CN103372110B - Preparation method of uterus anti-inflammatory tablet of traditional Chinese medicine preparation - Google Patents
Preparation method of uterus anti-inflammatory tablet of traditional Chinese medicine preparation Download PDFInfo
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- CN103372110B CN103372110B CN201210128229.4A CN201210128229A CN103372110B CN 103372110 B CN103372110 B CN 103372110B CN 201210128229 A CN201210128229 A CN 201210128229A CN 103372110 B CN103372110 B CN 103372110B
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Abstract
The invention belongs to the field of pharmacy, and relates to a preparation method of a uterus anti-inflammatory tablet. The preparation method is characterized by comprising the following steps: (1) preparing a callicarpa kwangtungensis chun plaster, namely taking callicarpa kwangtungensis chun, adding water to decoct, filtering decoction, and concentrating to obtain the plaster; (2) preparing motherwort dry extract powder, namely taking motherwort, adding water to decoct, filtering decoction, concentrating, drying at reduced pressure, and crushing to obtain dry paste; (3) preparing lindera aggregata dry extract powder, namely taking lindera aggregata, adding water to decoct, filtering decoction, concentrating, drying at reduced pressure, and crushing to obtain dry paste; (4) adding auxiliary materials to the motherwort dry extract powder and the lindera aggregata dry extract powder to evenly mix, adding the callicarpa kwangtungensis chun plaster, preparing into granules and tabletting to obtain the uterus anti-inflammatory tablet.
Description
Technical field
The invention belongs to pharmaceutical field, relate to a kind of Chinese medicinal tablet and preparation method thereof, be specifically related to a kind of Chinese medicine preparation KANGGONGYAN PIAN and preparation method thereof.
Background technology
KANGGONGYAN PIAN is a kind of Chinese patent medicine gone on the market, added appropriate amount of auxiliary materials made by Callicarpa kwangtungensis Chun grass, Herba Leonuri, the Callicarpa kwangtungensis Chun dry extract of Radix Linderae extraction, Herba Leonuri dry extract, Radix Linderae dry extract, as: above three taste dry extracts, are ground into fine powder, add right amount of auxiliary materials, mixing, make granule, dry, be pressed into 1000, sugar coating, to obtain final product.KANGGONGYAN PIAN has heat clearing away, damp eliminating, blood stasis dispelling, leukorrhagia stopping.For the leukorrheal diseases caused by damp invasion of lower energizer, disease sees that leucorrhea with red and white discharge, amount are many.
KANGGONGYAN PIAN prepared by prior art also exists Callicarpa kwangtungensis Chun Main Ingredients and Appearance forsythiaside B and the low problem of poliumoside extraction ratio, affects the treatment, and makes KANGGONGYAN PIAN and there is hidden danger of quality before the deadline.
For overcoming above-mentioned shortcoming, the present invention is by the Callicarpa kwangtungensis Chun extract of research by directly adding undried in preparation process, KANGGONGYAN PIAN of the present invention is made with the mixture mixing granulation tabletting of the Herba Leonuri dry extract prepared, Radix Linderae dry extract and adjuvant, improve Callicarpa kwangtungensis Chun Main Ingredients and Appearance forsythiaside B and the poliumoside extraction rate of transform, thus improve effect and the quality of KANGGONGYAN PIAN.Preparation technology of the present invention is convenient and practical, and is easy to control product quality.
Summary of the invention
The object of the present invention is to provide new method prepared by a kind of KANGGONGYAN PIAN, the present invention realizes by the following method.
KANGGONGYAN PIAN of the present invention, its preparation method is:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, decoct with water, decoction liquor filters, concentrated, obtains clear paste.
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, decoct with water, decoction liquor filters, concentrated, and drying under reduced pressure is pulverized, got dry extract.
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, decoct with water, decoction liquor filters, concentrated, and drying under reduced pressure is pulverized, got dry extract.
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add Callicarpa kwangtungensis Chun clear paste, make granule, tabletting, obtain Tablets.
Preferably, KANGGONGYAN PIAN of the present invention, preparation method is as follows:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains clear paste.
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, gets dry extract.
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, gets dry extract.
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add Callicarpa kwangtungensis Chun clear paste, make granule, and dry, be pressed into 1000, sugar coating or film-coat, obtain Tablets.
Preparation method of the present invention, relative to the preparation method of existing KANGGONGYAN PIAN, Callicarpa kwangtungensis Chun clear paste is adopted directly to granulate, this point improves, create beyond thought effect: the Callicarpa kwangtungensis Chun clear paste made with improving one's methods, its Main Ingredients and Appearance forsythiaside B and poliumoside extract the rate of transform and double than former method, KANGGONGYAN PIAN reserved sample observing 24 months forsythiaside Bs and poliumoside stable content.
Prepared by Callicarpa kwangtungensis Chun dry extract: get Callicarpa kwangtungensis Chun clear paste in vacuum drying oven, drying under reduced pressure, to obtain final product.
Callicarpa kwangtungensis Chun clear paste and Callicarpa kwangtungensis Chun dry extract content balance result of the test:
Note: 100801 batches of dry extracts are made up by drying under reduced pressure of 100801 batches of clear paste, 100802 batches of dry extracts are made up by drying under reduced pressure of 100802 batches of clear paste, and 100803 batches of dry extracts are made up by drying under reduced pressure of 100803 batches of clear paste.
KANGGONGYAN PIAN long-term stable experiment result:
Lot number: 100801
Lot number: 100802
Lot number: 100803
Detailed description of the invention
Embodiment one:
Prescription: the dry cream 39g of the Callicarpa kwangtungensis Chun clear paste 300g Herba Leonuri dry cream 44g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product.
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add Callicarpa kwangtungensis Chun clear paste, make granule, and dry, be pressed into 1000, sugar coating or film-coat, to obtain final product.
Embodiment two:
Prescription: the dry cream 39g of the Callicarpa kwangtungensis Chun clear paste 300g Herba Leonuri dry cream 44g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product.
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, pulverize, then add residue 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, be pressed into 1000, sugar coating or film-coat, to obtain final product.
Embodiment three:
Prescription: the dry cream 78g of the Callicarpa kwangtungensis Chun clear paste 600g Herba Leonuri dry cream 88g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product.
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add Callicarpa kwangtungensis Chun clear paste, make granule, dry, are pressed into 1000, film coating, obtain final product.
Embodiment four:
Prescription: the dry cream 78g of the Callicarpa kwangtungensis Chun clear paste 600g Herba Leonuri dry cream 88g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product.
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, filters.Filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product.
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, pulverize, then add residue 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, be pressed into 1000, film coating, obtain final product.
Claims (4)
1. a preparation method for KANGGONGYAN PIAN, is characterized in that, step is as follows:
Prescription: the dry cream 39g of the Callicarpa kwangtungensis Chun clear paste 300g Herba Leonuri dry cream 44g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product,
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add Callicarpa kwangtungensis Chun clear paste, make granule, and dry, be pressed into 1000, sugar coating or film-coat, to obtain final product.
2. a preparation method for KANGGONGYAN PIAN, is characterized in that, step is as follows:
Prescription: the dry cream 39g of the Callicarpa kwangtungensis Chun clear paste 300g Herba Leonuri dry cream 44g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product,
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, pulverize, then add residue 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, be pressed into 1000, sugar coating or film-coat, to obtain final product.
3. a preparation method for KANGGONGYAN PIAN, is characterized in that, step is as follows:
Prescription: the dry cream 78g of the Callicarpa kwangtungensis Chun clear paste 600g Herba Leonuri dry cream 88g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product,
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add Callicarpa kwangtungensis Chun clear paste, make granule, dry, are pressed into 1000, film coating, obtain final product.
4. a preparation method for KANGGONGYAN PIAN, is characterized in that, step is as follows:
Prescription: the dry cream 78g of the Callicarpa kwangtungensis Chun clear paste 600g Herba Leonuri dry cream 88g Radix Linderae
Method for making:
(1) preparation of Callicarpa kwangtungensis Chun clear paste: get Callicarpa kwangtungensis Chun, run through, be cut into segment, decoct with water secondary, 3 hours first times, second time 2 hours, filters, and filtrate merges, and is concentrated into relative density 1.28, obtains final product,
(2) preparation of Herba Leonuri dry extract powder: get Herba Leonuri, chopping, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(3) preparation of Radix Linderae dry extract powder: get the Radix Linderae, section, decocts with water secondary, each 2 hours, collecting decoction, and filter, filtrate is condensed into paste, drying under reduced pressure, pulverizes, to obtain final product,
(4) Herba Leonuri dry extract powder, Radix Linderae dry extract powder add auxiliary materials and mixing, add 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, pulverize, then add residue 50% Callicarpa kwangtungensis Chun clear paste, make granule, dry, be pressed into 1000, film coating, obtain final product.
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| CN201210128229.4A CN103372110B (en) | 2012-04-27 | 2012-04-27 | Preparation method of uterus anti-inflammatory tablet of traditional Chinese medicine preparation |
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| CN201210128229.4A CN103372110B (en) | 2012-04-27 | 2012-04-27 | Preparation method of uterus anti-inflammatory tablet of traditional Chinese medicine preparation |
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| CN101664484A (en) * | 2009-09-15 | 2010-03-10 | 江西天施康中药股份有限公司 | Anti-cervicitis preparation and preparation method thereof |
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| CN101664484A (en) * | 2009-09-15 | 2010-03-10 | 江西天施康中药股份有限公司 | Anti-cervicitis preparation and preparation method thereof |
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Address after: 336000 Yuanzhou pharmaceutical industry park, Jiangxi, Yichun Co-patentee after: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Patentee after: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. Address before: 336001 Yuanzhou pharmaceutical industry park, Yichun, Yichun, Jiangxi, Jiangxi Co-patentee before: JIANGXI JIMINKEXIN JINSHUIBAO PHARMACEUTICAL Co.,Ltd. Patentee before: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. |