CN103463453A - Dendrobium stem tablets and extraction and preparation methods thereof - Google Patents
Dendrobium stem tablets and extraction and preparation methods thereof Download PDFInfo
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Abstract
The invention relates to a Chinese extract preparation and particularly relates to dendrobium stem tablets which have a function of increasing immunity and have a gastrointestinal tract bio-adsorption performance as well as extraction and preparation methods of dendrobium stem tablets. The medicinal composition of the dendrobium stem tablets is prepared from the following raw material components in parts by weight: 50-80 parts of dendrobium stem extract, 25-55 parts of radix pseudostellariae extract, 25-55 parts of gynostemma pentaphylla extract and 5-10 parts of propolis extract. The invention also provides the extraction method of various components in the medicinal composition of the dendrobium stem and a preparation method of the dendrobium stem tablets. The dendrobium stem tablets which have the function of remarkably increasing the immunity and have the gastrointestinal tract bio-adsorption performance are prepared by selecting the medicinal composition and proportions thereof and reasonably matching the medicinal composition with selected auxiliary materials; compared with conventional tablets, the dendrobium stem tablets have the advantages that molecules can be absorbed more completely, the bioavailability is high and the function in the aspect of increasing the immunity is stronger.
Description
Technical field
The present invention relates to a kind of Chinese medicine extract preparation, particularly a kind of have the enhancing immunity function and have the Dendrobium nobile tablet of gastrointestinal tract bioadhesion performance and extraction, preparation method.
Background technology
The people of 60% left and right is arranged according to investigations in the world in sub-health state.Sub-health state easily causes the immunity continuous decrease also and then suffers from disease.Improving immunity is the effective way of improving sub-health state, improving the quality of living.Therefore, effectively medicine and the health food of enhancing immunity have important realistic meaning in searching.Although medicine and the health food of at present existing many enhancing immunity are available, but still can not meet social demand, therefore, continually develop the medicine of new enhancing immunity and the inexorable trend that health food is this field.
The agent of gastrointestinal tract bioadhesion matrix is by adding the bioadhesive material, make tablet oral, the drug microparticles produced after disintegrate can be adhered to the long period at the harmonization of the stomach small bowel, with drug microparticles and the absorption site overcome due to gastrointestinal peristalsis, shorten time of contact, thereby promote drug molecule to absorb, with conventional tablet, compare, but the gastrointestinal tract bioadhesion matrix agent time of staying of prolong drug in the harmonization of the stomach small intestinal, control the rate of release of tablet microgranule Chinese medicine molecule, increase the absorbance of drug molecule, improve the blood drug level of drug molecule, thereby improve the bioavailability of drug molecule.At present, in the technical field that can inquire about, with golden hairpin dendrobium extract, Radix Pseudostellariae extract, Herb Gynostemmae Pentaphylli extract and propolis extract, do not make research report and the product of the agent of gastrointestinal tract bioadhesion matrix.
Summary of the invention
The technical problem to be solved in the present invention is the above-mentioned defect that how to overcome prior art, provides a kind of and has the enhancing immunity function and have the Dendrobium nobile tablet of gastrointestinal tract bioadhesion performance and extraction, preparation method.
For solving the problems of the technologies described above, this Dendrobium nobile Lindl Herba Dendrobii tablet active ingredient by following raw material components, pressed shown in weight ratio scope preparation, golden hairpin dendrobium extract 50～80, Radix Pseudostellariae extract 25～55, Herb Gynostemmae Pentaphylli extract 25～55, propolis extract 5～10.
As optimum ratio, this Dendrobium nobile Lindl Herba Dendrobii sheet active ingredient by following supplementary material, pressed shown in weight ratio preparation, golden hairpin dendrobium extract 65, Radix Pseudostellariae extract 40, Herb Gynostemmae Pentaphylli extract 40, propolis extract 8.
As optimum ratio, this Dendrobium nobile Lindl Herba Dendrobii sheet active ingredient by following supplementary material, pressed shown in weight ratio preparation, golden hairpin dendrobium extract 80, Radix Pseudostellariae extract 25, Herb Gynostemmae Pentaphylli extract 55, propolis extract 5.
As optimum ratio, this Dendrobium nobile Lindl Herba Dendrobii sheet active ingredient by following supplementary material, pressed shown in weight ratio preparation, golden hairpin dendrobium extract 50, Radix Pseudostellariae extract 55, Herb Gynostemmae Pentaphylli extract 25, propolis extract 10.
The extracting method of each raw material components of the active ingredient of this Dendrobium nobile Lindl Herba Dendrobii tablet is as follows:
1) golden hairpin dendrobium extract: Dendrobium nobile extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain 95% ethanol extraction; Separately get the medical material residue after 95% ethanol extraction, after removing ethanol, decoct with water and extract 2 times, each 1h, each amount of water is pressed the solid-liquid weight ratio and is added at 1: 10, merges aqueous extract, under 60 ℃, it is 1.15 that survey is concentrated into relative density, and then spray drying, obtain water solubility extract; By 95% ethanol extraction and water solubility extract mix homogeneously, obtain golden hairpin dendrobium extract;
2) Radix Pseudostellariae extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Radix Pseudostellariae extract;
3) Herb Gynostemmae Pentaphylli extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Herb Gynostemmae Pentaphylli extract;
4) propolis extract: propolis extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain propolis extract.
As prioritization scheme, also be added with adjuvant in described Dendrobium nobile tablet, described adjuvant comprises and adds adhesive agent, filler, lubricant; Dendrobium nobile tablet gross mass is in 1, and described active ingredient mass percent is that mass percent is 25%～55%, and surplus is described adjuvant.
As prioritization scheme, described adhesive agent is highland barley Beta-dextran grafting soybean protein copolymer, carbomer, the sodium alginate mixture of 10: 4: 1 compositions by weight.
As prioritization scheme, the method for making of described highland barley Beta-dextran grafting soybean protein copolymer is, the weight ratio highland barley Beta-dextran of 1: 1 and soybean protein are stirred in the phosphate buffer of pH=8.5, lyophilizing, be ground into fine powder, be placed in the container that is placed with saturated potassium bromide solution, in 60 ℃ of xeothermic reaction 24h.
As prioritization scheme, described filler and lubricant are selected from acceptable pharmaceutic adjuvant on pharmaceutics.
The preparation method of this Dendrobium nobile Lindl Herba Dendrobii tablet is that each raw material components of described active ingredient and described adhesive agent, filler, mix lubricant popularize law are suppressed in flakes.Described popularize law is the tablet moulding technique of field of pharmaceutical preparations routine.
Using method: the adult takes the amount of Dendrobium nobile sheet of the present invention, and by tablet active ingredient-extract gross mass, be 800～1600mg every day, divides and takes for 2～4 times.
Active ingredient is analyzed:
1, Dendrobium nobile: be the fresh or dry stem of orchid Dendrobium nobile Dendrobium nobile Lindl., effect with reinforcing stomach reg fluid, nourishing YIN and clearing away heat, contain the multiple alkaloids compositions such as dendrobine, Herba Dendrobii time alkali, also contain phenols component as gigantol, sesquiterpenoids composition as dendronobilin J and polysaccharide composition, pharmacological evaluation shows that golden hairpin dendrobium extract has enhancing immunity, improves gastrointestinal function, improves the hypomnesis function, blood sugar lowering, anti-cataract, antitumor isoreactivity.
2, Radix Pseudostellariae: be the dried root of pinkwort Radix Ginseng Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm, effect with replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, contain saponin component as pseudostellarinoside A, cyclic peptide composition as heterophyllin B and volatile oil and polysaccharide etc., pharmacological evaluation shows that Radix Pseudostellariae extract has the effects such as enhancing immunity, resisting fatigue, anti peroxidation of lipid, antiinflammatory, blood sugar lowering.
3, Herb Gynostemmae Pentaphylli: be the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunb.) Makino, effect with replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, contain on various structures the saponin component that is similar to the ginsenoside, sterol, polysaccharide etc., pharmacological evaluation shows that Herb Gynostemmae Pentaphylli extract has the effects such as enhancing immunity, resisting fatigue, slow down aging, improvement sleep, antitumor, blood fat reducing, blood sugar lowering.
4, propolis: be the secreted resin-like stickums such as Apidae animal apis mellifera Linnaeus Apis mellifera L., there is the effect that tonify deficiency is weak, change turbid fat, only quench one's thirst, propolis contains multiple flavones ingredient, resin, volatilization wet goods, and pharmacological evaluation shows that propolis extract has the effects such as enhancing immunity, resisting fatigue, antioxidation, antitumor, blood pressure lowering.
A kind of Dendrobium nobile tablet of the present invention is by selected active ingredient and proportioning thereof, and with the reasonable compatibility of selected adjuvant, make and there is remarkable enhancing immunity function and there is gastrointestinal tract bioadhesion performance, compare conventional tablet, the absorption of this Dendrobium nobile Lindl Herba Dendrobii sheet agent molecule is more complete, bioavailability is higher, and aspect enhancing immunity, effect is stronger.The present invention also provides each component extracting process in a kind of this Dendrobium nobile tablet active ingredient, and the preparation method of this Dendrobium nobile sheet.
The specific embodiment
Embodiment 1: the preparation of this Dendrobium nobile Lindl Herba Dendrobii tablet comprises the following steps:
Step (1) active ingredient raw material components extracts: 1) golden hairpin dendrobium extract: Dendrobium nobile extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merge 95% ethanol extract, reclaim ethanol, drying, obtain 95% ethanol extraction; Separately get the medical material residue after 95% ethanol extraction, after removing ethanol, decoct with water and extract 2 times, each 1h, each amount of water is pressed the solid-liquid weight ratio and is added at 1: 10, merges aqueous extract, under 60 ℃, it is 1.15 that survey is concentrated into relative density, and then spray drying, obtain water solubility extract; By 95% ethanol extraction and water solubility extract mix homogeneously, obtain golden hairpin dendrobium extract; 2) Radix Pseudostellariae extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Radix Pseudostellariae extract; 3) Herb Gynostemmae Pentaphylli extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Herb Gynostemmae Pentaphylli extract; 4) propolis extract: propolis extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain propolis extract.
The preparation of step (2) adhesive agent: the weight ratio highland barley Beta-dextran of 1: 1 and soybean protein are stirred in the phosphate buffer of pH=8.5, lyophilizing, be ground into fine powder, be placed in the container that is placed with saturated potassium bromide solution, in 60 ℃ of xeothermic reaction 24h, make highland barley Beta-dextran grafting soybean protein copolymer, highland barley Beta-dextran grafting soybean protein copolymer, carbomer, sodium alginate were mixed by weight 10: 4: 1.
The preparation of step (3) tablet: depletion hairpin Herba Dendrobii extract 70g, Radix Pseudostellariae extract 32g, Herb Gynostemmae Pentaphylli extract 30g, propolis extract 7g, adhesive agent 120g, starch 40g, magnesium stearate 1g, by medicine and the auxiliary materials and mixing except magnesium stearate, make soft material with 95% ethanol, cross 20 mesh sieves, 60 ℃ of dry 1h, with 24 mesh sieve granulate, add magnesium stearate and mix tabletting, make 1000 this Dendrobium nobile Lindl Herba Dendrobii tablet A.
Embodiment 2: the preparation of this Dendrobium nobile Lindl Herba Dendrobii tablet comprises the following steps:
Step (1) active ingredient raw material components extracts: 1) golden hairpin dendrobium extract: Dendrobium nobile extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merge 95% ethanol extract, reclaim ethanol, drying, obtain 95% ethanol extraction; Separately get the medical material residue after 95% ethanol extraction, after removing ethanol, decoct with water and extract 2 times, each 1h, each amount of water is pressed the solid-liquid weight ratio and is added at 1: 10, merges aqueous extract, under 60 ℃, it is 1.15 that survey is concentrated into relative density, and then spray drying, obtain water solubility extract; By 95% ethanol extraction and water solubility extract mix homogeneously, obtain golden hairpin dendrobium extract; 2) Radix Pseudostellariae extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Radix Pseudostellariae extract; 3) Herb Gynostemmae Pentaphylli extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Herb Gynostemmae Pentaphylli extract; 4) propolis extract: propolis extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain propolis extract.
The preparation of step (2) adhesive agent: the weight ratio highland barley Beta-dextran of 1: 1 and soybean protein are stirred in the phosphate buffer of pH=8.5, lyophilizing, be ground into fine powder, be placed in the container that is placed with saturated potassium bromide solution, in 60 ℃ of xeothermic reaction 24h, make highland barley Beta-dextran grafting soybean protein copolymer, highland barley Beta-dextran grafting soybean protein copolymer, carbomer, sodium alginate were mixed by weight 10: 4: 1.
The preparation of step (3) tablet: depletion hairpin Herba Dendrobii extract 63g, Radix Pseudostellariae extract 50g, Herb Gynostemmae Pentaphylli extract 45g, propolis extract 5.5g, adhesive agent 105g, sucrose 80g, magnesium stearate 1.5g, by medicine and the auxiliary materials and mixing except magnesium stearate, make soft material with 95% ethanol, cross 20 mesh sieves, 60 ℃ of dry 1h, with 24 mesh sieve granulate, add magnesium stearate and mix tabletting, make 1000 this Dendrobium nobile Lindl Herba Dendrobii tablet B.
Embodiment 3: the preparation of this Dendrobium nobile Lindl Herba Dendrobii tablet comprises the following steps:
Step (1) active ingredient raw material components extracts: 1) golden hairpin dendrobium extract: Dendrobium nobile extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merge 95% ethanol extract, reclaim ethanol, drying, obtain 95% ethanol extraction; Separately get the medical material residue after 95% ethanol extraction, after removing ethanol, decoct with water and extract 2 times, each 1h, each amount of water is pressed the solid-liquid weight ratio and is added at 1: 10, merges aqueous extract, under 60 ℃, it is 1.15 that survey is concentrated into relative density, and then spray drying, obtain water solubility extract; By 95% ethanol extraction and water solubility extract mix homogeneously, obtain golden hairpin dendrobium extract; 2) Radix Pseudostellariae extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Radix Pseudostellariae extract; 3) Herb Gynostemmae Pentaphylli extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Herb Gynostemmae Pentaphylli extract; 4) propolis extract: propolis extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain propolis extract.
The preparation of step (2) adhesive agent: the weight ratio highland barley Beta-dextran of 1: 1 and soybean protein are stirred in the phosphate buffer of pH=8.5, lyophilizing, be ground into fine powder, be placed in the container that is placed with saturated potassium bromide solution, in 60 ℃ of xeothermic reaction 24h, make highland barley Beta-dextran grafting soybean protein copolymer, highland barley Beta-dextran grafting soybean protein copolymer, carbomer, sodium alginate were mixed by weight 10: 4: 1.
The preparation of step (3) tablet: depletion hairpin Herba Dendrobii extract 55g, Radix Pseudostellariae extract 50g, Herb Gynostemmae Pentaphylli extract 32g, propolis extract 6.5g, adhesive agent 130g, lactose 125g, magnesium stearate 1.5g, by medicine and the auxiliary materials and mixing except magnesium stearate, make soft material with 95% ethanol, cross 20 mesh sieves, 60 ℃ of dry 1h, with 24 mesh sieve granulate, add magnesium stearate and mix tabletting, make 1000 this Dendrobium nobile Lindl Herba Dendrobii tablet C.
Through pharmacological testing, confirm: Dendrobium nobile sheet of the present invention can significantly strengthen the lymphocyte transfer reaction that mice stimulates PHA, improves lymhocyte transformation rate; And can improve significantly mice carbon clearance index, there is the effect of enhancing immunity.The mixture that highland barley Beta-dextran grafting soybean protein copolymer, carbomer, sodium alginate formed by weight 10: 4: 1 for adhesive agent so that the gastrointestinal tract bioadhesion performance of described Dendrobium nobile sheet to be provided.Through stripping method (Xiang great Xiong etc. China Dispensary, 2002,13 (8): 459-460) test shows: the tablet made from identical effect raw material, the tablet that does not add adhesive agent is 0g/cm to the adhesion of the in vitro gastric tissue of rabbit
2, to the adhesion of isolated small intestines of rabbits tissue, be 0g/cm2, the Dendrobium nobile sheet A made by embodiment 1 is 13.2g/cm2, is 25.5g/cm to the adhesion of isolated small intestines of rabbits tissue the adhesion of the in vitro gastric tissue of rabbit
2, illustrate that Dendrobium nobile sheet of the present invention has gastrointestinal tract bioadhesion performance.
Above-mentioned embodiment is intended to illustrate the present invention and can be professional and technical personnel in the field's realization or use; it will be apparent for those skilled in the art that above-mentioned embodiment is modified; therefore the present invention includes but be not limited to above-mentioned embodiment; any these claims or description of meeting described; meet and principle disclosed herein and novelty, the method for inventive features, technique, product, within all falling into protection scope of the present invention.
Claims (10)
1. a Dendrobium nobile tablet is characterized in that: its active ingredient by following raw material components, pressed shown in the preparation of weight ratio scope, golden hairpin dendrobium extract 50～80, Radix Pseudostellariae extract 25～55, Herb Gynostemmae Pentaphylli extract 25～55, propolis extract 5～10.
2. Dendrobium nobile tablet according to claim 1 is characterized in that: its active ingredient by following supplementary material, pressed shown in the weight ratio preparation, golden hairpin dendrobium extract 65, Radix Pseudostellariae extract 40, Herb Gynostemmae Pentaphylli extract 40, propolis extract 8.
3. Dendrobium nobile tablet according to claim 1 is characterized in that: its active ingredient by following supplementary material, pressed shown in the weight ratio preparation, golden hairpin dendrobium extract 80, Radix Pseudostellariae extract 25, Herb Gynostemmae Pentaphylli extract 55, propolis extract 5.
4. Dendrobium nobile tablet according to claim 1 is characterized in that: its active ingredient by following supplementary material, pressed shown in the weight ratio preparation, golden hairpin dendrobium extract 50, Radix Pseudostellariae extract 55, Herb Gynostemmae Pentaphylli extract 25, propolis extract 10.
5. the extracting method of a Dendrobium nobile tablet, it is characterized in that: described Dendrobium nobile sheet is the arbitrary described Dendrobium nobile sheet of claim 1 to 4, and the extracting method of each raw material components of its active ingredient is as follows:
1) golden hairpin dendrobium extract: Dendrobium nobile extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain 95% ethanol extraction; Separately get the medical material residue after 95% ethanol extraction, after removing ethanol, decoct with water and extract 2 times, each 1h, each amount of water is pressed the solid-liquid weight ratio and is added at 1: 10, merges aqueous extract, under 60 ℃, it is 1.15 that survey is concentrated into relative density, and then spray drying, obtain water solubility extract; By 95% ethanol extraction and water solubility extract mix homogeneously, obtain golden hairpin dendrobium extract;
2) Radix Pseudostellariae extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Radix Pseudostellariae extract;
3) Herb Gynostemmae Pentaphylli extract: by 1), the extraction process of golden hairpin dendrobium extract is extracted, and obtains Herb Gynostemmae Pentaphylli extract;
4) propolis extract: propolis extracts 2 times with 95% alcohol heating reflux, each 1h, and the amount that at every turn adds 95% ethanol is added by the solid-liquid weight ratio at 1: 10, merges 95% ethanol extract, reclaims ethanol, and drying, obtain propolis extract.
6. Dendrobium nobile tablet according to claim 5 is characterized in that: also be added with adjuvant in described Dendrobium nobile tablet, described adjuvant comprises and adds adhesive agent, filler, lubricant; Dendrobium nobile tablet gross mass is in 1, and described active ingredient mass percent is that mass percent is 25%～55%, and surplus is described adjuvant.
7. Dendrobium nobile tablet according to claim 6 is characterized in that: described adhesive agent is the mixture that highland barley Beta-dextran grafting soybean protein copolymer, carbomer, sodium alginate formed by weight 10: 4: 1.
8. Dendrobium nobile tablet according to claim 7, it is characterized in that: the method for making of described highland barley Beta-dextran grafting soybean protein copolymer is, the weight ratio highland barley Beta-dextran of 1: 1 and soybean protein are stirred in the phosphate buffer of pH=8.5, lyophilizing, be ground into fine powder, be placed in the container that is placed with saturated potassium bromide solution, in 60 ℃ of xeothermic reaction 24h.
9. Dendrobium nobile tablet according to claim 6, it is characterized in that: described filler and lubricant are selected from acceptable pharmaceutic adjuvant on pharmaceutics.
10. the preparation method of a Dendrobium nobile tablet, it is characterized in that: described Dendrobium nobile sheet is the arbitrary described Dendrobium nobile sheet of claim 1 to 9, its preparation method is that each raw material components of described active ingredient and described adhesive agent, filler, mix lubricant popularize law are suppressed in flakes.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582430A (en) * | 2017-10-31 | 2018-01-16 | 西华大学 | A kind of methods for making and using same of highland barley beta glucan poly-aspartate compound |
| CN109394977A (en) * | 2018-11-29 | 2019-03-01 | 遵义医学院 | A kind of Chinese medicine composition and preparation method and application with hypolipemic function |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075644A (en) * | 1993-01-22 | 1993-09-01 | 陈升铿 | Compound Taizi ginsen oral liquid and preparation method thereof |
| CN102250733A (en) * | 2011-06-08 | 2011-11-23 | 钟桂英 | Health-care wine matched with gynostemma pentaphylla and preparation method thereof |
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2013
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075644A (en) * | 1993-01-22 | 1993-09-01 | 陈升铿 | Compound Taizi ginsen oral liquid and preparation method thereof |
| CN102250733A (en) * | 2011-06-08 | 2011-11-23 | 钟桂英 | Health-care wine matched with gynostemma pentaphylla and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582430A (en) * | 2017-10-31 | 2018-01-16 | 西华大学 | A kind of methods for making and using same of highland barley beta glucan poly-aspartate compound |
| CN107582430B (en) * | 2017-10-31 | 2020-10-27 | 西华大学 | Preparation and application method of highland barley beta-glucan-polyaspartic acid compound |
| CN109394977A (en) * | 2018-11-29 | 2019-03-01 | 遵义医学院 | A kind of Chinese medicine composition and preparation method and application with hypolipemic function |
| CN109394977B (en) * | 2018-11-29 | 2021-07-06 | 遵义医科大学 | Traditional Chinese medicine composition with blood fat reducing function and preparation method and application thereof |
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