CN1330318C - Preparation of pills by pressing process - Google Patents
Preparation of pills by pressing process Download PDFInfo
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- CN1330318C CN1330318C CNB2004100455959A CN200410045595A CN1330318C CN 1330318 C CN1330318 C CN 1330318C CN B2004100455959 A CNB2004100455959 A CN B2004100455959A CN 200410045595 A CN200410045595 A CN 200410045595A CN 1330318 C CN1330318 C CN 1330318C
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- honey
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- 238000002360 preparation method Methods 0.000 title description 13
- 230000008569 process Effects 0.000 title description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 235000012907 honey Nutrition 0.000 claims abstract description 33
- 239000003814 drug Substances 0.000 claims description 63
- 239000000843 powder Substances 0.000 claims description 45
- 238000000576 coating method Methods 0.000 claims description 33
- 239000008187 granular material Substances 0.000 claims description 33
- 239000011248 coating agent Substances 0.000 claims description 31
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 22
- 229940079593 drug Drugs 0.000 claims description 20
- 238000007429 general method Methods 0.000 claims description 19
- 206010011224 Cough Diseases 0.000 claims description 13
- 208000000059 Dyspnea Diseases 0.000 claims description 13
- 206010013975 Dyspnoeas Diseases 0.000 claims description 13
- 206010062717 Increased upper airway secretion Diseases 0.000 claims description 13
- 208000026435 phlegm Diseases 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 9
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 238000005550 wet granulation Methods 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 5
- 230000003177 cardiotonic effect Effects 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 3
- 241000208340 Araliaceae Species 0.000 claims description 2
- 241001489978 Eupolyphaga Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- 239000002574 poison Substances 0.000 claims description 2
- 231100000614 poison Toxicity 0.000 claims description 2
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a technology for preparing pills by a pressing method, particularly to a technology for preparing water pills by a pressing technology. Compared with traditional pills, the honey containing amount of pills prepared by the new technology is greatly reduced; compared with ordinarily prepared water pills, the dissolving time limit is obviously reduced. Besides, the automatic pipeline operation of the traditional pills is realized, the quality and the stability of products are enhanced, and the production cost is greatly reduced.
Description
Technical field
The present invention relates to the technology that pressing prepares pill, especially contain the technology of mulse ball, make it to become a kind of watered pill dosage form of new technology with the tablet forming technique preparation of tablet.
This dosage form contains honey to be measured tradition and moulds the pill agent and greatly reduce, and the more general controlling the water circulation ball of dissolve scattered time limit obviously reduces, and has realized the automation engineering production operation of traditional watered pill, has improved constant product quality, greatly reduces production cost.
Background technology
In the prior art, pill notion, category are as described below:
2000 editions appendix IA of the Pharmacopoeia of the People's Republic of China " rules of preparations pill ", pill is meant that medical material fine powder or medicinal substances extract add sphere or the spherical preparation of class that suitable binding agent or other adjuvants are made, are divided into types such as honeyed pill, water-honeyed pill, the watered pill, paste pill, concentrated pill, wax pill and micropill.Wherein:
The watered pill means that the medical material fine powder is the bonding pill made from water (or according to method for making with yellow wine, vinegar, rare medicine juice, liquid glucose etc.).
Concentrated pill is meant the clear paste or the extractum of medical material or part medicinal material extract, with suitable adjuvant or fine drug powder, is the pill that binding agent is made with water, Mel, sugar or Mel and water, sugar and water.According to the difference of adhesive therefor, be divided into concentrated watered pill, concentrate honeyed pill and condensed water honeyed pill.
Except as otherwise herein provided, the medicated powder of using for the pill agent should be fine powder that crude drug directly pulverizes or fine powder, and adjuvant should comprise honey or mulse mixture at least.
When preparing the watered pill with agitation procedure, the general good watered pill is hyperthermia drying for a long time, and this can bring drug loss in various degree.For example, the general system method of tradition has comprised steps such as mother, general ball, choosing grain, oven dry, coating, needs 16 hours altogether, and the coating number of plies reaches 12 layers, and (wherein stratum granulosum is 4 layers, 6 layers on Talcum layer, hit bright 2 layers), supplementary product consumption accounts for the 1/2-1/4 of finished weight, the watered pill density height that makes, medicated powder is arranged closely, be not easy to stripping, disintegration time reaches 1 hour 40 minutes, is unfavorable for the absorption of effective ingredient.This operates general ball operation as semi-hand, and workload is very big, and the cost of labor height is not easy to grasp every standard, can't realize before and after each operation that automatization is connected; In addition, whole process was heated when traditional handicraft prepared pill, and heating-up temperature is up to 80-110 ℃, and high temperature certainly will cause the loss of the medicine that contains volatile ingredient, causes the reduction of quality and curative effect, and mostly the volatility medical material is valuable medicine thereby causes a large amount of wastes.In addition, coatings contains a large amount of sugar, makes the use crowd be restricted.
In addition, for the product that contains the relatively poor component of cohesive, general method for making usually adopts some special materials and method to be handled.The cardiotonic pill that makes with general method for making is an example, the Cinnabaris that contains poor adhesion in its prescription, needing to add a kind of pharmaceutically useful glue in the practical operation of technology is binding agent, be used for increasing the adhesion strength of Cinnabaris, the shortcoming of bringing thus that can't overcome be the cardiotonic pill that makes of this method to go out the time limit long especially, almost can't reach the disintegrate requirement of state-promulgated pharmacopoeia, cause great inconvenience and difficulty to clinical practice to this dosage form.
Therefore, need be improved traditional pharmaceutical technology.
Summary of the invention
The inventor gropes through a large amount of experiments, has improved traditional preparation process, and the pressing of tablet successfully is applied to pill especially among the preparation technology of the watered pill, develops the new technology that successfully prepares watered pill dosage form with pressing, has solved the problems referred to above.
The invention provides the technology that a kind of pressing prepares the watered pill, it is characterized in that: adopt the crude drug of the drug matching component of traditional Chinese patent medicine watered pill prescription as this method, with described traditional Chinese patent medicine watered pill prescription proportioning is the consumption of this method, crude drug is mixed with an amount of honey and/or water, according to material medicine voltinism matter difference in traditional Chinese patent medicine formula, also crude drug and an amount of honey and/or sugar and/or water can be mixed, granulate, again granule is pressed into the spheric watered pill, described traditional Chinese patent medicine watered pill is the Chinese patent medicine watered pill that general method for making makes, and the drug matching component is the former powder of Chinese crude drug and/or its extract.This product is continued to use original trade name, is the novel watered pill of traditional watered pill after improvement.
Many stampings of this process using machine, this equipment is on the basis of traditional tablet machine, it (is spherical mould that the arc angle that increases former plunger chip die makes it to become hemispherical, concrete punch die structure is referring to shown in the 307th page of Figure 10-11 of the third edition " pharmaceutics " (People's Health Publisher)), the tablet machine that miscellaneous part is constant.The watered pill with this explained hereafter is to form through described spherical mould compacting, and lot of experiments proves, uses the watered pill of the pressing preparation of such tablets, and its technology is the system granule earlier, again granule is pressed into ball.
The present invention is directed to various pills, especially the spice of watered pill prescription characteristics, finding out can be with the technology method of the spherical mould compacting watered pill on many stampings machine, and this law meets " every regulation of relevant pill method for making under 2000 editions appendix IA of Chinese pharmacopoeia " rules of preparations pill ".
Compare with the general ball of general method for making, the advantage of mechanical compaction method pill of the present invention is:
1) accuracy
Every and per hundred different comparisons of the ball method of double differences, pressing obviously reduces than general method for making ball weight differential, and the two has compared significant difference, illustrates that pressing and the more accurate degree of general method for making have improved.
2) technological process
General method for making: play mother, general ball, choosing grain, oven dry, coating, need about 16 hours altogether;
Pressing: granulation, granulate, oven dry, pelleting, coating need about 4 hours altogether.
3) heat time heating time
General method for making: playing female, general ball and coating all needs 80 ℃ of-110 ℃ of temperature to heat about 16 hours, and all compositions comprise that all inevitable whole process of volatile and valuable fines medicine is heated;
Pressing: granule was dried about 3 hours, and Calculus Bovis, Borneolum Syntheticum, Moschus etc. are volatile, added behind the system granule by thermally labile and valuable composition, the failure loss of having avoided being heated, and heating-up temperature is below 75 ℃, and the low temperature hot blast dries up for 40～50 ℃ during coating.
4) coating
General method for making: watered pill rough surface, concavo-convex obvious, routine techniques coating difficulty.The coating adjuvant adopts starch, Pulvis Talci, white sugar, gelatin, river wax powder more, and the coating number of plies is 12 layers of (4 layers of stratum granulosums, 6 layers on Talcum layer nearly, hit bright 2 layers), supplementary product consumption accounts for 1/2～1/4 of finished weight, finished product weightening finish big (for example more than 30%) behind the coating, and stability is undesirable;
Pressing: any surface finish, the no concave-convex cicatrix is suitable for adopting coating materials such as the medicinal damp-proof Opadry of inertia colorful film to carry out film coating, both can prevent the pill moisture absorption, has improved the outward appearance of pill again; The coating number of plies has only 2 layers (sealing coat and color dress layers), and the pill weightening finish is not more than 5% behind the coating, and stability significantly improves.
5) disintegration
According to " 2000 editions appendix XIIA of Chinese pharmacopoeia " inspection technique disintegration " measure.
| Disintegration time | The product that pressing obtains | 25～30 minutes |
| The product that general method for making obtains is moulded method for making (honeyed pill) | 1 hour 20 minutes～1 hour 40 minutes 30～45 minutes |
6) but automaticity
General method for making: the pill operation is from operating as semi-hand, can't realize before and after each operation that automatization is connected, with capital system cough phlegm dyspnea ball is example, pill in the general method for making of the former watered pill at first must play mothers and sons with medicine juice and powder, training face in coating pan then, in the coating pan that rotates continuously, spread one deck powder, spread one deck water ... reach regulatory specifications up to pill so repeatedly, this step needs 6 hours approximately, oven dry in 6 hours in 80 ℃ of baking ovens then, coating in the sugar-coat jar again, need altogether bag Floor 12 clothing, whenever wrapped on one deck 80 ℃ of oven for drying 20 minutes for preceding four layers, back six layers of clothing were whenever wrapped on one deck 80 ℃ of oven for drying 30 minutes.Preparation process operation complexity, semi-hand operation, labor intensity greatly, only can semi-mechanization.
Pressing: but the full automatic working of pill operation can realize before and after each operation that automatization is connected.
In sum, the modern production that realizes traditional Chinese patent medicine (comprising the honeyed pill of the system of moulding and the watered pill of general system) is a great problem of puzzlement Chinese medicine industry development always, this law is at traditional big honeyed pills, propose under the modernized big insutry process modification prerequisite of the watered pill, simplified technological process, shortened the flow process time, especially heat time heating time and temperature have been shortened, truly realized the automatic industrial manufacturing line operation of conventional dosage forms (watered pill of general system), realized the big production of modernization projectization for the traditional Chinese patent medicine that solves the industry development of puzzlement Chinese medicine and played great progradation.
In one embodiment, the inventive method comprises: 1) granulate, adopting honey and/or water is binding agent, in 100g medicated powder, adding the honey amount is 0.5～30g, and water is 5～100ml, and preferred honey is 3～10g, water is 40-80ml, and more preferably the about 70ml of amount of water is preferably wet granulation; 2) with spherical stamping machine granule is pressed into the watered pill and is pressed into ball, the diameter of gained ball is 1.0～15.0mm, and average ball heavily is per 100 heavy 2g～300g, hardness 2～8Mpa.
It is binding agent that the inventive method adopts wide material sources and low honey, water or the mulse mixture of cost, crude drug physico-chemical property difference according to Chinese patent medicine, binding agent also can be selected honey and/or sugar and/or water, make the most suitable ball that is pressed into of the granule that makes with this, compare with the required a large amount of binding agent of the loose active force of the general system technology of tradition, the required adhesive consumption of the inventive method obviously reduces, do not contain or only contain a small amount of sugar in the product, therefore use the specific crowd (for example diabetics) of medicine of the present invention highly beneficial needs.In addition, technology of the present invention has changed compressibility indexs such as the intensity of each component particles, bulk density, angle of repose, shatter value in the product by granulate in advance.Obtain the watered pill, concentrated watered pill, condensed water honeyed pill with general method for making and compare, the product that pressing of the present invention makes has reduced density, has shortened dissolve scattered time limit, and has improved preparation stability.With regulation and the regulation detection down of corresponding product quality standard item down of an appendix rules of preparations of Chinese Pharmacopoeia pill item, adopt the accelerated stability test method, investigate its every index, result's proof can guarantee 2 year shelf-life at least.
Advantageously, technology of the present invention may further comprise the steps:
The system granule:
Employing is binding agent with the mulse, according to crude drug physico-chemical property difference, every 100g medicated powder is converted refined honey 0.5～30g, preferred every 100g medicated powder is converted refined honey 3～10g and (is contained animal drugs, the particulate situation of medicated powder system that oiliness is strong in forming for the crude drug of former Chinese medicine prescription, can take the circumstances into consideration to select for use sugar or sweet sugaring as binding agent, to increase the viscosity of medicated powder, more be suitable for granulating efficiency), and suitable quantity of water (medicated powder and water ratio are 100: 5～100), wet granulation, granule is crossed 10～16 mesh sieves, and granule is 25～80 ℃ of temperature, preferred 60～75 ℃ of oven dry.
Concrete method of granulating: with the 100 ℃ of left and right sides hot water refined honey is dissolved mixing earlier; put again and be chilled to preference temperature (below 50 ℃); evenly add in the medicated powder in stirring; stir and stick together; hold agglomerating with the medicine hands that sticks together; promptly loosing of pinching is advisable, and the medicine that will become reconciled sticks together and granulates preferred 12～14 orders with 10～16 eye mesh screens with oscillating granulator again.
Pelleting:
With spherical stamping machine granule is pressed into the watered pill, ball shape is φ 1.0～15.0mm, and average ball heavily is per 100 heavy 2g～300g, hardness 2～8Mpa.
Concrete pelleting operating parameter is: 28 being example towards high speed tablet press, and setting pressure: 40～70KN; Actual mean pressure: 10～15KN; Output: 60～75KT/h; The monodrome upper limit: 85～60KN; Monodrome lower limit: 30～60KN; Pulse width: 4 (are divided into 1～9 gear, are respectively 15～150ms); Gap compensation: 3 (1～9 is the same); Standard deviation: 3KN; Overproof number of times: 15; Adjust number of times: 10; Measuring range: 2 grades; At interval lubricated: 7 minutes.
The product that pressing of the present invention makes is compared except having shortened dissolve scattered time limit with traditional pill (watered pill), also having an outstanding feature is any surface finish, the no concave-convex cicatrix, can adopt conventional coating raw material and packaging technique to carry out coating, the packaging technique that adopts the advanced person preferably, film coating for example is to increase finished product stability; And the watered pill rough surface that the general method for making of Chinese medicine makes is concavo-convex obvious, routine techniques coating difficulty, and adjuvant comprises that the consumption of sugar is big, stability so not really desirable.
Pill prescription by traditional Chinese patent medicine is got an amount of drug matching active component, adopt technology of the present invention, conventional medicament coptos bolus for clearing the upper heat, Ginseng Bolus for tonifying spleen, dermopathic blood poison pill, Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae, TONGREN DAHUOLUO WAN, capital system cough phlegm dyspnea ball and the cardiotonic pill of our company are improved.To be example with " capital system cough phlegm dyspnea ball " below, the present invention will be described in further detail.
Preferably, in one embodiment, capital system of the present invention cough phlegm dyspnea ball compacting ball has kept the whole components (for example former powder of Chinese crude drug and/or its extract) and the original prescription proportioning of the capital system cough phlegm dyspnea ball that original general method for making makes, the honey amount of wherein adding accounts for plain ball and weighs in 10%, be to contain the honey amount in the capital system cough phlegm dyspnea ball that makes of described pressing to be 6-10%, preferred 7-9%, more preferably 8%.
The inventive method comprises:
With the 36-flavor Glutinous Chinese medicine of former prescription, except that Rhizoma Zingiberis Recens, Folium Eriobotryae, its excess-three 14 flavors are ground into medicated powder; Ratio in 1ml Sucus Zingberis/1g Rhizoma Zingiberis Recens is squeezed the juice Rhizoma Zingiberis Recens; Folium Eriobotryae decocts into medicine juice, filters, and being concentrated into relative density is 1.10 (50 ℃); Add described Rhizoma Zingiberis Recens juice and refined honey and water in this medicine juice, add and stir in the medicated powder and stick together, granulate, drying is pressed into ball.
In a preferred embodiment, the inventive method comprises:
(1) the refined honey amount adds refined honey 6-10g by 100g medicated powder; With adding Rhizoma Zingiberis Recens juice and refined honey and water in the Folium Eriobotryae medicine juice, mix the compound that makes into 35ml/100g medicated powder, add the medicated powder neutralization again and stick together, described medicated powder is the medicinal powder except that Folium Eriobotryae and Rhizoma Zingiberis Recens;
(2) granulating is wet granulation;
(3) drying is 65～75 ℃;
(4) being pressed into ball is towards pellet press granule to be pressed into ball with sphere.
Wherein more preferably:
(1) granulates to every 100g medicated powder (removing Folium Eriobotryae and Rhizoma Zingiberis Recens) adds refined honey 6-10g, preferably add the honey amount and be 8g, decoct the medicine juice that obtains with Folium Eriobotryae, Sucus Zingberis and the water that Rhizoma Zingiberis Recens obtains mixes the compound that makes into about 35ml, wet granulation;
Wherein according to the rules, recipe quantity (removing Folium Eriobotryae and Rhizoma Zingiberis Recens) is a 2301g medicated powder, and the Rhizoma Zingiberis Recens of a recipe quantity is 120g, and to obtain Sucus Zingberis be 120ml approximately through squeezing, and amounts to 1ml Sucus Zingberis/every gram Rhizoma Zingiberis Recens, promptly by 100g medicated powder, adds the 5.2ml Sucus Zingberis approximately; The Folium Eriobotryae 480g of a recipe quantity, the extract that obtains after the water extraction filtering and concentrating (being medicine juice) is 160～190ml approximately, average about 175ml, amounting to the extraction ratio is 0.333～0.396ml medicine juice/every gram Folium Eriobotryae, average 0.365ml medicine juice/every gram Folium Eriobotryae, promptly, add about 7-8.3ml medicine juice that 21g Folium Eriobotryae water boiling and extraction obtains approximately, preferred 7.67ml by 100g medicated powder.
(2) drying, preferred temperature is 65～75 ℃;
(3) be pressed into ball, towards pellet press dried granule be pressed into ball with sphere, preferred ball shape is φ 6.5mm, and average ball heavily is per 100 heavy 21g.
The aforesaid operations process is also optional to comprise the coating that is pressed into behind the ball, for example adopt preferred inert medicinal damp-proof Opadry colorful film coating material to carry out film coating, advantage is both can prevent the pill moisture absorption, improved the outward appearance of pill again, the coating material consumption is that the pill weightening finish is not more than 5% behind the coating.
In a further preferred embodiment, granulate and be every 100g medicated powder (removing Folium Eriobotryae and Rhizoma Zingiberis Recens), add refined honey 6-10g, the medicine juice 7-8.3ml of Folium Eriobotryae (21g), the Sucus Zingberis 5.2ml and the water of preferred 7.67ml, Rhizoma Zingiberis Recens (5.2g) are when making compound reach 35ml after the mixing, the most suitable pressing of the present invention of the granule that makes, its repressed novel pill that obtains, its each side effect is best, and especially dissolve scattered time limit obviously shortens.
Because pressing of the present invention is the preparation granule earlier, repress is made pill, make product dissolve scattered time limit of the present invention (being disintegration) prepare about 2 hours of pill and be reduced to about 20 minutes that drug release time shortens dramatically, and has greatly improved bioavailability by former general method for making.In addition, the product that this law makes has improved the heavy accuracy of ball of per hundred granule products, solved the problem that traditional product concave-convex surface cicatrix that former general method for making makes is difficult to wrap film-coat, and, the capital system cough phlegm dyspnea ball that makes with this law is an example, and finished product increased weight below 5% after coating material was reduced to film coating from original every 100g medicated powder with Pulvis Talci 25g, sugared 6.5g (be coating after finished product weightening finish more than 30%).The optional moisture-proofing film coating material that adopts of product of the present invention, carry out coating through high speed coating pan film-coated technique, more improved product stability, so the product after this dosage form improvement has improved the compliance of patient to treatment to a great extent under the prerequisite that guarantees curative effect.
The specific embodiment
Below in conjunction with specific embodiment the present invention further being elaborated, is not in order to limit the present invention.
Embodiment 1: the capital system cough phlegm dyspnea ball of pressing preparation
Below be the composition and the consumption of the capital system cough phlegm dyspnea ball of a recipe quantity:
Radix Peucedani 60g Rhizoma Cynanchi Stauntonii 60g Semen Armeniacae Amarum (peeling is fried) 90g Folium Mori 120g
Herba Ephedrae 42g Pinellia leaven (parched with bran) 60g Radix Platycodonis 60g Bulbus Fritillariae Cirrhosae 30g
Fructus Perillae (stir-fry) 60g Exocarpium Citri Grandis (salt is processed) 30g Radix Asteris 60g Flos Farfarae (processed with honey) 30g
Flos Inulae 60g Pumex (forging) 60g Fructus Aristolochiae (processed with honey) 30g Poria 60g
Radix Glycyrrhizae Preparata 30g Radix Polygalae (parching to brown) 60g Gypsum Fibrosum 120g Herba Asari 18g
Fructus Schisandrae Chinensis (processed with vinegar) 30g Ramulus Cinnamomi (stir-fry) the 30g Bulbus Fritillariae Thunbergii 60g Radix Paeoniae Alba (wine is processed) 60g
The Semen Lepidii (Semen Descurainiae) 30g Rhizoma Belamcandae 30g Radix Stemonae (processed with honey) 60g Bulbus Allii Macrostemonis 60g
Radix Scutellariae 60g Radix Codonopsis 240g Fructus Jujubae 480g calcined CONCHA MERETRICIS SEU CYCLINAE powder 46.2g
Indigo Naturalis 13.8g Pericarpium Papaveris (processed with honey) 111g Rhizoma Zingiberis Recens 120g Folium Eriobotryae 480g
Method for making: above 36-flavor Glutinous, except that Rhizoma Zingiberis Recens, Folium Eriobotryae, 34 flavors such as all the other Radix Peucedanis are ground into
Fine powder sieves, mixing.Getting Rhizoma Zingiberis Recens adds little water and squeezes the juice; Folium Eriobotryae decocts with water secondary, and collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.10 (50 ℃) (being medicine juice), add Rhizoma Zingiberis Recens juice and an amount of refined honey and water, stir evenly, add above-mentioned powder mixing, make granule, drying, employing is many towards pellet press, is pressed into ball with spherical mould, the bag film-coat, promptly.
Concrete operations are as follows:
1, the system granule: by every 100g medicated powder, add refined honey 8g, the about 7-8.3ml of medicine juice, the about 5.2ml of Sucus Zingberis and suitable quantity of water (being added to approximately and making compound is 35ml), mixing, with medicated powder with stick together, wet granulation, granule is 65～75 ℃ of oven dry in temperature;
2, pelleting: towards pellet press granule is pressed into ball with sphere, ball shape is φ 6.5mm, and average ball heavily is per 100 heavy 21g;
3, adopt conventional medical coating technology coatings.
For 100g medicated powder, when the mixing ointment of same ratio during at 35ml, the granule the best that makes, the most suitable ball that is pressed into becomes every index the best behind the ball;
This product is that film-coat contains mulse ball (condensed water honeyed pill), and trade name still is capital system cough phlegm dyspnea ball, shows lark after removing coating; Mildly bitter flavor.
Claims (7)
1, a kind of method for preparing pill, it is characterized in that: by the prescription and the consumption of traditional Chinese patent medicine pill, the extract of getting the former powder of Chinese crude drug and/or the former powder of Chinese crude drug is as the crude drug in this method, the medicated powder of crude drug is mixed with honey and water, and in 100g medicated powder, adding the honey amount is 0.5～30g, water is 5～100ml, wet granulation, granule are crossed 10～16 mesh sieves, 25～80 ℃ of dryings; Again the repressed method of gained granule is pressed into spheric pill with spherical stamping machine, the diameter of this ball is 1.0～15.0mm, and average ball heavily is per 100 heavy 2g～300g, hardness 2～8Mpa.
2, the method for claim 1, wherein said traditional Chinese patent medicine pill are the Chinese medicine watered pill that general method for making makes.
3, the method for claim 1, wherein adding the honey amount is 3～10g, water is 40～80ml.
4, method as claimed in claim 3, the optional coating steps that comprises.
5, the method for claim 1, wherein said described traditional Chinese patent medicine pill is capital system cough phlegm dyspnea ball, Rhizoma Coptidis supernatant nine, Ginseng Bolus for tonifying spleen, Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae, dermopathic blood poison pill, TONGREN DAHUOLUO WAN or cardiotonic pill.
6, the method for claim 1, wherein said traditional Chinese patent medicine pill is capital system cough phlegm dyspnea ball, described method comprises:
36-flavor Glutinous Chinese medicine in the capital system cough phlegm dyspnea ball prescription that the general method for making of tradition is made, except that Rhizoma Zingiberis Recens, Folium Eriobotryae, its excess-three 14 flavors are ground into thin medicated powder; Ratio in 1ml Sucus Zingberis/1g Rhizoma Zingiberis Recens is squeezed the juice Rhizoma Zingiberis Recens; Folium Eriobotryae decocts into medicine juice, filters, and being concentrated into relative density is 1.10; Add described Rhizoma Zingiberis Recens juice and refined honey and water in this medicine juice, by 100g medicated powder, wherein the amount of refined honey is 6-10g, adds in the thin medicated powder mixedly and stick together again, granulates, and drying is pressed into ball.
7, method as claimed in claim 6, the described ball that is pressed into is towards pellet press granule to be pressed into spheric ball with sphere, carry out coating to the compacting watered pill optional comprising.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100455959A CN1330318C (en) | 2004-06-11 | 2004-06-11 | Preparation of pills by pressing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100455959A CN1330318C (en) | 2004-06-11 | 2004-06-11 | Preparation of pills by pressing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1583124A CN1583124A (en) | 2005-02-23 |
| CN1330318C true CN1330318C (en) | 2007-08-08 |
Family
ID=34601894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100455959A Expired - Lifetime CN1330318C (en) | 2004-06-11 | 2004-06-11 | Preparation of pills by pressing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1330318C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054937A (en) * | 2012-11-28 | 2013-04-24 | 高慧芳 | Medicament for treating bronchus asthma |
| CN105596700A (en) * | 2014-03-12 | 2016-05-25 | 郑于静 | Preparation method of traditional Chinese medicine for clearing lung and eliminating phlegm |
| CN103920078B (en) * | 2014-04-25 | 2016-04-27 | 刘子令 | A kind of medicine for the treatment of cough with asthma and preparation method thereof |
| CN107115309A (en) * | 2017-05-04 | 2017-09-01 | 威海百合生物技术股份有限公司 | A kind of Chinese medicine water pill preparation method |
| CN107951989A (en) * | 2017-11-01 | 2018-04-24 | 绍兴文理学院元培学院 | A kind of method moulded preparation method and prepare shenmai rehmannia pill |
| CN109288952B (en) * | 2018-12-12 | 2021-08-20 | 怀化正好制药有限公司 | Jingangteng pill and its preparing process |
| CN109876127B (en) * | 2019-03-29 | 2021-07-06 | 四川大千药业有限公司 | Blood-nourishing angelica sinensis capsule and preparation method thereof |
-
2004
- 2004-06-11 CN CNB2004100455959A patent/CN1330318C/en not_active Expired - Lifetime
Non-Patent Citations (4)
| Title |
|---|
| 中药成方制剂第20册 卫生部药典委员会，151，卫生部药典委员会 1998 * |
| 中药药剂学 范碧亭，361-367，401-447，上海科学技术出版社 1997 * |
| 药剂学 奚念朱，307，人民卫生出版社 1980 * |
| 药剂学 奚念朱，307，人民卫生出版社 1980;中药成方制剂第20册 卫生部药典委员会，151，卫生部药典委员会 1998;中药药剂学 范碧亭，361-367，401-447，上海科学技术出版社 1997 * |
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| Publication number | Publication date |
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| CN1583124A (en) | 2005-02-23 |
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