CN103613424B - The production method of flos traditional Chinese medicine - Google Patents

The production method of flos traditional Chinese medicine Download PDF

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CN103613424B
CN103613424B CN201310579846.0A CN201310579846A CN103613424B CN 103613424 B CN103613424 B CN 103613424B CN 201310579846 A CN201310579846 A CN 201310579846A CN 103613424 B CN103613424 B CN 103613424B
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grams
nutrient
chinese medicine
flos
traditional chinese
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CN103613424A (en
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孙鹏
纪东汉
白广东
修效友
张广友
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Anhui ShiMao Chineses Medicine Co., Ltd.
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ANHUI ZHONGTIANFANG BIOTECHNOLOGY Co Ltd
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Priority to CN201510403215.2A priority Critical patent/CN105030870A/en
Priority to CN201510399796.7A priority patent/CN104997830A/en
Priority to CN201510383096.9A priority patent/CN104973910A/en
Priority to CN201510399793.3A priority patent/CN105036848A/en
Priority to CN201310579846.0A priority patent/CN103613424B/en
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Abstract

The invention discloses the production method of flos traditional Chinese medicine, belong to Producing medicinal herbs field, Chinese medicine refers to Flos Chrysanthemi;In its growth course, execute nutrient: a. etc. measure the potassium salt (b, sodium salt) totally 4 grams of four kind of 5 ' mixed nucleotides, manganese sulfate 3 grams, Borax 2 grams, 4 grams of ferrous sulfate;C. weighing 8 grams of nucleotide potassium salt, corn starch 7 grams, middle trace element 5 grams obtains nutrient;To Flos Chrysanthemi: be seedling stage or germination period for the first time, using c nutrient, second time is initial bloom stage, uses a nutrient, and third time is full-bloom stage b nutrient;It is watered 20 liters respectively, uniformly sprays on one mu of Flos Chrysanthemi;Can increase production 19%, the Flos Chrysanthemi flower of results is big and uniform, and the uniformity is up to 70 90%, and its main component: luteoloside content is more than 0.088%, chlorogenic acid content is more than 0.27%.

Description

The production method of flos traditional Chinese medicine
Technical field
The present invention relates to the production method of fruit seed traditional Chinese medicines, particularly fruit and seed class medicinal plants and decoction pieces thereof and The production method of extract.
Background technology
, there is compositions active component more, do not save in the production method of existing flos traditional Chinese medicine, active component proportioning is not The most rationally, it is difficult to long term storage and preparation method is simple not, purposes problem the most widely.Authorization Notice No. CN 102079666 B, Patent No. 201010514231.6, entitled: a kind of nutrient promoting flos traditional Chinese medicine material to grow, it Being made up of nucleoside hydrochlorate, glucose, aminoacid and middle trace element, its percentage by weight is: nucleoside hydrochlorate 10-30%, Fructus Vitis viniferae Sugar 20-70%, amino acid/11 0-20%, middle trace element 10-30%, described nucleoside hydrochlorate refers to: after ribonucleic acid basic hydrolysis Arrive: 5'-AMP dipotassium, 5 '-bird adenylic acid dipotassium, 5'-CMP dipotassium, uridine 5'-monophosphate dipotassium four kind 5 '-mixed The potassium salt of synkaryon thuja acid, described middle trace element refers to: Mn, B and Fe, specifically: manganese sulfate, Borax and ferrous sulfate.Just deposit In the problems referred to above.
Summary of the invention
The purpose of the present invention overcomes above-mentioned deficiency exactly, it is provided that one decreases active component in compositions, reasonable mixture ratio, Its effect remains able to meet or exceed Patent No.: a kind of of " 201010514231.6 " promotes what flos traditional Chinese medicine material grew The production method of the flos traditional Chinese medicine of the patent of invention of nutrient.
The present invention is achieved in that
The production method of flos traditional Chinese medicine, described flos traditional Chinese medicine material refers to Flos Chrysanthemi;Nutrient is used: institute in its growth course Stating nutrient is: a. etc. measure the potassium salt totally 4 grams of four kinds of 5 '-mixed nucleotides, manganese sulfate 3 grams, Borax 2 grams, ferrous sulfate 4 Gram, mix, pulverize, cross 100 mesh sieves, the nutrient obtained;
Etc. b. the sodium salt totally 4 grams of four kinds of 5 '-mixed nucleotides is measured, manganese sulfate 3 grams, Borax 2 grams, 4 grams of ferrous sulfate, mixed Close, pulverize, cross 100 mesh sieves, the nutrient obtained;
C. weighing 8 grams of nucleotide potassium salt, corn starch 7 grams, middle trace element 5 grams, by nucleotide potassium salt, middle trace element Pulverize, sieve, add corn starch, mix homogeneously, the nutrient obtained;
Described nucleotide potassium salt refers to: obtain after ribonucleic acid basic hydrolysis: 5'-AMP dipotassium, 5'-guanyl two Potassium, 5'-CMP dipotassium, 5 '-uridylic acid dipotassium, the potassium salt of four kinds of 5'-mixed nucleotides;
Described middle trace element refers to: Mn, B and Fe, specifically: manganese sulfate, Borax and ferrous sulfate;
The application process of described nutrient is: spray with after water dissolution;
The opportunity of using of described nutrient and concentration is: for the first time for seedling stage or germination period, in April, uses c nutrient, converts 20 liters of water, uniformly sprays on one mu of Flos Chrysanthemi;
Second time is initial bloom stage, uses a nutrient, is watered 20 liters, uniformly sprays on one mu of Flos Chrysanthemi;
Third time is full-bloom stage b nutrient, is watered 20 liters, uniformly sprays on one mu of Flos Chrysanthemi.
Promoting the nutrient of flos traditional Chinese medicine material growth, it is made up of nucleoside hydrochlorate, middle trace element, does not comprise glucose Or/and aminoacid, percentage by weight is: nucleoside hydrochlorate 30-70%, middle trace element 30-70%, and described nucleoside hydrochlorate refers to: Obtain after ribonucleic acid basic hydrolysis: 5'-AMP dipotassium or sodium, 5'-bird adenylic acid dipotassium or sodium, 5'-CMP dipotassium or Sodium, the potassium of 5 '-uridylic acid dipotassium or sodium four kind 5 '-mixed nucleotides or sodium salt, described middle trace element refers to: Mn, B and Fe, specifically: manganese sulfate, Borax and ferrous sulfate.
Promoting the nutrient of flos traditional Chinese medicine material growth, optimization formula percentage by weight is: nucleoside hydrochlorate 40-60%, in Trace element 30-70%.
Promoting the nutrient of flos traditional Chinese medicine material growth, the weight ratio of middle trace element is: Mn:B:Fe=3:2:4.
Promoting the nutrient of flos traditional Chinese medicine material growth, it also includes filler: starch, dextrin, cellulose, polyvidone, hard One or more of fatty acid magnesium, calcium sulfate or magnesium sulfate.
Promoting the nutrient of flos traditional Chinese medicine material growth, nucleoside hydrochlorate, middle trace element with the percentage by weight of filler are : nucleoside hydrochlorate 10-30 %, middle trace element 10-30%, filler 40-80%.
Promoting the nutrient of flos traditional Chinese medicine material growth, filler is: corn starch, dextrin, cellulose, magnesium stearate, sulfur Acid magnesium or one or more of zinc sulfate, nucleoside hydrochlorate, trace element with the percentage by weight of filler be: nucleoside hydrochlorate 15-20%, middle trace element 15-20%, filler 40-70%.
Promoting the preparation method of the nutrient of flos traditional Chinese medicine material growth, it is made up of, no nucleoside hydrochlorate, middle trace element Comprising glucose or/and aminoacid, percentage by weight is: nucleoside hydrochlorate 30-70%, middle trace element 30-70%, described core Thuja acid salt refers to: obtain after ribonucleic acid basic hydrolysis: 5'-AMP dipotassium or sodium, 5'-bird adenylic acid dipotassium or sodium, 5 ' -cytidylic acid dipotassium or sodium, the potassium of 5 '-uridylic acid dipotassium or sodium four kind 5 '-mixed nucleotides or sodium salt, described middle trace unit Element refers to: Mn, B and Fe, specifically: manganese sulfate, Borax and ferrous sulfate, by nucleoside hydrochlorate, the mixing of middle trace element, powder Broken, cross 50-200 mesh sieve.
Promoting the preparation method of the nutrient of flos traditional Chinese medicine material growth, optimization formula percentage by weight is: nucleoside hydrochlorate 40-60%, middle trace element 30-70%.
Promoting the preparation method of the nutrient of flos traditional Chinese medicine material growth, the weight ratio of middle trace element is: Mn:B:Fe=3: 2:4.
Promoting the preparation method of nutrient of flos traditional Chinese medicine material growth, it also includes filler: starch, dextrin, fiber One or more of element, polyvidone, magnesium stearate, calcium sulfate or magnesium sulfate.
Promote the preparation method of the nutrient of flos traditional Chinese medicine material growth, nucleoside hydrochlorate, middle trace element and filler Percentage by weight is: nucleoside hydrochlorate 10-30 %, middle trace element 10-30%, filler 40-80%.
Promoting the preparation method of nutrient of flos traditional Chinese medicine material growth, filler is: corn starch, dextrin, cellulose, One or more of magnesium stearate, magnesium sulfate or zinc sulfate, nucleoside hydrochlorate, trace element with the percentage by weight of filler are : nucleoside hydrochlorate 15-20%, middle trace element 15-20%, filler 40-70%.
The production method of flos traditional Chinese medicine, uses nutrient: described nutrient is mainly by nucleotide in its growth course Salt, middle trace element form, and do not comprise glucose or/and aminoacid, and percentage by weight is: nucleoside hydrochlorate 30-70%, middle trace Element 30-70%, described nucleoside hydrochlorate refers to: obtain after ribonucleic acid basic hydrolysis: 5'-AMP dipotassium or sodium, 5 '- Bird adenylic acid dipotassium or sodium, 5'-CMP dipotassium or sodium, uridine 5'-monophosphate dipotassium or the potassium of four kinds of 5'-mixed nucleotides of sodium or Sodium salt, described middle trace element refers to: Mn, B and Fe, specifically: manganese sulfate, Borax and ferrous sulfate, executing of described nutrient By method it is: spray with after water dissolution.
The production method of flos traditional Chinese medicine, is 100-400ppm by the concentration sprayed after water dissolution.
The production method of flos traditional Chinese medicine, the weight ratio of middle trace element is: Mn:B:Fe=3:2:4.
The production method of flos traditional Chinese medicine, it also includes filler: starch, dextrin, cellulose, polyvidone, magnesium stearate, One or more of calcium sulfate or magnesium sulfate, the percentage by weight of nutrient compositions is: nucleoside hydrochlorate 10-30 %, middle trace Element 10-30%, filler 40-80%.
The production method of flos traditional Chinese medicine, the opportunity of using of described nutrient is: in seedling stage or the germination of flos traditional Chinese medicine material Phase, bud stage or/and initial bloom stage, full-bloom stage the most once.
The production method of flos traditional Chinese medicine, the opportunity of using of described nutrient is: flos traditional Chinese medicine material bud stage or/and Initial bloom stage, full-bloom stage are the most once.
The production method of flos traditional Chinese medicine, the consumption of described nutrient is every mu 2-8 gram, is every mu by water-soluble water consumption 20-40 liter.
The production method of flos traditional Chinese medicine, its feature is being: the consumption of described nutrient is each every mu 15-30 gram, uses water The water consumption dissolved is each every mu of 20-40 liter.
Stating the production method of flos traditional Chinese medicine, its feature is being: the flos traditional Chinese medicine material flower of results is big and uniform, and the uniformity can Reaching 70-90%, high by 19% than produced in conventional processes of its yield, its Contents of Main Components, will than the high 7-11% of produced in conventional processes The Chinese crude drug of results can make high-quality decoction pieces or effective component extracting yield 7-10% higher than the Chinese crude drug of produced in conventional processes.
Filler of the present invention: starch refers to: green starch, potato starch, wheaten starch, sweet potato starch, Semen Maydis Starch, water caltrop starch, Lotus Root Starch, Corm Eleocharitis starch etc., preferably corn starch.Dextrin refers to: white dextrin, yellow starch gum and Britain Glue, cyclodextrin.Cellulose refers to: methylcellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose etc..
In the preparation of nutrient provided by the present invention, with nucleic acid as raw material: one is with commercially available nucleic acid as raw material, two Be the nucleic acid that the mycelium after fermentation plant ferments uses dry or wet to produce be raw material: 1., the hydrolysis of nucleic acid is according to core Acid, aqueous alkali weight ratio are the ratio mixed nucleus bronsted lowry acids and bases bronsted lowry liquid of 1:20 30, and alkali liquor is 5.5 7N, under the conditions of 30-45 DEG C, stirs Mixing 10 14 hours, obtain nucleoside hydrochlorate and deoxynucleoside acid salt solution, filter, filtrate adjusts pH8 8.5, concentrating under reduced pressure;
2., decolour, be dried: concentrated solution is added activated carbon decolorizing, sucking filtration it, filtrate reduced in volume is to aqueous 10-25%;
3., crystallization: dissolving the nucleoside hydrochlorate after doing and deoxynucleoside hydrochlorate with clear water, its solution adds ethanol and separates out, will knot Brilliant sucking filtration is dried, and obtains white core thuja acid salt and deoxynucleoside hydrochlorate (the mycelium employing dry method or wet after fermentation plant ferments Method produce nucleic acid be raw material possibly together with water soluble mixt i.e. impurity);
4., middle trace element is taken;
, by nucleoside hydrochlorate trace element mixing, pulverize, sieve.
During nucleic acid hydrolysis described in this preparation method, alkali liquor used is sodium hydroxide or potassium hydroxide solution.
With commercially available nucleic acid as raw material, impure few after hydrolysis.
Three is commercially available: nucleoside hydrochlorate is primarily referred to as: 5 '-adenylic acid disodium or potassium, 5 '-bird adenylic acid disodium or potassium, 5 ' -cytidylic acid disodium or potassium, 5 '-uridine monophosphate disodium or the sodium salt of four kinds of 5 '-mixed nucleotides of potassium or potassium salt;Deoxynucleoside Hydrochlorate refers to: 5 '-deoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid disodium or potassium, 5 '-dCMP 1beta-Deoxyribofuranosylcytosine-5'-phosphate two Sodium or potassium, 5 '-BrdU acid disodium, 5 '-deoxyribosylthymine acid disodium or five kinds of 5 '-deoxidation mixed nucleotides of potassium Sodium salt or potassium salt.
The source of nucleoside hydrochlorate and deoxynucleoside hydrochlorate is with nucleic acid as raw material, is the bacterium after fermentation plant ferments The nucleic acid that filament uses dry or wet to produce is raw material, and this kind of nucleic acid is a small amount of the taking off of main mixing with ribonucleic acid (RNA) Oxygen ribonucleic acid (DNA), makes with alkali liquor hydrolysis.
Beneficial effects of the present invention:
Owing to the present invention decreases compositions active component, so more economizing in raw materials and becoming without glucose, aminoacid This.
Coordinate nucleoside hydrochlorate, reasonable mixture ratio owing to the present invention contains middle trace element, promote more targeted specifically in tubers The growth of medicine.
Although the present invention decreases active component, its effect does not the most subtract and even produces more preferable effect.
The present invention is particularly without glucose, and glucose easily absorbs moisture deliquescence, and the nutrient containing glucose is typically Place the deliquescence that the most i.e. absorbs water under condition of storage, occur that product lumps, make nucleoside hydrochlorate, cause product quality to reduce and even lose Effect, so, the present invention solves the problem being difficult to long term storage of nutrient.
Owing to present invention additionally comprises filler: starch, dextrin, cellulose, polyvidone, magnesium stearate, calcium sulfate or sulphuric acid One or more of magnesium etc., the addition of filler has adapted to be not less than 20 grams generally as the foliage fertilizer minimum package of merchandise sales Pertinent regulations;Filler starch, dextrin, cellulose etc. are also equipped with certain viscosity, make nutrient be attached to blade face after spraying Longer with the plant surface time so that it is action effect is more preferable;Filler polyvidone, magnesium stearate, calcium sulfate or magnesium sulfate etc. have There are dispersibility and lubricity, it is possible to extend the shelf-life of nutrient.
The purposes of the present invention is: promoting especially as foliage fertilizer or nutrient or plant growth regulator as fertilizer Application in the growth of flos traditional Chinese medicine;Or the production being applied to flos traditional Chinese medicine can improve its Yield and quality, quality, enhancing resist Property, the uniformity, reduce nuisance content, cost-effective, increase income, potentiation.
The present invention is applied to the production of flos traditional Chinese medicine, with strong points, it is possible to increase its Yield and quality, quality, enhancing resist Property, the uniformity, reduce nuisance content, cost-effective, increase income, potentiation.
So product of the present invention: saving, environmental protection (nontoxic, harmless, noresidue, without any adverse side effect), to flower apoplexy due to endogenous wind The purposes of medicine is comprehensive, increases production, increases income, potentiation, strengthens resistance, improves quality effective.
The present invention and No. 201010514231.6 patents, traditional product and method contrast table 1
The present invention and No. 201010514231.6 patents, traditional product and method contrast table 2
Concrete crop is implemented to spray effect part effect and is shown in Table 3 by the present invention
Note: content's index detection method is carried out with reference to national standard or industry standard, content is pressed dry product and is calculated
Detailed description of the invention:
Embodiment 1: waiting the potassium salt totally 4 grams measuring four kinds of 5 '-mixed nucleotides, manganese sulfate 3 grams, Borax 2 grams, sulphuric acid is sub- Ferrum 4 grams, mixes, pulverizes, and crosses 100 mesh sieves.
Embodiment 2: waiting the sodium salt totally 4 grams measuring four kinds of 5 '-mixed nucleotides, manganese sulfate 3 grams, Borax 2 grams, sulphuric acid is sub- Ferrum 4 grams, mixes, pulverizes, and crosses 100 mesh sieves.
Embodiment 3: weighing 8 grams of nucleotide potassium salt, corn starch 7 grams, middle trace element 5 grams, by nucleoside hydrochlorate, middle trace Element is pulverized, and sieves, and adds corn starch, mix homogeneously, obtains nutrient.
Embodiment 4: Flos Chrysanthemi: be seedling stage (germination period) for the first time, in April, with 20 grams of nutrients, be watered 20 liters, uniformly spray Execute on one mu of Flos Chrysanthemi;Second time is initial bloom stage embodiment 1 nutrient, is watered 20 liters, uniformly sprays on one mu of Flos Chrysanthemi;3rd Secondary full-bloom stage embodiment 2 nutrient, is watered 20 liters, uniformly sprays on one mu of Flos Chrysanthemi, it is possible to volume increase 19%, the Flos Chrysanthemi of results Flower is big and uniform, and the uniformity is up to 70-90%, and high by 19% than produced in conventional processes of its yield, its Contents of Main Components is than passing The high 7-11% that system method produces.
Embodiment 5: Flos Lonicerae, seedling stage (germination period), alabastrum initial stage, respectively by embodiment 1,2,3, be watered 30 kilograms, respectively spray Once, it is possible to volume increase 22%.
Embodiment 6: the flos traditional Chinese medicine material of results can be made high-quality decoction pieces or effective component extracting yield than tradition side The flos traditional Chinese medicine material height 7-10% that method produces.

Claims (1)

1. the production method of flos traditional Chinese medicine, is characterized in that: described flos traditional Chinese medicine material refers to Flos Chrysanthemi;Battalion is used in its growth course Support element: described nutrient is: a. etc. measure the potassium salt totally 4 grams of four kinds of 5 '-mixed nucleotides, manganese sulfate 3 grams, Borax 2 grams, sulphuric acid Ferrous 4 grams, mix, pulverize, cross 100 mesh sieves, the nutrient obtained;
Etc. b. the sodium salt totally 4 grams of four kinds of 5 '-mixed nucleotides is measured, manganese sulfate 3 grams, Borax 2 grams, 4 grams of ferrous sulfate, mixing, Pulverize, cross 100 mesh sieves, the nutrient obtained;
C. weighing 8 grams of nucleotide potassium salt, corn starch 7 grams, middle trace element 5 grams, by nucleotide potassium salt, middle microelement powder Broken, sieve, add corn starch, mix homogeneously, the nutrient obtained;
Described nucleotide potassium salt refers to: obtain after ribonucleic acid basic hydrolysis: 5'-AMP dipotassium, 5'-guanyl dipotassium, 5'-CMP dipotassium, 5 '-uridylic acid dipotassium, the potassium salt of four kinds of 5'-mixed nucleotides;
Described middle trace element refers to: Mn, B and Fe, specifically: manganese sulfate, Borax and ferrous sulfate;
The application process of described nutrient is: spray with after water dissolution;
The opportunity of using of described nutrient and concentration is: for the first time for seedling stage or germination period, in April, uses c nutrient, is watered 20 Rise, uniformly spray on one mu of Flos Chrysanthemi;
Second time is initial bloom stage, uses a nutrient, is watered 20 liters, uniformly sprays on one mu of Flos Chrysanthemi;
Third time is full-bloom stage b nutrient, is watered 20 liters, uniformly sprays on one mu of Flos Chrysanthemi.
CN201310579846.0A 2013-11-19 2013-11-19 The production method of flos traditional Chinese medicine Active CN103613424B (en)

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CN201510403215.2A CN105030870A (en) 2013-11-19 2013-11-19 Preparation method of chrysanthemum flower decoction pieces
CN201510399796.7A CN104997830A (en) 2013-11-19 2013-11-19 Production method of flower type traditional Chinese medicinal decoction pieces
CN201510383096.9A CN104973910A (en) 2013-11-19 2013-11-19 Production method for flower traditional Chinese medicine
CN201510399793.3A CN105036848A (en) 2013-11-19 2013-11-19 Honeysuckle flower extract production method
CN201310579846.0A CN103613424B (en) 2013-11-19 2013-11-19 The production method of flos traditional Chinese medicine

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CN201510383096.9A Division CN104973910A (en) 2013-11-19 2013-11-19 Production method for flower traditional Chinese medicine
CN201510399793.3A Division CN105036848A (en) 2013-11-19 2013-11-19 Honeysuckle flower extract production method
CN201510399796.7A Division CN104997830A (en) 2013-11-19 2013-11-19 Production method of flower type traditional Chinese medicinal decoction pieces
CN201510403215.2A Division CN105030870A (en) 2013-11-19 2013-11-19 Preparation method of chrysanthemum flower decoction pieces

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CN201510399793.3A Withdrawn CN105036848A (en) 2013-11-19 2013-11-19 Honeysuckle flower extract production method
CN201510383096.9A Withdrawn CN104973910A (en) 2013-11-19 2013-11-19 Production method for flower traditional Chinese medicine
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CN107823238A (en) * 2017-11-20 2018-03-23 安徽佳凯药业股份有限公司 A kind of production method of flos traditional Chinese medicine medicine materical crude slice

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CN102079666B (en) * 2010-10-21 2013-06-12 高旌 Nutrient for promoting growth of flower Chinese medicinal material
CN103288508A (en) * 2010-10-21 2013-09-11 高旌 Preparation method of nutrient for promoting growth of flower Chinese medicinal materials
CN103314690A (en) * 2010-10-21 2013-09-25 高旌 High-quality high-yield flower-type traditional Chinese medicinal material production method

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CN103113166B (en) * 2010-10-21 2014-07-23 合肥市济泉医药科技有限公司 Production method with good quality and high yield for medicinal plants trichosanthes kirilowii maxim and radices trichosanthis
CN103141201B (en) * 2010-10-21 2014-07-23 合肥市济泉医药科技有限公司 Good-quality and high-yield production method of fruit and seed medicinal plants

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CN102079666B (en) * 2010-10-21 2013-06-12 高旌 Nutrient for promoting growth of flower Chinese medicinal material
CN103288508A (en) * 2010-10-21 2013-09-11 高旌 Preparation method of nutrient for promoting growth of flower Chinese medicinal materials
CN103314690A (en) * 2010-10-21 2013-09-25 高旌 High-quality high-yield flower-type traditional Chinese medicinal material production method

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