CN103599419A - 一种治疗痛风的中药组合物 - Google Patents
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Abstract
本发明涉及一种治疗痛风的中药组合物，它是由以下重量配比的原料药材制备而成：安息香0.6～l.5份、白茅根9～30份、川芎3～10份、独一味2～3份、茯苓10～15份、鸡血藤9～15份、火麻仁10～15份、昆布6～12份、麻黄2～10份、桂枝3～10份。临床实验证明，本发明能够安全有效治疗痛风。
Description
技术领域
本发明涉及一种中药组合物，具体涉及一种治疗痛风的中药组合物。
背景技术
痛风又称“高尿酸血症”，病因为嘌呤代谢障碍，属于关节炎一种。痛风是人体内嘌呤的物质的新陈代谢发生紊乱，尿酸的合成增加或排出减少，造成高尿酸血症，血尿酸浓度过高时，尿酸以钠盐的形式沉积在关节、软骨和肾脏中，引起组织异物炎性反应，即痛风。床特点是：高尿酸血症、急性关节炎反复发作、痛风石形成、慢性关节炎和关节畸形，以及在病程后期出现肾尿酸结石和痛风性肾实质病变。
目前痛风治疗主要是根据临床症状针对给药，主要是在发作期吃秋水仙碱加止痛药，以便快速消炎，解除痛苦，间歇期吃别嘌呤等药物降低尿酸，预防再次发作。消炎止痛药治标不治本；秋水仙碱有严重的毒副反应；别嘌呤等降尿酸药物，不但停药反弹较快，而且经常因为尿酸溶解过快而引起转移性痛风发作。最可怕的是，长期吃这些药物，会损伤肝肾脾，导致无法逆转的痛风反复加剧发作。所以目前很多痛风患者宁可忍着剧痛也不肯吃药。因此研究开发一种安全有效治疗痛风的中药非常有临床实用价值。
本发明中药所涉及药材的研究现状如下：
安息香，本品为安息香科植物白花树Styraxtonkinensis(Pierre)CraibexHart.的干燥树脂。【性味与归经】辛、苦，平。归心、脾经。【功能与主治】开窍醒神，行气活血，止痛。用于中风痰厥，气郁暴厥，中恶昏迷，心腹疼痛，产后血晕，小儿惊风。【用法与用量】0.6～l.5g，多入丸散用。
白茅根，本品为禾本科植物白茅Imperatacylindrica.Beauv.Var.major(Nees)C.E.Hubb.的干燥根茎。【性味与归经】甘，寒。归肺、胃、膀胱经。【功能与主治】凉血止血，清热利尿。用于血热吐血，衄血，尿血，热病烦渴，湿热黄疸，水肿尿少，热淋涩痛。【用法与用量】9～30g。
川芎，本品为伞形科植物川芎LigusticumchuanxiongHort.的干燥根茎。【性味与归经】辛，温。归肝、胆、心包经。【功能与主治】活血行气，祛风止痛。用于胸痹心痛，胸胁刺痛，跌扑肿痛，月经不调，经闭痛经，瘕瘕腹痛，头痛，风湿痹痛。【用法与用量】3～10g。
独一味，本品系藏族习用药材。为唇形科植物独一味Lamz-phlomisrotata(Benth.)Kudo的干燥地上部分。【性味与归经】甘、苦，平。归肝经。【功能与主治】活血止血，祛风止痛。用于跌打损伤，外伤出血，风湿痹痛，黄水病。【用法与用量】2～3g。
茯苓，本品为多孔菌科真菌茯苓Poriacocos(Schw.)Wolf的干燥菌核。【性味与归经】甘、淡，平。归心、肺、脾、肾经。【功能与主治】利水渗湿，健脾，宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。【用法与用量】10～15g。
鸡血藤，本品为豆科植物密花豆SpatholobussuberectusDunn的干燥藤茎。【性味与归经】苦、甘，温。归肝、肾经。【功能与主治】活血补血，调经止痛，舒筋活络。用于月经不调，痛经.经闭，风湿痹痛，麻木瘫痪，血虚萎黄。【用法与用量】9～15g。
火麻仁，本品为桑科植物大麻CannabissativaL.的干燥成熟种子．【性味与归经】甘，平。归脾、胃、大肠经。【功能与主治】润肠通便。用于血虚津亏，肠燥便秘。【用法与用量】10～15g。
昆布，本品为海带科植物海带LaminarriajaponicaAresch.或翅藻科植物昆布EckloniakuromeOkam.的干燥叶状体。【性味与归经】咸，寒。归肝、胃、肾经。【功能与主治】消痰软坚散结，利水消肿。用于瘿瘤，瘰疬，睾丸肿痛，痰饮水肿。【用法与用量】6～12g。
麻黄，本品为麻黄科植物草麻黄EphedrasinicaStapf.中麻黄EphedraintermediaSchrenketC.A.Mey.或木贼麻黄EphedraequisetinaBge.的干燥草质茎。【性味与归经】辛、微苦，温。归肺、膀胱经。【功能与主治】发汗散寒，宣肺平喘，利水消肿。用于风寒感冒，胸闷喘咳，风水浮肿。蜜麻黄润肺止咳。多用于表证已解，气喘咳嗽。【用法与用量】2～10g。
桂枝，本品为樟科植物肉桂CinnamomumcassiaPresl的干燥嫩枝。【性味与归经】辛、甘，温。归心、肺、膀胱经。【功能与主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【用法与用量】3～10g。【注意】孕妇慎用。
发明内容
本发明旨在提供一种治疗痛风的中药组合物，通过选择合适的药材及其配比，达到安全有效治愈痛风的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗痛风的中药组合物，其特征在于，它是由以下重量配比的原料药材制备而成：安息香 0.6～l.5份、白茅根9～30份、川芎3～10份、独一味2～3份、茯苓10～15份、鸡血藤9～15份、火麻仁10～15份、昆布6～12份、麻黄2～10份、桂枝3～10份。
其中优选：安息香 1份、白茅根12份、川芎6份、独一味2.5份、茯苓12份、鸡血藤12份、火麻仁12份、昆布9份、麻黄6份、桂枝8份。
下面结合中医理论说明本方明的有益效果：
发明人在实践过程中发现，痛风是由于寒凉外搏，热血得寒，寒凝血瘀，不通则痛；其夜则痛甚，说明行之于阳；其始之于稍，说明发之于寒。故治疗应从温阳纠正根本，兼之活血化瘀、排毒利尿。
本发明运用：麻黄发汗散寒，利水消肿；桂枝助阳化气，温通经脉；茯苓健脾宁心，以使温阳效果生生不息；安息香行气活血止痛；川芎活血行气，祛风止痛；独一味活血祛风止痛；鸡血藤活血补血，舒筋活络；白茅根清热利尿；火麻仁润肠通便；昆布消痰散结，利水消肿；诸药合用，从而温阳活血、利尿排毒，起到治疗痛风的效果。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年10月-2010年4月间共收集75例痛风患者，其中男55例，女20例，年龄43-65岁，病程2天-3年。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗方法
对照组口服别嘌醇片，按照说明书服用。疗程1个月。
治疗组口服本发明按照具体实施例1制得的胶囊，每日2次。疗程1个月。
2.2观察项目：实验前后，对关节肿痛、发作频率、疼痛程度、病痛蔓延情况等进行观察，实验室检测患者血尿酸、血糖、血脂。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状、实验室检查无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 50 | 42 | 6 | 2 | 1（2%） | 96% |
| 对照组 | 25 | 0 | 13 | 12 | 22（88%） | 52% |
可见，本发明优选实施方式制得的药物能够安全有效治疗痛风。
根据上述临床实验数据，结合本发明治疗痛风的中医学机理分析和本领域公知常识，本领域技术人员容易推知，运用本发明中的药材，在其常规用量范围内取值，即“安息香 0.6～l.5份、白茅根9～30份、川芎3～10份、独一味2～3份、茯苓10～15份、鸡血藤9～15份、火麻仁10～15份、昆布6～12份、麻黄2～10份、桂枝3～10份”，可以取得与本发明优选实施方式制得的药物类似的技术效果。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取安息香 1g、白茅根12g、川芎6g、独一味2.5g、茯苓12g、鸡血藤12g、火麻仁12g、昆布9g、麻黄6g、桂枝8g；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗痛风。口服，每日分早晚两次服用。
实施例2
称取安息香 0.6g、白茅根9g、川芎3g、独一味2g、茯苓10g、鸡血藤9g、火麻仁10g、昆布6g、麻黄2g、桂枝3g；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗痛风。口服，每日一次。
实施例3
称取安息香l.5g、白茅根30g、川芎10g、独一味3g、茯苓15g、鸡血藤15g、火麻仁15g、昆布12g、麻黄10g、桂枝10g；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗痛风。口服，每日分早中晚三次服用。
Claims (2)
1.一种治疗痛风的中药组合物，其特征在于，它是由以下重量配比的原料药材制备而成：安息香 0.6～l.5份、白茅根9～30份、川芎3～10份、独一味2～3份、茯苓10～15份、鸡血藤9～15份、火麻仁10～15份、昆布6～12份、麻黄2～10份、桂枝3～10份。
2.按照权利要求1所述的治疗痛风的中药组合物，其特征在于，它是由以下重量配比的原料药材制备而成：安息香 1份、白茅根12份、川芎6份、独一味2.5份、茯苓12份、鸡血藤12份、火麻仁12份、昆布9份、麻黄6份、桂枝8份。
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| CN101401846A (zh) * | 2008-11-09 | 2009-04-08 | 刘爱玲 | 一种治疗痹症的中药制剂 |
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