CN107115309A - A kind of Chinese medicine water pill preparation method - Google Patents
A kind of Chinese medicine water pill preparation method Download PDFInfo
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- CN107115309A CN107115309A CN201710307236.3A CN201710307236A CN107115309A CN 107115309 A CN107115309 A CN 107115309A CN 201710307236 A CN201710307236 A CN 201710307236A CN 107115309 A CN107115309 A CN 107115309A
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
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- A61K35/56—Materials from animals other than mammals
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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Abstract
The present invention relates to a kind of Chinese medicine water pill preparation method, solve prior art because Chinese medicine material medicinal powder it is sticky it is too high influence molding to occur softwood break bar easy to stick, graininess mould form the technical problem of difficult influence ball shape.The present invention provides a kind of Chinese medicine water pill preparation method, step includes molding, starch granules sieving, the sieving of traditional Chinese medicine extraction raw material, general ball, selects grain, drying and the step such as be coated, it is of the invention be widely used in so that polyoses content is high, tough Chinese medical extract as raw material the preparation of Chinese medicine water pill.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine preparation, and in particular to a kind of Chinese medicine water pill preparation method.
Background technology
Pill is the common big formulation of China's traditional Chinese medicine.It is suitable that pill refers to that fine medicinal material powder or medicinal substances extract add
The spherical or spherical preparation that adhesive or other auxiliary materials are made, is divided into the water-bindered pill, honeyed bolus, water-honeyed pill, starched pill, condensed pill, wax-wrapped pill
Deng, wherein again using the water-bindered pill as pill in one of two big most common formulations.
The water-bindered pill, also referred to as water pill, mean fine drug powder with water (or according to preparation method yellow rice wine, vinegar, concoction, medicinal extract, syrup
Deng) be adhesive, manually or the general system of machinery spherical pellets.Because water pill pill is small, surface compact is smooth, be easy to
Take, and its excipient is water miscible, the advantages of being disintegrated fast, effective fast after taking in vivo and be widely used.Water pill
Manufacture craft mainly include molding, general ball, select the flows such as grain, drying, coating.Molding, has been commonly called as mothers and sons, is to make water pill
Most basic, most critical link, the smooth degree of molding and the quality of mothers and sons decide the quality of general ball.The quality of general ball is determined again
The quality of the character, weight differential and pill finished product of pill is determined.Therefore, the link of molding and general ball determines pill quality
Quality, is most important, most critical two links in whole pill preparation engineering.
The molding of water pill and general ball process are with the direct molding of water, then by pill mould with fine drug powder mostly in production at present
Son carries out general ball with water, also has raw material medicinal powder directly with ethanol water molding and general ball, and Chinese medicine used in many water pills is former
Material is that polyoses content is high, tough Chinese medical extract, in pill preparation process, sticky too high due to Chinese medicine material medicinal powder
And influence molding, occur softwood break bar easy to stick, graininess mould formed it is difficult, when being unfavorable for general ball, influence ball shape, pill and leaching
The problems such as limit, so as to influence the quality of the character of pill, weight differential and pill finished product.
The content of the invention
The purpose of the present invention is in order to overcome molding and general ball technology in above-mentioned existing Chinese medicine water pill preparation process
It is not enough there is provided it is a kind of so that polyoses content is high, tough Chinese medical extract as raw material Chinese medicine water pill preparation method.
The technical proposal for solving the technical problem of the invention is：The present invention provides a kind of Chinese medicine water pill preparation side
Method, step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, sugar-coat
Pot makes starch heap scattered and uniformly moistened with liquid syrup with mechanical rotation, when starch occurs forming fine particulate in coating pan
When, then dispense a little starch into pot, starch is adhered to fine grained surface, then spray liquid syrup moistening, so operate repeatedly to
Obtain the starch granules of suitable size；Starch weight used in molding is the 2%~4% of pill finished weight, and molding is used to be bonded
Agent liquid syrup concentration is 40%~60%, and weight is the 8%~12% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes 16~20 purposes
Starch granules is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, 80~100 mesh are taken
Chinese medical extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the female weight of starch first to add weight
The Chinese medical extract that 0.5%~1.5% the step of (3) obtains, it is that 40%~60%, weight is pill weight to add concentration
10%~15% liquid syrup is wrapped up as adhesive；Chinese medicine material uniformly wraps starch imperial mother, then is dispensed into pot
Chinese medical extract, makees adhesive by 60%~80% ethanol water of concentration and carries out general ball, general ball pot with mechanical rotation with
Adhesive sprinkling adds Chinese medical extract repeatedly, gradually general that prescribed level, the pill of ball weight is made.
It is preferred that, the present invention provides a kind of Chinese medicine water pill preparation method, and step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, sugar-coat
Pot makes starch heap scattered and uniformly moistened with liquid syrup with mechanical rotation, when starch occurs forming fine particulate in coating pan
When, then dispense a little starch into pot, starch is adhered to fine grained surface, then spray liquid syrup moistening, so operate repeatedly to
Obtain the starch granules of suitable size；Starch weight used in molding is the 3% of pill finished weight, molding adhesive therefor syrup
Liquid concentration is 50%, and weight is the 10% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes 16~20 purposes
Starch granules is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, 80~100 mesh are taken
Chinese medical extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the female weight of starch first to add weight
The Chinese medical extract that 1.0% the step of (3) obtains, it is 12% liquid syrup that 50%, weight is pill weight to add concentration
Wrapped up as adhesive；Chinese medicine material uniformly wraps starch imperial mother, then dispenses into pot Chinese medical extract, using concentration as
70% ethanol water makees adhesive and carries out general ball, and general ball pot adds traditional Chinese medicine extraction repeatedly with mechanical rotation and adhesive sprinkling
Thing, it is gradually general that prescribed level, the pill of ball weight is made.
It is preferred that, coating pan mechanical rotation speed is 70~80r/min in step (1) molding.
It is preferred that, general ball pot mechanical rotation speed is 60~70r/min in step (4) general ball.
Present invention additionally comprises follow-up choosing grain, drying and coating steps.
It is preferred that, select grain step：The pill sieving that general ball step is obtained, the pill of size needed for obtaining.
It is preferred that, baking step：Temperature control is at 45~55 DEG C, and drying time is 5~10h.
It is preferred that, coating steps：By the pill film coating dried.
Beneficial effects of the present invention：Using starch, with the independent molding of liquid syrup, pearl starch mother is made, in the present invention
Medicine raw material medicinal powder wraps up starch imperial mother, then medication powder and carries out general ball with ethanol water.Adhesive is made with liquid syrup using starch
Act that to be molded as starch female, can avoid and solve that polyoses content is high, tough traditional Chinese medicine extraction raw material is directly being risen using medicinal powder
During mould due to caused by material viscosity is big softwood break bar easy to stick, graininess mould form difficult, influence ball shape, pill
The problems such as leaching the time limit.Suitable for molding, general ball and the pelletizing process of the larger Chinese medicine water pill of Chinese medicine material viscosity.
Embodiment
With reference to specific embodiment, the invention will be further described, to help understanding present disclosure.The present invention
Used in method unless otherwise required, be conventional production method；Used raw material, unless otherwise required, be
Conventional commercially available prod.
Embodiment 1：
A kind of Chinese medicine water pill preparation method, step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, sugar-coat
Pot makes starch heap scattered and uniformly moistened with liquid syrup with 70r/min mechanical rotations, when forming carefully occurs in starch in coating pan
During graininess, then into pot a little starch is dispensed, starch is adhered to fine grained surface, then spray liquid syrup moistening, so repeatedly
Operate to the starch granules for obtaining suitable size；Starch weight used in molding is the 2% of pill finished weight, and molding is used to be bonded
Agent liquid syrup concentration is 40%, and weight is the 8% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes 16~20 purposes
Starch granules is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, 80~100 mesh are taken
Chinese medical extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the female weight of starch first to add weight
The Chinese medical extract that 0.5% the step of (3) obtains, it is 10% liquid syrup that 40%, weight is pill weight to add concentration
Wrapped up as adhesive；Chinese medicine material uniformly wraps starch imperial mother, then dispenses into pot Chinese medical extract, using concentration as
60%~80% ethanol water makees adhesive and carries out general ball, and general ball pot is anti-with 60r/min mechanical rotations and adhesive sprinkling
It is added with into Chinese medical extract, it is gradually general that prescribed level, the pill of ball weight is made.
(5) grain is selected：The pill sieving that general ball step is obtained, the pill of size needed for obtaining.
(6) dry：Temperature control is at 45 DEG C, and drying time is 10h.
(7) it is coated：By the pill film coating dried.
Embodiment 2：
A kind of Chinese medicine water pill preparation method, step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, sugar-coat
Pot makes starch heap scattered and uniformly moistened with liquid syrup with 75r/min mechanical rotations, when forming carefully occurs in starch in coating pan
During graininess, then into pot a little starch is dispensed, starch is adhered to fine grained surface, then spray liquid syrup moistening, so repeatedly
Operate to the starch granules for obtaining suitable size；Starch weight used in molding is the 3% of pill finished weight, and molding is used to be bonded
Agent liquid syrup concentration is 50%, and weight is the 10% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes 16~20 purposes
Starch granules is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, 80~100 mesh are taken
Chinese medical extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the female weight of starch first to add weight
The Chinese medical extract that 1.0% the step of (3) obtains, it is 12% liquid syrup that 50%, weight is pill weight to add concentration
Wrapped up as adhesive；Chinese medicine material uniformly wraps starch imperial mother, then dispenses into pot Chinese medical extract, using concentration as
70% ethanol water makees adhesive and carries out general ball, and general ball pot is added repeatedly with 65r/min mechanical rotations with adhesive sprinkling
Chinese medical extract, it is gradually general that prescribed level, the pill of ball weight is made.
(5) grain is selected：The pill sieving that general ball step is obtained, the pill of size needed for obtaining.
(6) dry：Temperature control is at 50 DEG C, and drying time is 8h.
(7) it is coated：By the pill film coating dried.
Embodiment 3：
A kind of Chinese medicine water pill preparation method, step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, sugar-coat
Pot makes starch heap scattered and uniformly moistened with liquid syrup with 80r/min mechanical rotations, when forming carefully occurs in starch in coating pan
During graininess, then into pot a little starch is dispensed, starch is adhered to fine grained surface, then spray liquid syrup moistening, so repeatedly
Operate to the starch granules for obtaining suitable size；Starch weight used in molding is the 4% of pill finished weight, and molding is used to be bonded
Agent liquid syrup concentration is 60%, and weight is the 12% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes 16~20 purposes
Starch granules is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, 80~100 mesh are taken
Chinese medical extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the female weight of starch first to add weight
The Chinese medical extract that 1.5% the step of (3) obtains, it is 15% liquid syrup that 60%, weight is pill weight to add concentration
Wrapped up as adhesive；Chinese medicine material uniformly wraps starch imperial mother, then dispenses into pot Chinese medical extract, using concentration as
80% ethanol water makees adhesive and carries out general ball, and general ball pot is added repeatedly with 70r/min mechanical rotations with adhesive sprinkling
Chinese medical extract, it is gradually general that prescribed level, the pill of ball weight is made.
(5) grain is selected：The pill sieving that general ball step is obtained, the pill of size needed for obtaining.
(6) dry：Temperature control is at 55 DEG C, and drying time is 5h.
(7) it is coated：By the pill film coating dried.
Embodiment 4：
Traditional Chinese medicine pill A is using donkey-hide gelatin, angelica extract, prepared rehmannia root extract, Fructus lycii P.E as main Chinese medicine material
The common Chinese medicine water pill of in the market, these Chinese medicine material polyoses contents are higher, cause Chinese medicine material mixed powder viscosity big.Below
The direct molding of medicinal powder and general ball, starch molding and the general ball of medicinal powder that traditional Chinese medicine water pill A is respectively adopted are contrasted.
(1) the direct molding of Chinese medicine water pill A medicinal powder and general ball
Present case is with the direct molding of Chinese medicine material medicinal powder after pulverizing and sieving, general ball, respectively with pure water, liquid syrup, ethanol
The aqueous solution carries out lab scale as adhesive, analyzes preparation, general ball and pill molding effect (the best note of effect of graininess mould
For 5 points, score value is represented with asterisk, and asterisk is fewer, and effect is poorer；In addition, the viscosity to material is stated, with overall merit
The whole structure of molding, general ball and pelletization), and test leaching the time limit.As a result such as following table is recorded：
The Chinese medicine water pill A of the table 1 direct molding of medicinal powder and general ball effect analysis
Analysis upper table data can be drawn, because raw material mixed powder viscosity is big, graininess mould is made with the direct molding of medicinal powder
Son effect it is poor, and with water and liquid syrup make adhesive can make medicinal powder excessively glue and influence molding, general ball, pelletization effect and ball
Agent leaches the time limit.
(2) Chinese medicine water pill A starch molding and the general ball of medicinal powder
With starch molding pearl starch imperial mother is made, with the Chinese medicine material medicinal powder molding after pulverizing and sieving in present case
The liquid syrup parcel starch imperial mother of concentration used carries out general ball, is entered respectively using pure water, liquid syrup, ethanol water as adhesive
Row lab scale, analyze the preparation of graininess mould, general ball and pill molding effect (effect it is best be designated as 5 points, score value is with asterisk table
Show, asterisk is fewer, effect is poorer；In addition, the viscosity to material is stated, with overall merit molding, general ball and pelletization
Whole structure), and test leaching the time limit.As a result such as following table is recorded：
The Chinese medicine water pill A of table 2 starch molding and the general ball effect analysis of medicinal powder
Analysis upper table data can be drawn, the effect that graininess master batch is made in adhesive molding is made with 50% liquid syrup with starch
It is best；Obtained pearl starch mother Chinese medicine mixed powder made with 70% ethanol solution the general ball of adhesive, pelletization best results,
Leach the time limit most short.
Embodiment 5：
Traditional Chinese medicine pill B be using American ginseng extract, Shorthorned Epimedium P.E, oyster extract as main Chinese medicine material in the market
Common Chinese medicine water pill, these Chinese medicine material polyoses contents are higher, cause Chinese medicine material mixed powder viscosity big.Adopt separately below
Contrasted with traditional Chinese medicine water pill B direct molding of medicinal powder and general ball, starch molding and the general ball of medicinal powder.
(1) the direct molding of Chinese medicine water pill B medicinal powder and general ball
Present case is with the direct molding of Chinese medicine material medicinal powder after pulverizing and sieving, general ball, respectively with pure water, liquid syrup, ethanol
The aqueous solution carries out lab scale as adhesive, analyzes preparation, general ball and pill molding effect (the best note of effect of graininess mould
For 5 points, score value is represented with asterisk, and asterisk is fewer, and effect is poorer；In addition, the viscosity to material is stated, with overall merit
The whole structure of molding, general ball and pelletization), and test leaching the time limit.As a result such as following table is recorded：
The Chinese medicine water pill B of the table 3 direct molding of medicinal powder and general ball effect analysis
Analysis upper table data can be drawn, because raw material mixed powder viscosity is big, graininess mould is made with the direct molding of medicinal powder
Son effect it is poor, and with water and liquid syrup make adhesive can make medicinal powder excessively glue and influence molding, general ball, pelletization effect and ball
Agent leaches the time limit.
(2) Chinese medicine water pill B starch molding and the general ball of medicinal powder
Pearl starch imperial mother is made with 50% liquid syrup molding in present case starch, former with the Chinese medicine after pulverizing and sieving
Material medicinal powder carries out general ball with 50% liquid syrup parcel starch imperial mother, respectively with pure water, the liquid syrup and various concentrations of various concentrations
Ethanol water carry out lab scale, analyze general ball and pill molding effect (effect it is best be designated as 5 points, score value is represented with asterisk,
Asterisk is fewer, and effect is poorer；In addition, the viscosity to material is stated, with the entirety of overall merit molding, general ball and pelletization
Effect), and test leaching the time limit.As a result such as following table is recorded：
The effect analysis of the general ball of medication powder after the Chinese medicine water pill B starch moldings of table 4
Analysis upper table data can be drawn, the effect that graininess master batch is made in adhesive molding is made with 50% liquid syrup with starch
It is best；Obtained pearl starch mother Chinese medicine mixed powder made with 70% ethanol solution the general ball of adhesive, pelletization best results,
Leach the time limit most short.
The present invention from molding, starch granules sieving, the sieving of traditional Chinese medicine extraction raw material, general ball etc. entirely preparation flow, process
Control, raw material and consumption are complementary, should be gone wrong from overall control, any one link, the pill being made just reaches
Less than requiring.General ball is female from 16~20 mesh starch, if starch mother is less than 16 mesh, it may appear that " ball " is childlike, traditional Chinese medicine extraction
The problems such as thing self adheres into pimple, if higher than 20 mesh, it may appear that " core is female " is too big, and general 1.5~2g of a ball causes adhesion
Medicinal powder very little, the problems such as can not meet drug effect；General ball selects the Chinese medical extract of 80~100 mesh, too high or too low, occurs
Adhesiveness is bad, general ball effect is poor, in addition can not pelletization the problems such as.In general ball step, if omitting the Chinese medicine used after pulverizing and sieving
Raw material medicinal powder makees the female process of adhesive parcel starch with liquid syrup, directly makees adhesive with Chinese medicine material medicinal powder with ethanol water
Carry out general ball, it may appear that starch mother dissolves, loosely, it is not agglomerating, the problems such as be difficult to pelletization because being carried with the Chinese medicine after pulverizing and sieving
Take thing medicinal powder to make adhesive parcel starch with liquid syrup female, core starch can be made female and phase adhesion between medicinal powder, existing without layering
As playing a part of perfect transition.Wrap up after starch mother, carried out with Chinese medicine material medicinal powder with ethanol water as adhesive general
Ball, can avoid and solve the larger Chinese medicine material medicinal powder of viscosity with pure water pill or with material mistake caused by syrup liquid flooding ball
Glue, be unfavorable for general ball, influence pill the problems such as be molded, and as adhesive general ball is carried out with 60%~80% ethanol water
The pill that pure water pill can be shortened leaches the time limit.It was verified that coating pan, general ball pot mechanical rotation speed are controlled 70 respectively
~80r/min, 60~70r/min, molding of the present invention, general ball effect it is more satisfactory.Drying temperature is controlled at 45~55 DEG C, is dried
Time is 5~10h, and final ball shape and drug effect are more satisfactory.
It is of the invention to be essentially different with traditional pill preparation technology：Truly the preparation of pill is traditional
Method, that is, powder manually or machinery method bit by bit general ball.The traditional pill making craft improved at present
It is, first with most medicinal powder are made into particle after pulverizing medicinal materials, particle to be then pressed into spherical mold (the tabletting work with tablet
Skill is similar, is made after particle and is directly pressed into tablet), remaining sub-fraction medicinal powder be used for general ball, that is, be pressed into it is spherical after only its
One layer of surface is made up of the general ball of medicinal powder.Advantage/feature of the present invention essentially consists in the molding in the whole technique of pill
With general ball step, using starch with the independent molding of liquid syrup, pearl starch mother is made, then medication powder is carried out with ethanol water
General ball, can effectively solve that polyoses content is high, tough traditional Chinese medicine extraction raw material is during directly using medicinal powder molding
Due to material viscosity it is big caused by softwood break bar easy to stick, graininess mould formed it is difficult, be unfavorable for general ball, influence ball shape and molten
The problems such as dissipating the time limit.
Only as described above, is only the specific embodiment of the present invention, when can not limit the model implemented of the present invention with this
Enclose, all equivalent changes and modifications done according to scope of the present invention patent, such as Chinese medical extract can also be crushed with Chinese medicine
Afterwards instead of should all belong to the covering scope of the present invention.
Claims (8)
1. a kind of Chinese medicine water pill preparation method, it is characterised in that step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, coating pan with
Mechanical rotation makes starch heap scattered and uniformly moistened with liquid syrup, when fine particulate occurs forming in starch in coating pan, then
A little starch is dispensed into pot, starch is adhered to fine grained surface, then sprays liquid syrup moistening, is so operated repeatedly to being closed
The starch granules of suitable size；Starch weight used in molding is the 2%~4% of pill finished weight, molding adhesive therefor syrup
Liquid concentration is 40%~60%, and weight is the 8%~12% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes the starch of 16~20 mesh
Particle is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, taken in 80~100 purposes
Medicament extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the 0.5% of the female weight of starch first to add weight
The Chinese medical extract that~1.5% the step of (3) obtains, it is 10% that 40%~60%, weight is pill weight to add concentration
~15% liquid syrup is wrapped up as adhesive；Chinese medicine material uniformly wraps starch imperial mother, then dispenses into pot Chinese medicine
Extract, makees adhesive by 60%~80% ethanol water of concentration and carries out general ball, general ball pot is with mechanical rotation and bonding
Agent sprinkling adds Chinese medical extract repeatedly, gradually general that prescribed level, the pill of ball weight is made.
2. a kind of Chinese medicine water pill preparation method according to claim 1, it is characterised in that step is as follows：
(1) molding：A part of starch is placed in coating pan, liquid syrup is sprayed on starch heap with sprayer, coating pan with
Mechanical rotation makes starch heap scattered and uniformly moistened with liquid syrup, when fine particulate occurs forming in starch in coating pan, then
A little starch is dispensed into pot, starch is adhered to fine grained surface, then sprays liquid syrup moistening, is so operated repeatedly to being closed
The starch granules of suitable size；Starch weight used in molding is the 3% of pill finished weight, molding adhesive therefor liquid syrup concentration
For 50%, and weight is the 10% of starch weight；
(2) starch granules sieves：The starch granules that step (1) is obtained crosses 16 mesh, 20 mesh sieves respectively, takes the starch of 16~20 mesh
Particle is female as starch；
(3) traditional Chinese medicine extraction raw material sieves：Traditional Chinese medicine extraction raw material is crossed into 80 mesh, 100 mesh sieves respectively, taken in 80~100 purposes
Medicament extract；
(4) general ball：The starch mother that step (2) is obtained is added in general ball pot, and it is the 1.0% of the female weight of starch first to add weight
The step of (3) obtained Chinese medical extract, it is 12% liquid syrup that 50%, weight is pill weight as viscous to add concentration
Mixture is wrapped up；Chinese medicine material uniformly wraps starch imperial mother, then dispenses Chinese medical extract into pot, using concentration as 70%
Ethanol water makees adhesive and carries out general ball, and general ball pot adds Chinese medical extract repeatedly with mechanical rotation and adhesive sprinkling, by
It is gradually general that prescribed level, the pill of ball weight is made.
3. a kind of Chinese medicine water pill preparation method according to claim 1 or 2, it is characterised in that step (1) molding
Middle coating pan mechanical rotation speed is 70~80r/min.
4. a kind of Chinese medicine water pill preparation method according to claim 1 or 2, it is characterised in that the general ball of the step (4)
In general ball pot mechanical rotation speed be 60~70r/min.
5. a kind of Chinese medicine water pill preparation method according to claim 1 or 2, it is characterised in that also including follow-up choosing
Grain, drying and coating steps.
6. a kind of Chinese medicine water pill preparation method according to claim 5, it is characterised in that the choosing grain step：Will be general
The pill sieving that ball step is obtained, the pill of size needed for obtaining.
7. a kind of Chinese medicine water pill preparation method according to claim 5, it is characterised in that the baking step：Temperature
Control is at 45~55 DEG C, and drying time is 5~10h.
8. a kind of Chinese medicine water pill preparation method according to claim 5, it is characterised in that the coating steps：It will dry
The pill film coating made a good job of.
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| CN111569020A (en) * | 2020-06-19 | 2020-08-25 | 蒋力治 | Water-mixing pill for treating vertigo and preparation method thereof |
| CN113908135A (en) * | 2021-11-10 | 2022-01-11 | 北京同仁堂科技发展股份有限公司制药厂 | Preparation method of water-honeyed pill |
| CN114452328A (en) * | 2020-11-04 | 2022-05-10 | 沈阳清宫药业集团有限公司 | Sihuang Qingxin pills and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107929548A (en) * | 2018-01-09 | 2018-04-20 | 上海中医药大学附属岳阳中西医结合医院 | A kind of Chinese medicine water pill for treating ulcerative colitis and its preparation method and application |
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| CN114452328B (en) * | 2020-11-04 | 2023-02-28 | 沈阳清宫药业集团有限公司 | Sihuang heart-fire-clearing pill and preparation method thereof |
| CN114533810A (en) * | 2020-11-10 | 2022-05-27 | 沈阳清宫药业集团有限公司 | Hippocampus multiple penis pills and preparation method thereof |
| CN113908135A (en) * | 2021-11-10 | 2022-01-11 | 北京同仁堂科技发展股份有限公司制药厂 | Preparation method of water-honeyed pill |
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