CN103623094A - Medication for treating gouty arthritis and preparation method thereof - Google Patents
Medication for treating gouty arthritis and preparation method thereof Download PDFInfo
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- CN103623094A CN103623094A CN201310647608.9A CN201310647608A CN103623094A CN 103623094 A CN103623094 A CN 103623094A CN 201310647608 A CN201310647608 A CN 201310647608A CN 103623094 A CN103623094 A CN 103623094A
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Abstract
The invention discloses a medication for treating gouty arthritis and a preparation method thereof. The medication is mainly prepared by mixing the following medicine according to a proper weight ratio: radices trichosanthis, vicia amoena, scorpion, epimedium, cape jasmine fruit, tiger bone, and the like. The medication disclosed by the invention has the functions of dispelling wind, eliminating dampness, relaxing tendons, activating collaterals, and stopping pain, takes effect quickly when used for treating the gouty arthritis, has a good curative effect without recurrence.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of gouty arthritis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Gouty arthritis is the arthritis of outbreak repeatedly due to purine metabolism obstacle, hyperuricemia.Urate deposition in joint, periarticular tissue and subcutaneous tissue, cause arthritic outbreak repeatedly, have acute red, swollen, severe pain, produce gradually that B&J destroys, lopsided, ankylosis and dysfunction.Gouty arthritis is multiple is born in 40 years old above male, and women is rare, accounts for 5%.Part patient has family history.Current gouty arthritis Therapeutic Method comprises takes good care of auxiliary treatment, acupuncture and moxibustion therapy and Drug therapy etc., but exist, western medicine DeGrain, side effect are large, the problem such as slow takes effect.Therefore there is great demand to the Chinese medicine of rapid, effective treatment gouty arthritis in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment gouty arthritis, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment gouty arthritis.
Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Radix Trichosanthis, Herba Viciae Amoenae, Scorpio, Herba Epimedii, Fructus Gardeniae, Os Tigris, Folium Rhododendri Simsii, Herba Lysimachiae, Bombyx mori L., Oletum Trogopterori, Radix Notoginseng, the Radix Angelicae Dahuricae, Talcum, Gypsum Fibrosum, Rhizoma Drynariae, Folium Hibisci Mutabilis ten six medicaments to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat gouty arthritis.Wherein select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness acid is cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturizes, evacuation of pus, and the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Selecting Herba Viciae Amoenae, call bean seedling, mountain Semen sojae atricolor, Herba speranskiae tuberculatae, is that temperature, has wind-damp dispelling because of its nature and flavor sweetness and bitterness, invigorate blood circulation, and relaxing muscles and tendons, the function of pain relieving, dispelling the wind and dampness pathogens pain, sprain and contusion wound, innominate toxic swelling, eczema scrotum.The scorpion is because its salty taste symplectic, flat, toxic, expelling wind, antispasmodic, Tongluo, detoxification, treatment of convulsion, epilepsy, stroke, hemiplegia, mouth and eyes oblique, migraine, rheumatic pain, tetanus, tuberculosis of lymph nodes, rubella sores.Selecting Herba Epimedii is that temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, there is heat clearing away, pathogenic fire purging, the function of removing heat from blood, controls calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quenches one's thirst, conjunctival congestion, pharyngalgia, spits blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Os Tigris to be because its nature and flavor are pungent, temperature, enters liver, kidney channel, chases after wind analgesic therapy, strong bone, relieving convulsion function, controls severe and migratory arthralgia pain, spasm of the limbs, waist foot not with, palpitation with fear epilepsy, hemorrhoid complicated by anal fistula proctoptosis.Select Folium Rhododendri Simsii to be because its nature and flavor acid is sweet, temperature, has and blood, regulating menstruation, and the function of wind-damp dispelling, controls menoxenia, amenorrhea, metrorrhagia, traumatic injury, rheumatalgia, haematemesis, epistaxis.Select Herba Lysimachiae to be because its nature and flavor toil is cool, have heat clearing away, diuresis, antitussive, detumescence, the function of removing toxic substances, the subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough, spits blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition ， Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select Bombyx mori L. to be because its nature and flavor are sweet, pungent, warm, return liver, spleen channel, have expelling wind and removing dampness, the function of the analgesic therapy of invigorating blood circulation, dispelling the wind and dampness pathogens arthralgia pain, joint is unsuccessful, waist foot cold type of pain, rubella pruritus, wind syndrome of head headache, marginal blepharitis eye.Selecting Oletum Trogopterori is that temperature, enters liver, spleen channel because of its property bitter but sweet flavor, and the raw function with there being promoting the circulation of blood pain relieving, controls all pains of trusted subordinate's vim and vigour, women's amenorrhea, and postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, fry with hemostasis, controls metrorrhagia, menorrhagia, and leucorrhea with bloody discharge is without cease.Selecting Radix Notoginseng is that temperature, enters liver, stomach, large intestine channel, has hemostasis because of its property sweet and slightly bitter taste, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Talcum to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, there is inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, controls pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Select Gypsum Fibrosum to be because its property acrid-sweet flavor is cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select Rhizoma Drynariae to be because its nature and flavor are bitter, temperature, enters liver, kidney channel, has the kidney invigorating, invigorates blood circulation, and the function of hemostasis, controls suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.Select Folium Hibisci Mutabilis to be because its nature and flavor are micro-pungent, cool, return lung, Liver Channel, have Qingfei Liangxue, heat radiation removing toxic substances, the function of detumescence and apocenosis, controls cough due to lung-heat, acute appendicitis, external treatment carbuncle, glue ear, innominate toxic swelling, burn.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
8-15 gram of Scorpio 10-20 gram of Radix Trichosanthis 10-18 Keshan vetch
Herba Epimedii 8-18 gram of Fructus Gardeniae 10-22 gram of Os Tigris 5-9 gram
Folium Rhododendri Simsii 12-22 gram of Herba Lysimachiae 15-25 gram of Bombyx mori L. 10-20 gram
Oletum Trogopterori 10-18 gram of Radix Notoginseng 8-16 gram of Radix Angelicae Dahuricae 10-22 gram
Talcum 12-18 gram of Gypsum Fibrosum 8-15 gram of Rhizoma Drynariae 9-18 gram
Folium Hibisci Mutabilis 15-25 gram
Be preferably
12 grams of 10 grams of Scorpios of Radix Trichosanthis 15 Keshan vetch
6 grams of 15 grams of Os Tigriss of 9 grams of Fructus Gardeniaes of Herba Epimedii
15 grams of 18 grams of Bombyx mori L.s of 16 grams of Herba Lysimachiaes of Folium Rhododendri Simsii
20 grams of 10 grams of Radixs Angelicae Dahuricae of 16 grams of Radix Notoginseng of Oletum Trogopterori
15 grams of 9 grams of Rhizoma Drynariae of 14 grams of Gypsum Fibrosum of Talcum
22 grams of Folium Hibisci Mutabiliss
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Trichosanthis: choose decontamination, size block separately, saturating with blister to sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, and smashes into fritter;
2, Herba Viciae Amoenae: choose decontamination, dry;
3, Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
4, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
5, Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
6, Os Tigris: remove muscles, clean, dry in the shade, face the used time and smash to pieces;
7, Folium Rhododendri Simsii: the 4-5 month gathers when in full bloom, dries;
8, Herba Lysimachiae: choose clean impurity, sieve dedust bits, dry;
9, Bombyx mori L.: remove impurity, sieve dedust bits;
10, Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;
11, Radix Notoginseng: choose clean impurity, smash to pieces, grind or run through rear section into powder and dry;
12, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
13, Talcum: get crude drug, remove impurity, cleaning, drying;
14, Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;
15, Rhizoma Drynariae: remove sediment contamination, clean, slightly soak, run through, section, dries;
16, Folium Hibisci Mutabilis: remove residual branch stalk, impurity, water spray, slightly moistens, and shredding is dry.
Two, preparation
1, the Radix Trichosanthis of described weight, Herba Viciae Amoenae, Scorpio, Herba Epimedii, Fructus Gardeniae, Os Tigris, Folium Rhododendri Simsii, Herba Lysimachiae, Bombyx mori L., Oletum Trogopterori, Radix Notoginseng, the Radix Angelicae Dahuricae, Talcum, Gypsum Fibrosum, Rhizoma Drynariae, Folium Hibisci Mutabilis are total to pulverization.
2, the medicine of above-mentioned altogether pulverization being added to water and Mel is in harmonious proportion and makes paste and get final product.
Medicine of the present invention has expelling wind and removing dampness, chases after the function of wind analgesic therapy, relaxing muscles and tendons to promote blood circulation, is used for the treatment of gouty arthritis instant effect, and good effect, does not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get 20 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, first exposes skin by rabbit abdominal part hair removing, then by the external application of ointment mixing up at rabbit abdominal part baring skin place, with gauze, twine and tie up, change dressings every day once, external application is 5 days continuously, observes administration reaction every day, result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect data of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment, age the right side of fifty 38 examples, 51 years old above 62 example.
2, diagnostic criteria
The gouty arthritis of typical First-episode mostly is monarthritis, take the first sole of the foot toe and big toe joint as common, is secondly other joints of ankle, knee joint, elbow, wrist, hands and foot.Acute stage, is a lot of hurried, and the burst at night of being everlasting, can wake up and can not fall asleep all night because of pain.Relapse rate outbreak, can develop into polyarthritis, or wandering arthritis.The joint of getting involved is red, swollen, hot, bitterly, limitation of activity, and large joint involvement has sepage often.Can be with symptoms such as heating, shiver with cold, tired, anorexia, headaches.Generally last 1-2 week remission.Local skin redness transfers brownish red to and recovers gradually normal.Sometimes can there is desquamation and pruritus.Chronic phase,, uric acid sodium increased gradually in intraarticular calmness, show effect frequent gradually, intermission shortens, and increase in the joint of getting involved, and the pain increased, inflammation can not disappear completely, occur tophus, tophus is more common with joint and kidney, the helix of external ear, sole of the foot toe, refer between and metacarpophalangeal joints etc. locate also to there will be tophus, along with the continuous deposition of wind stone increases, cause that joint is loose, lopsided, stiff, limitation of activity.
3, Therapeutic Method
Select above-mentioned ointment, be applied to affected part to patient's external application, then with gauze, twine and tie up.Changing dressings every day 1 time, 20 days is a course for the treatment of, continuously three courses for the treatment of of the drug of topical application.
4, efficacy assessment standard
Effective: the recovery from illness of gouty arthritis symptom, it is normal that joint part recovers;
Take a turn for the better: gouty arthritis symptom takes a turn for the better, and it is normal that joint part recovers gradually;
Invalid: not reach improvement standard person.
5, efficacy result (seeing the following form):
In above-mentioned treatment, by Drug therapy gouty arthritis patient of the present invention 100 examples, effective 89 examples of result, obvious effective rate is 89%, 5 examples that take a turn for the better, and improvement rate is 5%, invalid 6 examples, total effective rate is 94%.
Claims (3)
1. a medicine for the treatment of gouty arthritis, is characterized in that: it is to be made by the crude drug in following weight range:
8-15 gram of Scorpio 10-20 gram of Radix Trichosanthis 10-18 Keshan vetch
Herba Epimedii 8-18 gram of Fructus Gardeniae 10-22 gram of Os Tigris 5-9 gram
Folium Rhododendri Simsii 12-22 gram of Herba Lysimachiae 15-25 gram of Bombyx mori L. 10-20 gram
Oletum Trogopterori 10-18 gram of Radix Notoginseng 8-16 gram of Radix Angelicae Dahuricae 10-22 gram
Talcum 12-18 gram of Gypsum Fibrosum 8-15 gram of Rhizoma Drynariae 9-18 gram
Folium Hibisci Mutabilis 15-25 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
12 grams of 10 grams of Scorpios of Radix Trichosanthis 15 Keshan vetch
6 grams of 15 grams of Os Tigriss of 9 grams of Fructus Gardeniaes of Herba Epimedii
15 grams of 18 grams of Bombyx mori L.s of 16 grams of Herba Lysimachiaes of Folium Rhododendri Simsii
20 grams of 10 grams of Radixs Angelicae Dahuricae of 16 grams of Radix Notoginseng of Oletum Trogopterori
15 grams of 9 grams of Rhizoma Drynariae of 14 grams of Gypsum Fibrosum of Talcum
22 grams of Folium Hibisci Mutabiliss.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Trichosanthis: choose decontamination, size block separately, saturating with blister to sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, and smashes into fritter;
(2) Herba Viciae Amoenae: choose decontamination, dry;
(3) Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
(4) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
(5) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(6) Os Tigris: remove muscles, clean, dry in the shade, face the used time and smash to pieces;
(7) Folium Rhododendri Simsii: the 4-5 month gathers when in full bloom, dries;
(8) Herba Lysimachiae: choose clean impurity, sieve dedust bits, dry;
(9) Bombyx mori L.: remove impurity, sieve dedust bits;
(10) Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;
(11) Radix Notoginseng: choose clean impurity, smash to pieces, grind or run through rear section into powder and dry;
(12) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
(13) Talcum: get crude drug, remove impurity, cleaning, drying;
(14) Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;
(15) Rhizoma Drynariae: remove sediment contamination, clean, slightly soak, run through, section, dries;
(16) Folium Hibisci Mutabilis: remove residual branch stalk, impurity, water spray, slightly moistens, and shredding is dry;
(2) preparation
(1) Radix Trichosanthis of described weight, Herba Viciae Amoenae, Scorpio, Herba Epimedii, Fructus Gardeniae, Os Tigris, Folium Rhododendri Simsii, Herba Lysimachiae, Bombyx mori L., Oletum Trogopterori, Radix Notoginseng, the Radix Angelicae Dahuricae, Talcum, Gypsum Fibrosum, Rhizoma Drynariae, Folium Hibisci Mutabilis are total to pulverization;
(2) medicine of above-mentioned altogether pulverization being added to water and Mel is in harmonious proportion and makes paste and get final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146343A (en) * | 1995-09-25 | 1997-04-02 | 石建民 | External compress paste for discopathy |
| CN101417104A (en) * | 2008-11-27 | 2009-04-29 | 杨中兴 | Bone knitting plaster and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2759842B1 (en) * | 1997-02-14 | 1999-04-16 | Seb Sa | ELECTRIC APPARATUS FOR GRILLING OR HEATING PLANAR FOOD |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146343A (en) * | 1995-09-25 | 1997-04-02 | 石建民 | External compress paste for discopathy |
| CN101417104A (en) * | 2008-11-27 | 2009-04-29 | 杨中兴 | Bone knitting plaster and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 白棣华: "十年来中医治疗痛风的概况", 《上海中医药杂志》, no. 09, 15 September 1993 (1993-09-15), pages 42 - 45 * |
| 赵先锋: "中医药在痛风中应用述要", 《甘肃中医学院学报》, vol. 24, no. 01, 28 February 2007 (2007-02-28), pages 36 - 39 * |
| 高应斗: "活血化淤中草药的临床应用及其作用机理的探讨", 《山西医药杂志》, no. 12, pages 94 - 110 * |
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