CN103613422A - Production method of bark-type traditional Chinese medicines - Google Patents
Production method of bark-type traditional Chinese medicines Download PDFInfo
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- CN103613422A CN103613422A CN201310579812.1A CN201310579812A CN103613422A CN 103613422 A CN103613422 A CN 103613422A CN 201310579812 A CN201310579812 A CN 201310579812A CN 103613422 A CN103613422 A CN 103613422A
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- class chinese
- chinese medicine
- nutrient substance
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- 238000004519 manufacturing process Methods 0.000 title claims description 30
- 229940126680 traditional chinese medicines Drugs 0.000 title 1
- 235000015097 nutrients Nutrition 0.000 claims abstract description 43
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims abstract description 26
- 230000012010 growth Effects 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 18
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011591 potassium Substances 0.000 claims abstract description 17
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 17
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims abstract description 13
- 235000019341 magnesium sulphate Nutrition 0.000 claims abstract description 13
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims abstract description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 11
- 239000008103 glucose Substances 0.000 claims abstract description 11
- 239000011777 magnesium Substances 0.000 claims abstract description 10
- 239000011701 zinc Substances 0.000 claims abstract description 10
- 150000001413 amino acids Chemical class 0.000 claims abstract description 8
- 159000000000 sodium salts Chemical class 0.000 claims abstract description 8
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 7
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 7
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 7
- 229910021538 borax Inorganic materials 0.000 claims abstract description 6
- 229910052796 boron Inorganic materials 0.000 claims abstract description 6
- 239000011790 ferrous sulphate Substances 0.000 claims abstract description 6
- 235000003891 ferrous sulphate Nutrition 0.000 claims abstract description 6
- 229910052742 iron Inorganic materials 0.000 claims abstract description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims abstract description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims abstract description 6
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 6
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 6
- 239000011572 manganese Substances 0.000 claims abstract description 6
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims abstract description 6
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 6
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 6
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 6
- 239000002777 nucleoside Substances 0.000 claims description 43
- 125000003835 nucleoside group Chemical group 0.000 claims description 43
- 239000000126 substance Substances 0.000 claims description 40
- 239000003814 drug Substances 0.000 claims description 30
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims description 26
- 229950006790 adenosine phosphate Drugs 0.000 claims description 26
- 239000011573 trace mineral Substances 0.000 claims description 26
- 235000013619 trace mineral Nutrition 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 16
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- 239000011734 sodium Substances 0.000 claims description 16
- 229910052708 sodium Inorganic materials 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims description 13
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229920002678 cellulose Polymers 0.000 claims description 10
- 235000010980 cellulose Nutrition 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 229920001353 Dextrin Polymers 0.000 claims description 8
- 239000004375 Dextrin Substances 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- 235000019425 dextrin Nutrition 0.000 claims description 8
- 230000007062 hydrolysis Effects 0.000 claims description 8
- 238000006460 hydrolysis reaction Methods 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000002773 nucleotide Substances 0.000 claims description 7
- 125000003729 nucleotide group Chemical group 0.000 claims description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 6
- 235000011132 calcium sulphate Nutrition 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 230000035784 germination Effects 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- WIXIBOVGGNRVQH-WFIJOQBCSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 WIXIBOVGGNRVQH-WFIJOQBCSA-N 0.000 claims description 4
- VHUKPXJCIYLZCH-WFIJOQBCSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)NC(=O)C=C1 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)NC(=O)C=C1 VHUKPXJCIYLZCH-WFIJOQBCSA-N 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- KURVIXMFFSNONZ-WFIJOQBCSA-L disodium;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(=O)NC(=O)C=C1 KURVIXMFFSNONZ-WFIJOQBCSA-L 0.000 abstract description 3
- 229920002477 rna polymer Polymers 0.000 abstract 2
- QGXLVXZRPRRCRP-IDIVVRGQSA-L Adenosine 5'-phosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O QGXLVXZRPRRCRP-IDIVVRGQSA-L 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- INTPYBRGLGSMRA-WFIJOQBCSA-L disodium cytidine 5'-monophosphate Chemical compound [Na+].[Na+].O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP([O-])([O-])=O)O1 INTPYBRGLGSMRA-WFIJOQBCSA-L 0.000 abstract 1
- 229960001781 ferrous sulfate Drugs 0.000 abstract 1
- 229960003390 magnesium sulfate Drugs 0.000 abstract 1
- 229940099596 manganese sulfate Drugs 0.000 abstract 1
- 235000007079 manganese sulphate Nutrition 0.000 abstract 1
- 239000011702 manganese sulphate Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 238000000855 fermentation Methods 0.000 description 6
- 230000004151 fermentation Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 239000003337 fertilizer Substances 0.000 description 3
- 239000001103 potassium chloride Substances 0.000 description 3
- 235000011164 potassium chloride Nutrition 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000218691 Cupressaceae Species 0.000 description 2
- 241000208688 Eucommia Species 0.000 description 2
- PNPLHKHBANFGMS-WFIJOQBCSA-N [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 PNPLHKHBANFGMS-WFIJOQBCSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 229940061671 uridine 5-mo-phos disod Drugs 0.000 description 2
- WUBAOANSQGKRHF-XVFCMESISA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]pyrimidine-2,4-dione Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C=C1 WUBAOANSQGKRHF-XVFCMESISA-N 0.000 description 1
- UGUILUGCFSCUKR-GJMOJQLCSA-N 1-[(2r,4s,5r)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(C)=C1 UGUILUGCFSCUKR-GJMOJQLCSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
- XGYIMTFOTBMPFP-KQYNXXCUSA-N 5'-deoxyadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 XGYIMTFOTBMPFP-KQYNXXCUSA-N 0.000 description 1
- WDRISBUVHBMJEF-MROZADKFSA-N 5-deoxy-D-ribose Chemical compound C[C@@H](O)[C@@H](O)[C@@H](O)C=O WDRISBUVHBMJEF-MROZADKFSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
- 150000007528 brønsted-lowry bases Chemical class 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- -1 filter Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
Abstract
The invention discloses a nutrient for promoting growth of bark-type traditional Chinese medicinal materials, which is composed of ribonucleates and secondary and minor elements and is free of glucose or/and amino acid. The nutrient is composed of 30-70 wt% of ribonucleates and 30-70 wt% of secondary and minor elements, wherein the ribonucleates are dipotassium or disodium 5'-adenylate, dipotassium or disodium 5'-guanadenylate, dipotassium or disodium 5'-cytidylate, dipotassium or disodium 5'-uridylate, or potassium or sodium salts of the four 5'-mixed ribonucleic acids prepared by performing alkaline hydrolysis on ribonucleic acid; and the secondary and minor elements are Zn, Mn, Mg, Fe and B, and specifically zinc sulfate, manganese sulfate, magnesium sulfate, ferrous sulfate and borax. The effect can reach and even exceed the patent of which the Publication Number is CN102079672B and the Patent Number is ZL201010514222.7; and the nutrient is economical and environment-friendly, has the advantages of higher pertinence, yield increase and higher resistance, and improves and enhances the product quality.
Description
Technical field
The present invention relates to the production method of skin class Chinese medicine, particularly the production method of skin class Traditional Chinese Medicine and extract.
Background technology
The production method of existing skin class Chinese medicine, exists composition activeconstituents more, do not save, activeconstituents proportioning not rationally, be difficult for standing storage and preparation method is simple not, purposes is problem not widely.Granted publication CN 102079672 B, the patent No. is ZL201010514222.7's, name is called: a kind of nutrient substance that promotes the growth of skin class Chinese medicinal materials, described nutrient substance is by nucleosides hydrochlorate, glucose, amino acid and middle trace element form, its weight percent is: nucleosides hydrochlorate 10-30%, glucose 20-70%, amino acid/11 0-20%, middle micro-10-30%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or potassium, 5 '-cytidylic acid disodium or potassium, sodium salt or the sylvite of four kind 5 '-mixed nucleotides of 5 '-uridine monophosphate disodium or potassium, described middle trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax.Just there are the problems referred to above.
Summary of the invention
Object of the present invention overcomes above-mentioned deficiency exactly, a kind of activeconstituents in composition that reduced is provided, reasonable ratio, its effect still can meet or exceed the patent No. and be: " 201010514222.7 " a kind of promotes the production method of skin class Chinese medicine of patent of invention of the nutrient substance of skin class Chinese medicinal materials growth.
Summary of the invention
The present invention is achieved in that
Promote the nutrient substance of skin class Chinese medicinal materials growth, it mainly by nucleosides hydrochlorate, in trace element form, do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, potassium or the sodium salt of 5 '-uridylic acid dipotassium or four kind 5 '-mixed nucleotides of sodium, described middle trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax;
The nutrient substance that promotes the growth of skin class Chinese medicinal materials, screening formulation weight percent is: nucleosides hydrochlorate 40-60%, middle micro-30-70%.
The nutrient substance that promotes the growth of skin class Chinese medicinal materials, the weight ratio of middle trace element is: Zn:Mn:Mg: Fe: B=2:2:2:1:2.
The nutrient substance that promotes the growth of skin class Chinese medicinal materials, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate.
The nutrient substance that promotes the growth of skin class Chinese medicinal materials, the weight percent of nucleosides hydrochlorate, middle trace element and weighting agent is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
Promote the nutrient substance of skin class Chinese medicinal materials growth, weighting agent is: one or more of W-Gum, dextrin, Mierocrystalline cellulose, Magnesium Stearate, magnesium sulfate or zinc sulfate, the weight percent of nucleosides hydrochlorate, trace element and weighting agent is: nucleosides hydrochlorate 15-20%, middle micro-15-20%, weighting agent 40-70%.
Promote the preparation method of the nutrient substance of skin class Chinese medicinal materials growth, it mainly by nucleosides hydrochlorate, in trace element form, do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, potassium or the sodium salt of 5 '-uridylic acid dipotassium or four kind 5 '-mixed nucleotides of sodium, described middle trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax;
By nucleosides hydrochlorate, middle trace element mixes, pulverizes, and crosses 50-150 mesh sieve.
2. according to the preparation method who promotes the nutrient substance of skin class Chinese medicinal materials growth described in claim 1, it is characterized in that: screening formulation weight percent is: nucleosides hydrochlorate 40-60%, middle micro-30-70%.
The preparation method who promotes the nutrient substance of skin class Chinese medicinal materials growth, the weight ratio of middle trace element is: Zn:Mn:Mg: Fe: B=2:2:2:1:2.
State the preparation method of the nutrient substance that promotes the growth of skin class Chinese medicinal materials, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nucleosides hydrochlorate, middle trace element and weighting agent is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%, adds the weighting agent of pulverizing to mix with nucleosides hydrochlorate, middle trace element.
Promote the preparation method of the nutrient substance of skin class Chinese medicinal materials growth, weighting agent is: one or more of W-Gum, dextrin, Mierocrystalline cellulose, Magnesium Stearate, the weight percent of nucleosides hydrochlorate, trace element and weighting agent is: nucleosides hydrochlorate 15-20%, middle micro-15-20%, weighting agent 40-70%.
The production method of skin class Chinese medicine, in its process of growth, use nutrient substance: described nutrient substance it mainly by nucleosides hydrochlorate, in trace element form, do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, potassium or the sodium salt of 5 '-uridylic acid dipotassium or four kind 5 '-mixed nucleotides of sodium, described middle trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax, the application process of nutrient substance is: with spraying after water dissolution.
The production method of skin class Chinese medicine is 100-400ppm by the concentration spraying after water dissolution.
The production method of skin class Chinese medicine, the weight ratio of middle trace element is: Zn:Mn:Mg: Fe: B=2:2:2:1:2.
The production method of skin class Chinese medicine, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nutrient substance composition is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
The production method of skin class Chinese medicine, be the opportunity of using of described nutrient substance: seedling or germination period, initial bloom stage, full-bloom stage each once.
The production method of skin class Chinese medicine, be the opportunity of using of described nutrient substance: in seedling or germination period, treelet phase, become the tree phase respectively to spray 1-2 time every year.
The production method of skin class Chinese medicine,, the consumption of described nutrient substance is every mu of 2-8 gram, by water-soluble water consumption, is every mu of 20-40 liter.
The production method of skin class Chinese medicine, the consumption of described nutrient substance is each every mu of 15-30 gram, by water-soluble water consumption, is each every mu of 20-40 liter.
The production method of skin class Chinese medicine, its output, than the high 10%-20% of produced in conventional processes, can be made high-quality medicine materical crude slice extracting effective components yield by the Chinese medicinal materials of results and can reach more than 20% than the skin class Chinese medicinal materials of produced in conventional processes.
In the preparation of nutrient substance provided by the present invention, take nucleic acid as raw material: the one, take commercially available nucleic acid as raw material, 1., the hydrolysis of the nucleic acid ratio mixed nucleus bronsted lowry acids and bases bronsted lowry liquid that is 1:20-30 according to nucleic acid, buck weight ratio the 2nd, it is raw material that the mycelium from fermentation plant fermentation adopts the nucleic acid of dry method or wet production:, alkali lye is 5.5-7N, under 30-45 ℃ of condition, stirs 10-14 hours, obtain nucleosides hydrochlorate and deoxynucleoside acid salt solution, filter, filtrate is adjusted pH8-8.5, concentrating under reduced pressure;
2., decolouring, dry: concentrated solution is added to activated carbon decolorizing, suction filtration it, filtrate decompression is concentrated into moisture 10-25%;
3., crystallization: dissolve nucleosides hydrochlorate and the deoxynucleoside hydrochlorate after doing with clear water, its solution adds alcohol and separates out, crystallization suction filtration is dry, obtain white nucleosides hydrochlorate and deoxynucleoside hydrochlorate (it is impurity that the mycelium from fermentation plant fermentation adopts the water soluble mixt that also contains that the nucleic acid of dry method or wet production is raw material);
4., get middle trace element;
, trace element in nucleosides hydrochlorate is mixed, is pulverized, sieve.
In nucleic acid hydrolysis process described in this preparation method, alkali lye used is sodium hydroxide or potassium hydroxide solution.
Take commercially available nucleic acid as raw material, impure few after hydrolysis.
The 3rd, commercially available: nucleosides hydrochlorate mainly refers to: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or potassium, 5 '-cytidylic acid disodium or potassium, sodium salt or the sylvite of four kind 5 '-mixed nucleotides of 5 '-uridine monophosphate disodium or potassium; Deoxynucleoside hydrochlorate refers to: 5 '-Desoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid (AMP) disodium or potassium, 5 '-Deoxyribose cytidine acid disodium or potassium, 5 '-deoxyuridine acid disodium,, sodium salt or the sylvite of five kind 5 '-deoxidation mixed nucleotides of 5 '-deoxythymidine acid disodium or potassium.
The source of nucleosides hydrochlorate and deoxynucleoside hydrochlorate is for take nucleic acid as raw material, that to adopt the nucleic acid of dry method or wet production be raw material for mycelium from fermentation plant fermentation, this kind of nucleic acid be take Yeast Nucleic Acid (RNA) as a small amount of thymus nucleic acid of main mixing (DNA), with alkali lye hydrolysis, makes.
Beneficial effect of the present invention:
Because the present invention has not reduced composition activeconstituents containing glucose, amino acid, so more economize in raw materials and cost.
Because the present invention contains middle trace element, coordinate nucleosides hydrochlorate, reasonable ratio, promotes the growth of skin class Chinese medicine more targeted specifically.
Although the present invention has reduced activeconstituents, its effect does not still subtract and even produces better effect.
The present invention is not particularly containing glucose, glucose easily absorbs moisture deliquescence, the nutrient substance that contains glucose is placed the deliquescence that absorbs water about a year under general condition of storage, there is product caking, make nucleosides hydrochlorate, cause quality of products even to lose efficacy, so, the invention solves the problem that is difficult for standing storage of nutrient substance.
Because the present invention also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate etc., the adding to have adapted to of weighting agent are generally not less than the relevant regulations of 20 grams as the foliage fertilizer minimum package of merchandise sales; Filler starch, dextrin, Mierocrystalline cellulose etc. also possess certain viscosity, after spraying, make nutrient substance be attached to blade face and the plant surface time longer, make its action effect better; Weighting agent polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate etc. have dispersiveness and oilness, can extend the quality guaranteed period of nutrient substance.
Purposes of the present invention is: as fertilizer sources is particularly as foliage fertilizer or nutrient substance or the application of plant-growth regulator in the growth that promotes skin class Chinese medicine; Or the production that is applied to skin class Chinese medicine can improve its Yield and quality, quality, enhancing resistance, uniformity coefficient, reduce nuisance content, cost-saving, increase income, synergy.
The present invention is applied to the production of skin class Chinese medicine, with strong points, can improve its Yield and quality, quality, enhancing resistance, uniformity coefficient, reduce nuisance content, cost-saving, increase income, synergy.
So product of the present invention: saving, environmental protection, nontoxic, harmless, noresidue, without any adverse side effect, comprehensive to the purposes of skin class Chinese medicine, increase production, increase income, synergy, strengthen resistance, improve quality effective.
The present invention and No. 201010514222.7 patents, traditional product and method contrast tables 1
The present invention and No. 201010514222.7 patents, traditional product and method contrast tables 2
Embodiment:
Embodiment 1: get 3 grams of nucleosides hydrochlorates, and middle micro-2 grams, nucleosides hydrochlorate, middle trace element are pulverized, sieve, mix.
Embodiment 2: take 5 grams of nucleosides hydrochlorates, and middle micro-5 grams, nucleosides hydrochlorate, middle trace element are mixed, pulverized, cross 100 mesh sieves, obtain nutrient substance.
Embodiment 3: take 8 grams of nucleosides hydrochlorates, and 10 grams of starch, 7 grams of Mierocrystalline celluloses, middle micro-5 grams, nucleosides hydrochlorate, middle trace element are pulverized, sieve, add starch, Mierocrystalline cellulose, mix, obtain nutrient substance.
Embodiment 4: the bark of eucommia: be seedling stage for the first time, in April, with embodiment 1 nutrient substance, be watered 20 liters, evenly spray in one mu of bark of eucommia; Be the treelet phase for the second time, each spray of the annual 3-4 month and the 5-6 month once; Be for the third time
Become the tree phase: each spray of the annual 4-5 month and the 7-8 month once.
Embodiment 5: golden cypress: be nursery stage for the first time, with 2 grams of nutrient substances of embodiment, be watered 20 liters, evenly spray on one mu of golden cypress seedling; Be setting date for the second time, spray once; For the third time for becoming the tree phase: each spray of the annual 4-5 month and the 7-8 month once.
Embodiment 6: mulberry skin: seedling or germination period, initial bloom stage, full-bloom stage use respectively embodiment-embodiment 3 method each once.
Claims (9)
1. the production method of skin class Chinese medicine, is characterized in that using nutrient substance in its process of growth: described nutrient substance it mainly by nucleosides hydrochlorate, in trace element form, do not comprise glucose or/and amino acid, its weight percent is:; Nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5 '-adenylic acid (AMP) dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, potassium or the sodium salt of 5 '-uridylic acid dipotassium or four kind 5 '-mixed nucleotides of sodium, described middle trace element refers to: Zn, Mn, Mg, Fe, B, specifically: zinc sulfate, manganous sulfate, magnesium sulfate, ferrous sulfate and borax, the application process of nutrient substance is: with spraying after water dissolution.
2. according to the production method of skin class Chinese medicine described in claim 1, it is characterized in that: by the concentration spraying after water dissolution, be 100-400ppm.
3. according to the production method of skin class Chinese medicine described in claim 1, it is characterized in that: the weight ratio of middle trace element is: Zn:Mn:Mg: Fe: B=2:2:2:1:2.
4. the production method of skin class Chinese medicine according to claim 1, it is characterized in that, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nutrient substance composition is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
5. the production method of skin class Chinese medicine according to claim 1, its feature is being: be the opportunity of using of described nutrient substance: seedling or germination period, initial bloom stage, full-bloom stage each once.
6. the production method of skin class Chinese medicine according to claim 1, its feature is being: be the opportunity of using of described nutrient substance: in seedling or germination period, treelet phase, become the tree phase respectively to spray 1-2 time every year.
7. according to the production method of skin class Chinese medicine described in claim 1,2,3,5 or 6,, its feature is being: the consumption of described nutrient substance is every mu of 2-8 gram, by water-soluble water consumption, is every mu of 20-40 liter.
8. the production method of skin class Chinese medicine according to claim 4, its feature is being: the consumption of described nutrient substance is each every mu of 15-30 gram, by water-soluble water consumption, is each every mu of 20-40 liter.
9. piece according to the production method of skin class Chinese medicine described in claim 1,2,3,4,5,6 or 8, its feature is being: its output, than the high 10%-20% of produced in conventional processes, can be made high-quality medicine materical crude slice extracting effective components yield by the Chinese medicinal materials of results and can reach more than 20% than the skin class Chinese medicinal materials of produced in conventional processes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310579812.1A CN103613422B (en) | 2013-11-19 | 2013-11-19 | The production method of skin class Chinese medicine |
| CN201510403212.9A CN105036849A (en) | 2013-11-19 | 2013-11-19 | Bark-type traditional Chinese medicine mulberry root-bark production method |
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| CN201310579812.1A CN103613422B (en) | 2013-11-19 | 2013-11-19 | The production method of skin class Chinese medicine |
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| CN201510403212.9A Division CN105036849A (en) | 2013-11-19 | 2013-11-19 | Bark-type traditional Chinese medicine mulberry root-bark production method |
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| CN201510403212.9A Withdrawn CN105036849A (en) | 2013-11-19 | 2013-11-19 | Bark-type traditional Chinese medicine mulberry root-bark production method |
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| CN102079672A (en) * | 2010-10-21 | 2011-06-01 | 高旌 | Nutrient for promoting growth of bark traditional Chinese medicinal materials |
| CN102241541A (en) * | 2010-05-11 | 2011-11-16 | 林光德 | Method for producing foliar fertilizer of tea |
| CN102311289A (en) * | 2010-07-02 | 2012-01-11 | 王祥林 | Organic water soluble fertilizer |
| CN102515948A (en) * | 2011-12-09 | 2012-06-27 | 大千生态景观股份有限公司 | Plant antifreezer and its preparation method |
| CN102746060A (en) * | 2012-06-18 | 2012-10-24 | 湖南中烟工业有限责任公司 | Root growth promoting agent for tobacco, its preparation and application |
| CN103058785A (en) * | 2013-02-05 | 2013-04-24 | 河南誉中奥农业科技有限公司 | Environment-friendly ecological full-nutrient fertilizer and production method of environment-friendly ecological full-nutrient fertilizer |
| CN103332998A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material |
| CN103332999A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material eucommia bark |
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2013
- 2013-11-19 CN CN201310579812.1A patent/CN103613422B/en not_active Expired - Fee Related
- 2013-11-19 CN CN201510403212.9A patent/CN105036849A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102241541A (en) * | 2010-05-11 | 2011-11-16 | 林光德 | Method for producing foliar fertilizer of tea |
| CN102311289A (en) * | 2010-07-02 | 2012-01-11 | 王祥林 | Organic water soluble fertilizer |
| CN102079672A (en) * | 2010-10-21 | 2011-06-01 | 高旌 | Nutrient for promoting growth of bark traditional Chinese medicinal materials |
| CN103332998A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material |
| CN103332999A (en) * | 2010-10-21 | 2013-10-02 | 高旌 | Method for producing high-quality high-yield bark type traditional Chinese medicinal material eucommia bark |
| CN102515948A (en) * | 2011-12-09 | 2012-06-27 | 大千生态景观股份有限公司 | Plant antifreezer and its preparation method |
| CN102746060A (en) * | 2012-06-18 | 2012-10-24 | 湖南中烟工业有限责任公司 | Root growth promoting agent for tobacco, its preparation and application |
| CN103058785A (en) * | 2013-02-05 | 2013-04-24 | 河南誉中奥农业科技有限公司 | Environment-friendly ecological full-nutrient fertilizer and production method of environment-friendly ecological full-nutrient fertilizer |
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| CN103613422B (en) | 2016-04-20 |
| CN105036849A (en) | 2015-11-11 |
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