameter 1-150 μ m is very large, and between powder, the space is large, and those skilled in the art are difficult to its direct compression or granulation usually, all need to add adjuvant and improve its mobility, viscosity, compressibility so that tabletting.Conventional method is by fluid bed or wet method plasmid, but easily cause the loss of volatile ingredient or the thermal sensitivity composition of Radix Rhodiolae in this method process, if in the wet method plasmid, moisture Control is not good, be prone to sticking, shedding, sliver, fall the technical problem of piece, loose sheet, if overcome defects, usually need add adjuvant to carry out excipient, improve mobility of particle, water content to guarantee the tabletting quality.But after having added adjuvant, inequality, the defective that tablet medicine content is inhomogeneous can appear mixing.After having added adjuvant simultaneously, increase invalid components, reduced effective medicinal ingredient of Radix Rhodiolae buccal tablet.
In a word, have not yet to see only with Radix Rhodiolae micropowder, in the situation that do not add the report that any adjuvant is pressed into tablet.
Summary of the invention
The object of the present invention is to provide a kind of Radix Rhodiolae medical material micropowder that only contains, do not add the tablet of any adjuvant, can not reduce or destroy the effective ingredient of Radix Rhodiolae in preparation process, its appearance character and hardness meet the tablet quality standard.
Realize that technical scheme of the present invention is as follows:
A kind of Radix Rhodiolae micropowder sheet, it is that only to adopt water content be 3～15%, particle diameter is the tablet that the Radix Rhodiolae powder compacting of 1 μ m～150 μ m gets.
Further, described Radix Rhodiolae micropowder particle diameter is 5～45 μ m.
Again further, the water content of described Radix Rhodiolae micropowder is 8%.
Further, during tabletting temperature at-10～10 ℃; As a kind of preferred, the tabletting temperature is 5 ℃.
As a kind of preferred, described tablet is buccal tablet.
The preparation method of above-mentioned Radix Rhodiolae micropowder sheet comprises the following steps:
(1) Radix Rhodiolae is crushed to the powder that particle diameter is 1～150 μ m, controlling water content is 3～15%;
(2) the Radix Rhodiolae micropowder direct pressing is in blocks, get product.
Further, the method for described direct compression is precompressed Radix Rhodiolae powder before tabletting, and wherein precompression is 0.5～1.5kN, and principal pressure is 5～10kN.As a kind of preferred, preload pressure is 1kN, and principal pressure is 8kN.
Above-mentioned preparation method comprises that also step (3) pulverizes step (2) gained micropowder tablet for after can mistake 60～80 mesh sieves, again tabletting.
In order better to realize the present invention, so repeating step (3) repeatedly.
Further, again first use the pressure precompressed of 5～10kN before tabletting, then carry out main pressure, principal pressure is 5～10kN; As a kind of preferred, the preload pressure of tabletting is 8kN again, and principal pressure is 8kN.
The another kind of preparation method of above-mentioned Radix Rhodiolae micropowder sheet comprises the following steps:
(1) Radix Rhodiolae is pulverized as particle diameter is the micropowder of 1～150 μ m, controlling water content is 3～15%;
(2) Radix Rhodiolae micropowder is pressed into large plate;
(3) large plate is crushed to crosses after 80～100 mesh sieves tabletting again, get product.
Further, again first use the pressure precompressed of 5～10kN before tabletting, then carry out main pressure, principal pressure is 5～10kN; As a kind of preferred, the preload pressure of tabletting is 8kN again, and principal pressure is 8kN.
The present invention has the following advantages and beneficial effect:
(1) tablet of the present invention is not adding under the situation of any adjuvant, the sheet type outward appearance that makes is good, pitted skin rate and sliver rate are low, tablet hardness, disintegration, friability meet the tablet quality requirement, and this hardness can also guarantee that the later stage carries out the processing of coating, overlay film to this tablet, is unlikely to cracked in preparation process; Simultaneously, tablet adds adjuvant because of nothing, and user needn't be taken the adjuvant without drug effect more, can guarantee as much as possible that the Radix Rhodiolae high concentration is to give full play to the activity of medicine.The Radix Rhodiolae micropowder tabletting is low than the preparation cost of Radix Rhodiolae extract tabletting, but also effective ingredient runs off can prevent from extracting the time, and preparation technology is simpler.When Radix Rhodiolae micropowder sheet of the present invention is used with buccal tablet, absorb approach by oral mucosa in conjunction with oral gastrointestinal, make the effective ingredient in Radix Rhodiolae micropowder enter rapidly in body, improve curative effect, and can make dose reduce to reduce even at double, the meaning of its clinical meaning and the utilization of resources is very great.
(2) tabletting temperature of the present invention is controlled at-10～10 ℃, can effectively prevent the extruding heat that the pinch roller surface produces through extruding, prevent that Radix Rhodiolae from cohering, glutinous wheel phenomenon, being more suitable for the Radix Rhodiolae micropowder compressed tablets, is mainly due to temperature during lower than-10 ℃, and in its production process, yield rate is only 15～17.2%, hardness is 1.11～1.21kg, the pitted skin rate is up to 80～81%, and the sliver rate is up to 71～76%, industrial can't the application; Temperature is during higher than 10 ℃, in the tabletting process part Cordyceps powder end bonds, the glutinous phenomenon of taking turns, be unfavorable for the production of product and industrial operation; In addition, when temperature is controlled at 5 ℃, the compacting and the tablet yield rate high, steady quality, conformance with standard also reaches the prescriptions such as the follow-up required product hardness of product, disintegration.
(3) by the control to the tabletting temperature, thereby can reduce preload pressure and principal pressure value, because when temperature surpasses 10 ℃, when the Cordyceps powder will bond, stick the wheel phenomenon, the pinch roller surface just has material, material subsequently just can not be directly directly contact build-up of pressure inhomogeneous with the pinch roller surface, can cause simultaneously two pinch roller gap changes greatly, thereby necessary intensified pressure to the pressure more than 10kN goes compacting, and the tablet of its preparation of guarantee meets the requirements.And in temperature range of the present invention the time, find that pressure is to be more suitable in the aweto micropowder compressed tablets at 5～10kN, and reduce force value, thereby reduced energy consumption, reduced production cost.
(4) by the control to above-mentioned tabletting temperature and tabletting pressure, find that moisture plays very important impact to product quality, if moisture is lower than 3% the time, the situations such as sliver, spring sheet can appear after tabletting, if moisture higher than 15% the time, sheet embryo variable color during tabletting, color burn, be dark-brown, the variable color reason is that its effective ingredient is separated out, and causes the reduction of its active ingredients of cordyceps sinensis; And moisture the situations such as sliver, spring sheet not only can not occur when being 3～15%, can not separate out effective ingredient simultaneously yet, has guaranteed the active constituent content of tablet, and the tablet yield rate of compacting is high, steady quality, conformance with standard; In addition, when the Radix Rhodiolae powder moisture was about 8%, the tablet yield rate of compacting was high, steady quality, and conformance with standard, this has played effect very easily in industrial application.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
In the present invention, the inventor is creationary to have invented under the pressing conditions that does not add any adjuvant, can not reduce or destroy in process in the situation of rhodiola active ingredient, Radix Rhodiolae micropowder has been pressed into efficient pure powder sheet truly, improve the bioavailability of Radix Rhodiolae.
Radix Rhodiolae micropowder sheet of the present invention, it is that the employing water content is 3-15%, particle diameter is 1-150 μ m, Radix Rhodiolae micropowder temperature when tabletting be-10-10 ℃ of tablet that get by the preparation of dry method plasmid tabletting, the while does not reduce in preparation process or destroys the Radix Rhodiolae bioactive ingredients.Do not add any adjuvant in preparation process, Radix Rhodiolae is unique component of tablet.
Selecting particle diameter in the present invention is the Radix Rhodiolae powder of 1-150 μ m, because the powder grinding particle size of this particle size range is evenly distributed, reached Cellular Level Pulverizing according to the parameter declaration of grain size analysis report, and result of study shows that the dissolution of total leachable of the inventive method and rhodioside is relevant with the grinding particle size of Radix Rhodiolae, grinding particle size is less, dissolution time is shorter, and namely dissolution is larger.
Below by different other active substance dissolution tests of level of pulverizing of Radix Rhodiolae, the foundation that micropowder is selected is described.Pulverizing rank is I powder D90=150-500 μ m, II powder D90=25-45 μ m, III powder D90=10-20 μ m.Effective ingredient stripping table 1 in time in different other Radix Rhodiolaes of pulverizing level.
1, the mensuration of total leachable
Precision takes Radix Rhodiolae decoction pieces, Radix Rhodiolae I powder, II powder, III powder, add 37 ℃ of pure water 100ml, after stirring, be placed in 37 ℃ ± 1 water-bath, respectively 3,10,20,30,45, the 60min sampling, centrifugal (3500 rev/mins) 1 minute, get supernatant 50ml, put in the evaporating dish of constant weight, 105 ℃ of dryings 3 hours are calculated total leachable amount.
Total leachable dissolution (%) in time in other Radix Rhodiolae of the different pulverizing level of table 1
| Time (min) | 3 | 10 | 20 | 30 | 45 | 60 |
| The Radix Rhodiolae decoction pieces | 1.73 | 3.83 | 8.03 | 9.06 | 9.12 | 9.27 |
| Radix Rhodiolae I powder | 11.65 | 12.43 | 12.94 | 13.10 | 13.62 | 13.91 |
| Radix Rhodiolae II powder | 33.84 | 34.15 | 34.90 | 36.40 | 37.20 | 37.39 |
| Radix Rhodiolae III powder | 33.86 | 34.25 | 34.94 | 36.49 | 37.20 | 37.39 |
In table 1, the different measurement results of pulverizing the total leachable of other Radix Rhodiolae of level show, respectively pulverize other dissolution of level and increase progressively in time.Radix Rhodiolae II powder, III powder are all rapid than Radix Rhodiolae decoction pieces and the stripping of I powder, and are keeping higher dissolution.Particularly when 3min, Radix Rhodiolae II powder (33.84%), III powder (33.86%) are higher than nearly 30 times of Radix Rhodiolae decoction pieces (1.73%), higher than (11.65%) 3 times, I powder.When 60min, Radix Rhodiolae II powder (37.29%) also higher than (9.27%) 4 times of Radix Rhodiolae decoction pieces, exceeds (13.91%) 2 times, I powder with III powder (37.29%).Radix Rhodiolae II powder and III powder there is no too big-difference on dissolution, reach the same when 60min.
2, the mensuration of rhodioside
(1) chromatographic condition: with reference to content assaying method under Chinese Pharmacopoeia Radix Rhodiolae medical material item.
Chromatographic column: TIANHE Kromail C18250 * 4.6mm5 μ m;
Mobile phase: methanol-water (15:85);
Detect wavelength: 275nm;
Flow velocity: 1ml/min;
Column temperature: 30 ℃.
(2) reference substance solution preparation: precision takes gets rhodioside reference substance 5.97mg, is placed in the 10ml measuring bottle, add methanol and be diluted to scale, then precision measures 3ml and is placed in the 10ml measuring bottle, is diluted with water to scale, shakes up, and get final product.
(3) need testing solution preparation:
Precision takes Radix Rhodiolae decoction pieces, Radix Rhodiolae I powder, II powder, III powder, is placed in tool plug conical flask, and precision adds methanol 10ml, close plug, weighed weight, supersound process 30 minutes, let cool, more weighed weight, supply the weight of less loss with methanol, shake up, filter, get subsequent filtrate 3ml and be placed in the 10ml measuring bottle, be diluted with water to scale, shake up, filter with 0.45 μ m microporous filter membrane, get filtrate, and get final product.
(4) algoscopy:
Get respectively each 10 μ l of reference substance solution and need testing solution, the injection liquid chromatography records peak area, calculates, and get final product.Wherein, rhodioside reference substance concentration: 0.1791mg/ml, rhodioside reference substance peak area: 501.4 and 502.6 is average: 502.0.
Rhodioside dissolution (%) in time in other Radix Rhodiolae of the different pulverizing level of table 2
| Time (min) | 3 | 10 | 20 | 30 | 45 | 60 |
| The Radix Rhodiolae decoction pieces | 0.06 | 0.08 | 0.18 | 0.29 | 0.33 | 0.56 |
| Radix Rhodiolae I powder | 0.42 | 0.53 | 0.68 | 0.80 | 0.93 | 1.04 |
| Radix Rhodiolae II powder | 1.70 | 1.74 | 1.75 | 1.76 | 1.80 | 1.85 |
| Radix Rhodiolae III powder | 1.72 | 1.75 | 1.76 | 1.78 | 1.80 | 1.85 |
In table 2, in different other Radix Rhodiolaes of pulverizing level, rhodioside dissolution determination result in time shows, each dissolution of pulverizing other rhodioside of level increases progressively in time.Radix Rhodiolae II powder, III powder are all rapid than Radix Rhodiolae decoction pieces and the stripping of I powder, and are keeping higher dissolution.Particularly when 3min, Radix Rhodiolae II powder (1.70%), III powder (1.72%) are higher than nearly 28 times of Radix Rhodiolae decoction pieces (0.06%), higher than (11.65%) 3 times, I powder.When 60min, Radix Rhodiolae II powder (1.85%) also higher than nearly 4 times of Radix Rhodiolae decoction pieces, exceeds nearly 2 times of I powder with III powder (1.85%).Radix Rhodiolae II powder and III powder there is no too big-difference on dissolution, reach the same when 60min.
Table 1,2 explanations, when the particle diameter of Radix Rhodiolae is 1-150 μ m, show in the comparison of test results of instantaneous (3min) dissolution, Radix Rhodiolae II powder and III powder can its effective ingredient of rapid, high volume stripping, and this moment Radix Rhodiolae decoction pieces and the strippings in a large number of effective ingredient of I powder.At 60min, Radix Rhodiolae II powder and III powder can keep higher dissolution, the dissolution that all is much higher than other groups, this is because micropowder has extremely strong stripping penetrating power, the dissolution of Radix Rhodiolae II powder and III powder is very approaching simultaneously, this explanation is after powder arrives 45 μ m, and its dissolution is just very rapid.Therefore what micropowder tablet of the present invention namely can be conventional is oral, also can the oral cavity buccal, absorb active ingredient by oral mucosa, make rhodiola active ingredient discharge rapidly in limited digestion time and enter in human body, thereby raising curative effect, and can make dose reduce to reduce even at double, the meaning of its clinical meaning and the utilization of resources is very great.
In addition, the present inventor is in the research process of tablet forming technique, at first find that the tabletting temperature is extremely important to controlling product quality, in the time of should being controlled at-10～10 ℃, can effectively prevent the extruding heat that the pinch roller surface produces through extruding, prevent that Radix Rhodiolae from cohering, glutinous wheel phenomenon, be more suitable for the Radix Rhodiolae micropowder compressed tablets.During lower than-10 ℃, its finished product rate is only 15～17.2% when the tabletting temperature, and hardness is 1.11～1.21kg, and the pitted skin rate is up to 80～81%, and the sliver rate is up to 71～76%, industrial can't the application.When tabletting, temperature is higher than 10 ℃, and during tabletting, part Radix Rhodiolae powder bonds, sticks the wheel phenomenon, is unfavorable for the production of product and industrial operation, is-10～10 ℃ therefore select the tabletting temperature, can realize the purpose of micropowder tabletting.According to drawing in the experiment of temperature on the impact of tabletting quality in pressing process at Radix Rhodiolae micropowder, temperature is in the time of 5 ℃ when tabletting, compacting and the tablet yield rate high, steady quality, conformance with standard also reaches the prescriptions such as the follow-up required product hardness of product, disintegration.
Simultaneously, moisture is also the very important parameter that affects on product quality, and during tabletting, temperature is when temperature is controlled at-10～10 ℃, and the inventor is in the screening process of tablet forming technique, find that moisture 3～15% the time, is more suitable in winter Radix Rhodiolae micropowder compressed tablets.If moisture lower than 3% the time, the situations such as sliver, disintegrating tablet can occur after tabletting, if moisture higher than 15% the time, during tabletting, the sheet embryo is with variable color, color burn is rufous, the variable color reason is that its effective ingredient is separated out, and causes the reduction of its rhodiola active ingredient.The inventor draws in the experiment of Radix Rhodiolae powder moisture on the impact of tabletting quality, and when the Radix Rhodiolae powder moisture was about 8%, the tablet yield rate of compacting was high, steady quality, and conformance with standard, this has played effect very easily in industrial application.
The inventor realizes by following preparation technology, and all do not add any adjuvant in order to figuration:
One, direct pressed powder technique, get the Radix Rhodiolae micropowder direct compression.
Two, circulation tablet forming technique: after the Radix Rhodiolae micropowder direct compression, then this micropowder tablet is pulverized as after passing through 60～80 mesh sieves; If do not reach the tablet requirement, repeat to appeal step, until qualified.
Three, dry granulation tablet forming technique: Radix Rhodiolae micropowder is pressed into large plate, then be crushed into can cross 60～80 mesh sieves after, at tabletting and get final product.
In the screening of technique, adopt the method compacting of precompression and principal pressure, its pressure is different because of the difference of technique, if adopt direct pressed powder technique, wherein preload pressure is 0.5～1.5KN, and principal pressure is 5～10kN, preferred preload pressure is 1kN, and principal pressure is 8kN.If adopt repeatedly tablet forming technique or dry method plasmid technique, preload pressure 5～10kN wherein, principal pressure is 5～10kN, preferred preload pressure 8kN, principal pressure 8kN.
Find in tabletting test, still there is difference qualitatively in three kinds of techniques in the present invention.Direct pressed powder technique wherein, yield rate is low, the tablet of preparation loose sheet, shedding easily occur, falls piece, sliver, loose sheet etc. problem.And repeatedly tablet forming technique and dry method plasmid technique all can obtain effect preferably, and prepared tablet meets the requirements.
Below the confirmation tablet forming technique screening test data that the inventor records.
Be below the confirmation tablet forming technique screening test data that the inventor records, product quality sees Table 3～5.
Table 3 technique of direct powder compression
Table 4 circulation tablet forming technique
Table 5 dry granulation technique
Embodiment 1 micropowder direct compression technique
1, raw material: Radix Rhodiolae micropowder, particle diameter D90=25-45 μ m, moisture approximately 8%.
2, tablet machine revolution 15/h, preload pressure 8kN, principal pressure 8kN.
3, the tabletting temperature setting is set to 5 ℃.
4, ambient temperature is 22 ℃, ambient humidity 48%.
According to above-mentioned technique compressed tablets, tablet specification 0.25g/ sheet, 100.
Embodiment 2 circulation tablet forming techniques
1, raw material: Radix Rhodiolae micropowder, particle diameter D90=25-45 μ m, moisture gets over 8%.
2, tablet machine revolution 15/h, preload pressure 8kN, principal pressure 8kN.
3, the tabletting temperature setting is set to 5 ℃.
4, ambient temperature is 22 ℃, ambient humidity 48%.
During according to above-mentioned technique compressed tablets, first with the powder compaction sheet, then pulverized the 60-80 mesh sieve, tabletting, if do not reach requirement, can repeat to appeal the step tabletting again, until tablet quality is qualified, and tablet specification 0.25g/ sheet, 100.
Embodiment 3 circulation tablet forming techniques
1, raw material: Radix Rhodiolae micropowder, particle diameter D90=25-45 μ m, moisture gets over 8%.
2, tablet machine revolution 15/h, preload pressure 8kN, principal pressure 8kN.
3, the tabletting temperature setting is set to 5 ℃.
4, ambient temperature is 22 ℃, ambient humidity 48%.
According to above-mentioned technique compressed tablets, first with the large plate of powder compaction, then pulverized the 60-80 mesh sieve, tabletting gets final product again, tablet specification 0.25g/ sheet, 100.
By three kinds of technique compactings with the Radix Rhodiolae compacting in flakes, the gained tablet carries out mass ratio, referring to table 6.
Three kinds of process results contrast tables of table 6 (in 100 tablets of micropowder tablets)
By comparing in above-mentioned table 6, use above-mentioned three kinds of techniques and all can prepare the pure powder sheet of the Radix Rhodiolae that conforms to quality requirements, but contrast by result, circulation tablet forming technique and dry granulation tablet forming technique all meet the tablet quality requirement in hardness, disintegration, emerald green broken degree aspect again, both are without significant difference, also can reach necessary requirement in appearance, and obviously be less than technique of direct powder compression.
To sum up tell, it is simple that the present invention prepares the tablet technology, and the site technique workflow reengineering is convenient, and feasibility is strong, applied range.
According to above-described embodiment, just can realize well the present invention.What deserves to be explained is; under prerequisite based on above-mentioned design, for solving same technical problem, even some that make in the present invention are without substantial change or polishing; the essence of the technical scheme that adopts is still the same with the present invention, therefore it also should be in protection scope of the present invention.
Claims (10)
1. a Radix Rhodiolae micropowder sheet, is characterized in that, it is that only to adopt water content be 3～15%, and particle diameter is the tablet that the Radix Rhodiolae powder compacting of 1 μ m～150 μ m gets.
2. a kind of Radix Rhodiolae micropowder sheet according to claim 1, is characterized in that, described Radix Rhodiolae micropowder particle diameter is 5～45 μ m.
3. a kind of Radix Rhodiolae micropowder sheet according to claim 1, is characterized in that, the water content of described Radix Rhodiolae micropowder is 8%.
4. the described a kind of Radix Rhodiolae micropowder sheet of according to claim 1～3 any one, is characterized in that, described tablet is buccal tablet.
5. the preparation method of the described a kind of Radix Rhodiolae micropowder sheet of claim 1～4 any one, is characterized in that, comprises the following steps:
(1) Radix Rhodiolae is crushed to the powder that particle diameter is 1～150 μ m, controlling water content is 3～15%;
(2) the Radix Rhodiolae micropowder direct pressing is in blocks, get product.
6. the preparation method of a kind of Radix Rhodiolae micropowder sheet according to claim 5, is characterized in that, the method for described direct compression is precompressed Radix Rhodiolae powder before tabletting, and wherein precompression is 0.5～1.5kN, and principal pressure is 5～10kN.
7. the preparation method of a kind of Radix Rhodiolae micropowder sheet according to claim 5, is characterized in that, comprises that also step (3) pulverizes step (2) gained micropowder tablet for after can mistake 60～80 mesh sieves, again tabletting.
8. the preparation method of a kind of Radix Rhodiolae micropowder sheet according to claim 7, is characterized in that, again first uses the pressure precompressed of 5～10kN before tabletting, then carry out main pressure, and principal pressure is 5～10kN.
9. the preparation method of the described a kind of Radix Rhodiolae micropowder sheet of claim 1～4 any one, is characterized in that, comprises the following steps:
(1) Radix Rhodiolae is pulverized as particle diameter is the micropowder of 1～150 μ m, controlling water content is 3～15%;
(2) Radix Rhodiolae micropowder is pressed into large plate;
(3) large plate is crushed to crosses after 80～100 mesh sieves tabletting again, get product.
10. the preparation method of a kind of Radix Rhodiolae micropowder sheet according to claim 9, is characterized in that, again first uses the pressure precompressed of 5～10kN before tabletting, then carry out main pressure, and principal pressure is 5～10kN.
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| CN109662990A (en) * | 2019-01-29 | 2019-04-23 | 韩佳妹 | A kind of Dong ling cao tablet process of preparing |
| CN110559186A (en) * | 2018-12-25 | 2019-12-13 | 安徽群康药业科技有限公司 | Production process for preparing traditional Chinese medicine decoction pieces |
| CN115399474A (en) * | 2022-08-29 | 2022-11-29 | 广西壮族自治区农业科学院 | Processing method of selenium-rich moringa oleifera leaf raw powder tablets |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108056340A (en) * | 2017-11-22 | 2018-05-22 | 向巴西热 | A kind of rhodiola root flood icing and preparation method thereof |
| CN110559186A (en) * | 2018-12-25 | 2019-12-13 | 安徽群康药业科技有限公司 | Production process for preparing traditional Chinese medicine decoction pieces |
| CN109662990A (en) * | 2019-01-29 | 2019-04-23 | 韩佳妹 | A kind of Dong ling cao tablet process of preparing |
| CN115399474A (en) * | 2022-08-29 | 2022-11-29 | 广西壮族自治区农业科学院 | Processing method of selenium-rich moringa oleifera leaf raw powder tablets |
| CN115399474B (en) * | 2022-08-29 | 2024-03-26 | 广西壮族自治区农业科学院 | Processing method of selenium-enriched moringa oleifera leaf raw powder tablet |
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| CN103381193B (en) | 2015-09-09 |
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