CN103655779B - A kind of pharmaceutical composition for the treatment of mosquito bite and insect bite - Google Patents
A kind of pharmaceutical composition for the treatment of mosquito bite and insect bite Download PDFInfo
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- CN103655779B CN103655779B CN201310736779.9A CN201310736779A CN103655779B CN 103655779 B CN103655779 B CN 103655779B CN 201310736779 A CN201310736779 A CN 201310736779A CN 103655779 B CN103655779 B CN 103655779B
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Abstract
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite.The present invention is made up of Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Moutan, and the parts by weight of each component are: Radix Et Rhizoma Rhei 2-10 weight portion, Rhizoma Coptidis 2-10 weight portion, Cortex Moutan 1-5 weight portion.The present invention has antiinflammation, can the symptom such as pruritus, erythema that causes of rapid recovery mosquito bite, has the damp and hot effect hindering eczema caused by the skin for the treatment of concurrently simultaneously.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite.
Background technology
People is by after mosquito bite, and skin there will be redness, pruritus, even causes local inflammation.Simultaneously due to the carrier that mosquito is multiple pathogens, people, particularly child is by mosquito bite, easily catches.The product of existing treatment mosquito bite mainly contains floral water, menthocamphorate, gentian voiet etc.Floral water can only relieving itch, do not have antiinflammation, and the zest of menthocamphorate is larger.
Prior art has problems: under needing reinforcement here, be specially the anophelifuges such as floral water and all contain dimefluthrin, pyrethrin etc., have toxic and side effects, life-time service has injury to Liver and kidney etc.In addition action time is short, and general outdoor only has 0.5h, and indoor are 1h, need repetition wiping.
Summary of the invention
The object of the present invention is to provide one can relieving itch, eliminate red and swollen, again can the pharmaceutical composition for the treatment of mosquito bite and insect bite of antiinflammatory.
The present invention also aims to provide a kind of can the damp and hot pharmaceutical composition hindering eczema caused by the skin for the treatment of.
Technical scheme of the present invention is as follows:
Treat a pharmaceutical composition for mosquito bite and insect bite, be made up of Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Moutan.
Further, described a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite, the parts by weight of each component are: Radix Et Rhizoma Rhei 2-10 weight portion, Rhizoma Coptidis 2-10 weight portion, Cortex Moutan 1-5 weight portion.
Further, described a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite, is characterized in that the ratio of weight and number of each component is: Radix Et Rhizoma Rhei 8 weight portion, Rhizoma Coptidis 8 weight portion, Cortex Moutan 4 weight portion.
Further, described a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite, said composition is ethanol extraction.
A kind of pharmaceutical composition for the treatment of mosquito bite and insect bite described in preparation, step is:
(1) get the Radix Et Rhizoma Rhei of certain part by weight, Rhizoma Coptidis, Cortex Moutan, pulverize respectively;
(2) add ethanol, mixing, placement, filtration, get filtrate, to obtain final product.
Further, in described step (1), No. two, rear mistake sieve pulverized respectively by Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Moutan.
Further, in described step (2), the concentration of ethanol is 60%-80%.
Further, in described step (2), the weight portion of ethanol is 10-25 part.
Further, in described step (2), standing time is 60-100 hour.
Further, described a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite can be liniment, spray, liniment.
Crude drug source and pharmacological action:
1, Radix Et Rhizoma Rhei, the dry root welding technology of polygonum rheum palmatum RheumpalmatumL., Rheum tanguticum Rheumtanguticum.Maxim.exBalf. or Rheum officinale RheumoffcihaleBaill..Hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.To stagnate constipation for excess-heat, heat in blood tells nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.
2, Rhizoma Coptidis, the dry rhizome of ranunculaceae plant Rhizoma Coptidis CoptischinensisFranch., Coptis deltoidea C.Y.Cheng et Hsiao CoptisdeltoideaC.Y.ChengetHsiao or Coptis Teeta Wall Coptisteetawall..Hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, palpitation and uneasiness, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, and carbuncle treats skin ulcer; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.
3, Cortex Moutan, the dry root bark of ranunculaceae peony PaeoniasuffruticosaAndr..Bitter, pungent, be slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, falls and flutters the pain of injury, carbuncle sore tumefacting virus.
Causes for pathological:
The most common i.e. mosquito bite of insect dermatitis causes, mosquito stabs skin by its mouthpart, its saliva or venom invade skin, owing to containing plurality of antigens composition in the saliva of mosquito or the leachate of poison gland, these antigens can produce atopic reaction with antibody and cause inflammation after entering human body skin, scratch where it itches, time serious, indivedual infant local produces the severe reaction such as bulla, hemorrhagic necrosis, is dermatology common disease disease in summer.
Function cures mainly
The present invention has the effect of heat-clearing and toxic substances removing, cool blood and remove dampness, killing parasites for relieving itching.For mosquito bite and insect bite and damp and hotly hinder eczema caused by the skin, see have pruritus, erythema, pimple, blister, ooze out, rotten to the corn acute eczema is shown in above-mentioned patient.
Beneficial effect:
1, the symptom such as pruritus, erythema that causes of energy rapid recovery mosquito bite of the present invention, has antiinflammation simultaneously, can effective prevention infection; Toxic and side effects is low, and action time is lasting, and the indoor time is 6-8, is obviously better than commercially available mosquito repellent product.
2, the present invention has the damp and hot effect hindering eczema caused by the skin for the treatment of concurrently, can treat damp and hot caused by eczema, as pruritus, erythema, pimple, blister, ooze out, rotten to the corn acute eczema is shown in above-mentioned patient.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of this bright above-mentioned theme is only limitted to following example, all technology realized based on foregoing of the present invention, all belong to scope of the present invention.
Embodiment 1
Prescription:
Radix Et Rhizoma Rhei 2 parts, Rhizoma Coptidis 2 parts, Cortex Moutan 1 part
Preparation method:
(1) get the Radix Et Rhizoma Rhei of above-mentioned weight portion, Rhizoma Coptidis, Cortex Moutan, pulverize respectively, cross No. two sieves;
(2) add 60% ethanol 10 parts, mixing, place 60 hours, filtration, get filtrate, to obtain final product.
Embodiment 2
Prescription:
Radix Et Rhizoma Rhei 10 parts, Rhizoma Coptidis 10 parts, Cortex Moutan 5 parts
Preparation method:
(1) get the Radix Et Rhizoma Rhei of above-mentioned weight portion, Rhizoma Coptidis, Cortex Moutan, pulverize respectively, cross No. two sieves;
(2) add 80% ethanol 25 parts, mixing, place 100 hours, filtration, get filtrate, to obtain final product.
Embodiment 3
Prescription:
Radix Et Rhizoma Rhei 8 parts, Rhizoma Coptidis 8 parts, Cortex Moutan 4 parts
Preparation method:
(1) get the Radix Et Rhizoma Rhei of above-mentioned weight portion, Rhizoma Coptidis, Cortex Moutan, pulverize respectively, cross No. two sieves;
(2) add 70% ethanol 20 parts, mixing, place 80 hours, filtration, get filtrate, to obtain final product.
Embodiment 4 antibacterial experiment
Experimental group: Example 1,2,3 gained filtrate, as experimental group sample A, B, C;
Matched group: get distilled water, as a control group sample;
Strain: staphylococcus aureus (Products in China calibrating provided);
Spawn culture: by S. aureus Inoculate in 10ml broth bouillon, cultivates 8h at 37 DEG C, the obtained broth bouillon containing staphylococcus aureus.
Experimental technique: get two sterile test tube, adds the broth bouillon of 1ml containing staphylococcus aureus respectively, then adds experimental group sample and control sample respectively, cultivate 24h at 37 DEG C.
Experimental result:
| Sample | Test tube outward appearance | Streak plate |
| Experimental group sample A | Solution is clarified | Asepsis growth |
| Experimental group sample B | Solution is clarified | Asepsis growth |
| Experimental group sample C | Solution is clarified | Asepsis growth |
| Control sample | Solution is muddy | Long bacterium |
As can be seen here, experimental group sample A, B, C all has antibacterial action.
Embodiment 5 treats mosquito bite experiment
Experimental group: Example 1,2,3 gained filtrate, as experimental group sample;
Matched group: get Liushen toilet water, as a control group sample;
Experimental technique:
By 80 by mosquito bite, and all occur red, swell, the experimenter of symptom of itching, be divided into A, B, C, D two groups at random, A group, B group, C group use experimental group sample, use embodiment 1,2,3 gained filtrate respectively, D group use control sample.Observe each group of experimenter when 2min, 5min, 10min, 15min, 20min, red, swell, symptom of itching eliminate experimenter's quantity.
Experimental result:
| 2min | 5min | 10min | 15min | 20min | |
| A group | 10 | 6 | 3 | 1 | 0 |
| B group | 9 | 7 | 4 | 0 | 0 |
| C group | 12 | 6 | 2 | 0 | 0 |
| D group | 5 | 4 | 8 | 2 | 1 |
In two groups of experimenters, in 2min, A group, B group, component C do not have 10,9,12 experimenters red, swell, symptom resolution of itching, and D group only have 5 experimenters red, swell, symptom resolution of itching; In 10min, B group, all experimenters of C group red, swell, symptom resolution of itching, and all experimenters of D group red, swell, itch symptom resolution used time 20min.As can be seen here, experimental group energy rapid recovery mosquito bite cause red, swell, symptom of itching, successful.
The anophelifuge experiment of field, embodiment 6 field
The test of field, field repelling effect
Summer, rice terrace ridge place, three people, with two shanks for test sample, consider that everyone abnormal smells from the patient is different, different to the allure of mosquito, there is people easily by mosquito bite, someone is quite different, so adopt the mode of self-contrast, a shank is smeared this product, and another shank does not smear this product, observe 4 hours, the shank that result smears this product does not have mosquito bite.
In mosquito bite season in summer, in cowshed, test method is the same, observes 4 hours, smear place can available protecting not by mosquito bite.
In the mosquito cage of suitable size, put into agalactous, but after the hungry a few days, have hundreds of culexs of strong attack, the arm first not being smeared this product stretches in cage, tens of mosquitoes are had to sting immediately, illustrate that the attack of mosquito is very strong, the arm then another being smeared this product stretches into, and observes 2 minutes, once, result all had no by mosquito bite in 6 hours in test in every 2 hours.
Adopt mosquito kind: aedes albopictus
Method of testing: manually bite
Experimental group: Example 1,2,3 gained filtrate, as experimental group sample, positive controls: Liushen toilet water
Table 2
| 2 hours | 4 hours | 6 hours | 8 hours |
| 0 | 0 | 0 | 13 |
| 0 | 0 | 0 | 12 |
| 0 | 0 | 0 | 13 |
| 0 | 4 | 10 | 17 |
| 18 | 24 | 12 | 17 |
Conclusion: be 6-8 hour by the known this product effective protecting time of upper table 2, and positive control drug Liushen toilet water only has 2 hours effectively, illustrates that this product has obvious repelling effect.
Between one in the room of 14 square metres, spraying this product solution 20mL, observes 8 hours, and there are no mosquito bite, indoor climate fragrance gracefulness, has the effect of cephalocathartic preventing respiratory tract infection in addition.
Claims (8)
1. treat a pharmaceutical composition for mosquito bite and insect bite, it is characterized in that said composition is made up of Radix Et Rhizoma Rhei 2-10 weight portion, Rhizoma Coptidis 2-10 weight portion, Cortex Moutan 1-5 weight portion.
2. a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite according to claim 1, is characterized in that said composition is made up of Radix Et Rhizoma Rhei 8 weight portion, Rhizoma Coptidis 8 weight portion, Cortex Moutan 4 weight portion.
3. prepare a method for the pharmaceutical composition of the treatment mosquito bite and insect bite described in any one of claim 1-2, it is characterized in that step is:
(1) get the Radix Et Rhizoma Rhei of recipe quantity, Rhizoma Coptidis, Cortex Moutan, pulverize respectively;
(2) add ethanol, mixing, placement, filtration, get filtrate, to obtain final product.
4. preparation method according to claim 3, is characterized in that in step (1), and No. two, rear mistake sieve pulverized respectively by Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Moutan.
5. preparation method according to claim 3, is characterized in that in step (2), and the concentration of ethanol is 60%-80%.
6. preparation method according to claim 3, is characterized in that in step (2), and the weight portion of ethanol is 10-25 part.
7. preparation method according to claim 3, is characterized in that, in step (2), standing time is 60-100 hour.
8. a kind of pharmaceutical composition for the treatment of mosquito bite and insect bite according to claim 1 or 2 any one, is characterized in that it is liniment, spray, liniment, ointment, paste.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310736779.9A CN103655779B (en) | 2013-12-27 | 2013-12-27 | A kind of pharmaceutical composition for the treatment of mosquito bite and insect bite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310736779.9A CN103655779B (en) | 2013-12-27 | 2013-12-27 | A kind of pharmaceutical composition for the treatment of mosquito bite and insect bite |
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| Publication Number | Publication Date |
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| CN103655779A CN103655779A (en) | 2014-03-26 |
| CN103655779B true CN103655779B (en) | 2016-04-13 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547080A (en) * | 2015-01-25 | 2015-04-29 | 汪甬伟 | Applications of rhubarb, panax notoginseng and moutan bark for resisting pruritus |
| CN106177123A (en) * | 2016-07-07 | 2016-12-07 | 无比滴（广东）药业有限公司 | A kind of infant topical composition for mosquito bite and insect bite of releiving |
| CN115400172B (en) * | 2022-10-28 | 2023-09-15 | 辽宁中医药大学附属医院 | A Chinese medicinal composition for treating insect bite, and its preparation method |
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| CN1055297A (en) * | 1991-03-28 | 1991-10-16 | 许聿祥 | A kind of autofrettage of skin-moistening burn and scald medicine |
| CN1175403A (en) * | 1997-05-26 | 1998-03-11 | 朱珊引 | Anti-inflammatory, antipruritic and prickly-heat-expelling skin liquid |
| CN1358542A (en) * | 2002-01-10 | 2002-07-17 | 杨文渊 | Jusheng oil and preparation process |
| CN101057897A (en) * | 2007-04-04 | 2007-10-24 | 王均明 | Medicine for treating scald and burn and its preparation method |
| CN102366486A (en) * | 2011-11-04 | 2012-03-07 | 刘百祥 | Traditional Chinese medicine for treating acne and preparation method thereof |
| CN102499956A (en) * | 2009-12-03 | 2012-06-20 | 杭卫平 | Plaster for burns and scalds and preparation method thereof |
| CN102670808A (en) * | 2012-05-24 | 2012-09-19 | 李承平 | Ointment for removing blood stasis and clearing heat |
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2013
- 2013-12-27 CN CN201310736779.9A patent/CN103655779B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055297A (en) * | 1991-03-28 | 1991-10-16 | 许聿祥 | A kind of autofrettage of skin-moistening burn and scald medicine |
| CN1175403A (en) * | 1997-05-26 | 1998-03-11 | 朱珊引 | Anti-inflammatory, antipruritic and prickly-heat-expelling skin liquid |
| CN1358542A (en) * | 2002-01-10 | 2002-07-17 | 杨文渊 | Jusheng oil and preparation process |
| CN101057897A (en) * | 2007-04-04 | 2007-10-24 | 王均明 | Medicine for treating scald and burn and its preparation method |
| CN102499956A (en) * | 2009-12-03 | 2012-06-20 | 杭卫平 | Plaster for burns and scalds and preparation method thereof |
| CN102366486A (en) * | 2011-11-04 | 2012-03-07 | 刘百祥 | Traditional Chinese medicine for treating acne and preparation method thereof |
| CN102670808A (en) * | 2012-05-24 | 2012-09-19 | 李承平 | Ointment for removing blood stasis and clearing heat |
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Effective date of registration: 20160316 Address after: Zhong Ling Jie Nanjing Xuanwu District of Jiangsu Province, No. 50 210000 Applicant after: Nanjing Jiagu Jiahe Biological Technology Co.,Ltd. Address before: Xuanwu District of Nanjing City, Jiangsu province 210014 Silver City Dongyuan 109-1002 room Applicant before: Geng Li |
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