CN102363017A - Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and preparation method thereof - Google Patents
Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and a preparation method thereof. The Chinese medicinal composition is prepared from sixteen traditional Chinese medicines, including puffball, vinegar-treated curcuma zedoary, honeysuckle flower, water-boiled peach kernel, figwort, vinegar-treated common burreed rhizome, safflower, red-rooted salvia root, isatis root, dwarf lilyturf root, thunberg fritillary bulb, oriental waterplantain rhizome, cicada shell, fried chicken gizzard membrane, indian trum etflower seed and dandelion, has the effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm, and is mainly used for treating hoarseness, injection of vocal cord and swelling caused by accumulation of toxic heat and qi depression to blood stasis, chronic laryngitis, vocal nodule and polyp of vocal cord. The clinical pharmacodynamic study effect of the Chinese medicinal composition is enhanced remarkably, and the Chinese medicinal composition does not have any toxic or side effect.
Description
Technical field
The present invention relates to a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing expectorant Chinese medicine composition and preparation method thereof of being used for, belong to the pharmaceutical technology field.
Technical background
Along with the sustainable development of China's industry, environmental pollution is more and more serious, and the people who thereupon suffers from throat disease is more and more, has seriously influenced daily life, has brought great misery to people.The medicine of treating at present throat disease clinically is few, and the medicine of especially treating pure Chinese medicines such as chronic laryngitis, vocal nodule, polyp of vocal cord still less.The prior art patent retrieval: 1, the Chinese patent communique disclosed name and has been called " Jinsangsanjie preparation and preparation method thereof " on August 29th, 2007, and publication number is the patent application of CN 101024060A.2, on November 10th, 2004 Chinese patent gazette disclose the name be called " a kind of Chinese medicine of treating throat chronic hoarseness symptom and preparation method thereof ", publication number is the patent application of CN 1544077A.3, on January 24th, 2007 Chinese patent gazette disclose the name be called " a kind of Chinese medicine preparation technology who treats vocal nodule, polyp of vocal cord symptom and uses thereof ", publication number is the patent application of CN 1899569A.4, on June 14th, 2006 Chinese patent gazette disclose the name be called " a kind of Jinsang sanjie fast dispersion solid preparation for treating throat and preparation method thereof ", publication number is the patent application of CN 1785406A.More than four patents all exist technology thicker, the unfavorable defective of curative effect in the process of practical application.In the past few years, we have rich by exploiting the motherland medicine resources, combined with a large number of theoretical and clinical medicine prescriptions pharmacodynamic studies, the application of modern pharmaceutical technology to make significant improvements to the product technology, through a large number of experiments to explore, accident The discovery changed the original process for vinegar Curcuma essential oil was extracted wood butterfly on cicada, fried Gallus gallus for alcohol, alcohol extraction conducted on Salvia, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushing, Safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix water extraction, preparation made using this technique, clinical pharmacodynamic trial results significantly improved, without any side effects, a high content of active ingredients, formulation and stability, a significant effect.We have processed by common process: pill, tablet, granule, capsule, soft capsule and drop pill.
Summary of the invention
It is advanced to the purpose of this invention is to provide a kind of technology, and active constituent content is high, and better stability of preparation, curative effect are used for heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the dampness removing Chinese medicine composition and preparation method thereof that reduces phlegm more significantly.This preparation is mainly used in that hot poison pents up, the hoarseness of caused by energy stagnation and blood stasis, injection of vocal cord, swelling; Chronic laryngitis, vocal nodule, polyp of vocal cord are seen above-mentioned patient.Its clinical pharmacodynamics test effect significantly improves, and without any side effects.
Prior art: 1, the Chinese patent communique disclosed name and has been called " Jinsangsanjie preparation and preparation method thereof " on August 29th, 2007, and publication number is the patent application of CN 101024060A.2, on November 10th, 2004 Chinese patent gazette disclose the name be called " a kind of Chinese medicine of treating throat chronic hoarseness symptom and preparation method thereof ", publication number is the patent application of CN 1544077A.3, on January 24th, 2007 Chinese patent gazette disclose the name be called " a kind of Chinese medicine preparation technology who treats vocal nodule, polyp of vocal cord symptom and uses thereof ", publication number is the patent application of CN 1899569A.4, on June 14th, 2006 Chinese patent gazette disclose the name be called " a kind of Jinsang sanjie fast dispersion solid preparation for treating throat and preparation method thereof ", publication number is the patent application of CN 1785406A.The applicant in recent years time back warp development test, finds all to exist technology thicker the unfavorable defective of curative effect in the process of practical application to above prior art.
To overcome the defects of the prior art, the applicant country by exploiting the rich resources of Chinese medicine, Chinese medicine combined with a large group of party theory and clinical pharmacodynamic studies, the application of modern pharmaceutical technology to make significant improvements to the product technology, through a large number of experiments to explore , the unexpected discovery changed the original process for vinegar Curcuma essential oil was extracted wood butterfly on cicada, fried Gallus gallus for alcohol, alcohol extraction conducted on Salvia, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix water extraction, preparation made using this process, the clinical efficacy School test results improved significantly, without any side effects, the active ingredient content, formulation stability, a significant effect.We have processed by common process: pill, tablet, granule, capsule, soft capsule and drop pill have better met needs of medical treatment.
The present invention is so constructed: it is dominated by "puffballs 25 parts, 50 parts vinegar Curcuma, honeysuckle 125 copies, Dan peach kernel 50, Scrophulariaceae 125 parts, 50 parts vinegar triangular, safflower 50 parts, 75 parts of Salvia , 125 parts of Radix, Radix 100, Fritillaria 75 parts, Alisma 75 parts, 75 parts of oneself, fried Gallus gallus 50 parts, 75 parts of wood butterfly, dandelion 125 copies." parts by weight of Chinese traditional medicine material the feedstock production pill, tablet, granule, capsule, soft capsule and the drop pill that form; Specific as follows:
1, the preparation of Chinese medicine composition of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly add water (8 to 12) times the amount of reflux extraction of volatile oil 2 times Every time (1 to 3) hours, collecting volatile oil reserve, merge two filtrate, spare; cicada, fried Gallus gallus with (6 ~ 10) times the amount (20% to 60%) ethanol was extracted two times ( 0.5 to 2) hours, the two combined filtrate under reduced pressure to recover ethanol extract solution obtained, spare; Salvia with (5-8) times the amount (75% to 85%) ethanol was extracted twice, each time (1 to 3 ) hours, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma , Ophiopogon flavor boiling water of 10 2, first addition of water (8 to 12) times the amount of boiling (1-3) hours, the second water (6 to 10) times the amount of boiling (1 - 3) hours, merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.07Mpa ~-0.08Mpa ,70-80 ℃) was concentrated to a relative density of 1.06 ~ 1.20 (60 ~ 80 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting and the spray dry powder formulations suitable for the above materials mixed, sprayed by conventional techniques into different forms of volatile oil, pellets, tablets, granules, capsules, soft capsules or drop pills.
2, the preparation of Chinese medicine composition of the present invention is preferably following:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, spray-dry and the resulting fine powder and the Suitable materials mix formulations, the formulations according to the conventional process is injected into the volatile oil, pellets, tablets, granules, capsules, soft capsules or drop pills.
3, the preparation of Chinese medicine composition pill of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix , sprayed into the volatile oil, add refining honey, made water pill or the pill, that was pills.
4, the preparation of Chinese medicine composition tablet of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above starch mixing, granulation, drying, whole, adding an appropriate amount of magnesium stearate, mix, sprayed into the volatile oil, tabletting, ie tablets.
5, the preparation of Chinese medicinal composition granules of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above dextrin mixing, granulation, drying, whole, sprayed into the volatile oil, bagging, ie granules.
6, the preparation of Chinese medicinal composition capsules agent of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above starch mixing, granulation, drying, whole, sprayed into the volatile oil, loaded capsules, ie capsules.
7, the preparation of Chinese medicine composition soft capsule of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix , with mixed powder, sprayed into the volatile oil, mix, adding polyethylene glycol 400, the colloid mill uniform; press gelatin: glycerol: water ratio of 1:0.3:1 glue, soft capsule machine pressure pills, that was soft capsules.
8, the preparation of Chinese medicine composition drop pill of the present invention:
Prescription consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix , sprayed into the volatile oil, mixing, screening, join a molten polyethylene glycol 4000, stir, add pill machine, drop into pills, that was dropping pills.
The present invention program is through inventor's repetition test repeatedly, updates that adjustment sums up out, and the clinical pharmacodynamics test effect of said medicine significantly strengthens, and technology is advanced, and active constituent content is high, and better stability of preparation is evident in efficacy.
Pharmacodynamic test of active extract is following:
One, the preparation of experiment medicine:
1, raw material:
The a group is pill group of the present invention: the method according to description embodiment 1 of the present invention makes.
B group is: be the pill that the method for description embodiment three of the patent application of CN 101024060A makes according to publication number;
Concrete method for making is following:
Take puffballs 50g, Curcuma (Cuchao) 100g, honeysuckle 250g, peach (Dan) 100g, Scrophulariaceae 250g, triangular (Cuchao) 100g, safflower 100g, Salvia 150g, Radix 250g, Radix 200g, Fritillaria 150g, Alisma 150g, Gallus gallus (fried) 100g, cicada 150g, wood butterfly 150g, dandelion 250g, spare;
In A, the above medicine, get Bulbus Fritillariae Thunbergii 50g, Endothelium Corneum Gigeriae Galli 33g, be ground into fine powder, sieve, mixing, subsequent use; The fine particle size is 200～300 purpose superfine powder;
B, Curcuma (Cuchao) 50g, peach kernel (Dan) 50g, safflower 50g essential oil was extracted, collected volatile oil, spare;
C, Herba Taraxaci 125g, Flos Lonicerae 125g add hydro-thermal with the residue Flos Carthami and soak secondary, each 3 hours, filter merging filtrate;
The surplus decocte with water of D, Radix Salviae Miltiorrhizae 75g, Lasiosphaera Seu Calvatia 25g and all the other flavour of a drug and above-mentioned flavour of a drug 3 times, each 3 hours, merge medicinal liquid, filter;
E, Radix Salviae Miltiorrhizae, Lasiosphaera Seu Calvatia surplus add 70% alcohol heating reflux secondary, and each 3 hours, filter, merging filtrate reclaims ethanol, with above-mentioned combining medicine; Medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); With the fine powder mixing, spray into volatile oil, add refined honey, process sphere or type spheric pill, polishing, drying gets concentrated pill.
C group is: be the tablet that the method for description embodiment 2 of the patent application of CN 1544077A makes according to publication number.
Concrete method for making is following:
More than ten Six-elements, extracting honeysuckle, Bulbus Fritillariae Thunbergii, Flos Carthami 1/2 amount is ground into fine powder, sieves; Mixing, the Lasiosphaera Seu Calvatia sieve is got the 10g fine powder, the surplus decocte with water secondary of all the other 12 flavors and above-mentioned four Chinese medicine, each 2 hours; Collecting decoction filters, filtrating be concentrated into when temperature is 85 ℃ relative density be 1.28～1.32 thick paste and above-mentioned fine powder and 80g starch, magnesium stearate 3g; It is being pressed into 1000, the bag film-coat promptly gets.
D group is: be the capsule that the method for description embodiment 2 of the patent application of CN 1899569A makes according to publication number.
Concrete method for making is following:
Prescription: Lasiosphaera Seu Calvatia 25g, Rhizoma Curcumae (vinegar stir-fry) 50g, Flos Lonicerae 125g, Semen Persicae 50g, Radix Scrophulariae 125g, triangular (vinegar stir-fry) 50g; Flos Carthami 50g, Radix Salviae Miltiorrhizae 75g, Radix Isatidis 125g, Radix Ophiopogonis 100g, Bulbus Fritillariae Thunbergii 75g; Rhizoma Alismatis 75g, Periostracum Cicadae 75g, Endothelium Corneum Gigeriae Galli (stir-fry) 50g, Semen Oroxyli 75g, Herba Taraxaci 125g;
Get 50% Flos Lonicerae, Bulbus Fritillariae Thunbergii, Flos Carthami of recipe quantity, the Lasiosphaera Seu Calvatia of recipe quantity 2% is ground into fine powder, sieve, and mixing, subsequent use; Surplus after the pulverizing of Rhizoma Curcumae, Semen Persicae, Radix Scrophulariae, triangular, Radix Salviae Miltiorrhizae, Radix Isatidis, Radix Ophiopogonis, Rhizoma Alismatis, Endothelium Corneum Gigeriae Galli, Periostracum Cicadae, Semen Oroxyli, Herba Taraxaci and Flos Lonicerae, Bulbus Fritillariae Thunbergii, Flos Carthami, Lasiosphaera Seu Calvatia four Chinese medicine is added 10 times, 8 times decoctings boil secondary, each 2 hours, collecting decoction; Filter; Filtrating is concentrated into the thick paste that relative density is 1.28～1.32 (60 ℃), adds 95% ethanol and makes and contain alcohol amount and reach 60%, stirs; Left standstill 24 hours; Filter, filtrate recycling ethanol, being evaporated to relative density is the clear paste of 1.38～1.40 (60 ℃); The fine powder and the appropriate amount of auxiliary materials mixing that add preparation, drying is pulverized, and processes fine particle, incapsulates, and promptly gets.
E group is: be the tablet that the method for description embodiment 2 of the patent application of CN 1785406A makes according to publication number.
Concrete method for making is following:
25 parts of Lasiosphaera Seu Calvatia, 50 parts of Rhizoma Curcumae (vinegar stir-fry), 125 parts of Flos Loniceraes, 50 parts in Semen Persicae (peeling), 125 parts of Radix Scrophulariaes, triangular (vinegar stir-fry) 50 parts; 50 parts on Flos Carthami, 75 parts of Radix Salviae Miltiorrhizaes, 125 parts of Radix Isatidis, 100 parts of Radix Ophiopogonis, 75 parts of Bulbus Fritillariae Thunbergiis, 75 parts of Rhizoma Alismatis; 50 parts of Endothelium Corneum Gigeriae Galli (stir-fry), 75 parts of Periostracum Cicadaes, 75 parts of Semen Oroxylis, 125 parts of Herba Taraxacis, more than ten Six-elements; Decoct extraction 2 hours with 8 times of amounts of water, filter, add 6 times of amounts of water again, decoct and extracted 2 hours, filter; Merge filtrating twice, be condensed into relative density and be 1.30～1.35 (60 ℃) thick paste, drying is ground into fine powder, sieves, micronizing is crossed 400 orders; Per 100 parts of powder and adjuvant mix homogeneously, full length film is pressed in the back of granulating, and promptly gets.
Two: process of the test and result of the test
Experiment purpose: through to the antiinflammatory of pill a group of the present invention and b, c, d, e group, ease pain, reduce phlegm, pharmacological experiment studies such as microcirculation improvement, blood circulation promoting and blood stasis dispelling, pill a group of the present invention is organized and is compared with b, c, d, e, observe the power of its pharmacological action.
Test method: the influence of pill a group of the present invention and b, c, d, e group xylol induced mice auricle edema; On Carrageenan causes the influence of mice foot swelling; To the bullate influence of rat granuloma; The influence of Dichlorodiphenyl Acetate induced mice writhing response;
The mice hot plate is caused the influence of pain; Influence to the phenol red excretion amount of mice trachea; Influence to the rat phlegm-dispelling functions;
Microcirculation of mouse auricle is influenced; Influence to stasis syndrome rat model hemorheological property.
Experimental result: pill a group of the present invention and b, c, d, e group can obviously suppress xylene induced mice auricle edema; It is inhibited that on Carrageenan causes the sufficient swelling of mice; Suppress the rat granulation tissue hyperplasia that cotton balls causes, reduce the weight of granulation tissue; The Dichlorodiphenyl Acetate induced mice is turned round body and is had the obvious suppression effect; Can prolong the pain threshold that hot plate causes the pain mice; Can obviously increase the phenol red excretion amount of mice trachea; Significantly increase the phlegm-dispelling functions of rat; The blood capillary opening amount is increased, and arteriole, thin vein external caliber obviously increase; The high shear rate of stasis syndrome rat model whole blood and low shear rate viscosity, plasma viscosity are obviously increased, and the blood Fibrinogen increases, and platelet adhesion rate raises.
Conclusion: pill a of the present invention group than the antiinflammatory of b, c, d, e group, ease pain, reduce phlegm, pharmacological actions such as microcirculation improvement, blood circulation promoting and blood stasis dispelling are strong; Therefore, to have a heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing expectorant effect than b, c, d, e group strong for pill a of the present invention group.
One, the influence of xylol induced mice auricle edema
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time is behind the last administration 2h; The ear surface is dripped and is coated with xylene 0.05ml and causes inflammation on a mice left side, cause scorching 15min after, and two basal parts of the ear cut about two ears; Two ears are together overlapping; Card punch with diameter 7mm is beaten circular piece, claims two auricle weight about it, and with the swelling degree of left and right sides auricle weight difference value representation mice ear inflammation.Experimental result: see table 1
The influence of swelling
due to the table 1 pair Mice Auricle xylene
Compare * * P＜0.01 with matched group; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: the control group mice auris dextra is obviously red and swollen, and thickness increases, and auricle swelling degree is big.A of the present invention and b, c, d, e group can obviously suppress xylene induced mice ease auricle swelling, the utmost point significant difference of having compared with matched group (P＜0.01); Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the antiinflammatory action of b, c, d, e group.
Two, on Carrageenan causes the influence of mice foot swelling
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time, before the last administration 2h will every sufficient sole of the foot of the left back foot of mice with 1% carrageenin 0.03mL.Animal is put to death in the 1h dislocation of cervical vertebra behind the medicine, and cut metapedes from ankle joint 0.5mm place and weigh respectively, be the swelling degree with the difference of two heavy sensation in the foot amounts.Experimental result: see table 2
Table 2 on Carrageenan causes the influence
of mice foot swelling
Compare * * P＜0.01 with matched group; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: pill a group of the present invention and b, c, d, e group can obviously suppress the swelling that carrageenin causes the mice foot, have compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d.It is thus clear that pill a group of the present invention is stronger than the antiinflammatory action of b, c, d, e group.
Three, to the bullate influence of rat granuloma
Experiment material
1, animal: the SD rat, male and female have concurrently, body weight 200～250g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of SD rats, male and female half and half, body weight 200～250g is divided into 6 groups at random, 10 every group.During test, the rat chesk hair is wiped out in the ether light anaesthesia, and iodine disinfection cuts skin of chest, fills in each one of the aseptic cotton balls of 50mg from otch respectively to two forelimb oxters, skin suture, and intramuscular injection is blue or green, the chain enzyme infection.Postoperative 1h gastric infusion, matched group are irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 5.6g crude drug/kg respectively.Successive administration 7d puts to death rat in the dislocation of 8d cervical vertebra every day 1 time, peels off the cotton balls granulation tissue, dry 12h in 60 ℃ of baking ovens, and the electronic balance precision is weighed (1/1000g), deducts the raw cotton ball weight, calculates granulation weight.Experimental result: see table 3
The bullate influence of table 3 pair rat granuloma
Compare * * P＜0.01 with matched group; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: the rat granulation tissue hyperplasia that pill a group of the present invention and b, c, d, e group cause cotton balls has very strong inhibitory action, reduces the weight of granulation tissue, has compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the antiinflammatory action of b, c, d, e group.
Four, the influence of Dichlorodiphenyl Acetate induced mice writhing response
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time, behind the last administration 1h, the equal lumbar injection 0.6% acetic acid 0.2ml/ of every Mus, mouse writhing number of times in the record 15min, and calculate each and organize analgesia percentage rate.Experimental result: see table 4
The influence of table 4 Dichlorodiphenyl Acetate induced mice writhing response
Compare * P＜0.05 with matched group, * * P＜0.01; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: pill a group of the present invention and b, c, d, e group Dichlorodiphenyl Acetate induced mice are turned round body and are had the obvious suppression effect.Pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the analgesic activity of b, c, d, e group.
Five, the mice hot plate is caused the influence of pain
Experiment material
1, animal: Kunming mouse, female, body weight 18～22g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
The electric hot plate appearance is transferred to (55 ± 0.5) ℃; To body weight is that the Kunming kind female mice of 18～22g screens, and the record mice is dropped into hot plate to the pain threshold of the time of metapedes as this mice occurring licking, 60 of the female mice of screening pain threshold in 30s; Be divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d behind the last administration 1h, is placed on mice in the electric hot plate appearance every day 1 time, and the time that metapedes occurs licking after the record administration, pain threshold was as difference before the pain threshold after the medication deducted medication.Experimental result: see table 5
Table 5 pair mice hot plate causes the influence
of pain
Compare * P＜0.05 with matched group, * * P＜0.01; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: pill a group of the present invention and b, c, d, e group all can prolong the pain threshold that hot plate causes the pain mice.Pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the analgesic activity of b, c, d, e group.
Six, to the influence of the phenol red excretion amount of mice trachea
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time is behind the last administration 0.5h; Lumbar injection 5% phenol red normal saline 0.1ml/10g body weight is put to death animal behind the 0.5h, peel off the trachea surrounding tissue; Cut one section trachea down to the trachea bifurcation from thyroid cartilage; Put in the test tube that the people fills the 2ml normal saline, add the NaOH of 0.1ml 5% again, survey the OD value with 722 type spectrophotometers (wavelength 540nm).Experimental result: see table 6
The influence
of the table 6 pair phenol red excretion amount of mice trachea
Compare * P＜0.05 with matched group, * * P＜0.01; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: pill a group of the present invention and b, c, d, e group can make the phenol red excretion amount of mice trachea obviously increase, and pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the resolve phlegm effect of b, c, d, e group.
Seven, to the influence of rat phlegm-dispelling functions
Experiment material
1, animal: the SD rat, male and female have concurrently, body weight 200～250g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of SD rats, male and female half and half, body weight 200～250g is divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 5.6g crude drug/kg respectively.Successive administration 7d, every day 1 time is after 50min anaesthetizes rat after the last administration with urethane (1g/kg); It is fixing to face upward the position, separates trachea, hits exactly the capillary glass tube (length is 10cm) that inserts known weight between two cartilages at the cricoid cartilage lower edge; Juice is risen along capillary tube; Respectively organize the secretions of rat trachea when collecting 1h, on electronic balance, weigh, and calculate the secretions amount of every 1kg body weight.
Experimental result: see table 7
The influence of table 7 pair rat phlegm-dispelling functions
With compare * P＜0.05 with matched group, * * P＜0.01; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: pill a group of the present invention and b, c, d, e group significantly increase the phlegm-dispelling functions of rat, and pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the resolve phlegm effect of b, c, d, e group.
Eight, microcirculation of mouse auricle is influenced
Experiment material
1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time.Before the administration and successive administration after 7 days, behind the last administration 30min, each organize mice with 20% urethane 0.07ml/10g intraperitoneal injection of anesthesia after; Mouse web portion is lain against downwards on the optical microscope object stage; Make Mice Auricle open and flat, and drip a little liquid paraffin, regulate light-source brightness on its surface; Under transillumination, observe and the open quantity of record Mice Auricle microcirculation blood capillary before and after medication (being the number of hits on blood capillary and border in the 1mm zone) with 16 times of eyepieces and 4 times of object lens.With 16 times of eyepieces and 10 times of object lens, observe and write down the external caliber of Mice Auricle arteriole, thin vein before and after administration.Experimental result: see table 8
Table 8 pair microcirculation of mouse auricle influence
Compare * * P＜0.01 with matched group; Organize than Δ P＜0.05 with pill a of the present invention.
The result shows: pill a group of the present invention and b, c, d, e group all make the blood capillary opening amount increase, and arteriole, thin vein external caliber obviously increase, and have compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the effect of the microcirculation improvement of b, c, d, e group.
Nine, to the influence of stasis syndrome rat model hemorheological property
Experiment material
1, animal: the SD rat, male and female have concurrently, body weight 200～250g.
2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine disposes with distilled water before experiment, gastric infusion.
Experimental technique
70 of SD rats, male and female half and half, body weight 200～250g is divided into 7 groups at random, 10 every group.Matched group and model group are irritated the normal saline of stomach with volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 5.6g crude drug/kg respectively.Successive administration 7d, every day 1 time, dosage 10ml/kg.Except that the blank group, other 5 groups in 7d subcutaneous injection epinephrine 0.08ml/100g, and totally 2 times, 4h at interval.Between 2 injection epinephrines, rat is immersed 5min in 0 ℃ of frozen water.Fasting then, carotid artery blood sampling under the etherization after 12 hours, anticoagulant heparin is used to measure the whole blood height and cuts (200s
-1) and the low viscosity (40s that cuts
-1), erythrocyte sedimentation rate; Measure the blood fibrinogen content with thermal precipitator method; Taking heparin anticoagulation centrifugal separation plasma is measured plasma viscosity in addition; Get the sodium citrate anticoagulation again, be used to measure platelet adhesion rate.
Experimental result: see table 9,10
The influence
of table 9 pair stasis syndrome rat model hemorheological property
Compare * * P＜0.01 with model group; Organize than Δ P＜0.05 with pill a of the present invention.
The influence
of table 10 pair stasis syndrome rat model hemorheological property
Compare * * P＜0.01 with model group; Organize than Δ P＜0.05 with pill a of the present invention
The result shows: pill a group of the present invention and b, c, d, e group all can make the high shear rate of stasis syndrome rat model whole blood and low shear rate viscosity, plasma viscosity obviously increase; The blood Fibrinogen increases; Platelet adhesion rate raises, and has compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.It is thus clear that pill a group of the present invention is stronger than the effect of the blood circulation promoting and blood stasis dispelling of b, c, d, e group.
Experiment conclusion: pill a of the present invention group than the antiinflammatory of b, c, d, e group, ease pain, reduce phlegm, pharmacological actions such as microcirculation improvement, blood circulation promoting and blood stasis dispelling are strong; Therefore, to have a heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing expectorant effect than b, c, d, e group strong for pill a of the present invention group.
Toxicological experiment:
Acute toxicity testing is the result show: with pill a group Cmax of the present invention, maximum volume gastric infusion, successive administration is 3 times in 24h, each 4h at interval, and accumulation medicine total amount reaches 65g crude drug/kg, is equivalent to 189.6 times of the clinical plan consumption of people.After the administration in the 7d, mice is movable, feed, drain all normal, well-grown, the hair color light, its average body weight average increases with the prolongation of test period.8d puts to death every mice perusal heart of back dissection, liver, spleen, lung, kidney, brain, thymus, stomach, intestinal etc. and does not all find color and paramophia, fails to measure LD50.Show the no acute toxic reaction of pill a group of the present invention.
Long term toxicity test is the result show: pill a component of the present invention is that basic, normal, high dosage is respectively 7,14,28g crude drug/kg/d; Be equivalent to 20.4,40.8,81.7 times of clinical dosage; Gastric infusion is after 12 weeks; Pill a group of the present invention does not all have tangible influence, the yet no abnormal pathological change of system's dissection, organ coefficient and histopathological examination to general situation, hematological indices, the blood parameters of animal.2 weeks of drug withdrawal are not seen obvious change yet.Pill a group of the present invention is not found overt toxicity reaction and delayed toxicity reaction in long term toxicity test.It is thus clear that, pill a group non-toxic reaction of the present invention, long-term prescription is safe and reliable.
The specific embodiment
1, the preparation of Chinese medicine composition pill of the present invention:
Prescription:
Method for preparing:
These sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly water 10 times the amount of reflux extraction volatile oil 2 times 2 hours, collecting volatile oil reserve , merge two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion , Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, boiling for 1.5 hours, Merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and after the extraction of volatile oil filtrate, cicada and fried Gallus gallus alcohol extract, alcohol extract of Salvia merge, subtract pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix, volatile oil sprayed into , added refining honey, made water pill or the pill, that was pills.
2, the preparation of Chinese medicine composition tablet of the present invention:
Prescription:
Method for preparing is:
These sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly water 10 times the amount of reflux extraction volatile oil 2 times 2 hours, collecting volatile oil reserve , merge two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion , Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, boiling for 1.5 hours, Merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and after the extraction of volatile oil filtrate, cicada and fried Gallus gallus alcohol extract, alcohol extract of Salvia merge, subtract pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the starch and mixing, granulation, drying, whole, adding an appropriate amount of magnesium stearate, mix, sprayed into the volatile oil, tabletting, ie tablets.
3, the preparation of Chinese medicinal composition granules of the present invention:
Prescription:
Method for preparing is:
These sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly water 10 times the amount of reflux extraction volatile oil 2 times 2 hours, collecting volatile oil reserve , merge two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion , Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, boiling for 1.5 hours, Merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and after the extraction of volatile oil filtrate, cicada and fried Gallus gallus alcohol extract, alcohol extract of Salvia merge, subtract pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above-described mixing dextrin , granulation, drying, whole, sprayed into the volatile oil, bagging, ie granules.
4, the preparation of Chinese medicinal composition capsules agent of the present invention:
Prescription:
Method for preparing is:
These sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly water 10 times the amount of reflux extraction volatile oil 2 times 2 hours, collecting volatile oil reserve , merge two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion , Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, boiling for 1.5 hours, Merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and after the extraction of volatile oil filtrate, cicada and fried Gallus gallus alcohol extract, alcohol extract of Salvia merge, subtract pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the starch and mixing, granulation, drying, whole, sprayed into the volatile oil, loaded capsules, ie capsules.
5, the preparation of Chinese medicine composition soft capsule of the present invention:
Prescription:
Method for preparing is:
These sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly water 10 times the amount of reflux extraction volatile oil 2 times 2 hours, collecting volatile oil reserve , merge two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion , Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, boiling for 1.5 hours, Merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and after the extraction of volatile oil filtrate, cicada and fried Gallus gallus alcohol extract, alcohol extract of Salvia merge, subtract pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix, with mixed powder , sprayed into the volatile oil, mix, adding polyethylene glycol 400, the colloid mill uniform; press gelatin: glycerol: water ratio of 1:0.3:1 glue, soft capsule machine pressure pills, that was soft capsules.
6, the preparation of Chinese medicine composition drop pill of the present invention:
Prescription:
Method for preparing is:
These sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly water 10 times the amount of reflux extraction volatile oil 2 times 2 hours, collecting volatile oil reserve , merge two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion , Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, boiling for 1.5 hours, Merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and after the extraction of volatile oil filtrate, cicada and fried Gallus gallus alcohol extract, alcohol extract of Salvia merge, subtract pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix, volatile oil sprayed into , mixing, sifting, add the melted polyethylene glycol 4000, stir, add pill machine, drop into pills, that was dropping pills.
Claims (9)
1. one kind is used for heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing expectorant Chinese medicine composition, it is characterized in that the prescription of said Chinese medicine composition consists of:
2. according to the method for preparing of the said Chinese medicine composition of claim 1, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly add water (8 to 12) times the amount of reflux extraction of volatile oil 2 times Every time (1 to 3) hours, collecting volatile oil reserve, merge two filtrate, spare; cicada, fried Gallus gallus with (6 ~ 10) times the amount (20% to 60%) ethanol was extracted two times ( 0.5 to 2) hours, the two combined filtrate under reduced pressure to recover ethanol extract solution obtained, spare; Salvia with (5-8) times the amount (75% to 85%) ethanol was extracted twice, each time (1 to 3 ) hours, merge two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria (half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma , Ophiopogon flavor boiling water of 10 2, first addition of water (8 to 12) times the amount of boiling (1-3) hours, the second water (6 to 10) times the amount of boiling (1 - 3) hours, merge two filtrate concentrated under reduced pressure to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.07Mpa ~-0.08Mpa ,70-80 ℃) was concentrated to a relative density of 1.06 ~ 1.20 (60 ~ 80 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting and the spray dry powder formulations suitable for the above materials mixed, sprayed by conventional techniques into different forms of volatile oil, pellets, tablets, granules, capsules, soft capsules or drop pills.
3. according to the method for preparing of the said Chinese medicine composition of claim 2, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, spray-dry and the resulting fine powder and the Suitable materials mix formulations, the formulations according to the conventional process is injected into the volatile oil, pellets, tablets, granules, capsules, soft capsules or drop pills.
4. according to the method for preparing of the said Chinese medicine composition of claim 3, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix , sprayed into the volatile oil, add refining honey, made water pill or the pill, that was pills.
5. according to the method for preparing of the said Chinese medicine composition of claim 3, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above starch mixing, granulation, drying, whole, adding an appropriate amount of magnesium stearate, mix, sprayed into the volatile oil, tabletting, ie tablets.
6. according to the method for preparing of the said Chinese medicine composition of claim 3, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above dextrin mixing, granulation, drying, whole, sprayed into the volatile oil, bagging, ie granules.
7. according to the method for preparing of the said Chinese medicine composition of claim 3, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder and the amount of the above starch mixing, granulation, drying, whole, sprayed into the volatile oil, loaded capsules, ie capsules.
8. according to the method for preparing of the said Chinese medicine composition of claim 3, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix , with mixed powder, sprayed into the volatile oil, mix, adding polyethylene glycol 400, the colloid mill uniform; press gelatin: glycerol: water ratio of 1:0.3:1 glue, soft capsule machine pressure pills, that was soft capsules.
9. according to the method for preparing of the said Chinese medicine composition of claim 3, it is characterized in that the prescription of said Chinese medicine composition consists of:
Preparation method: The above sixteen taste, Dan walnuts, Fritillaria (half dose), safflower (half dose) crushed into fine powder, spare; vinegar Curcuma, wooden butterfly 10 times the amount of water reflux extraction volatile oil 2 times 2 hours collecting volatile oil reserve, combined two filtrate, spare; cicada, fried Gallus gallus with eight times the amount 30% ethanol was extracted two times, each time for 1 hour, merge two filtrate, vacuum recovery of ethanol, obtained extract, spare ; Salvia with six times the amount of 80% ethanol was extracted two times, each 1.5 hours, merging two filtrate, vacuum recovery of ethanol extract obtained, spare; safflower (half dose), puffballs, honeysuckle, Fritillaria ( half dose), dandelion, Radix, vinegar triangular, Scrophulariaceae, Alisma, Radix 10 flavor boiling water two times, the first 10 times the amount of water, boiling for 2 hours, the second 8 times the amount of water, fried cook for 1.5 hours, twice a combined filtrate evaporated to a relative density of 1.08 ~ 1.10 (70 ℃) of clear paste, and the extraction of volatile oil filtrate, Gallus gallus fried cicada and the alcohol extract, salvia alcohol were combined, reduced pressure (-0.08Mpa, 70 ℃) was concentrated to a relative density of 1.08-1.12 (70 ℃) the clear cream, above through a 60 mesh strainer, spray drying, and the resulting spray dry powder mix , sprayed into the volatile oil, mixing, screening, join a molten polyethylene glycol 4000, stir, add pill machine, drop into pills, that was dropping pills.
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| CN113058014A (en) * | 2019-12-16 | 2021-07-02 | 西安碑林药业股份有限公司 | Preparation method of traditional Chinese medicine composition, traditional Chinese medicine composition and application thereof |
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| CN103550419A (en) * | 2013-11-13 | 2014-02-05 | 张笑飞 | Heat clearing traditional Chinese medicine for children |
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| CN113058014A (en) * | 2019-12-16 | 2021-07-02 | 西安碑林药业股份有限公司 | Preparation method of traditional Chinese medicine composition, traditional Chinese medicine composition and application thereof |
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