CN103613424A - Production method of flos traditional Chinese medicine - Google Patents

Production method of flos traditional Chinese medicine Download PDF

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CN103613424A
CN103613424A CN201310579846.0A CN201310579846A CN103613424A CN 103613424 A CN103613424 A CN 103613424A CN 201310579846 A CN201310579846 A CN 201310579846A CN 103613424 A CN103613424 A CN 103613424A
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chinese medicine
production method
class chinese
sodium
nutrient substance
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CN103613424B (en
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高旌
刘畅
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Anhui ShiMao Chineses Medicine Co., Ltd.
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HEFEI KAIGE INFORMATION TECHNOLOGY Co Ltd
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Priority to CN201510399796.7A priority patent/CN104997830A/en
Priority to CN201310579846.0A priority patent/CN103613424B/en
Priority to CN201510383096.9A priority patent/CN104973910A/en
Priority to CN201510399793.3A priority patent/CN105036848A/en
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Abstract

The invention discloses a production method of a flos traditional Chinese medicine. The production method is characterized in that nutrients are used during the growth of the flos traditional Chinese medicine, wherein the nutrients include the following components in percentage by weight: 30 to 70% of nucleotide salt and 30 to 70% of medium trace element, and exclude glucose or/and amino acids; the nucleotide salt is the sylvite or sodium salt of four 5'-mixed nucleotides and obtained by hydrolyzing ribonucleic acid alkaline, namely, wherein the four 5'-mixed nucleotides are namely 5'-adenylate dipotassium or sodium, 5'-guanylic dipotassium or sodium, 5'-cytidine monophosphate dipotassium or sodium, 5'-uridylic acid dipotassium or sodium; and the medium trace element includes Mn, B and Fe, namely manganese sulfate, borax and ferrous sulfate. The production method of the flos traditional Chinese medicine has the effect reaching and even exceeding the effect of a patent for invention with publication patent number of CN102079666B and patent number of ZL201010514231.6. The method is economic and simple. The obtained flos traditional Chinese medicine is large and uniform in flower, the uniformity is up to 70 to 90%, the output is 20 to 40% higher than that of flos traditional Chinese medicine produced by the traditional method, the main components account for 10 to 25%, the obtained traditional Chinese medicines can be prepared into quality decoction pieces, or active ingredients can be extracted, and the yield is up to 10 to 22%.

Description

The production method of flower class Chinese medicine
Technical field
The present invention relates to the production method of fruit and seed class Chinese medicine, particularly the production method of fruit and seed class medicinal plant and medicine materical crude slice thereof and extract.
Background technology
The production method of existing colored class Chinese medicine, exists composition activeconstituents more, do not save, activeconstituents proportioning not rationally, be difficult for standing storage and preparation method is simple not, purposes is problem not widely.Granted publication CN 102079666 B, the patent No. is 201010514231.6, name is called: a kind of nutrient substance that promotes the growth of flower class Chinese medicinal materials, it is by nucleosides hydrochlorate, glucose, amino acid and middle trace element form, its weight percent is: nucleosides hydrochlorate 10-30%, glucose 20-70%, amino acid/11 0-20%, middle micro-10-30%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5'-AMP dipotassium, 5 '-bird adenylic acid (AMP) dipotassium, 5'-CMP dipotassium, four kind 5 of uridine 5'-monophosphate dipotassium ' the sylvite of-mixed nucleotides, described middle trace element refers to: Mn, B and Fe, specifically: manganous sulfate, borax and ferrous sulfate.Just there are the problems referred to above.
Summary of the invention
Object of the present invention overcomes above-mentioned deficiency exactly, a kind of activeconstituents in composition that reduced is provided, reasonable ratio, its effect still can meet or exceed the patent No. and be: " 201010514231.6 " a kind of promotes the production method of colored class Chinese medicine of patent of invention of the nutrient substance of flower class Chinese medicinal materials growth.
The present invention is achieved in that
Promote the nutrient substance of flower class Chinese medicinal materials growth, it is by nucleosides hydrochlorate, middle trace element forms, do not comprise glucose or/and amino acid, weight percent is: nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5'-AMP dipotassium or sodium, 5'-bird adenylic acid (AMP) dipotassium or sodium, 5'-CMP dipotassium or sodium, potassium or the sodium salt of 5 '-uridylic acid dipotassium or sodium four kind 5 '-mixed nucleotides, described middle trace element refers to: Mn, B and Fe, specifically: manganous sulfate, borax and ferrous sulfate.
The nutrient substance that promotes the growth of flower class Chinese medicinal materials, screening formulation weight percent is: nucleosides hydrochlorate 40-60%, middle micro-30-70%.
The nutrient substance that promotes the growth of flower class Chinese medicinal materials, the weight ratio of middle trace element is: Mn:B:Fe=3:2:4.
The nutrient substance that promotes the growth of flower class Chinese medicinal materials, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate.
The nutrient substance that promotes the growth of flower class Chinese medicinal materials, the weight percent of nucleosides hydrochlorate, middle trace element and weighting agent is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
Promote the nutrient substance of flower class Chinese medicinal materials growth, weighting agent is: one or more of W-Gum, dextrin, Mierocrystalline cellulose, Magnesium Stearate, magnesium sulfate or zinc sulfate, the weight percent of nucleosides hydrochlorate, trace element and weighting agent is: nucleosides hydrochlorate 15-20%, middle micro-15-20%, weighting agent 40-70%.
Promote the preparation method of the nutrient substance of flower class Chinese medicinal materials growth, it is by nucleosides hydrochlorate, middle trace element forms, do not comprise glucose or/and amino acid, weight percent is: nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5'-AMP dipotassium or sodium, 5'-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, potassium or the sodium salt of 5 '-uridylic acid dipotassium or sodium four kind 5 '-mixed nucleotides, described middle trace element refers to: Mn, B and Fe, specifically: manganous sulfate, borax and ferrous sulfate, by nucleosides hydrochlorate, middle trace element mixes, pulverize, cross 50-200 mesh sieve.
The preparation method who promotes the nutrient substance of flower class Chinese medicinal materials growth, screening formulation weight percent is: nucleosides hydrochlorate 40-60%, middle micro-30-70%.
The preparation method who promotes the nutrient substance of flower class Chinese medicinal materials growth, the weight ratio of middle trace element is: Mn:B:Fe=3:2:4.
The preparation method who promotes the nutrient substance of flower class Chinese medicinal materials growth, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate.
The preparation method who promotes the nutrient substance of flower class Chinese medicinal materials growth, the weight percent of nucleosides hydrochlorate, middle trace element and weighting agent is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
Promote the preparation method of the nutrient substance of flower class Chinese medicinal materials growth, weighting agent is: one or more of W-Gum, dextrin, Mierocrystalline cellulose, Magnesium Stearate, magnesium sulfate or zinc sulfate, the weight percent of nucleosides hydrochlorate, trace element and weighting agent is: nucleosides hydrochlorate 15-20%, middle micro-15-20%, weighting agent 40-70%.
The production method of flower class Chinese medicine, in its process of growth, use nutrient substance: described nutrient substance is mainly by nucleosides hydrochlorate, middle trace element forms, do not comprise glucose or/and amino acid, weight percent is: nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5'-AMP dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5'-CMP dipotassium or sodium, potassium or the sodium salt of uridine 5'-monophosphate dipotassium or four kinds of 5'-mixed nucleotides of sodium, described middle trace element refers to: Mn, B and Fe, specifically: manganous sulfate, borax and ferrous sulfate, the application process of described nutrient substance is: with spraying after water dissolution.
The production method of flower class Chinese medicine is 100-400ppm by the concentration spraying after water dissolution.
The production method of flower class Chinese medicine, the weight ratio of middle trace element is: Mn:B:Fe=3:2:4.
The production method of flower class Chinese medicine, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nutrient substance composition is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
The production method of flower class Chinese medicine, be the opportunity of using of described nutrient substance: at seedling stage of flower class Chinese medicinal materials or germination period, bud stage or/and initial bloom stage, full-bloom stage each once.
The production method of flower class Chinese medicine, be the opportunity of using of described nutrient substance: at the bud stage of flower class Chinese medicinal materials or/and initial bloom stage, full-bloom stage each once.
The production method of flower class Chinese medicine, the consumption of described nutrient substance is every mu of 2-8 gram, by water-soluble water consumption, is every mu of 20-40 liter.
The production method of flower class Chinese medicine, its feature is being: the consumption of described nutrient substance is each every mu of 15-30 gram, by water-soluble water consumption, is each every mu of 20-40 liter.
State the production method of colored class Chinese medicine, its feature is being: the colored class Chinese medicinal materials flower of results is large and even, uniformity coefficient can reach 70-90%, its output is higher by 19% than produced in conventional processes, its Contents of Main Components is than the high 7-11% of produced in conventional processes, and the Chinese medicinal materials of results can be made to high-quality medicine materical crude slice or extracting effective components yield than the high 7-10% of the Chinese medicinal materials of produced in conventional processes.
Weighting agent of the present invention: starch refers to: green starch, yam starch, wheat starch, sweet potato starch, W-Gum, water caltrop starch, Lotus Root Starch, Chinese Water Chestnut Starch etc., preferably W-Gum.Dextrin refers to: white dextrin, yellow starch gum and Britain glue, cyclodextrin.Mierocrystalline cellulose refers to: methylcellulose gum, Vltra tears, Natvosol, carboxymethyl cellulose etc.
In the preparation of nutrient substance provided by the present invention, take nucleic acid as raw material: the one, take commercially available nucleic acid as raw material, 1., the hydrolysis of the nucleic acid ratio mixed nucleus bronsted lowry acids and bases bronsted lowry liquid that is 1:20-30 according to nucleic acid, buck weight ratio the 2nd, it is raw material that the mycelium from fermentation plant fermentation adopts the nucleic acid of dry method or wet production:, alkali lye is 5.5-7N, under 30-45 ℃ of condition, stirs 10-14 hours, obtain nucleosides hydrochlorate and deoxynucleoside acid salt solution, filter, filtrate is adjusted pH8-8.5, concentrating under reduced pressure;
2., decolouring, dry: concentrated solution is added to activated carbon decolorizing, suction filtration it, filtrate decompression is concentrated into moisture 10-25%;
3., crystallization: dissolve nucleosides hydrochlorate and the deoxynucleoside hydrochlorate after doing with clear water, its solution adds alcohol and separates out, crystallization suction filtration is dry, obtain white nucleosides hydrochlorate and deoxynucleoside hydrochlorate (it is impurity that the mycelium from fermentation plant fermentation adopts the water soluble mixt that also contains that the nucleic acid of dry method or wet production is raw material);
4., get middle trace element;
Figure 905065DEST_PATH_IMAGE001
, trace element in nucleosides hydrochlorate is mixed, is pulverized, sieve.
In nucleic acid hydrolysis process described in this preparation method, alkali lye used is sodium hydroxide or potassium hydroxide solution.
Take commercially available nucleic acid as raw material, impure few after hydrolysis.
The 3rd, commercially available: nucleosides hydrochlorate mainly refers to: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or potassium, 5 '-cytidylic acid disodium or potassium, sodium salt or the sylvite of four kind 5 '-mixed nucleotides of 5 '-uridine monophosphate disodium or potassium; Deoxynucleoside hydrochlorate refers to: 5 '-Desoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid (AMP) disodium or potassium, 5 '-Deoxyribose cytidine acid disodium or potassium, 5 '-deoxyuridine acid disodium,, sodium salt or the sylvite of five kind 5 '-deoxidation mixed nucleotides of 5 '-deoxythymidine acid disodium or potassium.
The source of nucleosides hydrochlorate and deoxynucleoside hydrochlorate is for take nucleic acid as raw material, that to adopt the nucleic acid of dry method or wet production be raw material for mycelium from fermentation plant fermentation, this kind of nucleic acid be take Yeast Nucleic Acid (RNA) as a small amount of thymus nucleic acid of main mixing (DNA), with alkali lye hydrolysis, makes.
Beneficial effect of the present invention:
Because the present invention has not reduced composition activeconstituents containing glucose, amino acid, so more economize in raw materials and cost.
Because the present invention contains middle trace element, coordinate nucleosides hydrochlorate, reasonable ratio, promotes the growth of Rhizomatic traditional Chinese medicine more targeted specifically.
Although the present invention has reduced activeconstituents, its effect does not still subtract and even produces better effect.
The present invention is not particularly containing glucose, glucose easily absorbs moisture deliquescence, the nutrient substance that contains glucose is placed the deliquescence that absorbs water more than a year under general condition of storage, there is product caking, make nucleosides hydrochlorate, cause quality of products even to lose efficacy, so, the invention solves the problem that is difficult for standing storage of nutrient substance.
Because the present invention also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate etc., the adding to have adapted to of weighting agent are generally not less than the relevant regulations of 20 grams as the foliage fertilizer minimum package of merchandise sales; Filler starch, dextrin, Mierocrystalline cellulose etc. also possess certain viscosity, after spraying, make nutrient substance be attached to blade face and the plant surface time longer, make its action effect better; Weighting agent polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate etc. have dispersiveness and oilness, can extend the quality guaranteed period of nutrient substance.
Purposes of the present invention is: as fertilizer sources is particularly as foliage fertilizer or nutrient substance or the application of plant-growth regulator in the growth that promotes flower class Chinese medicine; Or the production that is applied to flower class Chinese medicine can improve its Yield and quality, quality, enhancing resistance, uniformity coefficient, reduce nuisance content, cost-saving, increase income, synergy.
The present invention is applied to the production of flower class Chinese medicine, with strong points, can improve its Yield and quality, quality, enhancing resistance, uniformity coefficient, reduce nuisance content, cost-saving, increase income, synergy.
So product of the present invention: saving, environmental protection (nontoxic, harmless, noresidue, without any adverse side effect), comprehensive to the purposes of flower class Chinese medicine, increase production, increase income, synergy, strengthen resistance, improve quality effective.
The present invention and No. 201010514231.6 patents, traditional product and method contrast tables 1
Figure 831433DEST_PATH_IMAGE002
The present invention and No. 201010514231.6 patents, traditional product and method contrast tables 2
Figure 301597DEST_PATH_IMAGE003
The present invention implements to spray agency part effect in Table 3 to concrete crop
Note: content's index detection method is carried out with reference to national standard or industry standard, content is pressed dry product and is calculated
Embodiment:
Embodiment 1: wait totally 4 grams of sylvite that measure four kind 5 '-mixed nucleotides, and 3 grams of manganous sulfates, 2 grams of boraxs, 4 grams, ferrous sulfate, mixes, pulverizes, and crosses 100 mesh sieves.
Embodiment 2: wait totally 4 grams of sodium salts that measure four kind 5 '-mixed nucleotides, and 3 grams of manganous sulfates, 2 grams of boraxs, 4 grams, ferrous sulfate, mixes, pulverizes, and crosses 100 mesh sieves.
Embodiment 3: take 8 grams of Nucleotide sylvite, and 7 grams of W-Gums, middle micro-5 grams, nucleosides hydrochlorate, middle trace element are pulverized, sieve, add W-Gum, mix, obtain nutrient substance.
Embodiment 4: chrysanthemum: be seedling stage (germination period) for the first time, in April, with 20 grams of nutrient substances, be watered 20 liters, evenly spray on one mu of chrysanthemum; Be initial bloom stage embodiment 1 nutrient substance for the second time, be watered 20 liters, evenly spray on one mu of chrysanthemum; Embodiment 2 nutrient substances for full-bloom stage, are watered 20 liters for the third time, evenly spray on one mu of chrysanthemum, can increase production 19%, the chrysanthemum flower of results is large and even, and uniformity coefficient can reach 70-90%, its output is higher by 19% than produced in conventional processes, and its Contents of Main Components is than the high 7-11% of produced in conventional processes.
Embodiment 5: Japanese Honeysuckle, and seedling stage (germination period), bud initial stage are pressed respectively embodiment 1,2,3, are watered 30 kilograms, and each spray once, can increase production 22%.
Embodiment 6: the colored class Chinese medicinal materials of results can be made to high-quality medicine materical crude slice or extracting effective components yield than the high 7-10% of colored class Chinese medicinal materials of produced in conventional processes.

Claims (9)

1. spend the production method of class Chinese medicine, it is characterized in that, in its process of growth, use nutrient substance: described nutrient substance is mainly by nucleosides hydrochlorate, middle trace element forms, do not comprise glucose or/and amino acid, weight percent is: nucleosides hydrochlorate 30-70%, middle micro-30-70%, described nucleosides hydrochlorate refers to: after Yeast Nucleic Acid basic hydrolysis, obtain: 5'-AMP dipotassium or sodium, 5 '-bird adenylic acid (AMP) dipotassium or sodium, 5 '-cytidylic acid dipotassium or sodium, 5 ' potassium or the sodium salt of-uridylic acid dipotassium or four kinds of 5'-mixed nucleotides of sodium, described middle trace element refers to: Mn, B and Fe, specifically: manganous sulfate, borax and ferrous sulfate, the application process of described nutrient substance is: with spraying after water dissolution.
2. spend according to claim 1 the production method of class Chinese medicine, its feature is being: by the concentration spraying after water dissolution, be 100-400ppm.
3. spend according to claim 1 the production method of class Chinese medicine, it is characterized in that: the weight ratio of middle trace element is: Mn:B:Fe=3:2:4.
4. spend according to claim 1 the production method of class Chinese medicine, it is characterized in that, it also comprises weighting agent: one or more of starch, dextrin, Mierocrystalline cellulose, polyvidone, Magnesium Stearate, calcium sulfate or magnesium sulfate, the weight percent of nutrient substance composition is: nucleosides hydrochlorate 10-30 %, middle micro-10-30%, weighting agent 40-80%.
5. spend according to claim 1 the production method of class Chinese medicine, its feature is being: be the opportunity of using of described nutrient substance: at seedling stage of flower class Chinese medicinal materials or germination period, bud stage or/and initial bloom stage, full-bloom stage each once.
6. spend according to claim 1 the production method of class Chinese medicine, its feature is being: be the opportunity of using of described nutrient substance: at the bud stage of flower class Chinese medicinal materials or/and initial bloom stage, full-bloom stage each once.
7. according to the production method of flower class Chinese medicine described in claim 1,2,3,5 or 6, its feature is being: the consumption of described nutrient substance is every mu of 2-8 gram, by water-soluble water consumption, is every mu of 20-40 liter.
8. spend according to claim 4 the production method of class Chinese medicine, its feature is being: the consumption of described nutrient substance is each every mu of 15-30 gram, by water-soluble water consumption, is each every mu of 20-40 liter.
9. piece according to the production method of flower class Chinese medicine described in claim 1,2,3,4,5,6 or 8, its feature is being: the colored class Chinese medicinal materials flower of results is large and even, uniformity coefficient can reach 70-90%, its output is higher by 19% than produced in conventional processes, its Contents of Main Components is than the high 7-11% of produced in conventional processes, and the Chinese medicinal materials of results can be made to high-quality medicine materical crude slice or extracting effective components yield than the high 7-10% of the Chinese medicinal materials of produced in conventional processes.
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Application Number Priority Date Filing Date Title
CN201510403215.2A CN105030870A (en) 2013-11-19 2013-11-19 Preparation method of chrysanthemum flower decoction pieces
CN201510399796.7A CN104997830A (en) 2013-11-19 2013-11-19 Production method of flower type traditional Chinese medicinal decoction pieces
CN201310579846.0A CN103613424B (en) 2013-11-19 2013-11-19 The production method of flos traditional Chinese medicine
CN201510383096.9A CN104973910A (en) 2013-11-19 2013-11-19 Production method for flower traditional Chinese medicine
CN201510399793.3A CN105036848A (en) 2013-11-19 2013-11-19 Honeysuckle flower extract production method

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CN201510399793.3A Division CN105036848A (en) 2013-11-19 2013-11-19 Honeysuckle flower extract production method
CN201510383096.9A Division CN104973910A (en) 2013-11-19 2013-11-19 Production method for flower traditional Chinese medicine
CN201510399796.7A Division CN104997830A (en) 2013-11-19 2013-11-19 Production method of flower type traditional Chinese medicinal decoction pieces

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CN201510383096.9A Withdrawn CN104973910A (en) 2013-11-19 2013-11-19 Production method for flower traditional Chinese medicine
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823238A (en) * 2017-11-20 2018-03-23 安徽佳凯药业股份有限公司 A kind of production method of flos traditional Chinese medicine medicine materical crude slice

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CN103141201B (en) * 2010-10-21 2014-07-23 合肥市济泉医药科技有限公司 Good-quality and high-yield production method of fruit and seed medicinal plants
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CN102079666B (en) * 2010-10-21 2013-06-12 高旌 Nutrient for promoting growth of flower Chinese medicinal material
CN103288508A (en) * 2010-10-21 2013-09-11 高旌 Preparation method of nutrient for promoting growth of flower Chinese medicinal materials
CN103314690A (en) * 2010-10-21 2013-09-25 高旌 High-quality high-yield flower-type traditional Chinese medicinal material production method

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823238A (en) * 2017-11-20 2018-03-23 安徽佳凯药业股份有限公司 A kind of production method of flos traditional Chinese medicine medicine materical crude slice

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