CN103610737B - It pearl lactogenesis medicine - Google Patents
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Abstract
The present invention relates to a kind of Chinese medicine preparation, i.e. sky pearl lactogenesis medicine.Be made up of following crude drug: Radix Astragali Preparata 240-360 part, Radix Angelicae Sinensis 240-360 part, Rhizoma Atractylodis Macrocephalae (parched) 240-360 part, Radix Trichosanthis 240-360 part, Radix Rhapontici 240-360 part, vinegar Squama Manis (processed) 240-360 part, Fructus Liquidambaris 240-360 part, Semen Vaccariae (parched) 240-360 part, Medulla Tetrapanacis 80-120 part, Retinervus Luffae Fructus 160-240 part.Function cures mainly: benefiting QI and nourishing blood, active lactogenesis.Usage and dosage: for granule, each 1 bag, every bag of 10g, every day 3 times, boiled water is taken after mixing it with water, and within 5 days, is 1 course for the treatment of.For the auxiliary treatment of agalactosis caused by puerperal deficiency of vital energy blood deficiency.Observing after 150 routine patient consumes through clinical, is 98.24% to " hypogalactia " patient effective percentage; Be 91.66% to " agalactia " patient effective percentage, its total effective rate is 96.67%.This medicine can raise Hb, RBC in blood, has benefiting QI and nourishing blood, the effect of stimulating milk secretion of stimulating the menstrual flow.This medicine is to liver, and kidney is harmless.
Description
technical field
The present invention relates to a kind of Chinese medicine preparation, i.e. sky pearl lactogenesis medicine.It pearl is the abbreviation of Radix Trichosanthis, Squama Manis raw material.Trade name: sky pearl lactogenesis granule.There is good galgctogogue action.
Background technology
In the prior art, breast milk is the best wholefood of baby, and it changes its secretory volume and composition with the growth promoter of baby.The few matter of colostrum amount is thick, containing a large amount of protein, and fatsoluble vitamin, immunoglobulin.Ripe breast is the Main Foods of baby, and every day, secretory volume was about about 800ml, and the content of fat and lactic acid is higher, also has macrophage, immunocyte, the infection factors such as molten mattress enzyme, breast milk be Lac Bovis seu Bubali and other all milk replacers incomparable, be applicable to very much the growth promoter of baby.Motherland's Chinese medicine is thought, and " The spleen and stomach provide the material basis of the acquired, source of generating QI and blood." so milk be QI and blood life.As Xue Li vegetarian cloud: " blood person essence-QI from water and grain also, then turns to essence man, married woman is milk, and lower is arteries and veins." the strong fortune of taste, QI and blood is sufficient, and QI movement being in harmonious way is the condition keeping normal lactation.Current lactogenesis medicament categories is various, and curative effect is different.
Summary of the invention
The object of the invention is for above-mentioned situation and a kind of invigorating QI and blood, dredging collateral for promoting lactation are provided, there is the sky pearl lactogenesis medicine of good galgctogogue action.
Technical solution of the present invention is: sky pearl lactogenesis medicine, its effective medicinal components is made up of the crude drug of following parts by weight: Radix Astragali Preparata 240-360 part, Radix Angelicae Sinensis 240-360 part, Rhizoma Atractylodis Macrocephalae (parched) 240-360 part, Radix Trichosanthis 240-360 part, Radix Rhapontici 240-360 part, vinegar Squama Manis (processed) 240-360 part, Fructus Liquidambaris 240-360 part, Semen Vaccariae (parched) 240-360 part, Medulla Tetrapanacis 80-120 part, Retinervus Luffae Fructus 160-240 part.
Radix Astragali Preparata, Rhizoma Atractylodis Macrocephalae (parched), vinegar Squama Manis (processed), Semen Vaccariae (parched) adopt in pharmacopeia or routine fashion.
Preferred sky pearl lactogenesis medicine, its effective medicinal components is made up of the crude drug of following parts by weight: Radix Astragali Preparata 300 parts, Radix Angelicae Sinensis 300 parts, Rhizoma Atractylodis Macrocephalae (parched) 300 parts, Radix Trichosanthis 300 parts, Radix Rhapontici 300 parts, vinegar Squama Manis (processed) 300 parts, Medulla Tetrapanacis 100 parts, Retinervus Luffae Fructus 200 parts, Fructus Liquidambaris 300 parts, Semen Vaccariae (parched) 300 parts.
It pearl lactogenesis medicine, its effective medicinal components makes granule by the crude drug of following weight grams: Radix Astragali Preparata 300g, Radix Angelicae Sinensis 300g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Trichosanthis 300g, Radix Rhapontici 300g, vinegar Squama Manis (processed) 300g, Medulla Tetrapanacis 100g, Retinervus Luffae Fructus 200g, Fructus Liquidambaris 300g, Semen Vaccariae (parched) 300g.
The preparation method of it pearl lactogenesis medicine, its step is as follows:
(1) get Radix Angelicae Sinensis 110g and become fine powder with Rhizoma Atractylodis Macrocephalae 110g powder; Remain the effective ingredient of medicine to greatest extent, fine powder can substitute the common excipients such as dextrin, starch as the excipient of granule again
.
(2) get remaining Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici and put extracting in water volatile oil in extraction pot (, all containing volatile oil, volatile oil is active substance for Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici), the another device of volatile oil is preserved, decocting liquid filters, filtrate reduced in volume to relative density is 1.20-1.25,50 DEG C of surveys, and extractum is for subsequent use;
(3) all the other seven flavor medicine material and the Radix Angelicae Sinensis such as the Radix Astragali are got, the Rhizoma Atractylodis Macrocephalae, Radix Rhapontici medicinal residues (can extract the active substance except volatile oil) decoct with water three times, first time adds 8 times amount, decoct 2 hours, second, respectively add water 6 times amount for the third time, each decoction 1 hour, gradation filters, merging filtrate, being evaporated to relative density is 1.20-1.25, 50 DEG C of surveys, merge with step (2) extractum, add ethanol (95% concentration of alcohol) triplication, stir, placement is spent the night, filter, decompression filtrate recycling ethanol, concentrated, dry, be ground into fine powder and ratio is the Radix Angelicae Sinensis of 1:1.5:5, Rhizoma Atractylodis Macrocephalae fine powder and sucrose mix homogeneously, granulate, dry, granulate,
(4) be sprayed on by the volatile oil in step (2) (for avoiding volatile oil to granulate in early stage, dry, to lose, be therefore in the end sprayed in granule in granulate process) in granule, airtight 2 hours subpackages, make 1000g, obtain lactogenesis granule.
Pharmaceutical dosage form is not limited thereto, by pharmaceutical carrier conventional in above-mentioned each medicinal raw material and pharmacy, as excipient or adjuvant can be mixed and made into tablet, capsule, powder, pill, liquid preparation or other conventional formulation.
Fang Zhong: monarch drug selects Qi-tonifying drug Radix Astragali Preparata, replenishing vital QI with drugs of warm nature taste, the spleen being the foundation of acquired constitution, source of generating QI and blood, with this strong Central Region, sending up the lucid YANG, cloth are precise and tiny, and support internal organs, essentials of Matea Medica is said: " processing with invigorating middle warmer, beneficial vigour, Wen Sanjiao; strong taste, hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea ".Chinese angelica blood supplementing is invigorated blood circulation, and adjusts smart pain relieving, and to for commonly using key medicine puerperal before gynecological's tire, essentials of Matea Medica is said: " stasis can be led to, and blood deficiency can be mended, and blood depletion can be moistened, and blood disorderly can be comforted ", and must join the Radix Astragali is that tradition is enriched blood recipe " Chinese angelica blood supplementing ", with plentiful newborn source.Minister Rhizoma Atractylodis Macrocephalae invigorating the spleen and regulating the stomach, dehumidifying disappears painful abdominal mass, and " book on Chinese herbal medicine is looked for the truth " is said: " be good for food to disappear public affairs, for spleen QI invigorating first key medicine also ".Radix Trichosanthis clearing away heat and promoting production of body fluid, nourishing YIN to relieve dryness, " herbal classic " is said: " tonify deficiency regulating the spleen and stomach, continuous wound absolutely ".The Radix Astragali assisted by two medicines, and Radix Angelicae Sinensis nourishes QI and blood hypertrophy milk.Assistant is enriched blood capable stagnant with Radix Rhapontici, Compendium of Material Medica is said: " Radix Rhapontici, lower milk "; Medulla Tetrapanacis ventilation row arteries and veins, " Japan hanako materia medica " is said: " Medulla Tetrapanacis, stimulating milk secretion "; Retinervus Luffae Fructus is sweet light gentle, suitable the meridian dredging; Fructus Liquidambaris promoting the circulation of QI to alleviate the stagnation in middle-JIAO promoting blood circulation to remove obstruction in the collateral, four compatibilities, by means of the property of its tonneau, can go the retardance of loose liver (nipple be Liver Channel belonging to) stomach (breast is that stomach is through affiliated) meridians, and gaseous pulse Yong Sai galactozemia and meridians are stagnated, distending pain of the breast, stay and store evil poison, or carbuncle person, make it to dissipate.Make with big gun Squama Manis, Semen Vaccariae, the special tonneau of merit, walks and does not keep, and logical hundred arteries and veins of a surname, walk help medicine gesture, has the proverb of " river Squama Manis, Wang Buliu, married woman has taken newborn permanent current ".Ten medicine contracts, have effect of invigorating QI and blood dredging collateral for promoting lactation.
Character: for granule, this product is the granule of brown color; Feeble QI is bitter, sweet, the micro-hardship of taste.
Function cures mainly: benefiting QI and nourishing blood, active lactogenesis.
Usage and dosage: for granule, each 1 bag, every bag of 10g, every day 3 times, boiled water is taken after mixing it with water, and within 5 days, is 1 course for the treatment of.For the auxiliary treatment of agalactosis caused by puerperal deficiency of vital energy blood deficiency.Be suitable for " hypogalactia ", " agalactia " puerpera.
Advantage of the present invention is: 1, reasonable recipe, and curative effect is reliable, does not find any toxic and side effects and untoward reaction, have good galgctogogue action during observing medication.2, observing after 150 routine patient consumes through clinical, is 98.24% to " hypogalactia " patient effective percentage; Be 91.66% to " agalactia " patient effective percentage, its total effective rate is 96.67%.3, this medicine can raise Hb, RBC in blood, has benefiting QI and nourishing blood, the effect of stimulating milk secretion of stimulating the menstrual flow.4, this medicine is to liver, and kidney is harmless.
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.Above or following description, just the specific embodiment of the present invention, various illustrating is not construed as limiting flesh and blood of the present invention.
Detailed description of the invention
Embodiment 1
It pearl lactogenesis granule: prescription: Radix Astragali Preparata 300g, Radix Angelicae Sinensis 300g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 300g, Radix Trichosanthis 300g, Radix Rhapontici 300g, Squama Manis (vinegar system) 300g, Medulla Tetrapanacis 100g, Retinervus Luffae Fructus 200g, Fructus Liquidambaris 300g, Semen Vaccariae (stir-fry) 300g.
Embodiment 2
It pearl lactogenesis particle recipe: above ten tastes, gets Radix Angelicae Sinensis 110g and becomes fine powder with Rhizoma Atractylodis Macrocephalae 110g powder, get remaining Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici and put extracting in water volatile oil in extraction pot, the another device of volatile oil is preserved, and decocting liquid filters, and filtrate reduced in volume to relative density is 1.20-1.25 (50 DEG C of survey), for subsequent use, separately get all the other seven flavor medicine material and the Radix Angelicae Sinensis such as the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Rhapontici medicinal residues decoct with water three times, first time adds 8 times amount, decoct 2 hours, second, add water 6 times amount for the third time, each decoction 1 hour, gradation filters, merging filtrate, being evaporated to relative density is 1.20-1.25 (50 DEG C of surveys), merge with extractum such as above-mentioned Radix Angelicae Sinensis, add ethanol triplication, stir, placement is spent the night, filter, decompression filtrate recycling ethanol, concentrated, dry, be ground into fine powder and Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae fine powder and sucrose (1:1.5:5) mix homogeneously, granulate, dry, granulate, the volatile oil such as Radix Angelicae Sinensis are sprayed in granule, airtight 2 hours, subpackage, make 1000g, both.
By this technique, the regular dosage form such as tablet, capsule can also be made.
Experimental example
It pearl lactogenesis granule " control " hypogalactia ", " agalactia " 150 routine clinical report
" sky pearl lactogenesis granule " is a kind of health care medicinal of control women puerperal " hypogalactia ", " agalactia ".Along with the reach of science, people recognize that breast milk is the optimal wholefood of baby, and breast feeding, direct rooming-in are advocated by current WHO, develop this medicine and have realistic meaning.In order to verify the clinical efficacy of this medicine, at Changchun Traditional Chinese Medical College's department of obstetrics and gynecology that Department of Public Health of Jilin Province specifies, Changchun hospital for obstetrics and gynaecology, spring city, Changchun gynecological of hospital carries out clinical work, now result is summarized as follows.
One, physical data
1, sex and the age
In 150 routine observers, be all young primipara, the age was 20 ~ 24 years old person 68 example; Age was 25 ~ 30 years old person 70 example; More than 30 years old person 12 examples; Wherein age reckling 20 years old, 40 years old mean age of the maximum is 25.98 years old.
2, occupation and the course of disease
In 150 routine observers, cadre 16 example; Workman 34 example; Peasant 27 example; Intellectual 13 example; Other is 60 examples at loose ends.The shortest person 2 days in the course of disease, most elder 60 days, average course of disease is 9.28 days.
3, symptom classifying
In 150 routine observers, examine as " hypogalactia " person 114 example; " agalactia " person 36 example.Dialectical genus asthenia of qi and blood weak person 102 example; Irritability stasis person 48 example.
Two, observational technique
1, case selection
The milk amount that all puerperal discharges is few, even completely without, inadequate feeding infant person, the traditional Chinese medical science can be examined as " hypogalactia ", " agalactia ".The outpatient service or the inpatient that meet diagnosis all can be used as this product object of observation.
2, administrated method
Give experimenter to take " sky pearl lactogenesis granule ", each 1 bag, every day 3 times, warm boiled water 5 days is 1 course for the treatment of.(for guaranteeing the accuracy of medication effect, during medication, forbidding other galactopoietic).
3, curative effect determinate standard
Effective: to produce the comparatively front showed increased of breast milk after medication, neonate substantially can be made to have enough; Or supplementary milk is no more than 50ml every day, other symptom is not clearly better person yet.
Effective: to produce breast milk juice after medication and increase, every day supplements milk to neonate and is no more than 100ml, other symptom improvement person.
Invalid: produce breast milk juice after medication without increase, other symptom is not improved, or comparatively before adds severe one.
Three, observed result
1, the total effectively situation of 150 example application " sky pearl lactogenesis granule " lactogenic, in table 1.
Table 1 " sky pearl lactogenesis granule " 150 routine lactogenic total effectses
After taking medicine in 150 routine observers as seen from the table, " hypogalactia " effective percentage is 98.24%; " agalactia " effective percentage is 91.66%, and its total effective rate is 96.67%.Through statistical procedures P>o.05, illustrate that this medicine is to there was no significant difference in " hypogalactia ", " agalactia " control, all effectively.
2, the impact on routine blood test before and after " sky pearl lactogenesis granule " medication, in table 2.
Before and after table 2 " sky pearl lactogenesis granule " medication, routine blood test is affected
All have before Hb, RBC, WBC and medicine in routine blood test after visible " sky pearl lactogenesis granule " medication in table 2
Significant difference, this medicine can raise Hb, RBC in blood as seen, has QI invigorating nourishing blood function.
3, " sky pearl lactogenesis granule " is on the impact of observer's routine urinalysis and liver function.
By comparing before and after the medication of part observer liver function, and contrast before and after routine urinalysis medication, we find all to change without obvious liver function and routine urinalysis before and after this medicinal medicine, and illustrate that this medicine is to liver, kidney is harmless.
4, before and after " sky pearl lactogenesis granule " 150 routine observer's medications, situation is improved, in table 3 to symptom.
Before and after the routine observer's medication of table 3150, symptom improves situation
In table 3, visible " sky pearl lactogenesis granule " improves through statistics Ridit analytic process P<O.01 cardinal symptom before and after taking medicine, and illustrates that this medicine has significant differences to before and after cardinal symptom medication.
Brief summary and discussion:
Breast milk is the best wholefood of baby, and it changes its secretory volume and composition with the growth promoter of baby.The few matter of colostrum amount is thick, containing a large amount of protein, and fatsoluble vitamin, immunoglobulin.Ripe breast is the Main Foods of baby, and every day, secretory volume was about about 800ml, and the content of fat and lactic acid is higher, also has macrophage, immunocyte, the infection factors such as molten mattress enzyme, breast milk be Lac Bovis seu Bubali and other all milk replacers incomparable, be applicable to very much the growth promoter of baby.Motherland's Chinese medicine is thought, and " The spleen and stomach provide the material basis of the acquired, source of generating QI and blood." so milk be QI and blood life.As Xue Li vegetarian cloud: " blood person essence-QI from water and grain also, then turns to essence man, married woman is milk, and lower is arteries and veins." the strong fortune of taste, QI and blood is sufficient, and QI movement being in harmonious way is the condition keeping normal lactation, and " sky pearl lactogenesis granule " with Squama Manis, Radix Rhapontici etc. are principal agent, have benefiting QI and nourishing blood, the effect of stimulating milk secretion of stimulating the menstrual flow, galactopoietic of can yet be regarded as top grade.After normal pregnancies childbirth, Estrogen and progestin level declines, prolactin level rises, occur oozing newborn phenomenon, but this medicine preclinical pharmacology, toxicologic study result show, this medicine has the secretion strengthening pituitary prolactin, promote the effect of galactopoiesis, long-term excess takes the hemogram to rat, liver, and kidney merit is harmless, illustrate that this product is good effect, the galactopoietic that safety can take for a long time.
We can make as drawn a conclusion by 150 routine clinical observations, " sky pearl lactogenesis granule " truly has good galgctogogue action, its total effective rate is 96.67%, rising trend is all had to Hb, RBc in routine blood test after medication, prompting this product has benefiting QI and nourishing blood, the effect of enriching blood, well improves disappearance obviously to cardinal symptom." sky pearl lactogenesis granule " has benefiting QI and nourishing blood, the effect of stimulating milk secretion of stimulating the menstrual flow as can be seen here, and observes during medication and do not find any toxic and side effects and untoward reaction, determines it is the best good medicine of lactogenic both at home and abroad at present.
Claims (4)
1. a sky pearl lactogenesis medicine, it is characterized in that its effective medicinal components is made up of the crude drug of following parts by weight: Radix Astragali Preparata 240-360 part, Radix Angelicae Sinensis 240-360 part, Rhizoma Atractylodis Macrocephalae (parched) 240-360 part, Radix Trichosanthis 240-360 part, Radix Rhapontici 240-360 part, vinegar Squama Manis (processed) 240-360 part, Fructus Liquidambaris 240-360 part, Semen Vaccariae (parched) 240-360 part, Medulla Tetrapanacis 80-120 part, Retinervus Luffae Fructus 160-240 part.
2. according to sky according to claim 1 pearl lactogenesis medicine, it is characterized in that its effective medicinal components is made up of the crude drug of following parts by weight: Radix Astragali Preparata 300 parts, Radix Angelicae Sinensis 300 parts, Rhizoma Atractylodis Macrocephalae (parched) 300 parts, Radix Trichosanthis 300 parts, Radix Rhapontici 300 parts, vinegar Squama Manis (processed) 300 parts, Medulla Tetrapanacis 100 parts, Retinervus Luffae Fructus 200 parts, Fructus Liquidambaris 300 parts, Semen Vaccariae (parched) 300 parts.
3. according to the sky pearl lactogenesis medicine described in claim 1 or 2, it is characterized in that its effective medicinal components makes granule by the crude drug of following weight grams: Radix Astragali Preparata 300g, Radix Angelicae Sinensis 300g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Trichosanthis 300g, Radix Rhapontici 300g, vinegar Squama Manis (processed) 300g, Medulla Tetrapanacis 100g, Retinervus Luffae Fructus 200g, Fructus Liquidambaris 300g, Semen Vaccariae (parched) 300g.
4. a preparation method for sky pearl lactogenesis medicine as claimed in claim 3, is characterized in that step is as follows:
(1) get Radix Angelicae Sinensis 110g and become fine powder with Rhizoma Atractylodis Macrocephalae 110g powder;
(2) get remaining Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici and put extracting in water volatile oil in extraction pot, the another device of volatile oil is preserved, and decocting liquid filters, and filtrate reduced in volume to relative density is 1.20-1.25,50 DEG C of surveys, and extractum is for subsequent use;
(3) get all the other seven flavor medicine materials such as the Radix Astragali and Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Rhapontici medicinal residues decoct with water three times, first time adds 8 times amount, decocts 2 hours, second, third time respectively adds water 6 times amount, each decoction 1 hour, gradation filters, merging filtrate, being evaporated to relative density is 1.20-1.25,50 DEG C of surveys, merge with step (2) extractum, add ethanol triplication, stir, placement is spent the night, and filters, decompression filtrate recycling ethanol, concentrated, dry, pulverize into Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae fine powder and the sucrose that fine powder and ratio are 1:1.5:5 to mix homogeneously, granulate, drying, granulate;
(4) be sprayed in granule by the volatile oil in step (2), airtight 2 hours, subpackage, made 1000g, to obtain final product.
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