CN103613422B - The production method of skin class Chinese medicine - Google Patents
The production method of skin class Chinese medicine Download PDFInfo
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- CN103613422B CN103613422B CN201310579812.1A CN201310579812A CN103613422B CN 103613422 B CN103613422 B CN 103613422B CN 201310579812 A CN201310579812 A CN 201310579812A CN 103613422 B CN103613422 B CN 103613422B
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- nutrient substance
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- 239000003814 drug Substances 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 235000015097 nutrients Nutrition 0.000 claims abstract description 49
- 239000011573 trace mineral Substances 0.000 claims abstract description 47
- 235000013619 trace mineral Nutrition 0.000 claims abstract description 47
- 239000002777 nucleoside Substances 0.000 claims abstract description 46
- 125000003835 nucleoside group Chemical group 0.000 claims abstract description 46
- 239000000126 substance Substances 0.000 claims abstract description 46
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 21
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 20
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 20
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000011591 potassium Substances 0.000 claims abstract description 19
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 19
- 230000012010 growth Effects 0.000 claims abstract description 17
- 239000007921 spray Substances 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000007062 hydrolysis Effects 0.000 claims abstract description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 10
- 239000002773 nucleotide Substances 0.000 claims abstract description 9
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 9
- 159000000000 sodium salts Chemical class 0.000 claims abstract description 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 8
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 8
- 229910052796 boron Inorganic materials 0.000 claims abstract description 7
- 238000004090 dissolution Methods 0.000 claims abstract description 7
- 229910052742 iron Inorganic materials 0.000 claims abstract description 7
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 7
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 7
- 241000208688 Eucommia Species 0.000 claims abstract description 6
- 238000005507 spraying Methods 0.000 claims abstract description 6
- 241000208689 Eucommia ulmoides Species 0.000 claims abstract description 3
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims description 26
- 229950006790 adenosine phosphate Drugs 0.000 claims description 26
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 22
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 20
- 239000011734 sodium Substances 0.000 claims description 20
- 229910052708 sodium Inorganic materials 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 15
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims description 13
- 239000011777 magnesium Substances 0.000 claims description 12
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 11
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 11
- 239000011701 zinc Substances 0.000 claims description 11
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims description 8
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 7
- 229960001763 zinc sulfate Drugs 0.000 claims description 7
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 7
- 229910021538 borax Inorganic materials 0.000 claims description 6
- 239000011790 ferrous sulphate Substances 0.000 claims description 6
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 6
- 239000011572 manganese Substances 0.000 claims description 6
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 6
- 239000004328 sodium tetraborate Substances 0.000 claims description 6
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 6
- WIXIBOVGGNRVQH-WFIJOQBCSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 WIXIBOVGGNRVQH-WFIJOQBCSA-N 0.000 claims description 5
- VHUKPXJCIYLZCH-WFIJOQBCSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)NC(=O)C=C1 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)NC(=O)C=C1 VHUKPXJCIYLZCH-WFIJOQBCSA-N 0.000 claims description 5
- PBXLDZQFPFHOSW-LGVAUZIVSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C=NC=2C(=O)NC(N)=NC12 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C=NC=2C(=O)NC(N)=NC12 PBXLDZQFPFHOSW-LGVAUZIVSA-N 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 9
- 239000003795 chemical substances by application Substances 0.000 description 18
- 239000000463 material Substances 0.000 description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 14
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 10
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 229920001353 Dextrin Polymers 0.000 description 7
- 239000004375 Dextrin Substances 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 239000001913 cellulose Substances 0.000 description 7
- 229920002678 cellulose Polymers 0.000 description 7
- 235000019425 dextrin Nutrition 0.000 description 7
- 235000019359 magnesium stearate Nutrition 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 6
- 238000000855 fermentation Methods 0.000 description 6
- 230000004151 fermentation Effects 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 235000011132 calcium sulphate Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 239000003513 alkali Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000003337 fertilizer Substances 0.000 description 3
- 230000035784 germination Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000218691 Cupressaceae Species 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- PNPLHKHBANFGMS-WFIJOQBCSA-N [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 PNPLHKHBANFGMS-WFIJOQBCSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- KURVIXMFFSNONZ-WFIJOQBCSA-L disodium;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(=O)NC(=O)C=C1 KURVIXMFFSNONZ-WFIJOQBCSA-L 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- -1 filter Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 229940061671 uridine 5-mo-phos disod Drugs 0.000 description 2
- WUBAOANSQGKRHF-XVFCMESISA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]pyrimidine-2,4-dione Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C=C1 WUBAOANSQGKRHF-XVFCMESISA-N 0.000 description 1
- UGUILUGCFSCUKR-GJMOJQLCSA-N 1-[(2r,4s,5r)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(C)=C1 UGUILUGCFSCUKR-GJMOJQLCSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
- XGYIMTFOTBMPFP-KQYNXXCUSA-N 5'-deoxyadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 XGYIMTFOTBMPFP-KQYNXXCUSA-N 0.000 description 1
- WDRISBUVHBMJEF-MROZADKFSA-N 5-deoxy-D-ribose Chemical compound C[C@@H](O)[C@@H](O)[C@@H](O)C=O WDRISBUVHBMJEF-MROZADKFSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 241000218636 Thuja Species 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
- 150000007528 brønsted-lowry bases Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
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Abstract
The invention discloses the production method of skin class Chinese medicine, belong to Chinese medicine production field, during Growth of Eucommia ulmoides, use nutrient substance: get 3 grams of nucleosides hydrochlorates, medium trace element 2 grams, pulverizes, is mixed to get nutrient substance; Nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: the potassium of four kinds of 5 '-mixed nucleotides or sodium salt; Medium trace element refers to: Zn, Mn, Mg, Fe, B, and its weight ratio is: Zn:Mn:Mg:Fe:B=2:2:2:1:2; Spray with after water dissolution; First time is seedling stage, in April, uses described nutrient substance, is watered 20 liters, evenly spray in one mu of bark of eucommia; Second time is the treelet phase, and the annual 3-4 month and the 5-6 month respectively spray once; Third time is for becoming the tree phase: annual 4-5 month and respectively spraying once the 7-8 month.Present method is easy, more economizes in raw materials, cost, improves the seed output and quality of the bark of eucommia.
Description
Technical field
The present invention relates to the production method of skin class Chinese medicine, particularly the production method of skin class Traditional Chinese Medicine and extract.
background technology
, there is composition activeconstituents more, do not save in the production method of existing skin class Chinese medicine, not rationally, not easily standing storage and preparation method are simple not for activeconstituents proportioning, and purposes is problem not widely.Authorization Notice No. CN102079672B, the patent No. is ZL201010514222.7's, name is called: a kind ofly promote the nutrient substance that skin class Chinese medicinal materials grows, described nutrient substance is by nucleosides hydrochlorate, glucose, amino acid and medium trace element composition, its weight percent is: nucleosides hydrochlorate 10-30%, glucose 20-70%, amino acid/11 0-20%, medium trace element 10-30%, described nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or potassium, 5 '-cytidylic acid disodium or potassium, the sodium salt of 5 '-uridine monophosphate disodium or potassium four kinds of 5 '-mixed nucleotides or sylvite, described medium trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax.Just there are the problems referred to above.
Summary of the invention
Object of the present invention overcomes above-mentioned deficiency exactly, one is provided to decrease activeconstituents in composition, reasonable ratio, its effect still can meet or exceed the patent No. and be: a kind of production method promoting the skin class Chinese medicine of the patent of invention of the nutrient substance that skin class Chinese medicinal materials grows of " 201010514222.7 ".
The present invention is achieved in that
The production method of skin class Chinese medicine, uses nutrient substance during Growth of Eucommia ulmoides, and described nutrient substance gets 3 grams of nucleosides hydrochlorates, medium trace element 2 grams, nucleosides hydrochlorate, medium trace element is pulverized, sieves, mix, the nutrient substance obtained;
Described nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-guanylic acid dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, 5 '-uridylic acid dipotassium or sodium, the potassium of four kinds of 5 '-mixed nucleotides or sodium salt;
Described medium trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax;
The weight ratio of medium trace element is: Zn:Mn:Mg:Fe:B=2:2:2:1:2;
The application process of nutrient substance is: spray with after water dissolution;
The application process of nutrient substance is: spray with after water dissolution;
Described nutrient substance use opportunity and concentration is: first time for seedling stage, in April, is used described nutrient substance, is watered 20 liters, evenly spray in one mu of bark of eucommia; Second time is the treelet phase, and the annual 3-4 month and the 5-6 month respectively spray once; Third time is for becoming the tree phase: annual 4-5 month and respectively spraying once the 7-8 month.
Promote the nutrient substance of skin class Chinese medicinal materials growth, it is primarily of nucleosides hydrochlorate, medium trace element composition, and do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, medium trace element 30-70%, described nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, the potassium of 5 '-uridylic acid dipotassium or sodium four kinds of 5 '-mixed nucleotides or sodium salt, described medium trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax; Promote the nutrient substance of skin class Chinese medicinal materials growth, screening formulation weight percent is: nucleosides hydrochlorate 40-60%, medium trace element 30-70%.
Promote the nutrient substance of skin class Chinese medicinal materials growth, the weight ratio of medium trace element is: Zn:Mn:Mg:Fe:B=2:2:2:1:2.[0006] promote the nutrient substance of skin class Chinese medicinal materials growth, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate.
Promote the nutrient substance of skin class Chinese medicinal materials growth, the weight percent of nucleosides hydrochlorate, medium trace element and weighting agent is
: nucleosides hydrochlorate 10-30%, medium trace element 10-30%, weighting agent 40-80%.
Promote the nutrient substance of skin class Chinese medicinal materials growth, weighting agent is: one or more of W-Gum, dextrin, Mierocrystalline cellulose, Magnesium Stearate, magnesium sulfate or zinc sulfate, the weight percent of nucleosides hydrochlorate, trace element and weighting agent is: nucleosides hydrochlorate 15-20%, medium trace element 15-20%, weighting agent 40-70%.
Promote the preparation method of the nutrient substance of skin class Chinese medicinal materials growth, it is primarily of nucleosides hydrochlorate, medium trace element
Composition, do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, medium trace element
30-70%, described nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, the potassium of 5 '-uridylic acid dipotassium or sodium four kinds of 5 '-mixed nucleotides or sodium salt, described medium trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax; By nucleosides hydrochlorate, medium trace element mixing, pulverizing, cross 50-150 mesh sieve.
2. promote the preparation method of the nutrient substance of skin class Chinese medicinal materials growth according to claim 1, it is characterized in that:
Screening formulation weight percent is: nucleosides hydrochlorate 40-60%, medium trace element 30-70%.
Promote the preparation method of the nutrient substance of skin class Chinese medicinal materials growth, the weight ratio of medium trace element is: Zn:Mn:Mg
:Fe:B=2:2:2:1:2。
State the preparation method of the nutrient substance promoting the growth of skin class Chinese medicinal materials, it also comprises weighting agent: starch, dextrin, fiber
One or more of element, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nucleosides hydrochlorate, medium trace element and weighting agent is: nucleosides hydrochlorate 10-30%, medium trace element 10-30%, weighting agent 40-80%, the weighting agent adding pulverizing mixes with nucleosides hydrochlorate, medium trace element.
Promote the preparation method of the nutrient substance of skin class Chinese medicinal materials growth, weighting agent is: W-Gum, dextrin, fiber
One or more of element, Magnesium Stearate, nucleosides hydrochlorate, trace element and the weight percent of weighting agent are: nucleosides hydrochlorate
15-20%, medium trace element 15-20%, weighting agent 40-70%.
The production method of skin class Chinese medicine, in its process of growth, use nutrient substance: described nutrient substance it primarily of nucleosides hydrochlorate, medium trace element composition, do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, medium trace element 30-70%, described nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, the potassium of 5 '-uridylic acid dipotassium or sodium four kinds of 5 '-mixed nucleotides or sodium salt, described medium trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax, the application process of nutrient substance is: spray with after water dissolution.
The production method of skin class Chinese medicine is 100-400ppm by the concentration sprayed after water dissolution.
The production method of skin class Chinese medicine, the weight ratio of medium trace element is: Zn:Mn:Mg:Fe:B=2:2:2:1:2.
The production method of skin class Chinese medicine, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nutrient compositions is: nucleosides hydrochlorate 10-30%, medium trace element 10-30%, weighting agent 40-80%.
The production method of skin class Chinese medicine, the opportunity of using of described nutrient substance is: at seedling or germination period, initial bloom stage, full-bloom stage respectively once.
The production method of skin class Chinese medicine, the opportunity of using of described nutrient substance is: in seedling or germination period, treelet phase, become the tree phase respectively to spray 1-2 time every year.
The production method of skin class Chinese medicine, the consumption of described nutrient substance is every mu of 2-8 gram, is every mu of 20-40 liter by water-soluble water consumption.
The production method of skin class Chinese medicine, the consumption of described nutrient substance is at every turn every mu of 15-30 gram, is at every turn every mu of 20-40 liter by water-soluble water consumption.
The production method of skin class Chinese medicine, the Chinese medicinal materials of results, than the high 10%-20% of produced in conventional processes, can be made high-quality medicine materical crude slice extracting effective components yield and can reach more than 20% than the skin class Chinese medicinal materials of produced in conventional processes by its output.
In the preparation of nutrient substance provided by the present invention, take nucleic acid as raw material: one is for raw material with commercially available nucleic acid, two is adopt the nucleic acid of dry method or wet production to be raw material from the mycelium after fermentation plant fermentation: 1., the hydrolysis of nucleic acid is the ratio mixed nucleus bronsted lowry acids and bases bronsted lowry liquid of 1:20-30 according to nucleic acid, buck weight ratio, alkali lye is 5.5-7N, under 30-45 DEG C of condition, stirs 10-14 hours, obtain nucleosides hydrochlorate and deoxynucleoside acid salt solution, filter, filtrate adjusts pH8-8.5, concentrating under reduced pressure; 2., decolouring, dry: concentrated solution is added activated carbon decolorizing, suction filtration it, filtrate reduced in volume is to moisture 10-25%; 3., crystallization: dissolve the nucleosides hydrochlorate after doing and deoxynucleoside hydrochlorate with clear water, its solution adds alcohol and separates out, crystallization suction filtration is dry, obtain white core thuja acid salt and deoxynucleoside hydrochlorate (from the mycelium after fermentation plant fermentation adopt the nucleic acid of dry method or wet production be raw material also containing water soluble mixt and impurity);
4., medium trace element is got;
, by nucleosides hydrochlorate medium trace element mix, pulverize, sieve.
In nucleic acid hydrolysis process described in this preparation method, alkali lye used is sodium hydroxide or potassium hydroxide solution.
With commercially available nucleic acid for raw material, impure few after hydrolysis.
Three is commercially available: nucleosides hydrochlorate mainly refers to: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium
Or potassium, 5 '-cytidylic acid disodium or potassium, the sodium salt of 5 '-uridine monophosphate disodium or potassium four kinds of 5 '-mixed nucleotides or potassium
Salt; Deoxynucleoside hydrochlorate refers to: 5 '-Desoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid (AMP) disodium or potassium,
5 '-Deoxyribose cytidine acid disodium or potassium, 5 '-deoxyuridine acid disodium, 5 '-deoxythymidine acid disodium or potassium five
Plant sodium salt or the sylvite of 5 '-deoxidation mixed nucleotides.
The source of nucleosides hydrochlorate and deoxynucleoside hydrochlorate is be raw material with nucleic acid, is from the bacterium after fermentation plant fermentation
Filament adopts the nucleic acid of dry method or wet production to be raw material, and this kind of nucleic acid is a small amount of thymus nucleic acid (DNA) of main mixing with Yeast Nucleic Acid (RNA), makes with alkali lye hydrolysis.
Beneficial effect of the present invention:
Because the present invention does not decrease composition activeconstituents, so more economize in raw materials and cost containing glucose, amino acid.
Coordinate nucleosides hydrochlorate, reasonable ratio because the present invention contains medium trace element, promote skin class Chinese medicine more targeted specifically
Growth.
Although the present invention decreases activeconstituents, its effect does not still subtract and even produces better effect.
The present invention is not particularly containing glucose, and glucose easily absorbs moisture deliquescence, and the nutrient substance containing glucose is generally
Place the deliquescence that namely absorbs water for about a year under condition of storage, occur that product lumps, make nucleosides hydrochlorate, cause quality product to reduce even
Lost efficacy, so, the invention solves the problem of the not easily standing storage of nutrient substance.
Because the present invention also comprises weighting agent: starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or sulphur
One or more of acid magnesium etc., adding of weighting agent has adapted to generally be not less than 20 as the foliage fertilizer minimum package of merchandise sales
Gram relevant regulations; Filler starch, dextrin, Mierocrystalline cellulose etc. also possess certain viscosity, make nutrient substance be attached to leaf after spraying
Face and the plant surface time longer, make its action effect better; Weighting agent polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate etc.
There is dispersiveness and oilness, the quality guaranteed period of nutrient substance can be extended.
Purposes of the present invention is: as fertilizer particularly as foliage fertilizer or nutrient substance or plant-growth regulator in promotion
Application in the growth of skin class Chinese medicine; Or the production being applied to skin class Chinese medicine can improve its Yield and quality, quality, enhancing resist
Property, uniformity coefficient, reduce nuisance content, cost-saving, increase income, synergy.
The present invention is applied to the production of skin class Chinese medicine, with strong points, can improve its Yield and quality, quality, enhancing resist
Property, uniformity coefficient, reduce nuisance content, cost-saving, increase income, synergy.
So product of the present invention: saving, environmental protection, nontoxic, harmless, noresidue, without any adverse side effect, comprehensive to the purposes of skin class Chinese medicine, increase production, increase income, synergy, strengthen resistance, improve quality effective.
The present invention and No. 201010514222.7 patents, traditional product and method contrast tables 1
The present invention and No. 201010514222.7 patents, traditional product and method contrast tables 2
Embodiment:
Embodiment 1: get 3 grams of nucleosides hydrochlorates, medium trace element 2 grams, pulverizes nucleosides hydrochlorate, medium trace element, sieves, mix.
Embodiment 2: take 5 grams of nucleosides hydrochlorates, medium trace element 5 grams, by nucleosides hydrochlorate, medium trace element mixing, pulverizes, crosses 100 mesh sieves, obtain nutrient substance.
Embodiment 3: take 8 grams of nucleosides hydrochlorates, starch 10 grams, Mierocrystalline cellulose 7 grams, medium trace element 5 grams, pulverizes nucleosides hydrochlorate, medium trace element, sieves, add starch, Mierocrystalline cellulose, mix, obtain nutrient substance.
Embodiment 4: the bark of eucommia: first time is seedling stage, in April, with embodiment 1 nutrient substance, is watered 20 liters, evenly sprays in one mu of bark of eucommia; Second time is the treelet phase, and the annual 3-4 month and the 5-6 month respectively spray once; Third time is for becoming the tree phase: annual 4-5 month and respectively spraying once the 7-8 month.
Embodiment 5: golden cypress: first time is nursery stage, with embodiment 2 grams of nutrient substances, is watered 20 liters, evenly sprays on one mu of golden cypress seedling; Second time is setting date, and spray once; Third time is for becoming the tree phase: annual 4-5 month and respectively spraying once the 7-8 month.
Embodiment 6: mulberry skin: use the method for embodiment 1-embodiment 3 each once respectively at seedling or germination period, initial bloom stage, full-bloom stage.
Claims (1)
1. the production method of skin class Chinese medicine, is characterized in that: during Growth of Eucommia ulmoides, use nutrient substance, and described nutrient substance is:
Get 3 grams of nucleosides hydrochlorates, medium trace element 2 grams, nucleosides hydrochlorate, medium trace element are pulverized, sieves, mix, the nutrient substance obtained;
Described nucleosides hydrochlorate refers to: obtain after Yeast Nucleic Acid basic hydrolysis: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-guanylic acid dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, 5 '-uridylic acid dipotassium or sodium, the potassium of four kinds of 5 '-mixed nucleotides or sodium salt;
Described medium trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax;
The weight ratio of medium trace element is: Zn:Mn:Mg:Fe:B=2:2:2:1:2;
The application process of nutrient substance is: spray with after water dissolution;
The application process of nutrient substance is: spray with after water dissolution;
Described nutrient substance use opportunity and concentration is: first time for seedling stage, in April, is used described nutrient substance, is watered 20 liters, evenly spray in one mu of bark of eucommia; Second time is the treelet phase, and the annual 3-4 month and the 5-6 month respectively spray once; Third time is for becoming the tree phase: annual 4-5 month and respectively spraying once the 7-8 month.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310579812.1A CN103613422B (en) | 2013-11-19 | 2013-11-19 | The production method of skin class Chinese medicine |
| CN201510403212.9A CN105036849A (en) | 2013-11-19 | 2013-11-19 | Bark-type traditional Chinese medicine mulberry root-bark production method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310579812.1A CN103613422B (en) | 2013-11-19 | 2013-11-19 | The production method of skin class Chinese medicine |
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| CN201510403212.9A Division CN105036849A (en) | 2013-11-19 | 2013-11-19 | Bark-type traditional Chinese medicine mulberry root-bark production method |
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| CN103613422A CN103613422A (en) | 2014-03-05 |
| CN103613422B true CN103613422B (en) | 2016-04-20 |
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| CN201310579812.1A Expired - Fee Related CN103613422B (en) | 2013-11-19 | 2013-11-19 | The production method of skin class Chinese medicine |
| CN201510403212.9A Withdrawn CN105036849A (en) | 2013-11-19 | 2013-11-19 | Bark-type traditional Chinese medicine mulberry root-bark production method |
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|---|---|---|---|---|
| CN102079672A (en) * | 2010-10-21 | 2011-06-01 | 高旌 | Nutrient for promoting growth of bark traditional Chinese medicinal materials |
| CN102241541A (en) * | 2010-05-11 | 2011-11-16 | 林光德 | Method for producing foliar fertilizer of tea |
| CN102311289A (en) * | 2010-07-02 | 2012-01-11 | 王祥林 | Organic water soluble fertilizer |
| CN102515948A (en) * | 2011-12-09 | 2012-06-27 | 大千生态景观股份有限公司 | Plant antifreezer and its preparation method |
| CN102746060A (en) * | 2012-06-18 | 2012-10-24 | 湖南中烟工业有限责任公司 | Root growth promoting agent for tobacco, its preparation and application |
| CN103058785A (en) * | 2013-02-05 | 2013-04-24 | 河南誉中奥农业科技有限公司 | Environment-friendly ecological full-nutrient fertilizer and production method of environment-friendly ecological full-nutrient fertilizer |
| CN103332998A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material |
| CN103332999A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material eucommia bark |
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2013
- 2013-11-19 CN CN201310579812.1A patent/CN103613422B/en not_active Expired - Fee Related
- 2013-11-19 CN CN201510403212.9A patent/CN105036849A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102241541A (en) * | 2010-05-11 | 2011-11-16 | 林光德 | Method for producing foliar fertilizer of tea |
| CN102311289A (en) * | 2010-07-02 | 2012-01-11 | 王祥林 | Organic water soluble fertilizer |
| CN102079672A (en) * | 2010-10-21 | 2011-06-01 | 高旌 | Nutrient for promoting growth of bark traditional Chinese medicinal materials |
| CN103332998A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material |
| CN103332999A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material eucommia bark |
| CN102515948A (en) * | 2011-12-09 | 2012-06-27 | 大千生态景观股份有限公司 | Plant antifreezer and its preparation method |
| CN102746060A (en) * | 2012-06-18 | 2012-10-24 | 湖南中烟工业有限责任公司 | Root growth promoting agent for tobacco, its preparation and application |
| CN103058785A (en) * | 2013-02-05 | 2013-04-24 | 河南誉中奥农业科技有限公司 | Environment-friendly ecological full-nutrient fertilizer and production method of environment-friendly ecological full-nutrient fertilizer |
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|---|---|
| CN103613422A (en) | 2014-03-05 |
| CN105036849A (en) | 2015-11-11 |
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