CN103610737A - Lactation-promoting medicine containing mongolian snakegourd root and pangolin - Google Patents
Lactation-promoting medicine containing mongolian snakegourd root and pangolin Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal preparation, and in particular relates to a lactation-promoting medicine containing mongolian snakegourd root and pangolin. The medicine is prepared from the following bulk drugs in parts by weight: 240-360 parts of roasted astragalus membranaceus, 240-360 parts of Chinese angelica, 240-360 parts of fried atractylodes macrocephala koidz, 240-360 parts of mongolian snakegourd root, 240-360 parts of uniflower swisscentaury root, 240-360 parts of vinegar-processed pangolin, 240-360 parts of liquidambar formosana hance, 240-360 parts of fried cowherb seed, 80-120 parts of tetrapanax papyriferus, and 160-240 parts of loofah sponge. The medicine mainly has the effects of tonifying qi and nourishing blood, and activating collaterals and promoting lactation. The medicine, taking granules for instance, is taken 1 bag with 10g each time and 3 times a day, and is dissolved with boiled water, and 5 days are taken as a course of treatment. The medicine is used for assistant treatment of agalactosis caused by qi-blood deficiency. Clinical observation on 150 patients indicates that the effective rate to hypogalactia patients is 98.24 percent, the effective rate to agalactia patients is 91.66 percent, and the total effective rate is 96.67 percent. The medicine can increase Hb (haemoglobin) and RBC (red blood cell) in blood, has the effects of tonifying qi and nourishing blood and dredging collaterals for promoting lactation, and does not have injury to liver and kidney.
Description
technical field
The present invention relates to a kind of Chinese medicine preparation, i.e. day pearl lactogenesis medicine.It pearl is the abbreviation of Radix Trichosanthis, Squama Manis raw material.Trade name: day pearl lactogenesis granule.There is good galgctogogue action.
Background technology
In the prior art, breast milk is baby's best wholefood, and it changes its secretory volume and composition with baby's growth promoter.The few matter of colostrum amount is thick, contains a large amount of protein, fatsoluble vitamin, immunoglobulin.Ripe breast is baby's Main Foods, the about 800ml of secretory volume every day left and right, and the content of fat and lactic acid is higher, also has macrophage, immunocyte, the infection factors such as molten mattress enzyme, breast milk is that Lac Bovis seu Bubali and other all milk replacers are incomparable, is applicable to very much baby's growth promoter.Motherland's Chinese medicine thinks that " The spleen and stomach provide the material basis of the acquired, source of generating QI and blood." so milk be QI and blood life.As Xue Li vegetarian cloud: " blood person essence-QI from water and grain also, turns to essence man, is milk on married woman, and lower is arteries and veins." the strong fortune of taste, QI and blood is sufficient, and QI movement being in harmonious way is the condition that keeps normal lactation.Current lactogenesis drug kinds is various, and curative effect is different.
Summary of the invention
The object of the invention is provides a kind of invigorating QI and blood, dredging collateral for promoting lactation for above-mentioned situation, has the sky pearl lactogenesis medicine of good galgctogogue action.
Technical solution of the present invention is: day pearl lactogenesis medicine, its effective medicinal components is made by the crude drug of following parts by weight: Radix Astragali Preparata 240-360 part, Radix Angelicae Sinensis 240-360 part, Rhizoma Atractylodis Macrocephalae (parched) 240-360 part, Radix Trichosanthis 240-360 part, Radix Rhapontici 240-360 part, vinegar Squama Manis (processed) 240-360 part, Fructus Liquidambaris 240-360 part, Semen Vaccariae (parched) 240-360 part, Medulla Tetrapanacis 80-120 part, Retinervus Luffae Fructus 160-240 part.
Radix Astragali Preparata, Rhizoma Atractylodis Macrocephalae (parched), vinegar Squama Manis (processed), Semen Vaccariae (parched) adopt in pharmacopeia or routine fashion.
Preferred day pearl lactogenesis medicine, its effective medicinal components is made by the crude drug of following parts by weight: 300 parts of Radix Astragali Preparatas, 300 parts of Radix Angelicae Sinensis, 300 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 300 parts of Radix Trichosanthis, 300 parts of Radix Rhapontici, 300 parts of vinegar Squama Manis (processed), 100 parts of Medulla Tetrapanaciss, 200 parts of Retinervus Luffae Fructuss, 300 parts of Fructus Liquidambaris, 300 parts of Semen Vaccariae (parched)s.
It pearl lactogenesis medicine, its effective medicinal components is by the crude drug granulation of following weight grams: Radix Astragali Preparata 300g, Radix Angelicae Sinensis 300g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Trichosanthis 300g, Radix Rhapontici 300g, vinegar Squama Manis (processed) 300g, Medulla Tetrapanacis 100g, Retinervus Luffae Fructus 200g, Fructus Liquidambaris 300g, Semen Vaccariae (parched) 300g.
The preparation method of it pearl lactogenesis medicine, its step is as follows:
(1) get Radix Angelicae Sinensis 110g and become fine powder with Rhizoma Atractylodis Macrocephalae 110g powder; The effective ingredient that has retained to greatest extent medicine, fine powder can substitute the conventional excipient such as dextrin, starch as the excipient of granule again
.
(2) get remaining Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici and put extracting in water volatile oil in extraction pot (Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici are all containing volatile oil, and volatile oil is active substance), the another device of volatile oil is preserved, decocting liquid filters, it is 1.20-1.25 that filtrate decompression is concentrated into relative density, 50 ℃ of surveys, and extractum is standby;
(3) get all the other seven flavor medicine material and the Radix Angelicae Sinensis such as the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Rhapontici medicinal residues (can extract the active substance except volatile oil) decoct with water three times, add for the first time 8 times of amounts, decoct 2 hours, second, respectively add for the third time 6 times of amounts of water, each decocts 1 hour, gradation filters, merging filtrate, being evaporated to relative density is 1.20-1.25, 50 ℃ of surveys, merge with step (2) extractum, add ethanol (95% concentration of alcohol) triplication, stir, placement is spent the night, filter, decompression filtrate recycling ethanol, concentrated, dry, be ground into the Radix Angelicae Sinensis that fine powder and ratio are 1:1.5:5, Rhizoma Atractylodis Macrocephalae fine powder and sucrose mix homogeneously, granulate, dry, granulate,
(4) volatile oil in step (2) is sprayed in granule and (for avoiding volatile oil to granulate in early stage, is dried, in granulate process, loses, be therefore in the end sprayed in granule), airtight 2 hours subpackages, make 1000g, obtain lactogenesis granule.
Pharmaceutical dosage form is not limited to this, by pharmaceutical carrier conventional in above-mentioned each medicinal raw material and pharmacy, as excipient or adjuvant can be mixed and made into tablet, capsule, powder, pill, liquid preparation or other conventional formulation.
In side: monarch drug is selected Qi-tonifying drug Radix Astragali Preparata, replenishing vital QI with drugs of warm nature taste, the spleen being the foundation of acquired constitution, source of generating QI and blood, with this strong Central Region, sending up the lucid YANG, cloth are precise and tiny, support internal organs, < < Bencao Beiyao > > says: " processing with invigorating middle warmer beneficial vigour, warm three warmers; strong taste; hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea ".Chinese angelica blood supplementing is invigorated blood circulation, adjust smart pain relieving, Xiang Wei gynecological tire conventional key medicine in front puerperal, < < Bencao Beiyao > > says: " stasis can be led to; blood deficiency can be mended, and blood depletion can be moistened, and blood disorderly can be comforted ", must join the Radix Astragali and be the tradition recipe " Chinese angelica blood supplementing " of enriching blood, with plentiful newborn source.Minister Rhizoma Atractylodis Macrocephalae invigorating the spleen and regulating the stomach, the dehumidifying painful abdominal mass that disappears, the < < book on Chinese herbal medicine > > that looks for the truth says: " the strong public affairs that disappear of eating, for spleen QI invigorating the first key medicine also ".Radix Trichosanthis clearing away heat and promoting production of body fluid, nourishing YIN to relieve dryness, < < herbal classic > > says: " tonify deficiency regulating the spleen and stomach, continuous wound absolutely ".Two medicines are assisted the Radix Astragali, and Radix Angelicae Sinensis nourishes QI and blood hypertrophy milk.Assistant is enriched blood capable stagnant with Radix Rhapontici, < < Compendium of Materia Medica > > says: " Radix Rhapontici, lower milk "; Medulla Tetrapanacis ventilation row arteries and veins, < < Japan hanako materia medica > > says: " Medulla Tetrapanacis, stimulating milk secretion "; Retinervus Luffae Fructus is sweet light gentle, suitable the meridian dredging; Fructus Liquidambaris promoting the circulation of QI to alleviate the stagnation in middle-JIAO promoting blood circulation to remove obstruction in the collateral, four compatibilities, the property of borrowing its tonneau, can go the retardance of loose liver (nipple is under Liver Channel) stomach (breast is that stomach is through affiliated) meridians, and gaseous pulse Yong Sai galactozemia and meridians are stagnated, distending pain of the breast, stay and hold evil poison, or carbuncle person, make it to dissipate.Make with big gun Squama Manis, Semen Vaccariae, the special tonneau of merit, walks and does not keep, logical hundred arteries and veins of a surname, and walk help medicine gesture, has the proverb of " river Squama Manis, Wang Buliu, married woman has taken newborn permanent current ".Ten medicine contracts, have the effect of invigorating QI and blood dredging collateral for promoting lactation.
Character: take granule as example, the granule that this product is brown color; Feeble QI is bitter, sweet, the micro-hardship of taste.
Function cures mainly: benefiting QI and nourishing blood, active lactogenesis.
Usage and dosage: take granule as example, each 1 bag, every bag of 10g, every day 3 times, boiled water is taken after mixing it with water, and within 5 days, is 1 course for the treatment of.Auxiliary treatment for agalactosis due to puerperal deficiency of vital energy blood deficiency.Applicable " hypogalactia ", " agalactia " puerpera.
Advantage of the present invention is: 1, reasonable recipe, curative effect is reliable, during observation medication, does not find any toxic and side effects and untoward reaction, has good galgctogogue action.2, through clinical, 150 routine patients being taken to observation post administration, is 98.24% to " hypogalactia " patient effective percentage; To " agalactia " patient effective percentage, be 91.66%, its total effective rate is 96.67%.3, can raise Hb, RBC in blood of this medicine, has benefiting QI and nourishing blood, the effect of the stimulating milk secretion of stimulating the menstrual flow.4, this medicine is to liver, and kidney is harmless.
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.Above or following description, the specific embodiment of the present invention just, various not illustrating is construed as limiting flesh and blood of the present invention.
The specific embodiment
Embodiment 1
It pearl lactogenesis granule: prescription: Radix Astragali Preparata 300g, Radix Angelicae Sinensis 300g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 300g, Radix Trichosanthis 300g, Radix Rhapontici 300g, Squama Manis (vinegar system) 300g, Medulla Tetrapanacis 100g, Retinervus Luffae Fructus 200g, Fructus Liquidambaris 300g, Semen Vaccariae (stir-fry) 300g.
Embodiment 2
It pearl lactogenesis granule method for making: above ten tastes, get Radix Angelicae Sinensis 110g and become fine powder with Rhizoma Atractylodis Macrocephalae 110g powder, get remaining Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici and put extracting in water volatile oil in extraction pot, the another device of volatile oil is preserved, and decocting liquid filters, and filtrate decompression is concentrated into relative density and is 1.20-1.25 (50 ℃ of surveys), standby, separately get all the other seven flavor medicine material and the Radix Angelicae Sinensis such as the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Rhapontici medicinal residues decoct with water three times, add for the first time 8 times of amounts, decoct 2 hours, second, add for the third time 6 times of amounts of water, each decocts 1 hour, gradation filters, merging filtrate, being evaporated to relative density is 1.20-1.25 (50 ℃ of surveys), merge with the extractum such as above-mentioned Radix Angelicae Sinensis, add ethanol triplication, stir, placement is spent the night, filter, decompression filtrate recycling ethanol, concentrated, dry, be ground into fine powder and Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae fine powder and sucrose (1:1.5:5) mix homogeneously, granulate, dry, granulate, the volatile oil such as Radix Angelicae Sinensis are sprayed in granule, airtight 2 hours, subpackage, make 1000g, both.
By this technique, can also make the regular dosage forms such as tablet, capsule.
Experimental example
It pearl lactogenesis granule " control " hypogalactia ", " agalactia " 150 routine clinical reports
" day pearl lactogenesis granule " is a kind of health care medicinal of control women's puerperal " hypogalactia ", " agalactia ".Along with the reach of science, people recognize that breast milk is the optimal wholefood of baby, and breast feeding, direct rooming-in are advocated by WHO at present, develop this medicine and have realistic meaning.In order to verify Changchun Traditional Chinese Medical College's department of obstetrics and gynecology of the clinical efficacy ， Jilin Province Department of Public Health appointment of this medicine, Changchun hospital for obstetrics and gynaecology, spring city, Changchun gynecological of hospital carries out clinical research work, now result is summarized as follows.
One, physical data
1, sex and age
In 150 routine observers, be all young primipara, the age was 20 ~ 24 years old person's 68 example; Age was 25 ~ 30 years old person's 70 example; 30 years old above person's 12 examples; Wherein age reckling is 20 years old, and 40 years old mean age of the maximum is 25.98 years old.
2, occupation and the course of disease
In 150 routine observers, cadre's 16 examples; Workman's 34 examples; Peasant's 27 examples; Intellectual's 13 examples; Other is 60 examples at loose ends.In the course of disease, the shortest person is 2 days, elder 60 days, and average course of disease is 9.28 days.
3, disease classification
In 150 routine observers, examine 114 examples into " hypogalactia " person; " agalactia " person 36 examples.Dialectical genus asthenia of qi and blood weak person 102 examples; Irritability stasis person 48 examples.
Two, observational technique
1, case selection
The milk amount that discharge all puerperal is few, even completely without, inadequate feeding infant person, the traditional Chinese medical science can be examined as " hypogalactia ", " agalactia ".The outpatient service or the inpatient that meet diagnosis all can be used as this product object of observation.
2, administrated method
Give experimenter and take " day pearl lactogenesis granule ", each 1 bag, every day 3 times, warm boiled water, 5 days is 1 course for the treatment of.(for guaranteeing the accuracy of medication effect, during medication, forbidding other galactopoietic).
3, curative effect determinate standard
Effective: after medication, to produce the front showed increased of breast milk, substantially can make neonate have enough; Or supplementary milk is no more than 50ml every day, other symptom person that is not also clearly better.
Effective: after medication, produce breast milk juice and increase, supplement milk to neonate and be no more than 100ml, other symptom improvement person every day.
Invalid: after medication, produce breast milk juice without increase, other symptom is not improved, or before adds severe one.
Three, observed result
1, the total effectively situation of 150 example application " day pearl lactogenesis granule " lactogenic, in Table 1.
Table 1 " day pearl lactogenesis granule " 150 routine lactogenic total effectses
After taking medicine in 150 routine observers as seen from the table, " hypogalactia " effective percentage is 98.24%; " agalactia " effective percentage is 91.66%, and its total effective rate is 96.67%.Learn and process P>o.05 by statistics, illustrate that this medicine is to there was no significant difference in " hypogalactia ", " agalactia " control, all effective.
2, the impact on routine blood test before and after " day pearl lactogenesis granule " medication, in Table 2.
Before and after table 2 " day pearl lactogenesis granule " medication, routine blood test is affected
After visible in table 2 " day pearl lactogenesis granule " medication, in routine blood test, before Hb, RBC, WBC and medicine, all have
Significant difference, can raise Hb, RBC in blood of this medicine, has QI invigorating nourishing blood function as seen.
3, " day pearl lactogenesis granule " impact on observer's routine urinalysis and liver function.
By Partial Observation person liver function medication front and back relatively, and contrast before and after routine urinalysis medication, we find before and after this medicinal medicine, liver function and routine urinalysis all to be changed without obvious, illustrate that this medicine is to liver, and kidney is harmless.
4, before and after " day pearl lactogenesis granule " 150 routine observer's medications, symptom is improved to situation, in Table 3.
Before and after the routine observer's medication of table 3 150, symptom is improved situation
Visible in table 3 " day pearl lactogenesis granule " improves and learns by statistics Ridit analytic process P<O.01 cardinal symptom before and after taking medicine, and illustrates that this medicine is to there being significant differences before and after cardinal symptom medication.
Brief summary and discussion:
Breast milk is baby's best wholefood, and it changes its secretory volume and composition with baby's growth promoter.The few matter of colostrum amount is thick, contains a large amount of protein, fatsoluble vitamin, immunoglobulin.Ripe breast is baby's Main Foods, the about 800ml of secretory volume every day left and right, and the content of fat and lactic acid is higher, also has macrophage, immunocyte, the infection factors such as molten mattress enzyme, breast milk is that Lac Bovis seu Bubali and other all milk replacers are incomparable, is applicable to very much baby's growth promoter.Motherland's Chinese medicine thinks that " The spleen and stomach provide the material basis of the acquired, source of generating QI and blood." so milk be QI and blood life.As Xue Li vegetarian cloud: " blood person essence-QI from water and grain also, turns to essence man, is milk on married woman, and lower is arteries and veins." the strong fortune of taste, QI and blood is sufficient, and QI movement being in harmonious way is the condition that keeps normal lactation, and " day pearl lactogenesis granule " with Squama Manis, Radix Rhapontici etc. are principal agent, have benefiting QI and nourishing blood, the effect of the stimulating milk secretion of stimulating the menstrual flow, product on the galactopoietic of can yet be regarded as.Female after normal pregnancies childbirth, progesterone level declines, prolactin level rises, the newborn phenomenon that occurs oozing, but this medicine preclinical pharmacology, toxicologic study result show, and this medicine has the secretion that strengthens pituitary prolactin, promote the effect of galactopoiesis, long-term excess is taken the hemogram to rat, liver, and kidney merit is harmless, illustrate that this product is good effect, the galactopoietic that safety can take for a long time.
We can make as drawn a conclusion by 150 routine clinical observations, " day pearl lactogenesis granule " truly has good galgctogogue action, its total effective rate is 96.67%, after medication, Hb, RBc in routine blood test are all had to rising trend, prompting this product has benefiting QI and nourishing blood, the effect of enriching blood, well improves and disappears obviously cardinal symptom." day pearl lactogenesis granule " has benefiting QI and nourishing blood as can be seen here, the effect of the stimulating milk secretion of stimulating the menstrual flow, and do not find any toxic and side effects and untoward reaction during observing medication, determine it is the best good medicine of at present domestic and international lactogenic.
Claims (4)
1. a sky pearl lactogenesis medicine, it is characterized in that its effective medicinal components made by the crude drug of following parts by weight: Radix Astragali Preparata 240-360 part, Radix Angelicae Sinensis 240-360 part, Rhizoma Atractylodis Macrocephalae (parched) 240-360 part, Radix Trichosanthis 240-360 part, Radix Rhapontici 240-360 part, vinegar Squama Manis (processed) 240-360 part, Fructus Liquidambaris 240-360 part, Semen Vaccariae (parched) 240-360 part, Medulla Tetrapanacis 80-120 part, Retinervus Luffae Fructus 160-240 part.
2. according to claimed in claim 1 day pearl lactogenesis medicine, it is characterized in that its effective medicinal components made by the crude drug of following parts by weight: 300 parts of Radix Astragali Preparatas, 300 parts of Radix Angelicae Sinensis, 300 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 300 parts of Radix Trichosanthis, 300 parts of Radix Rhapontici, 300 parts of vinegar Squama Manis (processed), 100 parts of Medulla Tetrapanaciss, 200 parts of Retinervus Luffae Fructuss, 300 parts of Fructus Liquidambaris, 300 parts of Semen Vaccariae (parched)s.
3. according to the sky pearl lactogenesis medicine described in claim 1 or 2, it is characterized in that its effective medicinal components is by the crude drug granulation of following weight grams: Radix Astragali Preparata 300g, Radix Angelicae Sinensis 300g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Trichosanthis 300g, Radix Rhapontici 300g, vinegar Squama Manis (processed) 300g, Medulla Tetrapanacis 100g, Retinervus Luffae Fructus 200g, Fructus Liquidambaris 300g, Semen Vaccariae (parched) 300g.
4. a preparation method for day pearl lactogenesis medicine as claimed in claim 3, is characterized in that step is as follows:
(1) get Radix Angelicae Sinensis 110g and become fine powder with Rhizoma Atractylodis Macrocephalae 110g powder;
(2) get remaining Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae and Radix Rhapontici and put extracting in water volatile oil in extraction pot, the another device of volatile oil is preserved, and decocting liquid filters, and it is 1.20-1.25 that filtrate decompression is concentrated into relative density, 50 ℃ of surveys, and extractum is standby;
(3) get all the other seven flavor medicine materials such as the Radix Astragali and Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Rhapontici medicinal residues and decoct with water three times, add for the first time 8 times of amounts, decoct 2 hours, second, third time respectively adds 6 times of amounts of water, each decocts 1 hour, and gradation filters, merging filtrate, being evaporated to relative density is 1.20-1.25,50 ℃ of surveys, merge with step (2) extractum, add ethanol triplication, stir, placement is spent the night, and filters decompression filtrate recycling ethanol, concentrated, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae fine powder and sucrose that to dry, pulverize into fine powder be 1:1.5:5 with ratio are mixed homogeneously, and granulate, dry, granulate;
(4) volatile oil in step (2) is sprayed in granule, airtight 2 hours, subpackage, made 1000g, obtains.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103830502A (en) * | 2014-03-26 | 2014-06-04 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicine composition for lactagogue |
| CN103977202A (en) * | 2014-05-20 | 2014-08-13 | 张跃华 | Pharmaceutical composition and pharmaceutical preparation and preparation method and application thereof |
| CN105434515A (en) * | 2016-01-27 | 2016-03-30 | 林天东 | Traditional Chinese medicine composition and preparation and application thereof |
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| CN103055093A (en) * | 2012-12-23 | 2013-04-24 | 徐化利 | Traditional Chinese medicine prescription for treating postpartum agalactia |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830502A (en) * | 2014-03-26 | 2014-06-04 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicine composition for lactagogue |
| CN103977202A (en) * | 2014-05-20 | 2014-08-13 | 张跃华 | Pharmaceutical composition and pharmaceutical preparation and preparation method and application thereof |
| CN105434515A (en) * | 2016-01-27 | 2016-03-30 | 林天东 | Traditional Chinese medicine composition and preparation and application thereof |
| CN105434515B (en) * | 2016-01-27 | 2018-03-27 | 林天东 | It is a kind of to treat varicocele, fallopian tube obstruction smooth Chinese medicine composition, its preparation and application |
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