CN103623094B - Medication for treating gouty arthritis and preparation method thereof - Google Patents

Abstract

The invention discloses a medication for treating gouty arthritis and a preparation method thereof. The medication is mainly prepared by mixing the following medicine according to a proper weight ratio: radices trichosanthis, vicia amoena, scorpion, epimedium, cape jasmine fruit, tiger bone, and the like. The medication disclosed by the invention has the functions of dispelling wind, eliminating dampness, relaxing tendons, activating collaterals, and stopping pain, takes effect quickly when used for treating the gouty arthritis, has a good curative effect without recurrence.

Description

A kind of medicine for the treatment of gouty arthritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of gouty arthritis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

The arthritis that gouty arthritis is disorders of purine metabolism, blood uric acid increases caused recurrent exerbation.Urate deposition in joint, periarticular tissue and subcutaneous tissue, cause arthritic recurrent exerbation, have acute red, swollen, severe pain, produce that B&J destroys, deformity, ankylosis and dysfunction gradually.Gouty arthritis is multiple is born in more than 40 years old male, and women is rare, accounts for 5%.Some patients has family history.Current gouty arthritis Therapeutic Method comprises takes good care of auxiliary treatment, acupuncture and moxibustion therapy and Drug therapy etc., but also exists that western medicine DeGrain, side effect are large, take effect the problem such as slow.Therefore there is great demand in the Chinese medicine of people to rapid, effective treatment gouty arthritis, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment gouty arthritis, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment gouty arthritis.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Radix Trichosanthis, Herba Viciae Amoenae, Scorpio, Herba Epimedii, Fructus Gardeniae, Os Tigris, Folium Rhododendri Simsii, Herba Lysimachiae, Bombyx mori L., Oletum Trogopterori, Radix Notoginseng, the Radix Angelicae Dahuricae, Talcum, Gypsum Fibrosum, Rhizoma Drynariae, Folium Hibisci Mutabilis ten six medicaments to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat gouty arthritis.Radix Trichosanthis is wherein selected to be that cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturize, evacuation of pus, the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula because its nature and flavor sweetness and bitterness acid.Select Herba Viciae Amoenae, call bean seedling, mountain Semen sojae atricolor, Herba speranskiae tuberculatae, be because its nature and flavor sweetness and bitterness, temperature, has wind-damp dispelling, invigorates blood circulation, relaxing muscles and tendons, the function of pain relieving, and dispelling the wind and dampness pathogens pain, sprain and contusion are hindered, innominate toxic swelling, eczema scrotum.Selects the scorpion because of their sexual taste salty, flat, toxic, with functions, antispasmodic, t2dm, the function of detoxification, epilepsy, epilepsy, stroke, hemiplegia, mouth askew, migraine, rheumatism bi pain, tetanus, lymph node tuberculosis, measles sore swollen.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Os Tigris to be that temperature, enters liver, kidney channel, chase after wind analgesic therapy because its nature and flavor are pungent, strong bone, relieving convulsion function, controls severe and migratory arthralgia pain, spasm of the limbs, waist foot not with, palpitation with fear epilepsy, hemorrhoid complicated by anal fistula proctoptosis.Select Folium Rhododendri Simsii to be because its nature and flavor acid is sweet, temperature, have and blood, regulating menstruation, the function of wind-damp dispelling, controls menoxenia, amenorrhea, metrorrhagia, traumatic injury, rheumatalgia, haematemesis, epistaxis.Herba Lysimachiae is selected to be because its nature and flavor toil, cool, there is heat clearing away, diuresis, antitussive, detumescence, the function of removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough, spit blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition ， Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select Bombyx mori L. to be that return liver, spleen channel, have expelling wind and removing dampness, the function of analgesic therapy of invigorating blood circulation, dispelling the wind and dampness pathogens arthralgia pain, joint is unsuccessful, waist foot cold type of pain, rubella pruritus because its nature and flavor are sweet, pungent, warm, wind syndrome of head is had a headache, marginal blepharitis eye.Select Oletum Trogopterori to be because its property bitter but sweet flavor, temperature, enters liver, spleen channel, and raw by the function having promoting the circulation of blood pain relieving, control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, stir-fry is stopped blooding, and control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.Select Radix Notoginseng to be because its property sweet and slightly bitter taste, temperature, enters liver, stomach, large intestine channel, has hemostasis, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, and retention of lochia falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Talcum is selected to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, have inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, control pyretic stranguria, stranguria caused by urinary stone, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Gypsum Fibrosum is selected to be because its property acrid-sweet flavor, cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Rhizoma Drynariae is selected to be that temperature, enters liver, kidney channel, have the kidney invigorating, invigorate blood circulation, the function of hemostasis, control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus because its nature and flavor are bitter.Select Folium Hibisci Mutabilis to be because its nature and flavor are micro-pungent, cool, return lung, Liver Channel, have Qingfei Liangxue, heat radiation removing toxic substances, the function of detumescence and apocenosis, controls cough due to lung-heat, acute appendicitis, external treatment carbuncle, glue ear, innominate toxic swelling, burn.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Trichosanthis 10-18 Keshan vetch 8-15 gram of Scorpio 10-20 gram

Herba Epimedii 8-18 gram of Fructus Gardeniae 10-22 gram of Os Tigris 5-9 gram

Folium Rhododendri Simsii 12-22 gram of Herba Lysimachiae 15-25 gram of Bombyx mori L. 10-20 gram

Oletum Trogopterori 10-18 gram of Radix Notoginseng 8-16 gram of Radix Angelicae Dahuricae 10-22 gram

Talcum 12-18 gram of Gypsum Fibrosum 8-15 gram of Rhizoma Drynariae 9-18 gram

Folium Hibisci Mutabilis 15-25 gram

Be preferably

Radix Trichosanthis 15 Keshan vetch 10 grams of Scorpios 12 grams

Herba Epimedii 9 grams of Fructus Gardeniaes 15 grams of Os Tigriss 6 grams

Folium Rhododendri Simsii 16 grams of Herba Lysimachiaes 18 grams of Bombyx mori L.s 15 grams

Oletum Trogopterori 16 grams of Radix Notoginseng 10 grams of Radixs Angelicae Dahuricae 20 grams

Talcum 14 grams of Gypsum Fibrosum 9 grams of Rhizoma Drynariae 15 grams

Folium Hibisci Mutabilis 22 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister to sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, be pounded fritter;

2, Herba Viciae Amoenae: pick decontamination, dries;

3, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;

4, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

5, Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;

6, Os Tigris: remove muscles, cleans, dries in the shade, face the used time and smash to pieces;

7, Folium Rhododendri Simsii: gather when the 4-5 month blooms, dry;

8, Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;

9, Bombyx mori L.: removing impurity, sieve dedust bits;

10, Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

11, Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;

12, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

13, Talcum: get crude drug, removing impurity, cleaning, drying;

14, Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

15, Rhizoma Drynariae: remove sediment contamination, cleans, slightly soaks, run through, and section, dries;

16, Folium Hibisci Mutabilis: the residual branch stalk of removing, impurity, with Water spray, slightly moistens, shredding, dry.

Two, prepare

1, by the Radix Trichosanthis of described weight, Herba Viciae Amoenae, Scorpio, Herba Epimedii, Fructus Gardeniae, Os Tigris, Folium Rhododendri Simsii, Herba Lysimachiae, Bombyx mori L., Oletum Trogopterori, Radix Notoginseng, the Radix Angelicae Dahuricae, Talcum, Gypsum Fibrosum, Rhizoma Drynariae, Folium Hibisci Mutabilis pulverization altogether.

2, the medicine of above-mentioned altogether pulverization to be added water and Mel is in harmonious proportion and makes paste and get final product.

Medicine of the present invention has expelling wind and removing dampness, chases after the function of wind analgesic therapy, relaxing muscles and tendons to promote blood circulation, is used for the treatment of gouty arthritis instant effect, good effect, does not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 20, male and female dual-purpose, body weight 2.0-2.5kg, first exposes skin by rabbit abdominal part hair removing, then by the external application of ointment that mixes up at rabbit abdominal part baring skin place, twine with gauze and tie up, change dressings every day once, continuous external application 5 days, observes administration reaction every day, result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect data of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment, age the right side of fifty 38 example, more than 51 years old 62 example.

2, diagnostic criteria

The gouty arthritis of typical First-episode mostly is monarthritis, is common with the first sole of the foot toe and big toe joint, is secondly other joints of ankle, knee joint, elbow, wrist, hands and foot.Acute stage, is a lot of hurried, and burst at night of being everlasting, can wake up because of pain and can not fall asleep all night.Relapse rate shows effect, then can develop into polyarthritis, or wandering arthritis.Affected joints is red, swollen, hot, bitterly, limitation of activity, large joint involvement has sepage often.Can with symptoms such as heating, shiver with cold, tired, anorexia, headaches.Generally last 1-2 week remission.Local skin redness transfers brownish red to and recovers normal gradually.Sometimes desquamation and pruritus can be there is.Chronic phase, Monosodium urate increased gradually in intraarticular calmness, show effect frequent gradually, intermission shortens, and affected joints increases, and the pain increased, inflammation can not disappear completely, there is tophus, tophus with joint and kidney more common, helix, the sole of the foot toe of external ear, refer between and the place such as metacarpophalangeal joints also there will be tophus, along with the continuous deposition of wind stone increases, cause cartilage hypertrophy, deformity, stiff, limitation of activity.

3, Therapeutic Method

Select above-mentioned ointment, be applied to affected part to patient's external application, then twine with gauze and tie up.Changing dressings every day 1 time, 20 days is a course for the treatment of, three courses for the treatment of of the continuous drug of topical application.

4, efficacy assessment standard

Effective: gouty arthritis symptom is fully recovered, joint part recovers normal;

Take a turn for the better: gouty arthritis symptom takes a turn for the better, and joint part recovers normal gradually;

Invalid: not reach improvement standard person.

5, efficacy result (seeing the following form):

In above-mentioned treatment, by Drug therapy gouty arthritis patient 100 example of the present invention, effective 89 examples of result, obvious effective rate is 89%, and take a turn for the better 5 examples, and improvement rate is 5%, and invalid 6 examples, total effective rate is 94%.

Claims (3)

1. treat a medicine for gouty arthritis, it is characterized in that: it is made up of the crude drug in following weight range:

Radix Trichosanthis 10-18 Keshan vetch 8-15 gram of Scorpio 10-20 gram

Herba Epimedii 8-18 gram of Fructus Gardeniae 10-22 gram of Os Tigris 5-9 gram

Folium Rhododendri Simsii 12-22 gram of Herba Lysimachiae 15-25 gram of Bombyx mori L. 10-20 gram

Oletum Trogopterori 10-18 gram of Radix Notoginseng 8-16 gram of Radix Angelicae Dahuricae 10-22 gram

Talcum 12-18 gram of Gypsum Fibrosum 8-15 gram of Rhizoma Drynariae 9-18 gram

Folium Hibisci Mutabilis 15-25 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Radix Trichosanthis 15 Keshan vetch 10 grams of Scorpios 12 grams

Herba Epimedii 9 grams of Fructus Gardeniaes 15 grams of Os Tigriss 6 grams

Folium Rhododendri Simsii 16 grams of Herba Lysimachiaes 18 grams of Bombyx mori L.s 15 grams

Oletum Trogopterori 16 grams of Radix Notoginseng 10 grams of Radixs Angelicae Dahuricae 20 grams

Talcum 14 grams of Gypsum Fibrosum 9 grams of Rhizoma Drynariae 15 grams

Folium Hibisci Mutabilis 22 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister to sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, be pounded fritter;

(2) Herba Viciae Amoenae: pick decontamination, dries;

(3) Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;

(4) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

(5) Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;

(6) Os Tigris: remove muscles, cleans, dries in the shade, face the used time and smash to pieces;

(7) Folium Rhododendri Simsii: gather when the 4-5 month blooms, dry;

(8) Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;

(9) Bombyx mori L.: removing impurity, sieve dedust bits;

(10) Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

(11) Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;

(12) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

(13) Talcum: get crude drug, removing impurity, cleaning, drying;

(14) Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

(15) Rhizoma Drynariae: remove sediment contamination, cleans, slightly soaks, run through, and section, dries;

(16) Folium Hibisci Mutabilis: the residual branch stalk of removing, impurity, with Water spray, slightly moistens, shredding, dry;

(2) prepare

(1) by the Radix Trichosanthis of described weight, Herba Viciae Amoenae, Scorpio, Herba Epimedii, Fructus Gardeniae, Os Tigris, Folium Rhododendri Simsii, Herba Lysimachiae, Bombyx mori L., Oletum Trogopterori, Radix Notoginseng, the Radix Angelicae Dahuricae, Talcum, Gypsum Fibrosum, Rhizoma Drynariae, Folium Hibisci Mutabilis pulverization altogether;

(2) medicine of above-mentioned altogether pulverization to be added water and Mel is in harmonious proportion and makes paste and get final product.